Ukudla kwe-Myeloma eminingi!

Amaphuzu avelele

Awekho ama-cancer amabili afanayo, futhi awaphathwa ngendlela efanayo, futhi ukudla okunomsoco akufanele kufane kuwo wonke umuntu. Ukudla okunomsoco kuhlanganisa ukudla okufana nama-pulses, imifino, izithelo, amantongomane, amafutha, amakhambi nezinongo. Futhi ukudla okunomsoco kuhlanganisa izithasiselo zokudla okugxilile kakhulu noma ukugxila okuphezulu kwezithako ngazinye ezitholakala ekudleni. Emidlalweni efana ne-Multiple Myeloma lapho welashwa ngamakhemikhali noma lapho unquma ukuthi unengozi yofuzo yokuthola i-Multiple Myeloma ngenxa yokuguqulwa kofuzo kwe-NRAS ne-BRAF, umbuzo obaluleke kakhulu uthi “Yikuphi ukudla okufanele ngikugweme nokuthi yikuphi ukudla okunconyelwe mina ngokuqondile?” . Omunye umbuzo ohlobene uthi "Iziphi izithako zokudla okunomsoco okufanele ngizigweme?".

Ayikho impendulo yalo mbuzo zomdlavuza njenge-Multiple Myeloma engatholakala ngokusesha ku-inthanethi. Impendulo yombuzo ithi “Kuya ngokuthi” ngoba uhlelo lokudla okunomsoco ludinga ukwenziwa ngezifiso wena. Ukudla okunomsoco kufanele kuncike ekuboniseni umdlavuza, ulwazi lofuzo, umuntu omdala noma wezingane, isigaba, sokuqala noma sesibili, esithuthukisiwe, esine-metastatic, esibuyele emuva noma esiphikisayo, ukwelashwa okuqhubekayo uma kukhona, izithasiselo zokudla okunomsoco ezithathwayo, ubudala kanye nezici ezifana nobulili, isisindo, ubude, indlela yokuphila. , i-allergies kanye nezintandokazi zokudla.

Ngamafuphi - inqubo yokuphendula imibuzo efana nokuthi "Ingabe Kufanele Ngigweme Ukudla Isithelo I-Passion Fruit" noma "Faka isithelo I-Partridgeberry ekudleni kwami" noma "Ingabe kufanele nginciphise ukusetshenziswa kwe-Yam yemifino" noma "Ngingakwazi yini ukuthatha i-Ellagic Acid ne-Dim supplements" akuyona elula njengosesho lwe-inthanethi. Inqubo iyinkimbinkimbi kakhulu futhi izimpendulo zisekelwe ekwazini kofuzo, isenzo sokwelashwa, izithako ezisebenzayo ekudleni kanye nesenzo sazo sebhayoloji esihlobene. Ekugcineni impendulo yombuzo womsoco idinga ukwenziwa ngezifiso wena.

ISINQUMO: YENZA UKUDLA KWAKHO OKUNGEKHONA KANYE NEZENZELWE UKUZE WANDE I-MYELOMA, UKWELASHWA, ULWAZI LOFUZO, KANYE NEZINYE IZIMO.

Inhloso ephelele yokondleka komuntu siqu kwe-Multiple Myeloma ukunciphisa ukudla kanye nezithako zokudla okunomsoco ezinokusebenzelana okungalungile nabashayeli bamangqamuzana omdlavuza kanye nokwelashwa okuqhubekayo. Futhi khomba lokho kudla kanye nezithako ezinesenzo esizuzisayo. Noma nini lapho kuba noshintsho ekwelashweni noma ekuxilongweni - kubalulekile ukukhumbula ukuthi ukudla kwakho nezithako ezisizayo zidinga ukuhlolwa kabusha. Futhi izimpendulo zombuzo womsoco zingahluka ngokusekelwe kumongo omusha.

ISINQUMO: BUYEKEZA UKUDLA KWAKHO KWE-MYELOMA ENINGI, LAPHO UKWELASHWA, ISIMO SEZIFO KANYE NEZINYE IZIMO ZISHINTSHA.

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Mayelana ne-Myeloma eminingi

I-cBioPortal iwumthombo owodwa wokuqoqwa kwe umdlavuza idatha yesiguli evela ezivivinyweni zomtholampilo kuzo zonke izinkomba ezingama-350 kanye nezinkomba zomdlavuza. Idatha evela esivivinyweni ngasinye somtholampilo ihlanganisa igama lesilingo somtholampilo nemininingwane yocwaningo njengenombolo yeziguli, ubudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila, ukuphazamiseka kofuzo okutholiwe nokuhlaziywa kwayo yonke idatha. I-cBioPortal yeCancer Genomics yaqalwa yasungulwa eMemorial Sloan Kettering Cancer Center (MSK). Indawo yomphakathi ye-cBioPortal isingathwe yiCentre for Molecular Oncology kwa-MSK - https://www.cbioportal.org/about.

