Ukudla kwe-Acral Melanoma!

Isingeniso 

Ukudla kwe-Acral Melanoma kufanele kube okuqondene nomuntu ngamunye futhi kufanele kuzivumelanise nezimo lapho ukwelashwa komdlavuza noma ukuguquka kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene ngokuphathelene nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza kanye nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula. 

I-Acral Melanoma, uhlobo oluhlukile lwe-melanoma, ngokuvamile lubonakala ezandleni, ezinyaweni, nangaphansi kwezinzipho, luveza izimpawu ezihlukile njengokushintsha kombala wezinzipho noma izilonda zesikhumba. Lolu hlobo oluncane lwe-melanoma lungahlolwa nge-dermoscopy, nge-acral lentiginous melanoma evame ukubonwa onyaweni, kanye nezithombe zalokhu kubonakaliswa zisiza ekuqondeni okubonakalayo. Izimpawu ze-pathology ze-acral melanoma, kufaka phakathi amafomu e-situ, zibalulekile ekuxilongweni okunembile, futhi uhlelo lwe-ICD-10 lokufaka amakhodi luhlinzeka ngezigaba zalo. Ukwelashwa kuyehluka ngokuya ngesiteji kanye nohlobo loguquko, ngezinga lokubikezela kanye namazinga okusinda kuye ngezici ezifana nokuthi i-melanoma isakazeka ngokushesha kangakanani kanye nolaka lwayo lonke. Amapulatifomu aku-inthanethi afana ne-Reddit anikeza izingxoxo zomphakathi mayelana nolwazi lomuntu siqu nolwazi. Ukuqonda ukuthi i-acral melanoma ibukeka kanjani nokuthi iyibangelani, kubalulekile ukuze ibonwe kusenesikhathi nokuphathwa ngempumelelo, njengoba lolu hlobo oluncane lwe-melanoma lungakhula ezindaweni ezingavami ukuchayeka elangeni.

Nge-Acral Melanoma, ingabe kunendaba ukuthi iyiphi imifino, izithelo, amantongomane, imbewu umuntu ayidlayo?

Umbuzo ovame kakhulu wokudla okunomsoco obuzwa iziguli ezinomdlavuza kanye nabantu abasengozini yomdlavuza uwukuthi - kumdlavuza onjenge-Acral Melanoma ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe ezitshalweni ingabe kwanele umdlavuza onjenge-Acral Melanoma?

Isibonelo, ingabe kunendaba ukuthi iklabishi yemifino idliwa kakhulu uma iqhathaniswa ne-Chinese Broccoli? Ingabe kuyawenza umehluko uma isithelo i-Malus (i-crab Apple) sithandwa kune-Black Mulberry? Futhi uma ukukhetha okufanayo kwenzelwe amantongomane/imbewu efana ne-Common Hazelnut phezu kwe-European Chestnut kanye nama-pulses afana ne-Gram Bean phezu kwe-Moth Bean. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukuhlonza kanjani ukudla okunconyelwe i-Acral Melanoma futhi ingabe iyimpendulo efanayo yawo wonke umuntu onesifo esifanayo noma engozini yofuzo? 

Yebo! Ukudla okudlayo kuyindaba ye-Acral Melanoma!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.  

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana. 

Isibonelo i-Malus (i-crab Apple) iqukethe izithako ezisebenzayo i-Lupeol, i-Isoliquiritigenin, i-Formononetin, i-Catechol, i-Phloretin. Futhi I-Black Mulberry iqukethe izithako ezisebenzayo i-Quercetin, i-Lupeol, i-Isoliquiritigenin, i-Formononetin, i-Catechol kanye nezinye okungenzeka. 

Iphutha elivamile elenziwa lapho kunqunywa futhi kukhethwa ukudla okuzodliwa kwe-Acral Melanoma - ukuhlola izithako ezisebenzayo ezikhethiwe kuphela eziqukethwe ekudleni futhi ungazinaki ezinye. Ngenxa yokuthi izithako ezihlukahlukene ezisebenzayo eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo sokudla kwe-Acral Melanoma. 

