Ukudla Okusabalalisa I-B-Cell Lymphoma Enkulu!

Isingeniso

Ukudla Okusabalalisa I-B-cell Lymphoma enkulu kufanele kube okomuntu ngamunye futhi kufanele kuzivumelanise nezimo lapho ukwelashwa komdlavuza noma ukuguquka kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene ngokuphathelene nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza kanye nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula.

I-Diffuse B-cell lymphoma enkulu (DLBCL) iwuhlobo oluncane oluvame kakhulu futhi olunolaka lwe-non-Hodgkin's lymphoma. Ama-DLBCL anezinga lokukhula ngokushesha futhi atholakala njengezixuku ezingena ngaphakathi kwezicubu noma izitho ezivimbelayo. Lena i-heterogeneous b-cell lymphoma enezinhlobo ezincane ezisuselwe kuseli yoqobo kanye noma i-genomics. Izinhlobo ezincane eziyinhloko ezinezici ezihlukene zamangqamuzana nezakhi zofuzo zifaka i-GCB (i-germinal center b-cell subtype) kanye ne-non-GCB ehlanganisa i-ABC (uhlobo oluncane lwe-b-cell olucushiwe) kanye nolunye olungacacisiwe noma olungashiwongo ngenye indlela (NOS), lolo. faka phakathi ukwahluka kwe-DLBCL. I-DLBCL itholakala kakhulu kubantu abadala asebekhulile abangaphezu kweminyaka engama-60 ubudala, ngaphandle kokuhluka okuyinhloko kwe-DLBCL ye-mediastinal, ehlasela kakhulu abesifazane abaseminyakeni yawo-20 noma ekuqaleni kweminyaka engu-30. Izimpawu nezimpawu ze-DLBCL zihlanganisa ubuhlungu ku-lymph node ekhulisiwe noma esithweni, imfiva, ukujuluka okumanzi ebusuku, ukuncipha kwesisindo, i-pruritus evamile, i-anorexia, ukukhathala, ukungakhululeki kwesifuba kanye nokuphefumula. Izinga lokwelashwa kokunakekelwa kwe-DLBCL inhlanganisela yokwelapha ngamakhemikhali kanye ne-immunotherapy ebizwa nge-R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine ne-prednisone). Ezinye izinketho zokwelashwa komugqa wakamuva zihlanganisa ukufakelwa kwe-hematopoietic stem cell, ukwelashwa kwe-chimeric T-cell (CAR-T) nezinye izidakamizwa ezihlosiwe. Isilinganiso seminyaka engu-5 sokusinda kwe-non-Hodgkin lymphoma singama-73%, nokho, abesifazane neziguli ezingaphansi kweminyaka engama-65 banomphumela ongcono wokusinda. Uhlelo lokwelapha olwenziwe lwaba ngezakho ukuya esiteji nokuhlukile kohlobo oluncane lwe-DLBCL kanye nokudla okufanele (ukudla nezithako zemvelo) kungasiza ukuthuthukisa inhlalakahle yeziguli ezine-DLBCL.

Ukuze Usakaze I-Large B-cell Lymphoma ingabe kunendaba ukuthi iyiphi imifino, izithelo, amantongomane, imbewu umuntu ayidlayo?

Umbuzo ovame kakhulu wokudla okunomsoco obuzwa iziguli ezinomdlavuza kanye nabantu abasengozini yomdlavuza uwukuthi - komdlavuza njenge-Diffuse Large B-cell Lymphoma ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe ezitshalweni ingabe kwanele umdlavuza ofana ne-Diffuse Large B-cell Lymphoma?

