Yimuphi umdlavuza ongazuza ngokufaka isitshalo seqanda ekudleni kwabo?

Amaphuzu avelele

Isitshalo seqanda saziwa kabanzi ngezinzuzo zaso zezempilo futhi sivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Nokho, ukuphepha nokusebenza kahle kwe-Eggplant ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, isitshalo seqanda singazuzisa labo abane-Primary Solitary Fibrous Tumor abathola i-Avastin, kodwa kungase kungabi kuhle ezigulini ezithola i-Gemcitabine ye-Primary Sarcomoid Carcinoma ye-Urinary Bladder. Ngaphezu kwalokho, nakuba isitshalo seqanda singasiza abantu abanesici esiyingozi sofuzo “TERT”, angeke siphakanyiswe kulabo abasengozini yofuzo ehlukile “ATM”. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo ngokufaneleka kwe-Eggplant esigulini esinomdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi isitshalo seqanda siyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana nesitshalo seqanda esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukusishaya indiva ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake isitshalo seqanda ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle isitshalo seqanda uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-TERT? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela kufuzo lwe-ATM? Ingabe kunenzuzo ukufaka isitshalo seqanda ekudleni kwakho uma kutholakala ukuthi une-Primary Sarcomoid Carcinoma of the Urinary Bladder, noma uma ukuxilongwa kwakho kuyi-Primary Solitary Fibrous Tumor? Ngaphezu kwalokho, ukusebenzisa kwakho Isitshalo seqanda kufanele kulungiswe kanjani uma welashwa nge-Avastin noma uma uhlelo lwakho lokwelapha lusuka ku-Avastin luye ku-Gemcitabine? Kubalulekile ukuqaphela ukuthi ukugomela okulula okufana nokuthi 'Isitshalo seqanda singokwemvelo, ngakho sihlala sinenzuzo' noma 'Isitshalo seqanda sithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka isitshalo seqanda ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Eggplant ekudleni kwakho ukuze uthole izinzuzo zaso, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kofuzo kunikeza isithembiso esibalulekile ekuhloleni ubungozi bomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma sekutholakele ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Solitary Fibrous Tumor noma i-Primary Sarcomatoid Carcinoma ye-Urinary Bladder, amasu okwelapha kudingeka enziwe ngendlela oyifisayo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka neminyaka. ubulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokukhetha ukudla, njenge-Eggplant. Ingabe ingozi yofuzo yomdlavuza obangelwa ukuguqulwa kwe-TERT inemithelela efanayo ye-biochemical pathway njengoguquko ku-ATM? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Solitary Fibrous Tumor ilingana ne-Primary Sarcomoid Carcinoma ye-Urinary Bladder? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kufana nalabo abathola i-Gemcitabine njengalabo abathola i-Avastin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

Isitshalo seqanda - Isengezo Esinomsoco

Isitshalo seqanda esengeziwe sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Vitamin C, i-Linoleic Acid, i-Octadecanoic Acid, i-Retinol ne-L-histidine, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-MYC Signaling, i-MAPK Signaling kanye ne-DNA Repair, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele ezifana ne-Eggplant, iyodwa noma ihlanganiswe, kuba yisinqumo esibalulekile kumongo wokudla okunomdlavuza. Uma ucabangela ukusebenzisa i-Eggplant ngomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Eggplant akusona isinqumo esifanelekile kuwo wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithako zesitshalo seqanda

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngigweme isitshalo seqanda esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Eggplant kuyehluka kuye ngezimo zomuntu siqu. Izinto ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi isitshalo seqanda sifanelekile noma kufanele sigwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe Izithasiselo Zesitshalo Seqanda zizohlomula I-Primary Sarcomoid Carcinoma yeziguli ze-Urinary Bladder ezelashwa nge-Gemcitabine?

