Ukudla kweChondrosarcoma!

Isingeniso

Ukudla kwe-Chondrosarcoma kufanele kube okuqondene nomuntu ngamunye futhi kufanele kuzivumelanise nezimo lapho ukwelashwa komdlavuza noma ukuguquka kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene ngokuphathelene nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza kanye nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula.

I-Chondrosarcoma iyithumba eliyingozi elivela kumangqamuzana oqwanga. I-cartilage iyizicubu ezithambile ezixhumanisayo ezivumela ukunyakaza phakathi kwethambo namalunga. I-Chondrosarcoma ingathinta amadoda nabesifazane ngokulinganayo futhi ikhule kubantu abaphakathi kweminyaka engama-40 nengama-75. Kunezinhlobo eziningana ze-chondrosarcoma ezihlanganisa i-clear cell chondrosarcoma, i-dedifferentiated chondrosarcoma kanye ne-mesenchymal chondrosarcoma. Izimpawu ze-chondrosarcoma zingase zihluke kuye ngokuthi indawo kanye nobukhulu be-tumor, kuhlanganise nokukhathala, umkhuhlane kanye nokulahlekelwa isisindo okungahlosiwe. Ukubikezelwa kwe-chondrosarcoma kuncike ezintweni ezihlukahlukene, kuhlanganise nebanga kanye nesigaba sesimila. Izinketho zokwelapha ze-chondrosarcoma zingabandakanya ukuhlinzwa, ukwelapha ngemisebe, kanye nokwelashwa ngamakhemikhali, okwenziwe ngokwezifiso ezimweni ngazinye.

Ku-Chondrosarcoma, kunendaba ukuthi iyiphi imifino, izithelo, amantongomane, imbewu umuntu adlayo?

Umbuzo ojwayelekile wokudla okunomsoco obuzwa iziguli ezinomdlavuza kanye nabantu abasengozini yomdlavuza uwukuthi - kumdlavuza onjenge-Chondrosarcoma ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe esitshalweni ingabe kwanele umdlavuza njengeChondrosarcoma?

Isibonelo, ingabe kunendaba ukuthi iklabishi yemifino idliwa kakhulu uma iqhathaniswa nethawula leGourd? Ingabe kuyawenza umehluko uma isithelo iLongan sithandwa kuneCranberry yaseYurophu? Futhi uma ukukhetha okufanayo kwenziwa kumantongomane/imbewu efana ne-Butternut phezu kwe-European Chestnut kanye nama-pulses afana ne-Gram Bean phezu kwe-Pigeon Pea. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukukhomba kanjani ukudla okunconyelwe i-Chondrosarcoma futhi ingabe impendulo efanayo kuwo wonke umuntu onokuxilongwa okufanayo noma ingozi yofuzo?

Yebo! Ukudla okudlayo kuyindaba yeChondrosarcoma!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana.

Isibonelo i-Longan iqukethe izithako ezisebenzayo i-Curcumin, i-Apigenin, i-Lycopene, i-Phloretin, i-Daidzein. Futhi i-European Cranberry iqukethe izithako ezisebenzayo i-Curcumin, i-Apigenin, i-Ellagic Acid, i-Quercetin, i-Lycopene futhi mhlawumbe nezinye.

Iphutha elivamile elenziwe lapho kunqunywa futhi kukhethwa ukudla okuzodliwa yi-Chondrosarcoma - ukuhlola izithako ezisebenzayo ezikhethiwe kuphela eziqukethwe ekudleni futhi ungazinaki ezinye. Ngoba izithako ezisebenzayo ezahlukahlukene eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo sokudla kweChondrosarcoma.

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Adingekayo Ekwenzeni Ukudla Okunempilo Kwe-Chondrosarcoma?

Ukondleka komuntu siqu komdlavuza njengeChondrosarcoma kuqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe ku-Chondrosarcoma biology, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelapha umdlavuza kusebenza kanjani kanye nokuba sengcupheni okuhlobene lapho ukwelashwa kungayeka ukusebenza kahle.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA KWAMUNTU KOMDLALO YI: IBHYOLOGY YOMDLAVUZA, ISAYENSI YOKUDLA, UKWELASHWA KOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njenge-Chondrosarcoma

Wonke ama-cancer afana ne-Chondrosarcoma angabonakala ngesethi eyingqayizivele yezindlela ze-biochemical - izindlela zokusayina ze-Chondrosarcoma. Izindlela ze-Biochemical ezifana ne-Hypoxia, i-MAPK Signaling, i-Oncogenic Cancer Epigenetics, i-Energy Metabolism iyingxenye yencazelo yesiginesha ye-Chondrosarcoma. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Ukwelashwa okusebenzayo kwe-Chondrosarcoma kudinga ukuqaphela izindlela ezihambisanayo zesiginesha ye-biochemical yesiguli ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla kanye nezithako zokudla kunconywa i-Chondrosarcoma lapho uthatha ukwelashwa komdlavuza i-Pazopanib, futhi okunye ukudla nezithako zokudla akunconywa.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo.

