Imuphi umdlavuza ongazuza ngokufaka u-Ajwain ekudleni kwabo?

Amaphuzu avelele

I-Ajwain yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kwe-Ajwain ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nezingozi zofuzo zesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Ajwain ingase izuze labo abane-Primary Penile Squamous Cell Carcinoma abathola i-Mitomycin, kodwa kungase kungabi kuhle ezigulini ezithola i-Radiation for Primary Sclerosing Epithelioid Fibrosarcoma. Ngaphezu kwalokho, nakuba i-Ajwain ingasiza abantu abanesici esiyingozi sofuzo “TERT”, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo ngokufaneleka kwe-Ajwain esigulini somdlavuza kudinga umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi u-Ajwain uyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingavela, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kuhambisane nezinguquko zesimo sezempilo nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana ne-Ajwain esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukusishaya indiva ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile uphakama: Ingabe kufanele ufake i-Ajwain ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle i-Ajwain uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-TERT? Ingabe kunenzuzo ukufaka i-Ajwain ekudleni kwakho uma kutholakala ukuthi une-Primary Sclerosing Epithelioid Fibrosarcoma, noma uma ukuxilongwa kwakho kuyi-Primary Penile Squamous Cell Carcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Ajwain kufanele kulungiswe kanjani uma welashelwa i-Mitomycin noma uma uhlelo lwakho lokwelapha lusuka ku-Mitomycin luye kwiRadiation? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi ‘i-Ajwain ingokwemvelo, ngakho ihlale inenzuzo’ noma ‘i-Ajwain iqinisa ukuzivikela komzimba’ akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Ajwain ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Ajwain ekudleni kwakho ukuze uthole izinzuzo zako, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Penile Squamous Cell Carcinoma noma i-Primary Sclerosing Epithelioid Fibrosarcoma, amasu okwelapha kudingeka enziwe ngokwezifiso ngokusekelwe kufuzo lomuntu ngamunye, isigaba sesifo, kanye nezici ezifana neminyaka nobulili. ”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ngabe kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokukhetha ukudla, njengo-Ajwain. Ingabe ubungozi bofuzo lomdlavuza osukela ekuguqukeni kwe-TERT bunomthelela ofanayo we-biochemical pathway? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela kwezinye izingozi zofuzo? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Penile Squamous Cell Carcinoma ilingana ne-Primary Sclerosing Epithelioid Fibrosarcoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Radiation njengalabo abathola i-Mitomycin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Ajwain - Isengezo Sokudla Okunomsoco

Isengezo i-Ajwain sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Palmitic Acid, i-Linolenic Acid, i-Linoleic Acid ne-Beta-sitosterol, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-PI3K-AKT-MTOR Signaling, TGFB Signaling, Growth Factor Signaling kanye neCell Cycle Checkpoints, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Njengoba kunikezwe leli thonya lezinto eziphilayo, ukukhetha izithasiselo ezifanele ezifana ne-Ajwain, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla okunomdlavuza. Uma ucabangela ukusebenzisa i-Ajwain yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Ajwain akusona isinqumo somhlaba wonke esilungele yonke imidlavuza kodwa kudinga kube yizici eziqondene nawe.

Ukukhetha Izithako ze-Ajwain

Ukubhekana nombuzo othi ‘Kufanele ngimgweme nini u-Ajwain esimweni somdlavuza’ kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - imane nje ithi ‘Kuyame!’. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Ajwain kuyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi u-Ajwain ufanelekile noma kufanele agwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe I-Ajwain Supplements izozizuzisa Iziguli Eziyi-Primary Sclerosing Epithelioid Fibrosarcoma ezelashwa ngeRadiation?

I-Primary Sclerosing Epithelioid Fibrosarcoma ibonakala ngokuguquguquka okuthile kofuzo, okuyi-PBRM1, ATRX kanye ne-PIK3C2G, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-TGFB Signaling kanye ne-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Ajwain, esithinta i-TGFB Signaling, kungenzeka kungabi inketho efanele esimweni se-Primary Sclerosing Epithelioid Fibrosarcoma lapho ubhekene neRadiation. Lokhu kungenxa yokuthi kungase kukhulise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunomsoco, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, iminyaka, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo ze-Ajwain zizozizuzisa Iziguli Eziyinhloko ze-Penile Squamous Cell Carcinoma ezelashwa nge-Mitomycin?

I-Primary Penile Squamous Cell Carcinoma ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-ABRAXAS1, PIK3CB kanye ne-NUP93, okuholela ezinguqukweni zemizila ye-biochemical, ikakhulukazi i-PI3K-AKT-MTOR Signaling, Hematopoiesis kanye ne-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, njenge-Mitomycin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Ajwain siyindlela enengqondo kulabo abane-Primary Penile Squamous Cell Carcinoma abathola i-Mitomycin. Lokhu kungenxa yokuthi i-Ajwain ithonya izindlela ezifana ne-PI3K-AKT-MTOR Signaling, engavimbela izici ezishayela i-Primary Penile Squamous Cell Carcinoma noma izuzise ukusebenza kahle kwe-Mitomycin.

3. Ingabe Izithasiselo ze-Ajwain Ziphephile Kubantu Abanempilo Ene-TERT Mutation Associated Genetic Risk?

I-TERT idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-TERT kungaphazamisa izindlela ezibalulekile zamakhemikhali ezinto eziphilayo, okuhlanganisa Izindawo Zokuhlola I-Cell Cycle kanye Nokulungiswa KweDNA, okuthonya ukukhula komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-TERT ezihlobene Nomdlavuza Wegazi, cabanga ukufaka izithasiselo ze-Ajwain ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Cell Cycle Checkpoints, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-TERT kanye nokukhathazeka kwezempilo okuhlobene.

* Okunye Izici zifakiwe njenge-BMI, Ukwelashwa, Imikhuba Yokuphila

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Ajwain, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.

Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.

Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.

Okubhekwayo

• Ukwenziwa kusebenze kwe-PPAR gamma kanye ne-delta nge-conjugated linoleic acid kulamula ukuvikela esifweni sokuhlola samathumbu esivuvukalayo.
• cBioPortal for Cancer Genomics
• Ukubonakaliswa kwe-epidermal growth factor receptors ku-astrocytic glial namaseli e-neuronal kusiko eliyinhloko.
• Ukwelashwa komdlavuza kulolonga isimo sokufaneleka se-clonal hematopoiesis.
• Ukumelana nomsakazo kumaseli omdlavuza webele kulamula nge-TGF-β signalling, hybrid epithelial-mesenchymal phenotype kanye namaseli omdlavuza.
• I-β-Sitosterol iqondise i-Trx/Trx1 reductase ukuze yenze i-apoptosis kumaseli e-A549 nge-ROS mediated mitochondrial dysregulation kanye nokusebenza kwe-p53.
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• I-β-Sitosterol ne-Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.