Yimuphi umdlavuza ongahlomula ngokufaka i-Eicosapentaenoic Acid ekudleni kwabo?

Amaphuzu avelele

I-Eicosapentaenoic Acid yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivamise ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kwe-Eicosapentaenoic Acid yeziguli ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Eicosapentaenoic Acid ingase izuzise labo abane-Primary Adamantinoma abathola iRadiation, kodwa kungase kungabi kuhle ezigulini ezithola i-Imatinib for Primary Hypopharyngeal Cancer. Ngaphezu kwalokho, nakuba i-Eicosapentaenoic Acid ingasiza abantu abanesici sengozi yofuzo “CTNNB1”, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Eicosapentaenoic Acid yesiguli esinomdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Eicosapentaenoic Acid iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/ezithasiselweni ezifana ne-Eicosapentaenoic Acid esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Eicosapentaenoic Acid ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle i-Eicosapentaenoic Acid uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-CTNNB1? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela esakhiweni sofuzo? Ingabe kunenzuzo ukufaka i-Eicosapentaenoic Acid ekudleni kwakho uma kutholakala ukuthi Unomdlavuza Oyinhloko we-Hypopharyngeal, noma uma ukuxilongwa kwakho kuyi-Primary Adamantinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Eicosapentaenoic Acid kufanele kulungiswe kanjani uma welashwa ngeRadiation noma uma uhlelo lwakho lokwelapha lusuka ku-Radiation luye e-Imatinib? Kubalulekile ukuqaphela ukuthi ukugomela okulula okufana ne-'Eicosapentaenoic Acid kungokwemvelo, ngakho kuhlale kunenzuzo' noma 'I-Eicosapentaenoic Acid ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Eicosapentaenoic Acid ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Eicosapentaenoic Acid ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. izibikezelo, kanye nokukhetha kwendlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Adamantinoma noma I-Primary Hypopharyngeal Cancer, amasu okwelapha kudingeka enziwe ngendlela oyifisayo ngokusekelwe kufuzo lomuntu ngamunye, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokukhetha ukudla, njenge-Eicosapentaenoic Acid. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-CTNNB1 inemithelela efanayo yendlela ye-biochemical njengokuguqulwa kwesinye isakhi sofuzo? Ngokombono wokudla okunempilo, ingabe ubungozi obuhlobene ne-Primary Adamantinoma bulingana ne-Primary Hypopharyngeal Cancer? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Imatinib njengalabo abathola iRadiation? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Eicosapentaenoic Acid - Isengezo Somsoco

Isithasiselo se-Eicosapentaenoic Acid sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Eicosapentaenoic Acid, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-Epithelial to Mesenchymal Transition and Oxidative Stress, elawula izici ezibucayi zomdlavuza ezingeni lamangqamuzana, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Njengoba kunikezwe leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njenge-Eicosapentaenoic Acid, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla okunomdlavuza. Uma ucabangela ukusebenzisa i-Eicosapentaenoic Acid yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Eicosapentaenoic Acid akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha i-Eicosapentaenoic Acid Supplements

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngiyigweme i-Eicosapentaenoic Acid esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Eicosapentaenoic Acid kuyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Eicosapentaenoic Acid ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu. ezinqumweni ezinjalo.

1. Ingabe I-Eicosapentaenoic Acid Supplements izozizuzisa Iziguli Zomdlavuza we-Hypopharyngeal ezilashwa i-Imatinib?

I-Primary Hypopharyngeal Cancer ibonakala ngokuguqulwa kwezakhi zofuzo ezithile, okuyi-TP53, KMT2D kanye ne-ALK, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Oxidative Stress, Cell Cycle Checkpoints, i-Apoptosis, i-Oncogenic Histone Methylation, i-Amino Acid Metabolism, I-Growth Factor Signaling kanye ne-JAK-STAT. Ukusayina. Ukusebenza kokwelashwa komdlavuza, okufana ne-Imatinib, kuncike endleleni yayo yokusebenza kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Eicosapentaenoic Acid, esithinta i-Oxidative Stress, kungenzeka kungabi yisinqumo esifanele esimweni se-Primary Hypopharyngeal Cancer lapho uphathwa i-Imatinib. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izengezo ze-Eicosapentaenoic Acid zizozizuzisa Iziguli Eziyinhloko ze-Adamantinoma ezenza Ukwelashwa Ngemisebe?

I-Adamantinoma eyinhloko ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-ARHGAP45, PI4KB kanye ne-SDSL, okuholela ezinguqukweni zemizila ye-biochemical, ikakhulukazi i-Epithelial to Mesenchymal Transition kanye ne-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, njengeRadiation, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Eicosapentaenoic Acid siyinketho enengqondo kulabo abane-Primary Adamantinoma abathola iRadiation. Lokhu kungenxa yokuthi i-Eicosapentaenoic Acid ithonya izindlela ezifana ne-Epithelial kuya ku-Mesenchymal Transition, engavimbela izici ezishayela i-Primary Adamantinoma noma izuzise ukusebenza ngempumelelo Kokushisisa.

3. Ingabe Izithasiselo Ze-Eicosapentaenoic Acid Ziphephile Kubantu Abanempilo Ene-CTNNB1 Mutation Associated Genetic Risk?

I-CTNNB1 idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-CTNNB1 kungaphazamisa izindlela ezibalulekile zamakhemikhali ezinto eziphilayo, okuhlanganisa i-Adherens junction kanye ne-Epithelial to Mesenchymal Transition, okuthonya ukukhula komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-CTNNB1 ehambisana ne-Adrenocortical Carcinoma, cabanga ukufaka izithasiselo ze-Eicosapentaenoic Acid ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Epithelial kuya ku-Mesenchymal Transition, zizuze ngokunikeza ukwesekwa okufanelekile kwabantu abanezinguquko ze-CTNNB1 kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithasiselo ezifana ne-Eicosapentaenoic Acid, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• cBioPortal for Cancer Genomics
• I-Molecular Landscape ye-Recurrent and Metastatic Head and Neck Cancers: Imibono Evela Ku-Precision Oncology Sequencing Platform.
• I-Eicosapentaenoic acid ivimbela ukusinda kwe-CSF-induced human monocyte kanye nokuvuthwa ku-macrophage ngokugqugquzela ukukhiqizwa kwe-H2O2.
• Ubudlelwano bokucindezeleka okwenziwe nge-oxidative ekumelaneni ne-imatinib ezigulini zaseTunisia ezine-myeloid leukemia engapheli: isifundo esibuyela emuva.
• Imiphumela evimbelayo ye-eicosapentaenoic acid ehlanzekile kanye ne-docosahexaenoic acid ekukhuleni kanye ne-metastasis ye-murine transplantable mammary tumor.
• cBioPortal for Cancer Genomics
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• Ukumelana nomsakazo kumaseli omdlavuza webele kulamula nge-TGF-β signalling, hybrid epithelial-mesenchymal phenotype kanye namaseli omdlavuza.