Yimuphi umdlavuza ongahlomula ngokufaka Imbewu Emnyama ekudleni kwabo?

Amaphuzu avelele

Imbewu Emnyama yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Nokho, ukuphepha nokusebenza kahle kwe-Black Seed ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, Imbewu Emnyama ingase izuze labo abane-Primary Glioblastoma abathola i-Temozolomide. Ngaphezu kwalokho, nakuba Imbewu Emnyama ingasiza abantu abanesici sofuzo esiyingozi “TERT”, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kweMbewu Emnyama esigulini esinomdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi Imbewu Emnyama iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana ne-Black Seed esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele uhlanganise Imbewu Emnyama ekudleni kwakho njengento yokudla noma isengezo? Kuyafaneleka yini ukuthi udle Imbewu Emnyama uma unesimo sofuzo somdlavuza esihambisana nofuzo lwe-TERT? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela esakhiweni sofuzo? Ingabe kunenzuzo ukufaka Imbewu Emnyama ekudleni kwakho uma kutholakala ukuthi une-Primary Glioblastoma? Ngaphezu kwalokho, ukusebenzisa kwakho Imbewu Emnyama kufanele kulungiswe kanjani uma welashwa nge-Temozolomide noma uma uhlelo lwakho lokwelapha lusuka ku-Temozolomide? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'Imbewu Emnyama ingokwemvelo, ngakho ihlale inenzuzo' noma 'Imbewu Emnyama ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka Imbewu Emnyama ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Black Seed ekudleni kwakho ukuze uthole izinzuzo zako, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. izibikezelo, kanye nokukhetha kwendlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Glioblastoma, amasu okwelapha kudingeka enziwe ngokwezifiso ngokusekelwe kufuzo lomuntu ngamunye, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga okuthile komdlavuza lapho unquma ngokukhetha ukudla, njengeMbewu Emnyama. Ingabe ubungozi bofuzo lomdlavuza osukela ekuguqukeni kwe-TERT bunomthelela ofanayo we-biochemical pathway njengokuguqulwa kofuzo? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Glioblastoma ilingana nomunye umdlavuza? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola olunye ukwelashwa njengalabo abathola i-Temozolomide? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

Imbewu Emnyama – Isengezo Esinomsoco

Isithasiselo Sembewu Emnyama sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Thymol, i-Carvacrol ne-Thymoquinone, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-MAPK Signaling, Small Molecule Transport kanye neCell Cycle, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njengeMbewu Emnyama, iyodwa noma ihlangene, kuba yisinqumo esibalulekile kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa Imbewu Emnyama yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufanayo nokwelapha umdlavuza, ukusetshenziswa kwe-Black Seed akusona isinqumo esilungele wonke umuntu onesifo somdlavuza kodwa sidinga ukwenziwa umuntu siqu.

Ukukhetha Izithasiselo Zembewu Emnyama

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngigweme Imbewu Emnyama endabeni Yomdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Black Seed kuyehluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi iNzalo Emnyama ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu. ezinqumweni ezinjalo.

1. Ingabe Izithasiselo Zembewu Emnyama Zizosiza Iziguli Eziyinhloko ze-Glioblastoma ezelashwa nge-Temozolomide?

I-Glioblastoma eyinhloko ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-TRBV7-7, TAS2R46 ne-TP53, okuholela ezinguqukweni zemizila yamakhemikhali ezinto eziphilayo, ikakhulukazi i-MAPK Signaling, Cell Cycle Checkpoints kanye ne-Apoptosis. Ukusebenza kokwelashwa komdlavuza, njengeTemozolomide, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo Sembewu Emnyama siyinketho enengqondo yalabo abane-Primary Glioblastoma abathola i-Temozolomide. Lokhu kungenxa yokuthi Imbewu Emnyama ithonya izindlela ezifana ne-MAPK Signaling, engavimbela izici ezishayela i-Primary Glioblastoma noma izuzise ukusebenza kahle kwe-Temozolomide.

2. Ingabe Izithasiselo Zembewu Emnyama Ziphephile Kubantu Abanempilo Enempilo Ene-TERT Mutation Associated Genetic Risk?

I-TERT idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-TERT kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-Cell Cycle kanye ne-DNA Repair, okunomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-TERT ezihlobene Nomdlavuza Wegazi, cabanga ukufaka izithasiselo Zembewu Emnyama ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Cell Cycle, zizuze ngokunikeza ukwesekwa okufanelekile kwabantu abanezinguquko ze-TERT kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza kanye nokudla okunomsoco akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Black Seed, kuyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• cBioPortal for Cancer Genomics
• I-Cytochrome P450 kanye ne-P-Glycoprotein-Mediated Interactions Efaka Amakhambi ase-Afrika Akhonjiswe Izifo Ezivamile Ezingathathelwana.
• Ukusayinda kwe-MEK-ERK kunquma ukusho kofuzo lokulungisa i-DNA ye-MGMT kanye nokumelana ne-temozolomide kwamaseli e-glioblastoma anjengesiqu nge-eksisi ye-MDM2-p53.
• I-cumin emnyama (i-Nigella sativa) kanye nengxenye yayo (i-thymoquinone): ukubuyekezwa kwemiphumela ye-antimicrobial.
• I-Carvacrol ivimbela ukwanda futhi idala i-apoptosis kumaseli omdlavuza wekoloni lomuntu.
• I-somatic genomic landscape ye-glioblastoma.
• I-Carvacrol icindezela izimpendulo zokuvuvukala ku-rheumatoid arthritis fibroblast-like synoviocytes.