Okuvelele okubalulekile okulandelayo kuthathwe kudatha yomtholampilo ye-Multiple Myeloma evela ku-cBioPortal. Iziguli ezibhalisele izifundo ze-Multiple Myeloma zineminyaka ephakathi kuka-24 kuya kwengama-82 kanti isilinganiso seminyaka yobudala engama-61. U-66.2% wabesilisa kanye no-33.8% wabesifazane babe ukusatshalaliswa kobulili kulezi zifundo zomtholampilo. Kusukela kusayizi wesampula yesiguli wama-212; izakhi zofuzo eziphezulu ezinokuguquguquka nokunye okungavamile kwe-Multiple Myeloma kuhlanganisa izakhi zofuzo i-KRAS, i-NRAS, i-TP53, i-BRAF ne-MUC16. Ukusatshalaliswa kwemvamisa yokwenzeka kwalezi zakhi zofuzo ngokulandelana kungu-22.0%, 18.0%, 7.3%, 6.3% kanye no-6.3%. Le mininingwane yofuzo lwesimila ye-Multiple Myeloma ifakwe kumephu kubashayeli bendlela yamangqamuzana e-biochemical yomdlavuza ngaleyo ndlela inikeze incazelo yezici zesici se-Multiple Myeloma.

I-Multiple myeloma ingumdlavuza wegazi wamangqamuzana e-plasma atholakala emnkantsheni wethambo, izicubu eziyisiponji ngaphakathi emathanjeni ethu, ngokuvamile adala izingxenye ezihlukene zegazi lethu. Amaseli e-plasma ayingxenye eyinhloko yamasosha omzimba. Akhiqiza amasosha omzimba asiza umzimba ukulwa nezifo. I-Myeloma iqala lapho amangqamuzana e-plasma enempilo eshintsha futhi ekhula engalawuleki. Lokhu kungase kubangele izilonda eziningi zamathambo okwandisa ingozi yokuphuka kwamathambo, okubizwa ngokuthi i-myeloma eminingi. Amangqamuzana e-plasma angajwayelekile ahlukana ngokushesha angaminyanisa noma acindezele ukukhula kwamanye amangqamuzana omnkantsha, kuhlanganise namangqamuzana egazi abomvu, amangqamuzana egazi amhlophe namaplatelet. Lokhu akwehlisi nje kuphela ukuzivikela komzimba, kodwa futhi kungabangela i-anemia ngenxa yokushoda kwamangqamuzana abomvu egazi, ukopha ngokweqile ngokusikeka okuncane namanxeba ngenxa yokushoda kwama-platelet, nokuncipha kwekhono lokulwa nezifo, ngenxa yokuntuleka kwamangqamuzana amhlophe egazi. . Amaseli e-Myeloma awakwazi ukukhiqiza amasosha omzimba asebenzayo kodwa esikhundleni salokho enza iphrotheni engu-M enganqwabelana egazini nasemchamweni, engase ilimaze izinso nezinye izitho, ngaphandle kokunciphisa ukuzivikela komzimba. Umuntu onempilo otholakala enenani elincane le-M protein kuthiwa une-monoclonal gammopathy yokubaluleka okungaqinisekisiwe (MGUS), isandulela se-myeloma eminingi.

Kulinganiselwa ukuthi izehlakalo ezintsha ze-myeloma eminingi ngo-2022 zingaphezu kuka-30,000, cishe i-1.8% yazo zonke izehlakalo ezintsha zomdlavuza. Izinga lokusinda leminyaka engu-5 leziguli ezine-myeloma eminingi licishe libe ngu-58% (Ref: seer.cancer.gov). Ukwelashwa kwe-myeloma eminingi kuhlanganisa ukwelashwa ukulawula lesi sifo kanye nokunakekelwa okusekelayo ukuze kuthuthukiswe izinga lempilo, njengokudambisa izimpawu nokugcina ukudla okunomsoco ngokudla okufanele kanye nezithako zemvelo. Uhlelo lokwelapha luhlanganisa ukwelashwa kokungeniswa ukuze kulawulwe ngokushesha umdlavuza; ukwelapha okuqinisiwe nge-chemotherapy eyengeziwe noma ukufakelwa kwethambo lomnkantsha/i-stem cell kanye nokwelashwa kokulungisa isikhathi eside ukuze kuvinjelwe ukuphindeka komdlavuza. Imithi yokwelapha ihlanganisa i-chemotherapy, i-target therapy, i-immunomodulatory drugs, i-steroids, i-bone-modifying drugs, ne-immunotherapy. Ukudla okufanele kanye nezithako zemvelo ezihambisana nokwelashwa kungasiza ngokuqhubekayo ukuthuthukisa inhlalakahle yesiguli. (Ref: https://www.cancer.net/cancer-types/multiple-myeloma/introduction; https://www.cancer.org/cancer/multiple-myeloma/about/key-statistics.html)

Ukubaluleka Kokudla Kwe-Myeloma Eningi

Konke ukudla nezithako zokudla okunomsoco kuhlanganisa iqoqo lezithako zekhemikhali eyodwa noma ngaphezulu ezisebenzayo ngezilinganiso namanani ahlukene. Isenzo sezithako ezithile ezisebenzayo ekudleni singaba nokusebenzisana okungalungile kuyilapho ezinye izithako ezisebenzayo ekudleni okufanayo zingase zisekele kumongo we-Multiple Myeloma. Ngakho-ke ukudla okufanayo kunezenzo ezinhle nezingezinhle kangako futhi ukuhlaziya umphumela ohlangene kuzodingeka ukuze kuqhamuke nohlelo lomuntu siqu lokudla okunempilo.