I-TP53, IDH1, TET2, EPHA7 kanye ne-ATRX izakhi zofuzo ezisezingeni eliphezulu ezibikiwe ze-Chondrosarcoma. I-TP53 ibikwa ku-13.5 % weziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-IDH1 ibikwa ku-13.5%. Idatha ehlanganisiwe yesiguli ihlanganisa iminyaka yobudala esukela kweyi-14 kuye kwengama-79. Amaphesenti angama-66.4 emininingwane yesiguli ahlonzwa njengabesilisa. I-Chondrosarcoma biology kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimele izindlela ze-biochemical zesiginesha zalo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni nazo zaziwa lokho kufanele futhi kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla kanye Nezithako ze-Chondrosarcoma

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.

Khetha Iklabishi Yemifino noma IGANDA LETHAWULA?

Iklabishi Yemifino iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Apigenin, i-Quercetin, i-Benzyl Isothiocyanate, i-Lycopene. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-PI3K-AKT-MTOR Signaling, Epithelial to Mesenchymal Transition kanye ne-MYC Signaling nezinye. Iklabishi liyanconywa nge-Chondrosarcoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Pazopanib. Lokhu kungenxa yokuthi Iklabishi lishintsha lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umphumela we-Pazopanib.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-vegetable Towel Gourd yi-Curcumin, i-Apigenin, i-Lycopene, i-Phloretin, i-Daidzein. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling, Notch Signaling kanye ne-MAPK Signaling nezinye. Ithawula le-Gourd alinconyelwe i-Chondrosarcoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Pazopanib ngoba iguqula lezo zindlela ze-biochemical ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

IKABHISHI LEMIJINO KUNCONYWA NGAPHEZU KWEGANDA LETHAWULA LE-Chondrosarcoma KANYE NOKWELAPHA I-Pazopanib.

Khetha Isithelo EUROPEAN CRANBERRY noma LONGAN?

I-Fruit European Cranberry iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Apigenin, i-Ellagic Acid, i-Quercetin, i-Lycopene. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling, Epithelial to Mesenchymal Transition and Hypoxia nezinye. I-Cranberry yaseYurophu inconywa nge-Chondrosarcoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Pazopanib. Lokhu kungenxa yokuthi i-Cranberry yaseYurophu iguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umphumela we-Pazopanib.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni se-Longan yi-Curcumin, i-Apigenin, i-Lycopene, i-Phloretin, i-Daidzein. Lezi zithako ezisebenzayo zishintsha izindlela ezahlukahlukene ze-biochemical ezifana ne-WNT Beta Catenin Signaling kanye ne-Epithelial to Mesenchymal Transition nezinye. I-Longan ayinconyelwe i-Chondrosarcoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Pazopanib ngoba ilungisa lezo zindlela ze-biochemical ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

I-CRANBERRY YESITHELO YAseYurophu INCONYISWA NGESIKHATHI ESIDE NGE-Chondrosarcoma KANYE NOKWELASHWA I-Pazopanib.

Khetha Nut BUTTERNUT noma EUROPEAN CHESTNUT?

I-Butternut iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Apigenin, i-Lycopene, i-Phloretin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-PI3K-AKT-MTOR Signaling, Epithelial to Mesenchymal Transition, MAPK Signaling and Hypoxia nezinye. I-Butternut inconywa nge-Chondrosarcoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Pazopanib. Lokhu kungenxa yokuthi i-Butternut iguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umphumela we-Pazopanib.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yaseYurophu yi-Curcumin, i-Apigenin, i-Ellagic Acid, i-Quercetin, i-Phloretin. Lezi zithako ezisebenzayo zishintsha izindlela ezahlukahlukene ze-biochemical ezifana ne-WNT Beta Catenin Signaling kanye ne-Epithelial to Mesenchymal Transition nezinye. I-Chestnut yase-Europe ayinconyelwe i-Chondrosarcoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Pazopanib ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

I-BUTTERNUT INCONYISWA NGE-CHESTNUT YAseYurophu NGE-Chondrosarcoma KANYE NOKWELASHWA I-Pazopanib.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwa abantu abanengozi yofuzo ye-Chondrosarcoma noma umlando womndeni uthi "Yini Okufanele Ngiyidle Ngokuhlukile Kunangaphambili?" nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithako zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela - ukukhetha kokudla kanye nezithako kufanele kube okomuntu siqu.

Khetha imifino CALABASH noma i-DAIKON RADISH?

I-Vegetable Calabash iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Lupeol, i-Formononetin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-EPHRIN Signaling, Cell Cycle, JAK-STAT Signaling kanye ne-P53 Signaling nezinye. I-Calabash inconywa ngengozi ye-Chondrosarcoma lapho ingozi yofuzo ehlotshaniswa nayo i-ATRX. Lokhu kungenxa yokuthi i-Calabash inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino ye-Daikon Radish yi-Apigenin, i-Curcumin, i-Lupeol, i-Formononetin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress nezinye. I-Daikon Radish ayinconywa uma ingozi ye-Chondrosarcoma uma ingozi yofuzo ehlotshaniswa nayo i-ATRX ngoba inyusa izindlela zayo zokusayina.

I-VEGETABASH CALABASH INCONYISWA NGAPHEZU KWE-DAIKON RADISH NGE-ATRX GENETIC RISK OF CANCER.

