Yimuphi umdlavuza ongazuza ngokufaka i-Myricetin ekudleni kwabo?

Amaphuzu avelele

I-Myricetin yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kweMyricetin ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Myricetin ingase izuze labo abane-Primary Penile Squamous Cell Carcinoma abathola i-Mitomycin, kodwa kungase kungabi kuhle ezigulini ezithola i-Pembrolizumab ye-Primary High-Grade Neuroepithelial Tumor. Ngaphezu kwalokho, nakuba i-Myricetin ingasiza abantu abane-genetic risk factor "ALK", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "ASXL1". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Myricetin esigulini somdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Myricetin iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana neMyricetin esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile uphakama: Ingabe kufanele ufake i-Myricetin ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyatuseka ukuthi udle i-Myricetin uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-ALK? Kuthiwani uma esikhundleni salokho ubungozi bakho bofuzo busukela kufuzo lwe-ASXL1? Ingabe kunenzuzo ukufaka i-Myricetin ekudleni kwakho uma kutholakala ukuthi une-Primary High-Grade Neuroepithelial Tumor, noma uma ukuxilongwa kwakho kuyi-Primary Penile Squamous Cell Carcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Myricetin kufanele kulungiswe kanjani uma welashelwa i-Mitomycin noma uma uhlelo lwakho lokwelapha lusuka ku-Mitomycin luye e-Pembrolizumab? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'Myricetin ingokwemvelo, ngakho-ke ihlale inenzuzo' noma 'I-Myricetin inyusa ukuzivikela komzimba' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Myricetin ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Myricetin ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kofuzo kunikeza isithembiso esibalulekile ekuhloleni ubungozi bomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma sekutholakele ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Penile Squamous Cell Carcinoma noma i-Primary High-Grade Neuroepithelial Tumor, amasu okwelapha kudingeka enziwe ngendlela oyifisayo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka neminyaka. ubulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ngabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga umdlavuza othize lapho unquma ngokukhetha ukudla, njengeMyricetin. Ingabe ingozi yofuzo yomdlavuza obangelwa ukuguqulwa kwe-ALK inemithelela efanayo ye-biochemical pathway njengoguquko ku-ASXL1? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Penile Squamous Cell Carcinoma ilingana ne-Primary High-Grade Neuroepithelial Tumor? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Pembrolizumab njengalabo abathola i-Mitomycin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Myricetin - Isengezo Somsoco

Isengezo se-Myricetin sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Myricetin, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-MAPK Signaling, i-Oncogenic Cancer Epigenetics kanye ne-EPHRIN Signaling, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kweseli. Njengoba kunikezwe leli thonya lezinto eziphilayo, ukukhetha izithasiselo ezifanele njenge-Myricetin, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa i-Myricetin yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kweMyricetin akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithako ze-Myricetin

Ukubhekana nombuzo othi 'Kufanele ngiyigweme nini i-Myricetin esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo zeMyricetin kuyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Myricetin ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe I-Myricetin Supplements izozizuzisa Iziguli Ze-Primary High-Grade Neuroepithelial Tumor ezelashwa nge-Pembrolizumab?

I-Primary High-Grade Neuroepithelial Tumor ibonakala ngokuguqulwa kofuzo okuthile, okuyi-ASXL1, DNMT3A kanye ne-MYCN, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Oncogenic Cancer Epigenetics, i-Suppressive Histone Methylation, i-Focal Adhesion kanye ne-Cell Cycle. Ukusebenza kokwelashwa komdlavuza, okufana ne-Pembrolizumab, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isengezo se-Myricetin, esithinta i-Oncogenic Cancer Epigenetics, ingase ingabi yisinqumo esifanele esimweni se-Primary High-Grade Neuroepithelial Tumor lapho i-Pembrolizumab. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo ze-Myricetin zizozizuzisa Iziguli Eziyinhloko ze-Penile Squamous Cell Carcinoma ezelashwa nge-Mitomycin?

I-Primary Penile Squamous Cell Carcinoma ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-ABRAXAS1, PIK3CB kanye ne-NUP93, okuholela ezinguqukweni zemizila ye-biochemical, ikakhulukazi i-MAPK Signaling, Hematopoiesis kanye ne-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, njenge-Mitomycin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Myricetin siyinketho enengqondo kulabo abane-Primary Penile Squamous Cell Carcinoma abathola i-Mitomycin. Lokhu kungenxa yokuthi i-Myricetin ithonya izindlela ezifana ne-MAPK Signaling, engavimbela izici ezishayela i-Primary Penile Squamous Cell Carcinoma noma izuzise ukusebenza kahle kwe-Mitomycin.

3. Ingabe Izithasiselo Ze-Myricetin Ziphephile Kubantu Abanempilo Nge-ASXL1 Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-ASXL1 luvamise ukufakwa kulawa maphaneli okuhlolwa kwengozi yomdlavuza.

Ukuguqulwa kwezakhi zofuzo ze-ASXL1 kuthinta izindlela noma izinqubo ze-biochemical, njenge-Oncogenic Cancer Epigenetics kanye ne-Suppressive Histone Methylation, ehileleke ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ikhomba uguquko ku-ASXL1 ehambisana nengozi eyandayo ye-Chronic Myelomonocytic Leukemia, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwe-Myricetin eyengeziwe. Lokhu kungenxa yokuthi ukwesekwa kwe-Myricetin kuthonya izindlela ezifana ne-Oncogenic Cancer Epigenetics, engaholela emiphumeleni emibi kumongo wokuguqulwa kwe-ASXL1 kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo Ze-Myricetin Ziphephile Kubantu Abanempilo Ene-ALK Mutation Ehlobene Nengozi Yofuzo?

I-ALK idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-ALK kungaphazamisa izindlela ezibalulekile zamakhemikhali ezinto eziphilayo, okuhlanganisa i-EPHRIN Signaling kanye ne-Growth Factor Signaling, okuthonya ukukhula komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-ALK ehambisana ne-Central Nervous System, cabanga ukufaka izithasiselo ze-Myricetin ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-EPHRIN Signaling, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-ALK kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Myricetin, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• I-PD-1 blockade idala izimpendulo ngokuvimbela ukumelana nokuzivikela komzimba.
• cBioPortal for Cancer Genomics
• I-Hypoxia Ikhuthaza Ukubambisana phakathi kwe-Mitomycin C ne-Bortezomib ngokusebenzisa Inqubo Edidiyelwe ye-Bcl-xL Phosphorylation kanye Ne-Mitochondrial Translocation ye-p53.
• Ama-Flavonoids njengama-receptor tyrosine kinase FLT3 inhibitors.
• Ukwelashwa komdlavuza kulolonga isimo sokufaneleka se-clonal hematopoiesis.
• cBioPortal for Cancer Genomics