Yimuphi umdlavuza ongazuza ngokufaka i-Cordyceps ekudleni kwabo?

Amaphuzu avelele

I-Cordyceps yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kwe-Cordyceps ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Cordyceps ingase izuze labo abane-Primary Penile Squamous Cell Carcinoma abathola i-Mitomycin, kodwa kungase kungabi kuhle ezigulini ezithola i-Radiation for Primary Sclerosing Epithelioid Fibrosarcoma. Ngaphezu kwalokho, nakuba i-Cordyceps ingasiza abantu abanesici esiyingozi sofuzo “TERT”, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile ethi “B2M”. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo ngokufaneleka kwe-Cordyceps esigulini esinomdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Cordyceps iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana neCordyceps esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Cordyceps ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle i-Cordyceps uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-TERT? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela ohlotsheni lofuzo lwe-B2M? Ingabe kunenzuzo ukufaka i-Cordyceps ekudleni kwakho uma kutholakala ukuthi une-Primary Sclerosing Epithelioid Fibrosarcoma, noma uma ukuxilongwa kwakho kuyi-Primary Penile Squamous Cell Carcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Cordyceps kufanele kulungiswe kanjani uma welashelwa i-Mitomycin noma uma uhlelo lwakho lokwelapha lusuka ku-Mitomycin luye ku-Radiation? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'I-Cordyceps ingokwemvelo, ngakho-ke ihlale inenzuzo' noma 'i-Cordyceps ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Cordyceps ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Cordyceps ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele yonke imiphumela ye-biochemical yazo zonke izithako, ucabangela izici ezinjengohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Penile Squamous Cell Carcinoma noma i-Primary Sclerosing Epithelioid Fibrosarcoma, amasu okwelapha kudingeka enziwe ngokwezifiso ngokusekelwe kufuzo lomuntu ngamunye, isigaba sesifo, kanye nezici ezifana neminyaka nobulili. ”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga okuthile komdlavuza lapho unquma ngokukhetha ukudla, njengeCordyceps. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-TERT inemithelela efanayo ye-biochemical pathway njengoguquko ku-B2M? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Penile Squamous Cell Carcinoma ilingana ne-Primary Sclerosing Epithelioid Fibrosarcoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Radiation njengalabo abathola i-Mitomycin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Cordyceps - Isengezo Somsoco

Isithasiselo se-Cordyceps sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Linoleic Acid, i-Oleic Acid, i-Ergosterol Peroxide, i-Ergosterol ne-Beta-sitosterol, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-MAPK Signaling, TGFB Signaling, Chemokine Signaling kanye ne-Oncogenic Cancer Epigenetics, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Ngokunikezwa kwaleli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njengeCordyceps, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla okunomdlavuza. Lapho ucubungula ukusebenzisa i-Cordyceps yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezahlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Cordyceps akusona isinqumo esifanelekile kuwo wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithasiselo zeCordyceps

Ukubhekana nombuzo othi 'Kufanele ngigweme nini i-Cordyceps esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Cordyceps kuyahlukahluka kuye ngezimo zomuntu siqu. Izinto ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithasiselo ezithathwayo, indlela yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Cordyceps ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe Izithasiselo ze-Cordyceps zizozizuzisa Iziguli ze-Primary Sclerosing Epithelioid Fibrosarcoma ezelashwa ngeRadiation?

I-Primary Sclerosing Epithelioid Fibrosarcoma ibonakala ngokuguquguquka okuthile kofuzo, okuyi-PBRM1, ATRX kanye ne-PIK3C2G, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-TGFB Signaling kanye ne-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Cordyceps, esithinta i-TGFB Signaling, kungenzeka kungabi inketho efanele esimweni se-Primary Sclerosing Epithelioid Fibrosarcoma lapho ubhekene neRadiation. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo ze-Cordyceps zizozizuzisa Iziguli Eziyinhloko ze-Penile Squamous Cell Carcinoma ezelashwa nge-Mitomycin?

I-Primary Penile Squamous Cell Carcinoma ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-ABRAXAS1, PIK3CB kanye ne-NUP93, okuholela ezinguqukweni zemizila ye-biochemical, ikakhulukazi i-MAPK Signaling, Hematopoiesis kanye ne-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, njenge-Mitomycin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Cordyceps siyindlela enengqondo yalabo abane-Primary Penile Squamous Cell Carcinoma abathola i-Mitomycin. Lokhu kungenxa yokuthi i-Cordyceps ithonya izindlela ezifana ne-MAPK Signaling, engavimbela izici ezishayela i-Primary Penile Squamous Cell Carcinoma noma izuzise ukusebenza kahle kwe-Mitomycin.

3. Ingabe Izithasiselo Ze-Cordyceps Ziphephile Kubantu Abanempilo Enempilo Nge-B2M Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Isakhi sofuzo se-B2M sivame ukufakwa kulawa maphaneli ukuze kuhlolwe ingozi yomdlavuza.

Ukuguqulwa kofuzo lwe-B2M kuthinta izindlela ze-biochemical noma izinqubo, ezifana ne-Chemokine Signaling kanye ne-Antigen Presentation, ezibandakanyeka ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ihlonza uguquko ku-B2M oluhlobene nengozi eyengeziwe ye-Diffuse Large B-cell Lymphoma, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwe-Cordyceps yesithako. Lokhu kungenxa yokuthi isengezo se-Cordyceps sithonya izindlela ezifana ne-Chemokine Signaling, ezingaholela emiphumeleni emibi kumongo wokuguqulwa kwe-B2M kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo Ze-Cordyceps Ziphephile Kubantu Abanempilo Enempilo Nge-TERT Mutation Associated Genetic Risk?

I-TERT idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezinguquko ku-TERT kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-Oncogenic Cancer Epigenetics kanye ne-DNA Repair, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-TERT ehambisana Nomdlavuza Wegazi, cabanga ukufaka izithasiselo ze-Cordyceps ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Oncogenic Cancer Epigenetics, zizuze ngokunikeza usizo olufanele kubantu abanezinguquko ze-TERT kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza kanye nokudla okunomsoco akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithasiselo ezifana neCordyceps ngezinzuzo zayo, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Ukwenziwa kusebenze kwe-PPAR gamma kanye ne-delta nge-conjugated linoleic acid kulamula ukuvikela esifweni sokuhlola samathumbu esivuvukalayo.
• I-Omega-3 fatty acids ivimbela ukwanda kwama-cytokines ane-proinflammatory ezigulini ezine-Crohn's disease esebenzayo uma kuqhathaniswa nama-omega-6 fatty acids.
• cBioPortal for Cancer Genomics
• I-Hypoxia Ikhuthaza Ukubambisana phakathi kwe-Mitomycin C ne-Bortezomib ngokusebenzisa Inqubo Edidiyelwe ye-Bcl-xL Phosphorylation kanye Ne-Mitochondrial Translocation ye-p53.
• Ukuthuthukiswa kokuphendula kwe-glutamate nge-protein kinase encike ku-cAMP kuma-hippocampal neurons.
• Ukwelashwa komdlavuza kulolonga isimo sokufaneleka se-clonal hematopoiesis.
• I-Paederia foetida idala umsebenzi wokulwa nomdlavuza ngokushintsha ama-enzyme okuguqula i-chromatin futhi iguqule ukubonakaliswa kwezakhi zofuzo ze-cytokine ezinokuvuvukala kumaseli omdlavuza wendlala yesinye.
• Ukumelana nomsakazo kumaseli omdlavuza webele kulamula nge-TGF-β signalling, hybrid epithelial-mesenchymal phenotype kanye namaseli omdlavuza.
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.