Yimuphi umdlavuza ongazuza ngokufaka i-Andrographis ekudleni kwabo?

Amaphuzu avelele

I-Andrographis yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kwe-Andrographis ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Andrographis ingase izuze labo abane-Primary Glioblastoma abathola i-Temozolomide, kodwa ingase ingabi yinhle ezigulini ezithola i-Carmustine ye-Primary Pineoblastoma. Ngaphezu kwalokho, nakuba i-Andrographis ingasiza abantu abanesici sengozi yofuzo “CDKN2A”, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo ngokufaneleka kwe-Andrographis esigulini somdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Andrographis iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingavela, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kuhambisane nezinguquko zesimo sezempilo nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana ne-Andrographis esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Andrographis ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyancomeka ukuthi udle i-Andrographis uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-CDKN2A? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela kolunye ufuzo? Ingabe kunenzuzo ukufaka i-Andrographis ekudleni kwakho uma kutholakala ukuthi une-Primary Pineoblastoma, noma uma ukuxilongwa kwakho kuyi-Primary Glioblastoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Andrographis kufanele kulungiswe kanjani uma uthola ukwelashwa kwe-Temozolomide noma uma uhlelo lwakho lokwelapha lusuka ku-Temozolomide luye eCarmustine? Kubalulekile ukuqaphela ukuthi ukugomela okulula okufana ne-‘Andrographis kungokwemvelo, ngakho kuhlale kunenzuzo’ noma ‘I-Andrographis ithuthukisa ukungatheleleki’ akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Andrographis ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Andrographis ekudleni kwakho ukuze uthole izinzuzo zako, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Glioblastoma noma i-Primary Pineoblastoma, amasu okwelapha kudingeka enziwe ngendlela oyifisayo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi kumele kufakwe engcupheni yofuzo kanye nokuxilonga umdlavuza othize lapho unquma ngokudla okukhethwa kukho, njenge-Andrographis. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-CDKN2A inemithelela efanayo ye-biochemical pathway njengokuguqulwa kofuzo? Ngokombono wokudla okunempilo, ingabe ubungozi obuhlobene ne-Primary Glioblastoma bulingana ne-Primary Pineoblastoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kufana kulabo abathola i-Carmustine njengalabo abathola i-Temozolomide? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Andrographis - Isengezo Sokudla Okunomsoco

Isithasiselo se-Andrographis sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Andrographolide, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-Cell Cycle kanye ne-Oncogenic Cancer Epigenetics, elawula izici ezibucayi zomdlavuza ezingeni lamangqamuzana, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njenge-Andrographis, iyodwa noma ihlanganiswe, kuba yisinqumo esibucayi kumongo wokudla okunomdlavuza. Lapho ucabangela ukusebenzisa i-Andrographis yomdlavuza, kubalulekile ukucabangela lezi zici ezihlukahlukene nezindlela. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Andrographis akusona isinqumo esifanelekile kuwo wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithasiselo ze-Andrographis

Ukubhekana nombuzo othi ‘Kunini lapho kufanele ngigweme i-Andrographis kumongo womdlavuza’ kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - imane nje ithi ‘Kuyame!’. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Andrographis kuyahlukahluka kuye ngezimo zomuntu siqu. Izinto ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Andrographis ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe I-Andrographis Supplements izozizuzisa Iziguli Eziyinhloko ze-Pineoblastoma ezelashwa nge-Carmustine?

I-Primary Pineoblastoma ibonakala ngoshintsho oluthile lwezakhi zofuzo, okuyi-ATR, i-ATM kanye ne-CREBBP, okuholela ekuguqulweni kwezindlela zamakhemikhali ezinto eziphilayo, ikakhulukazi i-Oncogenic Cancer Epigenetics, Ukulungiswa KweDNA, Izindawo Zokuhlola I-Cell Cycle, I-G-protein-coupled Receptor Signaling kanye Nophawu Lokubalekela Amasosha omzimba. Ukusebenza kokwelashwa komdlavuza, okufana ne-Carmustine, kuncike endleleni yayo yokusebenza kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Andrographis, esithinta i-Oncogenic Cancer Epigenetics, kungenzeka kungabi yisinqumo esifanele esimweni se-Primary Pineoblastoma lapho kwenziwa i-Carmustine. Lokhu kungenxa yokuthi kungase kukhulise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunomsoco, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, iminyaka, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe I-Andrographis Supplements izozizuzisa Iziguli Eziyinhloko ze-Glioblastoma ezelashwa nge-Temozolomide?

I-Glioblastoma eyinhloko ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-TRBV7-7, TAS2R46 ne-TP53, okuholela ezinguqukweni zemizila yamakhemikhali ezinto eziphilayo, ikakhulukazi i-Cell Cycle, Cell Cycle Checkpoints kanye ne-Apoptosis. Ukusebenza kokwelashwa komdlavuza, njengeTemozolomide, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Andrographis siyinketho enengqondo kulabo abane-Primary Glioblastoma abathola i-Temozolomide. Lokhu kungenxa yokuthi i-Andrographis ithonya izindlela ezifana ne-Cell Cycle, engavimbela izici ezishayela i-Primary Glioblastoma noma izuzise ukusebenza kahle kwe-Temozolomide.

3. Ingabe Izithasiselo ze-Andrographis Ziphephile Kubantu Abanempilo Eminye abane-CDKN2A Mutation Associated Genetic Risk?

I-CDKN2A idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-CDKN2A kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa izindawo zokuhlola i-Cell Cycle kanye ne-Cell Cycle, ezithonya ukukhula komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-CDKN2A ehlotshaniswa Nomdlavuza Wesikhumba, cabanga ukufaka izithasiselo ze-Andrographis ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Cell Cycle, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-CDKN2A kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithasiselo ezifana ne-Andrographis, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Ukuphrinta ngeminwe kwezinhlobo ezihlukahlukene zezilwane ngama-DNA probe akhiqizwa kuzifanekiso ze-DNA ezinomucu owodwa onganyakazi.
• cBioPortal for Cancer Genomics
• I-Andrographolide iphikisana noguquko lwe-epithelial-mesenchymal olubangelwa intuthu kanye nokungasebenzi kahle kwamaphaphu ngokusebenzisa i-HOTAIR evimbela ukuvuvukala.
• Ukuguqulwa kwe-IDH1/2 kuwuphawu olubikezela ukuphila futhi lubikezela ukusabela kukhemotherapy kuma-glioma ebanga lesi-II alashwa kanyekanye ngokwelashwa ngemisebe.
• cBioPortal for Cancer Genomics
• Ukwelashwa komdlavuza kulolonga isimo sokufaneleka se-clonal hematopoiesis.
• I-MGMT-inhibitor ihlanganiswe ne-TGF-βRI inhibitor noma i-CDK 4/6 inhibitor inyusa ukuzwela kwe-temozolomide kumaseli e-temozolomide-resistant glioblastoma.
• I-somatic genomic landscape ye-glioblastoma.