I-Primary Sarcomoid Carcinoma ye-Urinary Bladder ibonakala ngokuguqulwa okuthile kofuzo, okuyi-ERCC2, KRAS kanye ne-LATS2, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi Ukusayinda kwe-MAPK, Ukulungiswa Kwe-DNA, Ukulungiswa kabusha kwe-Chromatin, Ukusayinwa kwe-G-protein-coupled Receptor, Ukusayinwa kwe-Growth Factor Signaling. kanye neHippo Signaling. Ukusebenza kokwelashwa komdlavuza, okufana ne-Gemcitabine, kuncike endleleni yayo yokusebenza kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo sesitshalo seqanda, esithinta Ukusayinda kwe-MAPK, kungase kungabi inketho efanele esimweni se-Primary Sarcomoid Carcinoma ye-Urinary Bladder lapho i-Gemcitabine. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo Zesitshalo Seqanda zizozizuzisa Iziguli Eziyinhloko Zodwa Ezine-Fibrous Tumor ezelashwa nge-Avastin?

I-Primary Solitary Fibrous Tumor ibonakala ngokuguqulwa kofuzo okukhethekile, okufana ne-BRD4, FLI1 kanye ne-KMT2C, okuholela ezinguqukweni zezindlela ze-biochemical, ikakhulukazi i-MYC Signaling, i-Chromatin Remodeling, i-DNA Repair, i-Oncogenic Histone Methylation kanye ne-Amino Acid Metabolism. Ukusebenza kokwelashwa komdlavuza, njenge-Avastin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Eggplant siyindlela enengqondo kulabo abane-Primary Solitary Fibrous Tumor ababhekana ne-Avastin. Lokhu kungenxa yokuthi isitshalo seqanda sithonya izindlela ezifana ne-MYC Signaling, engavimbela izici eziqhuba I-Primary Solitary Fibrous Tumor noma izuzise ukusebenza kahle kwe-Avastin.

3. Ingabe Izithasiselo Zesitshalo Seqanda Ziphephile Kubantu Abanempilo Ene-ATM Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-ATM luvamise ukufakwa kulawa maphaneli ukuze kuhlolwe ingozi yomdlavuza.

Ukuguqulwa kofuzo lwe-ATM kuthinta izindlela zamakhemikhali ezinto eziphilayo noma izinqubo, ezifana nokulungiswa kwe-DNA, ezibandakanyeka ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ihlonza uguquko ku-ATM oluhambisana nengozi eyengeziwe Ye-Chronic Myelomonocytic Leukemia, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwesitshalo seqanda sesengezo. Lokhu kungenxa yokuthi isengezo se-Eggplant sithonya izindlela ezifana nokulungiswa kwe-DNA, okungaholela emiphumeleni emibi kumongo wokuguqulwa kwe-ATM kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo Zesitshalo Seqanda Ziphephile Kubantu Abanempilo Ene-TERT Mutation Associated Genetic Risk?

I-TERT idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-TERT kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa Ukusayina kwe-MAPK kanye Nokulungiswa KweDNA, okunomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula ukuguqulwa kwe-TERT ehlotshaniswa ne-Hematological Cancer, cabanga ukufaka izithako zesitshalo seqanda ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-MAPK Signaling, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-TERT kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Eggplant, kuyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Ukwenziwa kusebenze kwe-PPAR gamma kanye ne-delta nge-conjugated linoleic acid kulamula ukuvikela esifweni sokuhlola samathumbu esivuvukalayo.
• Uvithamini C ubulala ngokukhetha amaseli omdlavuza we-colorectal we-KRAS kanye ne-BRAF ngokukhomba i-GAPDH.
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• cBioPortal for Cancer Genomics
• Ukuguqulwa kokumelana nezidakamizwa eziningi nge-gefitinib nge-RAF1/ERK indlela kumugqa weseli lomdlavuza we-pancreatic.
• cBioPortal for Cancer Genomics
• Indima ye-tumor microenvironment ekumelaneni ne-anti-angiogenic therapy.