Ngokwesibonelo Passion Fruit kuhlanganisa izithako ezisebenzayo Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid, Vitamin A nabanye. Futhi iPartridgeberry iqukethe izithako ezisebenzayo Resveratrol, Beta-sitosterol, Stigmasterol nabanye. Kungenzeka ukuthi ezinye zalezi zithako ezisebenzayo zokudla okufanayo zingaba nemiphumela ephikisanayo futhi yingakho kutuswa ukuhlonza ukudla okunconyiwe okusekelwe ekuhlaziyweni kwazo zonke izithako ezinomthamo ophezulu eziqukethwe ekudleni.

Emidlalweni efana ne-Multiple Myeloma, ukwenziwa kusebenze noma ukuvimbela izindlela ezikhethiwe ze-biochemical ezifana ne-Growth Factor Signaling, i-Extracellular Matrix Remodelling, i-RAS-RAF Signaling, i-MAPK Signaling idlala indima ebalulekile ekuqhubekiseni ukukhula komdlavuza. Ngokufanayo izindlela zokwelapha ezihlukene zisebenza ngezindlela ezahlukene zamangqamuzana okungafanele neze zikhanselwe ukudla kwakho nezithako zokudla. Ukudla kanye nezithako zokudla okunomsoco kuqukethe izithako ezisebenzayo ezihlukene ngasinye esinesenzo semolekyuli ethile ezindleleni ezihlukene ze-biochemical. Ngakho-ke, ukudla okunye ukudla kanye nezithako zokudla okunomsoco kunganconywa ngokwelashwa okukhethekile kwe-Multiple Myeloma, kuyilapho ukudla okunye ukudla nezithako ezingeziwe kungase kunganconyiwe.

Iphutha elilodwa elivamile lapho uthola ukudla ongakudla noma ungakudli - ukucabangela izithako ezimbalwa ezisebenzayo eziqukethwe ekudleni okusekelwe ekusesheni kwe-inthanethi futhi ungazinaki ezinye. Ngenxa yokuthi izithako ezihlukahlukene ezisebenzayo eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo ezindleleni ezifanele zamakhemikhali ezinto eziphilayo - kutuswa ukuba kucatshangelwe zonke izithako ezisebenzayo ezinomthamo omkhulu nezikhudlwana kunamanani amancane ekudleni.

ISINCOMO: UKUTHOLA UKUDLA OKUNCONYISWA KANYE OKUNGCONYISIWE KWE-MYELOMA ENINGI – CABANGA IZITHAKO EZISEBENZAYO ENENINGI ELIPHEZULU OKUQUKETHWE EKUDENI.

Ukudla kwe-Multiple Myeloma okwelashwa ngamakhemikhali

Ku-Multiple Myeloma - izakhi zofuzo i-KRAS, i-NRAS, i-TP53, i-BRAF ne-MUC16 zinezehlakalo eziphezulu zokungajwayelekile kwe-genomic. Akuzona zonke lezi zakhi zofuzo ezifanele umdlavuza – nakuba zibikiwe. Ezinye zalezi zakhi zofuzo ngokuqondile noma ngokungaqondile zigcina sezilawula izindlela ezihlukene zebhayoloji ehlobene nomdlavuza. Eminye yezindlela eziyizishayeli ezifanele ze-Multiple Myeloma i-Growth Factor Signaling, i-Extracellular Matrix Remodelling, i-Angiogenesis nezinye. I-Bortezomib ingenye ye-chemotherapies esetshenziselwa ukwelashwa komdlavuza. Inhloso yokwelashwa ukuphika noma ukukhansela imiphumela yezindlela zamakhemikhali ezinto eziphilayo ezishayela i-Growth Factor Signaling, i-Extracellular Matrix Remodelling, i-Angiogenesis ukuze kwehliswe ukuqhubeka kwesifo futhi kuvinjwe ukukhula. Lokho kudla okusebenza kwayo okuhlanganisiwe kwezithako ezisebenzayo kusekela isenzo sokwelashwa futhi kungathuthukisi abashayeli bezifo ukudla okunconyiwe kanye nezithako ezizofakwa ekudleni komuntu siqu. Futhi ngokufanayo - lokho kudla okusebenza kwakho okuhlanganisiwe kwezithako ezisebenzayo okungasekeli isenzo sokwelashwa kodwa okugcina kukhuthaza ukushayela kwezifo ngeke kunconywe ohlelweni lwakho lokudla okuqondene nawe.