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Ayadingeka Ekwenzeni Ukudla Okungokwakho Kwe-Acral Melanoma?

Ukondleka komuntu siqu komdlavuza njenge-Acral Melanoma kuqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe kubhayoloji ye-Acral Melanoma, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelapha umdlavuza kusebenza kanjani kanye nokuba sengozini okuhlobene lapho ukwelashwa kungayeka ukusebenza kahle.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA OKUDLA NGESINTU KOMKHANZA YI: IBHYOLOGY YOMKHANKAZA, ISAYENSI YOKUDLA, IZIKWELAPHA ZOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njenge-Acral Melanoma

Yonke imidlavuza efana ne-Acral Melanoma ingabonakala ngesethi eyingqayizivele yezindlela ze-biochemical - izindlela zokusayina ze-Acral Melanoma. Izindlela zamakhemikhali ezinto eziphilayo ezifana ne-Oncogenic Cancer Epigenetics, i-Suppressive Histone Methylation, i-PI3K-AKT-MTOR Signaling, Ukusayinda kwe-MAPK kuyingxenye yencazelo yesiginesha ye-Acral Melanoma. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Ukwelashwa okusebenzayo kwe-Acral Melanoma kudinga ukuqaphela izindlela ezihambisanayo zesiginesha ye-biochemical yesiguli ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla nezithako ezingeziwe kuyanconywa nge-Acral Melanoma lapho uthatha ukwelashwa komdlavuza i-Checkpoint Pdl1, futhi okunye ukudla nezithasiselo akunconywa.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo. 

I-DNMT3A, TET2, PPM1D, ASXL1 kanye ne-ATM yizakhi zofuzo ezikleliswe phezulu ze-Acral Melanoma. I-DNMT3A ibikwa kuma-31.6 % eziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-TET2 ibikwa ku-11.8%. Idatha ehlanganisiwe yesiguli ihlanganisa iminyaka yobudala esukela kweyi-5 kuye kwengama-96. Amaphesenti angama-60.8 emininingwane yesiguli ahlonzwa njengabesilisa. Ibhayoloji ye-Acral Melanoma kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimele izindlela ze-biochemical ezisayinwe kulo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni nazo zaziwa lokho kufanele futhi kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla Nezithako ze-Acral Melanoma

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.  

Khetha Iklabishi Yemifino noma I-BROCCOLI YASE-CHINESE?

Iklabishi Yemifino iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Quercetin, i-Lupeol, i-Isoliquiritigenin, i-Formononetin, i-Catechol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Angiogenesis, i-WNT Beta Catenin Signaling, i-Natural Killer Cell Activation kanye ne-Interferon Signaling nezinye. Iklabishi liyanconywa nge-Acral Melanoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Checkpoint Pdl1. Lokhu kungenxa yokuthi Iklabishi liguqula lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela we-Checkpoint Pdl1.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino yaseShayina Broccoli yiLupeol, Isoliquiritigenin, Formononetin, Catechol, Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Dendritic Cell Maturation, CD8 T-cell Activation kanye ne-Antigen Presentation nezinye. I-Chinese Broccoli ayinconyelwe i-Acral Melanoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Checkpoint Pdl1 ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

IKABHISHI LEMIJINO KUNCONYWA NGAPHEZU KWE-BROCCOLI YASE-CHINESE YE-Acral Melanoma KANYE NE-Checkpoint Pdl1 YOKWELASHWA.

Khetha Isithelo I-MULBERRY EMNYAMA noma i-MALUS (I-CRAB APPLE)?