Khetha isithelo WATERMELON noma EUROPEAN PLUM?

I-Watermelon yesithelo iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Lupeol, i-Formononetin, i-Daidzein, i-Beta-sitosterol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Cell Cycle, i-JAK-STAT Signaling ne-Hypoxia nezinye. I-Watermelon inconywa ngengozi ye-Chondrosarcoma lapho ingozi ehlobene nezakhi zofuzo i-ATRX. Lokhu kungenxa yokuthi i-Watermelon inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni sase-European Plum yi-Curcumin, i-Lupeol, i-Formononetin, i-Daidzein, i-Beta-sitosterol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress, PI3K-AKT-MTOR Signaling kanye ne-MAPK Signaling nezinye. I-European Plum ayinconywa uma ingozi ye-Chondrosarcoma uma ingozi yofuzo ehlotshaniswa nayo i-ATRX ngoba yandisa izindlela zesiginesha zayo.

I-WATERMELON YESITHELO INCONYISWA NGE-PLUM YASE-EUROPE NGE-ATRX GENETIC RISK OF CANCER.

Khetha Nut COMMON HAZELNUT noma BRAZIL NUT?

I-Hazelnut evamile iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Quercetin, i-Lupeol, i-Formononetin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-EPHRIN Signaling, Cell Cycle, JAK-STAT Signaling kanye ne-P53 Signaling nezinye. I-Hazelnut evamile inconywa engozini ye-Chondrosarcoma lapho ingozi yofuzo ehlotshaniswa nayo i-ATRX. Lokhu kungenxa yokuthi i-Common Hazelnut inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives e-Brazil Nut yi-Curcumin, i-Ellagic Acid, i-Lupeol, i-Formononetin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress, i-JAK-STAT Signaling kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Brazil Nut ayinconywa uma ingozi ye-Chondrosarcoma uma ingozi yofuzo ehlotshaniswa nayo i-ATRX ngoba yandisa izindlela zesiginesha zayo.

I-HAZELNUT EJWAYELEKILE INCONYISWA NGAPHEZU KWE-BRAZIL NUT NGENGOZI YOFUZO YE-ATRX YOMKHANZA.

Ekuphetheni

Ukudla kanye Nezithako ezikhethiwe yizinqumo ezibalulekile zomdlavuza njenge-Chondrosarcoma. Iziguli ze-Chondrosarcoma kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: "Yikuphi ukudla nezithako zokudla okunempilo engikunconyelwe futhi okungenjalo?" Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezahlukene zezinkomba zomdlavuza ezifana ne-Chondrosarcoma, ngayinye enezakhi zofuzo zesimila ezihlukile ngokuhlukahluka kofuzo kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana neklabishi kuqukethe ama-bioactive ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene wezindlela zamakhemikhali ezinto eziphilayo. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda izindlela zokwelapha ezihlukene ze-chemotherapy. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo somuntu siqu somsoco we-addon senza isinqumo sibe lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo othi, "Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli i-Chondrosarcoma?". Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha.

Okubhekwayo

• I-Kunga Msk ehlanganisiwe ka-2022
• Ukwelashwa komdlavuza kulolonga isimo sokufaneleka se-clonal hematopoiesis.
• Imiphumela yokuvikela iqhathaniswa nokuphromotha yetiye elimhlophe ne-caffeine ku-PhIP-induced tumorigenesis kanye nokuvezwa kwe-beta-catenin kugundane.
• I-Vitamin C ithuthukisa ukuguqulwa kwe-epigenetic okubangelwa i-5-azacytidine kanye nokuboshwa komjikelezo weseli kumigqa yeseli ye-hepatocellular carcinoma i-HLE ne-Huh7.
• Imiphumela yokuvimbela ye-butyric acid, i-nicotinamide, i-calcium glucarate iyodwa noma ihlangene ngesikhathi se-7, i-12-dimethylbenz (a) i-anthracene eyenge i-tumorigenesis yesikhumba segundane ngokumodulation kwe-K-Ras-PI3K-AKTpathway kanye nama-RNA amancane ahlobene.
• Ukukhuthazwa ukukhula kwamaseli e-adenocarcinoma yamaphaphu kanye namaseli amancane e-epithelial yomoya nge-beta-carotene ngokwenza kusebenze i-cAMP, i-PKA, i-CREB ne-ERK1/2.
• I-Paederia foetida idala umsebenzi wokulwa nomdlavuza ngokushintsha ama-enzyme okuguqula i-chromatin futhi iguqule ukubonakaliswa kwezakhi zofuzo ze-cytokine ezinokuvuvukala kumaseli omdlavuza wendlala yesinye.
• Aggerholm-Pedersen N, et al, Orthop Res. Umfundisi, 2019
• https://my.clevelandclinic.org/health/diseases/22112-chondrosarcoma#:~:text=Cartilage%20is%20soft%20connective%20tissue,alive%20five%20years%20after%20diagnosis.
• https://my.clevelandclinic.org/health/diseases/22112-chondrosarcoma
• https://www.ncbi.nlm.nih.gov/books/NBK538132