Isibonelo, ingabe kunendaba ukuthi imifino i-Wild Leek idliwa kakhulu uma iqhathaniswa ne-Chayote? Ingabe kuyawenza umehluko uma isithelo iPummelo sithandwa kuneRed Raspberry? Futhi uma ukukhetha okufanayo kwenziwa ngamantongomane/imbewu efana neButternut phezu kweCashew Nut kanye namapulses afana noBroad Bean phezu kweSoy Bean. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukuhlonza kanjani ukudla okunconyelwe I-Diffuse Large B-cell Lymphoma futhi ingabe iyimpendulo efanayo yawo wonke umuntu onesifo esifanayo noma ingozi yofuzo?

Yebo! Ukudla okudlayo kuyindaba ye-Diffuse Large B-cell Lymphoma!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana.

Isibonelo i-Pummelo iqukethe izithako ezisebenzayo i-Quercetin, i-Curcumin, i-Apigenin, i-Lupeol, i-Phloretin. Futhi okusajingijolo okubomvu kuqukethe izithako ezisebenzayo i-Ellagic Acid, i-Quercetin, i-Curcumin, i-Lupeol, i-Phloretin futhi mhlawumbe nabanye.

Iphutha elivamile elenziwa lapho kunqunywa futhi kukhethwa ukudla okuzodliwa kwe-Diffuse Large B-cell Lymphoma - ukuhlola izithako ezisebenzayo ezikhethiwe kuphela eziqukethwe ekudleni futhi ungazinaki ezinye. Ngoba izithako ezisebenzayo ezahlukahlukene eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo sokudla kwe-Diffuse Large B-cell Lymphoma.

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Ayadingeka Ekwenzeni Ukudla Okufana Nakho Ukuze Kusabalalise I-B-cell Lymphoma Enkulu?

Ukondleka komuntu siqu komdlavuza njenge-Diffuse Large B-cell Lymphoma iqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe ku-Diffuse Large B-cell Lymphoma biology, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelapha umdlavuza kusebenza kanjani kanye nokuba sengozini okuhambisana nakho lapho ukwelashwa kungayeka ukusebenza kahle.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA KWAMUNTU KOMDLALO YI: IBHYOLOGY YOMDLAVUZA, ISAYENSI YOKUDLA, UKWELASHWA KOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njenge-Diffuse Large B-cell Lymphoma

Yonke imidlavuza efana ne-Diffuse Large B-cell Lymphoma ingabonakala ngesethi ehlukile yezindlela ze-biochemical - izindlela zesiginesha ze-Diffuse Large B-cell Lymphoma. Izindlela zamakhemikhali ezinto eziphilayo ezifana ne-Vitamin Metabolism, I-Cell Cycle Checkpoints, i-NFKB Signaling, i-PI3K-AKT-MTOR Signaling ziyingxenye yencazelo yesiginesha ye-Diffuse Large B-cell Lymphoma. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Ukwelashwa okusebenzayo kwe-Diffuse Large B-cell Lymphoma kudinga ukuqaphela izindlela ezihambisanayo zesiginesha ye-biochemical yesiguli ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla nezithako ezingeziwe kuyanconywa nge-Diffuse Large B-cell Lymphoma lapho uthatha ukwelashwa komdlavuza i-Cyclophosphamide, futhi okunye ukudla nezithasiselo akunconywa.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo.

I-KMT2D, MYD88, PIM1, CREBBP kanye ne-SPEN yizakhi zofuzo ezisezingeni eliphezulu ezibikwayo ze-Diffuse Large B-cell Lymphoma. I-KMT2D ibikwa ku-18.2 % weziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-MYD88 ibikwa ku-12.6%. Idatha ehlanganisiwe yesiguli ihlanganisa iminyaka yobudala esukela kweyisi-8 kuye kwengama-85. Amaphesenti angama-55.6 emininingwane yesiguli ahlonzwa njengabesilisa. I-Diffuse Large B-cell Lymphoma biology kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimele izindlela zokusayina ze-biochemical kulo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni nazo zaziwa lokho kufanele futhi kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla Nezithako Zokusabalalisa I-B-cell Lymphoma Enkulu

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.

Khetha iVegetable WILD LEEK noma i-CHAYOTE?