ISINQUMO: GWEMA IZITHATHO KANYE NEKUDLA OKUNGASEKELI ISENZO SOKWELASHWA KOMDLAVUZA FUTHI KUTHUTHUKISE ABASHAYELI BEZIFO.

Yidla ama-pulses amaningi, uphizi onamehlo amnyama noma uphizi lwejuba?

Ama-pulses ayingxenye ebalulekile yokudla okuningi. Izithako ezisebenzayo eziqukethwe ku-Black-eyed Pea yi-Vitamin C, i-Daidzein, i-Oleic Acid, i-Linolenic Acid, i-Beta-carotene phakathi kwabanye. Nakuba izithako ezisebenzayo eziqukethwe ku-Pigeon Pea yi-Vitamin C, i-Oleic Acid, i-Linolenic Acid, i-Genistein, i-Linoleic Acid nezinye.

I-Vitamin C ingashintsha izindlela ze-biochemical WNT Beta Catenin Signaling, Angiogenesis kanye ne-Hypoxia. I-Daidzein inesenzo sebhayoloji ezindleleni ze-biochemical PI3K-AKT-MTOR Ukusayina, Ukucindezeleka Kwe-Oxidative kanye Ne-Endoplasmic Reticulum Stress.

I-Genistein ingashintsha izindlela ze-biochemical Oxidative Stress. I-Vitamin A inesenzo sebhayoloji ezindleleni zamakhemikhali ezinto eziphilayo Ukwenziwa kabusha kwe-Extracellular Matrix Remodelling. Njalo njalo.

Lapho ukwelapha i-Myeloma eminingi nge-chemotherapy Bortezomib - Ukudla okufana ne-Black-eyed Pea kunconywa uma kuqhathaniswa ne-Pigeon Pea. Lokhu kungenxa yokuthi izithako ezisebenzayo i-Genistein ne-Vitamin A ku-Pigeon Pea ziphazamisa isenzo sokwelashwa ngokukhansela izindlela zamakhemikhali ezinto eziphilayo lapho ukwelashwa ngamakhemikhali kusebenza khona. Nakuba izithako ezisebenzayo i-Vitamin C kanye ne-Daidzein eziqukethwe ku-Black-eyed Pea zisekela isenzo sokwelapha ngokuthuthukisa umphumela wendlela ye-biochemical lapho i-chemotherapy isebenza ngayo.

INCOMO: I-PEA ONAMNYAMA OMNYAMA INCONYWA PHEZU KWE-PIGEON PEA NGE-MYELOMA ENINGI EKWELASHWENI NGE-CHEMOTHERAPY BORTEZOMIB NGEZIMO EZINYE.

Yidla imifino eminingi, i-Giant Butterbur noma i-Yam?

Imifino iyingxenye ebalulekile yokudla okuningi. Izithako ezisebenzayo eziqukethwe ku-Giant Butterbur yi-Vitamin C, i-Melatonin, i-Beta-sitosterol, i-Kaempferol, i-Vitamin A phakathi kwabanye. Nakuba izithako ezisebenzayo eziqukethwe ku-Yam yi-Vitamin C, i-Beta-sitosterol, i-Oleic Acid, i-Linolenic Acid, i-Dioscin nabanye.

I-Vitamin C ingashintsha izindlela ze-biochemical WNT Beta Catenin Signaling, Angiogenesis kanye ne-Hypoxia. I-Melatonin inesenzo sebhayoloji ezindleleni ze-biochemical PI3K-AKT-MTOR Ukusayina, Ukusayinda Kwesici Sokukhula kanye Nokucindezeleka Kwe-Oxidative.

I-Citric Acid ingashintsha izindlela ze-biochemical Oxidative Stress. I-Dioscin inesenzo sebhayoloji emizileni ye-biochemical Notch Signaling. Njalo njalo.

Lapho ukwelapha i-Multiple Myeloma nge-chemotherapy Bortezomib - Ukudla okufana ne-Giant Butterbur kunconywa uma kuqhathaniswa ne-Yam. Lokhu kungenxa yokuthi izithako ezisebenzayo i-Citric Acid ne-Dioscin ku-Yam ziphazamisa isenzo sokwelashwa ngokukhansela izindlela zamakhemikhali ezinto eziphilayo lapho ukwelashwa ngamakhemikhali kusebenza khona. Nakuba izithako ezisebenzayo i-Vitamin C ne-Melatonin equkethwe ku-Giant Butterbur zisekela isenzo sokwelashwa ngokuthuthukisa umphumela wendlela ye-biochemical lapho i-chemotherapy isebenza ngayo.

ISINCOMO: IBUTTERBUR ENKULU IYANCONYISWA NGE-YAM NGE-MYELOMA ENINGI EKWELASHWENI NGECHEMOTHERAPY BORTEZOMIB NGEZINYE IZIMO.

Yehlulekile ukuxhuma ku-MySQL: Awukho umzila wokuba usokhaya

Yidla izithelo eziningi, iPartridgeberry noma Isithelo se-Passion?