I-Fruit Black Mulberry iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Quercetin, i-Lupeol, i-Isoliquiritigenin, i-Formononetin, i-Catechol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Macrophage M2, i-JAK-STAT Signaling, i-Natural Killer Cell Activation ne-Angiogenesis nezinye. I-Black Mulberry iyanconywa nge-Acral Melanoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Checkpoint Pdl1. Lokhu kungenxa yokuthi uMulberry Omnyama ulungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela we-Checkpoint Pdl1.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Malus (i-crab Apple) yi-Lupeol, i-Isoliquiritigenin, i-Formononetin, i-Catechol, i-Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Dendritic Cell Maturation, CD8 T-cell Activation kanye ne-Antigen Presentation nezinye. I-Malus (i-crab Apple) ayinconyelwe i-Acral Melanoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Checkpoint Pdl1 ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

I-MULBERRY OMNYAMA YESITHELO KUNCONYWA NGAPHEZU KWE-MALUS (I-CRAB APPLE) YE-Acral Melanoma KANYE NE-Checkpoint Pdl1 YOKWELASHWA.

Khetha Nut COMMON HAZELNUT noma EUROPEAN CHESTNUT?

I-Hazelnut evamile iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Quercetin, i-Lupeol, i-Isoliquiritigenin, i-Formononetin, i-Catechol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-JAK-STAT Signaling, Angiogenesis, Antigen Presentation kanye ne-T-Regulatory Cell Differentiation nezinye. I-Hazelnut evamile inconywa nge-Acral Melanoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Checkpoint Pdl1. Lokhu kungenxa yokuthi i-Hazelnut Ejwayelekile iguqula lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze kwazise umthelela we-Checkpoint Pdl1.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yaseYurophu yi-Quercetin, i-Ellagic Acid, i-Lupeol, i-Isoliquiritigenin, i-Formononetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Dendritic Cell Maturation, CD8 T-cell Activation kanye ne-G-protein-coupled Receptor Signaling nezinye. I-Chestnut yase-Europe ayinconyelwe i-Acral Melanoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Checkpoint Pdl1 ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

I-HAZELNUT EJWAYELEKILE INCONYISWA NGE-CHESTNUT YAseYurophu NGE-Acral Melanoma KANYE NE-Checkpoint Pdl1 YOKWELASHWA.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwa abantu abanengozi yofuzo ye-Acral Melanoma noma umlando womndeni uthi "Yini Okufanele Ngiyidle Ngokuhlukile Kunangaphambili?" nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithako zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela ye-Acral Melanoma - ukukhetha kokudla kanye nezithako zokudla kufanele kube okomuntu siqu. 

Khetha I-Vegetable CELERY STLKS noma i-ROMAINE LETTUCE?

I-Vegetable Celery Stalks iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Linalool, i-Lupeol, i-Lycopene. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oncogenic Cancer Epigenetics, i-RAS-RAF Signaling, i-Cell Cycle Checkpoints kanye ne-Apoptosis nezinye. I-Celery Stalks inconywa engcupheni ye-Acral Melanoma lapho ubungozi bofuzo obuhlobene buyi-ASXL1. Lokhu kungenxa yokuthi I-Celery Stalks inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino ye-Romaine Lettuce yi-Apigenin, i-Curcumin, i-Lupeol, i-Resveratrol, i-Protocatechuic Acid. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-P53 Signaling kanye ne-DNA Repair nezinye. I-Romaine Lettuce ayituswa uma ingozi ye-Acral Melanoma uma ingozi yofuzo ehlotshaniswa nayo i-ASXL1 ngoba yandisa izindlela zesiginesha ze-Acral Melanoma.

IZIHLABANI ZAMA-VEGETABLE CELERY KUNCONYWA NGAPHEZU KWE-ROMAINE LETTUCE YE-ASXL1 GENETIC INGOZI YOMKHANZA.

Khetha Isithelo NANCE noma GRAPEFRUIT?

I-Fruit Nance iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Lupeol, i-Protocatechuic Acid, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezehlukene ze-biochemical ezifana nokulungiswa kwe-DNA, Ukusayina kwe-RAS-RAF, Ukusayinda kwe-MYC kanye Nezindawo Zokuhlola I-Cell Cycle nezinye. I-Nance inconywa engcupheni ye-Acral Melanoma lapho ingozi yofuzo ehlotshaniswa nayo i-ASXL1. Lokhu kungenxa yokuthi i-Nance inyusa lezo zindlela ze-biochemical eziphikisana nabashayeli bamasignesha bayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni I-Grapefruit yi-Curcumin, i-Lupeol, i-Lycopene, i-Daidzein, i-Beta-sitosterol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali ezinto eziphilayo njenge-DNA Repair nezinye. I-Grapefruit ayinconywa uma ingozi ye-Acral Melanoma uma ingozi yofuzo ehlotshaniswa nayo i-ASXL1 ngoba yandisa izindlela zokusayina ze-Acral Melanoma.

