Yimuphi umdlavuza ongahlomula ngokufaka iBlack Cohosh ekudleni kwabo?

Amaphuzu avelele

IBlack Cohosh yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivamise ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kweBlack Cohosh ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Black Cohosh ingase izuze labo abane-Primary Penile Squamous Cell Carcinoma abathola i-Mitomycin, kodwa kungase kungabi kuhle ezigulini ezithola i-Pembrolizumab ye-Primary Mucinous Stomach Adenocarcinoma. Ngaphezu kwalokho, nakuba i-Black Cohosh ingasiza abantu abanesici sofuzo esiyingozi “CDKN2A”, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo ngokufaneleka kweBlack Cohosh esigulini esinomdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Black Cohosh iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana neBlack Cohosh esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake iBlack Cohosh ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle iBlack Cohosh uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-CDKN2A? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela esakhiweni sofuzo? Ingabe kunenzuzo ukufaka i-Black Cohosh ekudleni kwakho uma kutholakala ukuthi une-Primary Mucinous Stomach Adenocarcinoma, noma uma ukuxilongwa kwakho kuyi-Primary Penile Squamous Cell Carcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Black Cohosh kufanele kulungiswe kanjani uma welashelwa i-Mitomycin noma uma uhlelo lwakho lokwelapha lusuka ku-Mitomycin luye e-Pembrolizumab? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'I-Black Cohosh ingokwemvelo, ngakho ihlale inenzuzo' noma 'i-Black Cohosh ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Black Cohosh ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana neBlack Cohosh ekudleni kwakho ukuze uthole izinzuzo zako, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. izibikezelo, kanye nokukhetha kwendlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Penile Squamous Cell Carcinoma noma i-Primary Mucinous Stomach Adenocarcinoma, amasu okwelapha kudingeka enziwe ngendlela oyiyo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili. ”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga umdlavuza othize lapho unquma ngokukhetha ukudla, njengeBlack Cohosh. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-CDKN2A inemithelela efanayo ye-biochemical pathway njengokuguqulwa kofuzo? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Penile Squamous Cell Carcinoma ilingana ne-Primary Mucinous Stomach Adenocarcinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Pembrolizumab njengalabo abathola i-Mitomycin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Black Cohosh - Isengezo Sokudla Okunomsoco

Isithasiselo i-Black Cohosh sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Isoferulic Acid, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-Cell Cycle, i-Interferon Signaling kanye ne-Insulin Signaling, elawula izici ezibucayi zomdlavuza ezingeni lamangqamuzana, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njenge-Black Cohosh, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla okunomdlavuza. Uma ucabangela ukusebenzisa i-Black Cohosh yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kweBlack Cohosh akusona isinqumo esifanelekile kuwo wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithasiselo ze-Black Cohosh

Ukubhekana nombuzo othi 'Kufanele ngimgweme nini uBlack Cohosh esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Black Cohosh kuyahlukahluka kuye ngezimo zomuntu siqu. Izinto ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithasiselo ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi iBlack Cohosh ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucabangela komuntu siqu. ezinqumweni ezinjalo.

1. Ingabe I-Black Cohosh Supplements izozizuzisa Iziguli Eziyi-Primary Mucinous Stomach Adenocarcinoma ezelashwa nge-Pembrolizumab?

I-Primary Mucinous Stomach Adenocarcinoma ibonakala ngokuguqulwa kofuzo okuthile, okuyi-GRIN3A, TMEM26 kanye ne-TP53, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Interferon Signaling, i-Cell Cycle Checkpoints kanye ne-Apoptosis. Ukusebenza kokwelashwa komdlavuza, okufana ne-Pembrolizumab, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Black Cohosh, esithinta i-Interferon Signaling, kungase kungabi inketho efanele esimweni se-Primary Mucinous Stomach Adenocarcinoma lapho uphathwa i-Pembrolizumab. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe I-Black Cohosh Supplements izozizuzisa Iziguli Eziyinhloko Zomdlavuza We-Penile Squamous Cell Ezokwelapha I-Mitomycin?

I-Primary Penile Squamous Cell Carcinoma ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-ABRAXAS1, PIK3CB kanye ne-NUP93, okuholela ezinguqukweni zemizila ye-biochemical, ikakhulukazi i-Cell Cycle, Hematopoiesis kanye ne-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, njenge-Mitomycin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Black Cohosh siyindlela enengqondo yalabo abane-Primary Penile Squamous Cell Carcinoma abathola i-Mitomycin. Lokhu kungenxa yokuthi i-Black Cohosh ithonya izindlela ezifana ne-Cell Cycle, engavimbela izici ezishayela i-Primary Penile Squamous Cell Carcinoma noma izuzise ukusebenza kahle kwe-Mitomycin.

3. Ingabe Izithasiselo Ze-Black Cohosh Ziphephile Kubantu Abanempilo Nge-CDKN2A Mutation Associated Genetic Risk?

I-CDKN2A idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-CDKN2A kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa izindawo zokuhlola i-Cell Cycle kanye ne-Cell Cycle, ezithonya ukukhula komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-CDKN2A ehlotshaniswa Nomdlavuza Wesikhumba, cabanga ukufaka izithasiselo ze-Black Cohosh ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Cell Cycle, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-CDKN2A kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza kanye nokudla okunomsoco akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithasiselo ezifana neBlack Cohosh, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Amasethi angaphansi achazwe ngokofuzo omdlavuza we-pancreatic womuntu abonisa i-in vitro chemosensitivity ehlukile.
• cBioPortal for Cancer Genomics
• cBioPortal for Cancer Genomics
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• Ukwelashwa komdlavuza kulolonga isimo sokufaneleka se-clonal hematopoiesis.
• I-Isoferulic acid ivimbela ukukhula kweseli leukemia yabantu ngokungeniswa kokuboshwa kwesigaba se-G2/M‑ kanye nokuvinjwa kokusayina kwe-Akt/mTOR.
• [Ukwelashwa ngokuhlinzwa kokulunywa okuvulekile].
• Izingcaphuno ezinamanzi ze-Cimicifuga racemosa kanye nezakhi ze-phenolcarboxylic zivimbela ukukhiqizwa kwama-cytokines ane-proinflammatory egazini eliphelele lomuntu elivuselelwe yi-LPS.