Izithelo ziyingxenye ebalulekile yokudla okuningi. Izithako ezisebenzayo eziqukethwe kuPartridgeberry yiResveratrol, Beta-sitosterol, Stigmasterol phakathi kwezinye. Nakuba izithako ezisebenzayo eziqukethwe ku-Passion Fruit yi-Vitamin C, i-Oleic Acid, i-Linolenic Acid, i-Linoleic Acid, i-Vitamin A nezinye.

I-Resveratrol ingasebenzisa izindlela ze-biochemical Hypoxia, Angiogenesis kanye ne-Endoplasmic Reticulum Stress. I-Beta-sitosterol inesenzo sebhayoloji ezindleleni zamakhemikhali ezinto eziphilayo i-WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling and Oxidative Stress.

I-Vitamin A ingashintsha izindlela zamakhemikhali ezinto eziphilayo Ukwenziwa kabusha kwe-Extracellular Matrix Remodelling. I-Citric Acid inesenzo sebhayoloji ezindleleni ze-biochemical Oxidative Stress. Njalo njalo.

Lapho ukwelapha i-Multiple Myeloma nge-chemotherapy Bortezomib - Ukudla okufana ne-Partridgeberry kunconywa uma kuqhathaniswa ne-Passion Fruit. Lokhu kungenxa yokuthi izithako ezisebenzayo i-Vitamin A ne-Citric Acid ku-Passion Fruit ziphazamisa isenzo sokwelashwa ngokukhansela izindlela zamakhemikhali ezinto eziphilayo lapho ukwelashwa ngamakhemikhali kusebenza khona. Nakuba izithako ezisebenzayo i-Resveratrol ne-Beta-sitosterol equkethwe ku-Partridgeberry zisekela isenzo sokwelapha ngokuthuthukisa umphumela wendlela ye-biochemical lapho i-chemotherapy isebenza khona.

ISINCOMO: I-PARTRIDGEBERRY INCONYWA PHEZU KWESITHELO SOKUKHUTHAZWA KWE-MYELOMA ENINGI EKWELASHWENI NGECHEMOTHERAPY BORTEZOMIB NGEZINYE IZIMO.

Yidla amantongomane amaningi, i-Chestnut noma i-Macadamia Nut?

Amantongomane ayingxenye ebalulekile yokudla okuningi. Izithako ezisebenzayo eziqukethwe ku-Chestnut yi-Quercetin, i-Ellagic Acid, i-Vitamin C, i-Oleic Acid, i-Betulin phakathi kwabanye. Nakuba izithako ezisebenzayo eziqukethwe ku-Macadamia Nut yi-Beta-sitosterol, i-Lauric Acid, i-Palmitic Acid, i-Myristic Acid, i-Folic Acid nezinye.

I-Ellagic Acid ingashintsha izindlela ze-biochemical WNT Beta Catenin Signaling, Angiogenesis kanye Ne-Extracellular Matrix Remodelling. I-Betulin inesenzo sebhayoloji ezindleleni ze-biochemical Hypoxia, Oxidative Stress and PI3K-AKT-MTOR Signaling.

I-Lauric Acid ingashintsha izindlela ze-biochemical PI3K-AKT-MTOR Ukusayina. I-Palmitic Acid inesenzo sebhayoloji ezindleleni ze-biochemical WNT Beta Catenin Signaling, Angiogenesis kanye Ne-Extracellular Matrix Remodelling. Njalo njalo.

Lapho ukwelapha i-Multiple Myeloma nge-chemotherapy Bortezomib - Ukudla okufana ne-Chestnut kunconywa uma kuqhathaniswa ne-Macadamia Nut. Lokhu kungenxa yokuthi izithako ezisebenzayo i-Lauric Acid ne-Palmitic Acid ku-Macadamia Nut ziphazamisa isenzo sokwelashwa ngokukhansela izindlela zamakhemikhali ezinto eziphilayo lapho ukwelashwa ngamakhemikhali kusebenza khona. Nakuba izithako ezisebenzayo i-Ellagic Acid ne-Betulin equkethwe ku-Chestnut zisekela isenzo sokwelashwa ngokuthuthukisa umphumela wendlela ye-biochemical lapho ukwelashwa ngamakhemikhali kusebenza khona.

ISINCOMO: I-CHESTNUT INCONYISWA NGAPHEZU KWE-MACADAMIA NUT NGE-MYELOMA ENINGI EKWELASHWENI NGE-CHEMOTHERAPY BORTEZOMIB NGEZIMO EZINYE.