I-Vegetable Wild Leek iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Apigenin, i-Lupeol, i-Phloretin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezehlukene ze-biochemical ezifana Ne-Extracellular Matrix Remodelling, NFKB Signaling, Cell Cycle kanye ne-Epithelial to Mesenchymal Transition nezinye. I-Wild Leek iyanconywa nge-Diffuse Large B-cell Lymphoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Cyclophosphamide. Lokhu kungenxa yokuthi i-Wild Leek ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela we-Cyclophosphamide.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chayote yemifino yi-Curcumin, i-Apigenin, i-Myricetin, i-Lupeol, i-Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress, i-NFKB Signaling kanye ne-Epithelial to Mesenchymal Transition nezinye. I-Chayote ayinconyelwe i-Diffuse Large B-cell Lymphoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Cyclophosphamide ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

I-VEGETABLE WILD LEEK INCONYISWA NGAPHEZU KWE-CHAYOTE UKUZE Isakaze I-B-cell Lymphoma Enkulu KANYE NOKWELAPHA I-Cyclophosphamide.

Khetha Isithelo RED RASPBERRY noma i-PUMMELO?

I-Fruit Red Raspberry iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Ellagic Acid, i-Quercetin, i-Curcumin, i-Lupeol, i-Phloretin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-PI3K-AKT-MTOR Signaling, NFKB Signaling, JAK-STAT Signaling kanye ne-Epithelial to Mesenchymal Transition nezinye. I-Red Raspberry iyanconywa nge-Diffuse Large B-cell Lymphoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Cyclophosphamide. Lokhu kungenxa yokuthi i-Red Raspberry iguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umphumela we-Cyclophosphamide.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Pummelo yi-Quercetin, i-Curcumin, i-Apigenin, i-Lupeol, i-Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress and DNA Repair nezinye. I-Pummelo ayinconywa ukuthi i-Diffuse Large B-cell Lymphoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Cyclophosphamide ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

I-RASPBERRY EBOMVU YESITHELO INCONYISWA NGAPHEZU KWE-PUMMELO YOKUSAKAZA I-B-cell Lymphoma Enkulu KANYE NOKWELAPHA I-Cyclophosphamide.

Khetha Nut BUTTERNUT noma I-CASHEW NUT?

I-Butternut iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Apigenin, i-Myricetin, i-Lupeol, i-Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-NFKB Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling kanye neCell Cycle nezinye. I-Butternut iyanconywa nge-Diffuse Large B-cell Lymphoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Cyclophosphamide. Lokhu kungenxa yokuthi i-Butternut iguqula lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela we-Cyclophosphamide.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Cashew Nut yi-Quercetin, i-Curcumin, i-Myricetin, i-Lupeol, i-Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress, i-NFKB Signaling, i-PI3K-AKT-MTOR Signaling ne-Hypoxia nezinye. I-Cashew Nut ayinconywa ukuthi i-Diffuse Large B-cell Lymphoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Cyclophosphamide ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

IBUTTERNUT INCONYISWA NGAPHEZU KWENAMATI KASHEWU UKUZE Isakaze I-B-cell Lymphoma Enkulu KANYE NOKWELAPHA I-Cyclophosphamide.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwa ngabantu abasengozini yofuzo ye-Diffuse Large B-cell Lymphoma noma umlando womndeni uthi "Yini Okufanele Ngiyidle Ngokuhlukile Kunangaphambili?" nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithako zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela - ukukhetha kokudla kanye nezithako kufanele kube okomuntu siqu.

Khetha iVegetable WILD CARROT noma ISIPINSHI?