ISITHELO NANCE KUNCONYWA NGAPHEZU KWE-GRAPESIFRUIT NGE-ASXL1 GENETIC RISK OF CANCER.

Khetha Nut BUTTERNUT noma CHESTNUT?

I-Butternut iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Juglone, i-Lupeol, i-Lycopene. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oncogenic Cancer Epigenetics, i-RAS-RAF Signaling, i-MYC Signaling kanye ne-Cell Cycle Checkpoints nezinye. I-Butternut inconywa ngengozi ye-Acral Melanoma uma ingozi yofuzo ehlotshaniswa nayo i-ASXL1. Lokhu kungenxa yokuthi i-Butternut inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yi-Apigenin, i-Curcumin, i-Lupeol, i-Lycopene, i-Ellagic Acid. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali ezinto eziphilayo njenge-DNA Repair nezinye. I-Chestnut ayinconywa uma ingozi ye-Acral Melanoma uma ingozi yofuzo ehlotshaniswa nayo i-ASXL1 ngoba inyusa izindlela zesiginesha ze-Acral Melanoma.

I-BUTTERNUT INCONYISWA NGAPHEZU KWE-CHESTNUT NGENGOZI YOFUZO YE-ASXL1 YOMKHANZA.

Ekuphetheni

Ukudla kanye Nezithako ezikhethiwe izinqumo ezibalulekile zomdlavuza njenge-Acral Melanoma. Iziguli ze-Acral Melanoma kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: "Yikuphi ukudla kanye nezithako zokudla okunomsoco ezinconyelwe mina futhi ezingekho?" Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezahlukene zezinkomba zomdlavuza ezifana ne-Acral Melanoma, ngayinye enezakhi zofuzo zesimila ezihlukile ngokuhlukahluka kofuzo kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana neklabishi kuqukethe ama-bioactive ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene wezindlela zamakhemikhali ezinto eziphilayo. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda izindlela zokwelapha ezihlukene ze-chemotherapy. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo somuntu siqu somsoco we-addon senza ukwenza izinqumo kube lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo othi, “Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli i-Acral Melanoma?”. Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha. 

Okubhekwayo

1) I-Msk Impact 2017

2) Umthwalo we-tumor mutational ubikezela ukusinda ngemuva kwe-immunotherapy kuzo zonke izinhlobo zomdlavuza.

3) Ukulawulwa okungekuhle kwe-transducer yesiginali kanye ne-activator ye-transcription-3 signaling cascade nge-lupeol ivimbela ukukhula futhi yenze i-apoptosis kumaseli e-hepatocellular carcinoma.

4) Imiphumela ye-isoliquiritigenin kumaseli omdlavuza wesibeletho.

5) Imiphumela yokudla ye-D-glucarate kuma-biomarker okuvuvukala phakathi nezigaba zangaphambi kokuqala kwe-benzo[a]i-pyrene-induced lung tumorigenesis kumagundane e-A/J.

6) I-Luteolin ikhuthaza ukufa kwe-apoptotic cell nge-upregulation ye-Nrf2 inkulumo nge-DNA demethylase kanye nokuxhumana kwe-Nrf2 ne-p53 kumaseli omdlavuza wekoloni lomuntu.

7) I-Gallic acid idala ukulimala kwe-DNA futhi icindezela i-DNA yokulungisa isakhi sofuzo kumaseli omdlavuza womuntu we-prostate PC-3.

https://www.ncbi.nlm.nih.gov/books/NBK559113

https://www.cancercenter.com/cancer-types/melanoma/types/acral-lentiginous-melanoma

https://www.healthline.com/health/acral-lentiginous-melanoma