Ukudla Kwengozi Yofuzo Ye-Myeloma Eningi

Enye yezindlela zokuhlola ubungozi umdlavuza iwukubheka ukuba khona kokungajwayelekile kofuzo eqoqweni lezakhi zofuzo. Kukhona ulwazi lwangaphambili kuhlu lwezakhi zofuzo ukuguqulwa kwazo nokunye okungahle kube nomthelela engcupheni yomdlavuza ohlukene. I-NRAS ne-BRAF ziyizakhi zofuzo ezimbili okungavamile kwazo kuyizici zengozi ye-Multiple Myeloma. Esimeni esinjalo sobungozi bomdlavuza - kuyilapho ngokuvamile zingekho izindlela zokwelapha udokotela angakwazi ukuzinqumela - izindlela ezihlukahlukene ze-biochemical ezingase zibe umshayeli wamangqamuzana e-Multiple Myeloma zingasetshenziswa njengesiqondiso sokuza nohlelo lokudla komuntu siqu olunconywayo. Kufuzo lwe-Myeloma eminingi i-NRAS inomthelela oyimbangela ezindleleni zebhayoloji ezifana ne-G-protein-coupled Receptor Signaling, i-Growth Factor Signaling kanye ne-RAS-RAF Signaling. Futhi i-BRAF inomthelela oyimbangela ezindleleni zebhayoloji ezifana ne-RAS-RAF Signaling, MAPK Signaling kanye ne-Antigen Presentation. Ukudla kanye nezithako zokudla ezinomsoco ezinesenzo samangqamuzana ukukhansela imiphumela yezindlela zamakhemikhali ezinto eziphilayo zezakhi zofuzo ezifana ne-NRAS ne-BRAF kufanele zifakwe ohlelweni lokudla komuntu siqu. Futhi lokho kudla nezithako ezikhuthaza imiphumela yezakhi zofuzo i-NRAS ne-BRAF kufanele kugwenywe.

Yidla ama-pulses amaningi, i-Mung Bean noma i-Adzuki Bean?

Izithako ezisebenzayo eziqukethwe ku-Mung Bean yi-Quercetin, i-Oleic Acid, i-Linolenic Acid, i-Vitamin C, i-Vitexin phakathi kwezinye. Ngenkathi izithako ezisebenzayo eziqukethwe ku-Adzuki Bean ziyi-Isoliquiritigenin, i-Glucaric Acid, i-Genistein, i-Folic Acid nezinye.

I-Quercetin ingakhohlisa izindlela ze-biochemical ye-MAPK Ukusayinda, izindawo zokuhlola umjikelezo wamaseli kanye nokusayina kwe-RAS-RAF. I-Vitamin C inesenzo sebhayoloji ezindleleni ze-biochemical P53 Signaling, MYC Signaling kanye ne-PI3K-AKT-MTOR Signaling.

I-Folic Acid ingashintsha izindlela ze-biochemical ye-MAPK Signaling, Cell Cycle Checkpoints kanye ne-RAS-RAF Signaling. Njalo njalo.

Ngengozi yofuzo ye-Multiple Myeloma ngenxa yokungajwayelekile kwezakhi zofuzo i-NRAS ne-BRAF - Ukudla okufana ne-Mung Bean kuyanconywa uma kuqhathaniswa ne-Adzuki Bean. Lokhu kungenxa yokuthi izithako ezisebenzayo ze-Folic Acid ku-Adzuki Bean zithuthukisa imiphumela yezakhi zofuzo ezindleleni zamakhemikhali ezinto eziphilayo. Ngenkathi izithako ezisebenzayo i-Quercetin kanye ne-Vitamin C equkethwe ku-Mung Bean ndawonye inomphumela wokukhansela wofuzo emigudwini ye-biochemical.

ISINCOMO: I-MUNG BEAN INCONYISWA NGAPHEZU KWE-ADZUKI ENKOSI NGOKUNXIPHA INGOZI YOFUZO YE-MYELOMA ENINGI NGENXA YEGENES I-NRAS NE-BRAF

Yidla imifino eminingi, Umdumbula noma Isilimo esidliwayo esinamagatsha anamanzi?

Izithako ezisebenzayo eziqukethwe ku-Cassava yi-Beta-sitosterol, i-Oleic Acid, i-Linolenic Acid, i-Vitamin C, i-Linoleic Acid phakathi kwezinye. Nakuba izithako ezisebenzayo eziqukethwe ku-Celery yi-Apigenin, i-Quercetin, i-Oleic Acid, i-Linolenic Acid, i-Vitamin C nezinye.

I-Vitamin C ingashintsha izindlela ze-biochemical ye-MAPK Ukusayinda, izindawo zokuhlola umjikelezo wamaseli kanye nokusayina kwe-RAS-RAF. I-Beta-sitosterol inesenzo sebhayoloji ezindleleni ze-biochemical P53 Signaling, MYC Signaling kanye ne-PI3K-AKT-MTOR Signaling.

I-Luteolin ingashintsha izindlela ze-biochemical MYC Signaling. I-Chrysin inesenzo sebhayoloji ezindleleni zamakhemikhali ezinto eziphilayo I-MYC Signaling. Njalo njalo.

Ngengozi yofuzo ye-Multiple Myeloma ngenxa yokungajwayelekile kwezakhi zofuzo i-NRAS ne-BRAF - Ukudla okufana ne-Cassava kuyanconywa uma kuqhathaniswa ne-Celery. Lokhu kungenxa yokuthi izithako ezisebenzayo i-Luteolin ne-Chrysin ku-Celery zithuthukisa imiphumela yezakhi zofuzo ezindleleni ze-biochemical. Ngenkathi izithako ezisebenzayo i-Vitamin C kanye ne-Beta-sitosterol equkethwe ku-Cassava ndawonye inomphumela wokukhansela wofuzo emigudwini ye-biochemical.