I-Vegetable Wild Carrot iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Apigenin, i-Quercetin, i-Linalool, i-Formononetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-NFKB Signaling, i-Apoptosis, i-Notch Signaling kanye ne-RAS-RAF Signaling nezinye. I-Wild Carrot iyanconywa ngengozi ye-Diffuse Large B-cell Lymphoma lapho ubungozi bofuzo obuhambisanayo kuyi-CREBBP. Lokhu kungenxa yokuthi i-Wild Carrot inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zayo zokusayina.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino Isipinashi yi-Curcumin, i-Apigenin, i-Quercetin, i-Formononetin, i-Lupeol. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-NFKB Signaling, Notch Signaling kanye ne-PI3K-AKT-MTOR Signaling nezinye. Isipinashi asituswa uma ingozi ye-Diffuse Large B-cell Lymphoma uma ingozi yofuzo ehlotshaniswa nayo iyi-CREBBP ngoba inyusa izindlela zaso zesiginesha.

IZAQATHI ZASEMJINI INCONYWA NGAPHEZU KWESIPINSHI NGENGOZI YOFUZO YE-CREBBP YOMFUZA.

Khetha isithelo i-RABITEYE BLUEBERRY noma i-BLACK ELDERBERRY?

I-Fruit Rabbiteye Blueberry iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Quercetin, i-Linalool, i-Eugenol, i-Ferulic Acid, i-Epicatechin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-NFKB Signaling, TGFB Signaling, PI3K-AKT-MTOR Signaling kanye ne-Apoptosis nezinye. I-Rabbiteye Blueberry inconyelwa engcupheni ye-Diffuse Large B-cell Lymphoma lapho ingozi yofuzo ehlotshaniswa nayo iyi-CREBBP. Lokhu kungenxa yokuthi i-Rabbiteye Blueberry inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni esimnyama i-Elderberry yi-Curcumin, i-Apigenin, i-Quercetin, i-Linalool, i-Formononetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-WNT Beta Catenin Signaling, i-NFKB Signaling kanye ne-Cell Cycle Checkpoints nezinye. I-Black Elderberry ayinconywa uma ingozi ye-Diffuse Large B-cell Lymphoma uma ingozi yofuzo ehlotshaniswa nayo iyi-CREBBP ngoba inyusa izindlela zayo zokusayina.

ISITHELO I-RABITEYE BLUEBERRY INCONYISWA NGAPHEZU KWE-BLACK ELDERBERRY NGENGOZI YOFUZO YE-CREBBP YOMDLALO.

Khetha Nut BLACK WALNUT noma EUROPEAN CHESTNUT?

I-Walnut Emnyama iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Apigenin, i-Quercetin, i-Formononetin, i-Lupeol. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-NFKB Signaling, i-Apoptosis, i-PI3K-AKT-MTOR Signaling kanye ne-RAS-RAF Signaling nezinye. I-Walnut Emnyama inconywa engcupheni ye-Diffuse Large B-cell Lymphoma uma ingozi yofuzo ehlotshaniswa nayo iyi-CREBBP. Lokhu kungenxa yokuthi i-Black Walnut inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yaseYurophu yi-Curcumin, i-Apigenin, i-Quercetin, i-Formononetin, i-Lupeol. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-WNT Beta Catenin Signaling kanye ne-NFKB Signaling nezinye. I-Chestnut yase-Europe ayinconywa uma ingozi ye-Diffuse Large B-cell Lymphoma uma ingozi yofuzo ehlotshaniswa nayo iyi-CREBBP ngoba inyusa izindlela zayo zokusayina.

I-WALNUT EMNYAMA INCONYISWA NGAPHEZU KWE-CHESTNUT YASE-EUROPE NGENGOZI YOFUZO YE-CREBBP YOMFUZA.

Ekuphetheni

Ukudla kanye Nezithasiselo ezikhethiwe izinqumo ezibalulekile zomdlavuza njenge-Diffuse Large B-cell Lymphoma. Sabalalisa Iziguli Ezinkulu ze-B-cell Lymphoma kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: "Yikuphi ukudla nezithako zokudla okunempilo engikunconyelwe futhi okungekona?" Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezahlukene zezinkomba zomdlavuza ezifana ne-Diffuse Large B-cell Lymphoma, ngayinye enezakhi zofuzo zesimila ezihlukile ngokuhlukahluka kofuzo kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana ne-Wild Leek kuqukethe ama-bioactive ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene nahlukile wezindlela ze-biochemical. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda izindlela zokwelapha ezihlukene ze-chemotherapy. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo somuntu siqu somsoco we-addon senza ukwenza izinqumo kube lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo, "Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli I-Diffuse Large B-cell Lymphoma?". Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha.