ISINCOMO: I-CASSAVA INCONYISWA NGAPHEZU KWE-CELERY NGOKWEHLISA INGOZI YOFUZO YE-MYELOMA ENINGI NGENXA YEGENES NRAS NE-BRAF

Yidla izithelo eziningi, i-Orange noma iSitrobheli?

Izithako ezisebenzayo eziqukethwe ku-Orange yi-D-limonene, i-Linalool, i-Modified Citrus Pectin, i-Oleic Acid, i-Linolenic Acid phakathi kwezinye. Nakuba izithako ezisebenzayo eziqukethwe ku-Strawberry yi-Ellagic Acid, i-Lupeol, i-Cianidanol, i-Beta-sitosterol, i-Oleic Acid nezinye.

I-D-limonene ingashintsha izindlela ze-biochemical ye-MAPK Signaling, Cell Cycle Checkpoints kanye ne-RAS-RAF Signaling. I-Vitamin C inesenzo sebhayoloji ezindleleni ze-biochemical P53 Signaling, MYC Signaling kanye ne-PI3K-AKT-MTOR Signaling.

I-Fisetin ingashintsha izindlela ze-biochemical MYC Signaling. I-Pelargonidin inesenzo sebhayoloji ezindleleni ze-biochemical Cell Cycle Checkpoints, i-PI3K-AKT-MTOR Signaling kanye ne-MYC Signaling. Njalo njalo.

Ngengozi yofuzo ye-Multiple Myeloma ngenxa yokungajwayelekile kwezakhi zofuzo i-NRAS ne-BRAF - Ukudla okufana ne-Orange kuyanconywa uma kuqhathaniswa ne-Strawberry. Lokhu kungenxa yokuthi izithako ezisebenzayo i-Fisetin ne-Pelargonidin ku-Strawberry zithuthukisa futhi imiphumela yezakhi zofuzo ezindleleni ze-biochemical. Ngenkathi izithako ezisebenzayo i-D-limonene kanye ne-Vitamin C equkethwe ku-Orenji ndawonye inomphumela wokukhansela wezakhi zofuzo ezindleleni zamakhemikhali ezinto eziphilayo.

ISINCOMO: I-ORANGE INCONYISWA PHEZU KWE-STRAWBERRY NGOKWEHLISA INGOZI YOFUZO YE-MYELOMA ENINGI NGENXA YEGENES NRAS NE-BRAF

Yidla amantongomane amaningi, i-almond noma i-Cashew Nut?

Izithako ezisebenzayo eziqukethwe ku-Almond yi-Quercetin, i-Vitamin E, i-Beta-sitosterol, i-Oleic Acid, i-Linolenic Acid phakathi kwezinye. Nakuba izithako ezisebenzayo eziqukethwe ku-Cashew Nut ziyi-Palmitic Acid, i-Beta-sitosterol, i-Vitamin C, i-Gallic Acid, i-Butyric Acid nezinye.

I-Beta-sitosterol ingashintsha izindlela zamakhemikhali ezinto eziphilayo Ama-Cell Cycle Checkpoints, i-P53 Signaling kanye ne-MYC Signaling. I-Quercetin inesenzo sebhayoloji emizileni ye-biochemical ye-MAPK Ukusayinda, Ukusayinda kwe-RAS-RAF kanye nokusayina kwe-PI3K-AKT-MTOR.

I-Palmitic Acid ingashintsha izindlela ze-biochemical MAPK Signaling. I-Lauric Acid inesenzo sebhayoloji ezindleleni zamakhemikhali ezinto eziphilayo I-MYC Signaling, PI3K-AKT-MTOR Signaling kanye ne-MAPK Signaling. Njalo njalo.

Ngengozi yofuzo ye-Multiple Myeloma ngenxa yokungajwayelekile kwezakhi zofuzo i-NRAS ne-BRAF - Ukudla okufana ne-Almond kuyanconywa uma kuqhathaniswa ne-Cashew Nut. Lokhu kungenxa yokuthi izithako ezisebenzayo i-Palmitic Acid ne-Lauric Acid ku-Cashew Nut zithuthukisa imiphumela yezakhi zofuzo ezindleleni ze-biochemical. Ngenkathi izithako ezisebenzayo i-Beta-sitosterol ne-Quercetin equkethwe ku-Almond ndawonye inomphumela wokukhansela wezakhi zofuzo ezindleleni zamakhemikhali ezinto eziphilayo.

ISINCOMO: I-ALIMOND INCONYISWA NGAPHEZU KWENAMATI KASHEWU NGOKWEHLISA INGOZI YOFUZO YE-MYELOMA ENINGI NGENXA YEGENES NRAS NE-BRAF

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Ngokufigqiwe

Into ebalulekile okufanele uyikhumbule ukuthi umdlavuza Ukwelashwa kungase kungafani kuwo wonke umuntu - futhi nokudla kwakho akufanele kufane. Ukudla okunomsoco okuhlanganisa ukudla nezithako zokudla okunomsoco kuyithuluzi elisebenza kahle kakhulu elilawulwa nguwe.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa kumongo womdlavuza. Isibalo sempendulo siyinkimbinkimbi futhi sincike ohlotsheni lomdlavuza, i-genomics engaphansi, ukwelashwa kwamanje, noma yikuphi ukungezwani komzimba, ulwazi lwendlela yokuphila, kanye nezici ezifana ne-BMI.

Uhlelo lokudla okomuntu siqu kwe-addon luncoma ukudla nezithako ezinciphisa ukusebenzisana okunomsoco futhi zikhuthaze ukwesekwa ekwelashweni.

Usungaqalisa MANJE futhi udizayine uhlelo lokudla komuntu siqu lwe-Multiple Myeloma ngokuphendula imibuzo ngohlobo lomdlavuza, izindlela zokwelapha zamanje, izithasiselo zokudla, izinto ezingezwani nomzimba, iqembu lobudala, ubulili, nolwazi lwendlela yokuphila.

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Okubhekwayo

• I-Msk Impact 2017
• I-genetic heterogeneity ebanzi ku-myeloma eminingi: imiphumela yokwelashwa okuhlosiwe.
• Uvithamini C ubulala ngokukhetha amaseli omdlavuza we-colorectal we-KRAS kanye ne-BRAF ngokukhomba i-GAPDH.
• Umphumela we-Daidzein kumdlavuza we-prostate refractory we-hormone in vitro kanye ne-vivo uma kuqhathaniswa ne-genistein ne-soy extract: amandla e-radiotherapy.
• Ukunamathela kumatrix e-extracellular kulawulwa kahle yi-retinoic acid kumaseli we-HepG2.
• I-Resveratrol ingenisa i-autophagy ngokuvimbela ngokuqondile i-mTOR ngomncintiswano we-ATP.
• I-β-Sitosterol iqondise i-Trx/Trx1 reductase ukuze yenze i-apoptosis kumaseli e-A549 nge-ROS mediated mitochondrial dysregulation kanye nokusebenza kwe-p53.
• I-Melatonin Inciphisa i-Her-2, p38 MAPK, p-AKT, kanye namazinga we-mTOR ku-Ovarian Carcinoma ye-Ethanol-Preferring Rats.
• Umthelela we-dioscin ekukhuthazeni ukuvuselelwa kwesibindi ngokuvula indlela yesignali ye-Notch1/Jagged1.
• I-Indeno[1,2-b]okuphuma kwe-indole njengesigaba senoveli yama-protein kinase CK2 inhibitors womuntu anamandla.
• Amathrendi esifo senhliziyo sokuzalwa kwabazalwa base-Dallas County. 1971-1984.
• I-Taurine ithuthukisa ukumelana ne-insulin yezinga eliphansi le-arsenic-induced insulin ngokwenza kusebenze ukusayinda kwe-PPARγ-mTORC2 kanye nokuvimbela i-autophagy ye-hepatic.
• Ama-protein kinase kanye nama-HDAC inhibitors asuka ku-endophytic fungus i-Epicoccum nigrum.
• Inkulumo ye-protooncogene elandelanayo ekuvuseleleni izinso kulandela ukulimala kwezinso okukhulu.
• I-D-Limonene ishintsha ukuvuvukala, ukucindezeleka kwe-oxidative kanye nendlela ye-Ras-ERK yokuvimbela i-tumorigenesis yesikhumba se-murine.
• Isakhiwo sekristalu senkimbinkimbi encike ku-cyclin-kinase 6 yomuntu ene-flavonol inhibitor, i-fisetin.
• I-Pelargonidin icindezela i-adipogenesis kumaseli we-3T3-L1 ngokuvinjelwa kwendlela yokusayina ye-PPAR-γ.
• I-pharmacodynamics yomtholampilo yama-antihistamines.
• I-Resveratrol, i-pterostilbene, ne-piceatannol kumajikijolo e-vaccinium.
• I-HyperFoods: Imephu ehlakaniphile yomshini yama-molecule ashaya umdlavuza ekudleni.
• I-Fisetin: i-antioxidant yokudla yokukhuthaza impilo.

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• Yikuphi Ukudla Oku-3 Okufanele Kugwenywe Ngokushushuzela I-Myeloma Eminingi?
• Yiziphi Izinhlobo Zomdlavuza Okufanele Ngigweme Ukwelashwa Kwegalikhi?
• Yikuphi Ukudla Okunconyelwe i-Waldenstrom Macroglobulinemia?
• Yiziphi Izinhlobo Zomdlavuza Okufanele Ngikugweme Ukwelekelelwa Kosoya?
• Yiziphi Izinhlobo Zomdlavuza Okufanele Ngigweme I-Allspice Supplement?