Okubhekwayo

• I-Dlbcl Dfci 2018
• Amaphethini Eseli-Omsuka Abusa Ukuhlukaniswa Kwemolekyuli Yezimila Eziyi-10,000 Ezinhlotsheni Ezingu-33 Zomdlavuza.
• Indlela Yesayensi Evulekile Esheshayo Yokubizwa Kokuguqulwa Kokukhishwa Kwe-Tumor Kusetshenziswa Amapayipi E-Genomic Amaningi.
• Izindlela Ze-Genomic Nezisebenzayo Zokuqonda I-Cancer Aneuploidy.
• I-Driver Fusion kanye Nemithelela Yazo Ekuthuthukisweni Nokwelashwa Kwemidlavuza Yabantu.
• Insiza Yedatha Yomtholampilo Ye-TCGA Ehlanganisiwe Ye-Pan-Cancer ukuze Ushayele Ukuhlaziya Komphumela Wokusinda Kwekhwalithi Ephezulu.
• I-Oncogenic Signaling Pathways kuCancer Genome Atlas.
• Ukuhlaziywa kwe-Microbiome kwegazi nezicubu kusikisela indlela yokuxilonga umdlavuza.
• Umbono Wezinqubo Ze-Oncogenic Ekupheleni Kokuqala KweCancer Genomics.
• I-Landscape Yokungazinzi Kwe-Microsatellite Kuzo Zonke Izinhlobo Zomdlavuza ezingama-39.
• I-Curcumin ivimbela ukukhula ngendlela ye-Wnt/β-catenin kumaseli omdlavuza wamaphaphu angewona amancanyana.
• Ukulungiswa kwe-DNA kanye nemisebenzi ye-redox kanye nama-inhibitors e-apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1): ukuhlaziya okuqhathanisayo kanye nobubanzi bayo kanye nemikhawulo ekuthuthukisweni kwezidakamizwa ezilwa nomdlavuza.
• I-citrus flavonoid naringenin ikhuthaza ukulungiswa kwe-DNA kumaseli omdlavuza wendlala yesinye.
• I-Retinol yehlisa amazinga e-beta-catenin amaprotheni emigqeni yamaseli omdlavuza we-colon we-retinoic acid.
• Ukwethulwa kwe-apoptosis yamaseli omdlavuza wekholoni womuntu we-SW480 ngo-(-)-epicatechin ehlukanisiwe ne-Bulnesia sarmienti.
• Imiphumela yokuvikela iqhathaniswa nokuphromotha yetiye elimhlophe ne-caffeine ku-PhIP-induced tumorigenesis kanye nokuvezwa kwe-beta-catenin kugundane.
• I-Eugenol ithuthukisa umsebenzi we-cisplatin wokulwa nomdlavuza ngokuvinjwa kwamaseli e-stem omdlavuza webele we-ALDH-positive kanye nendlela yokubonisa i-NF-κB.
• I-retinoic acid receptor β ithuthukise umphumela wamaseli e-anti-cancer we-β-carotene ngokuveza okulawula phansi kwe-delta-like 1 homologue kumaseli e-neuroblastoma yomuntu.
• I-α-pinene ilawula i-miR-221 futhi yenza i-G₂Ukuboshwa komjikelezo wamaseli wesigaba se-M kumaseli we-hepatocellular carcinoma.
• https://emedicine.medscape.com/article/202969-overview#showall;
• https://www.ncbi.nlm.nih.gov/books/NBK557796/