Amaphuzu avelele
Ukulandelwa kweCancer genome / DNA kungasiza ngokuxilongwa komdlavuza okunembe kakhudlwana, ukubikezela okungcono kokubikezela kanye nokuhlonza izinketho zokwelashwa ezenzelwe umuntu ngokuya ngezimpawu zomdlavuza. Kodwa-ke, ngaphandle kokuthandwa okwandayo ne-hype mayelana nezinzuzo nokusetshenziswa kokulandelana komdlavuza, kunengxenyana kuphela yeziguli ezisizakala njengamanje kulokhu.
Okomuntu osanda kutholakala ukuthi unalo umdlavuza kanye nokubhekana nokushaqeka kwalokhu kuxilongwa, kunemibuzo eminingi yokuthi kanjani, ini, kungani kanye nezinyathelo ezilandelayo. Bakhungethwe amazwi amaningi kanye ne-jargon, enye yawo ukulandelana kwe-cancer genomic kanye nokwelashwa komuntu siqu.
Kuyini Ukulandelana Kwe-Tumor Genomic?
Ukulandelana kwe-tumor genomic kuyindlela yokuthola uhlobo lokuskena kwamangqamuzana e-DNA ekhishwe kumaseli wesimila atholakala kusampula ye-biopsy noma egazini noma umnkantsha wesiguli. Lolu lwazi luhlinzeka ngemininingwane yokuthi yiziphi izifunda ze-tumor DNA ezihluka ku-non-tumor cell DNA kanye nokuchazwa kwedatha yokulandelana kwe-genomic kunikeza ukuqonda ngezakhi zofuzo ezibalulekile kanye nezishayeli ze umdlavuza. Kube nentuthuko emangalisayo kubuchwepheshe bokulandelana okwenze ukuthola ulwazi lwe-genomic lwesimila kushibhile futhi kufinyeleleke kalula ukuthi lusetshenziswe emtholampilo. Amaphrojekthi amaningi ocwaningo axhaswe ohulumeni abahlukahlukene emhlabeni wonke ahlanganisa imininingwane yokulandelana kwe-tumor genomic yezinombolo eziningi zeziguli ezinomdlavuza, kanye nomlando wazo womtholampilo, imininingwane yokwelashwa kanye nemiphumela yomtholampilo, eyenziwe yatholakala ukuze ihlaziywe esizindeni somphakathi kumaphrojekthi. njenge: ICancer Genome Atlas (TCGA), Genomic England, cBIOPortal nabanye abaningi. Ukuhlaziywa okuqhubekayo kwalezi datha enkulu yabantu abanomdlavuza kunikeze imininingwane ebalulekile eshintsha isimo sezinqubo zokwelapha umdlavuza emhlabeni jikelele:
- Umdlavuza wemisuka ethile yezicubu njengawo wonke umdlavuza wamabele noma wonke umdlavuza wamaphaphu, obekucatshangwa phambilini ukuthi ubufana futhi uphathwa ngokufana, namuhla ubonwa njengokwehluka kakhulu futhi uhlukaniswe neziqeshana zamangqamuzana ezihlukile ezidinga ukuphathwa ngokuhlukile.
- Ngisho nangaphakathi kwesigaba samangqamuzana senkomba ethile yomdlavuza, iphrofayili yabo bonke abantu ye-tumor genomic ihlukile futhi ihlukile.
- Ukuhlaziywa kwe-genomic yomdlavuza we-DNA kunikeza imininingwane ngokungajwayelekile kwezakhi zofuzo (ukuguquka kwezakhi zofuzo) okunesibopho sokushayela lesi sifo futhi eziningi zazo zinemithi ethile eyenzelwe ukuvimba izenzo zazo.
- Ukungajwayelekile komdlavuza we-DNA kusiza ukuqonda kangcono izindlela eziyisisekelo iseli lomdlavuza elisebenzisela ukukhula nokuqhubekela phambili okusheshayo nokusabalala, futhi lokhu kuyasiza ekutholeni izidakamizwa ezintsha nezihlosiwe kakhulu.
Ngakho-ke, uma kukhulunywa ngesifo esifana nomdlavuza, esihlotshaniswa nemiphumela ebulalayo neyibulalayo, yonke imininingwane yolwazi esiza ekuqondeni izici zomdlavuza womuntu iyasiza.
Kungani Iziguli Ezinomdlavuza Kufanele Zicabangele Ukulandelana Kwe-Tumor Genomic?
Ngezansi kunezizathu ezintathu eziphezulu zokuthi kungani iziguli kufanele zicabangele ukulandelana kwe-DNA yazo kanye nochwepheshe bokubonisana nemiphumela yabo:
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Ukulandelana kweCancerome Cancer helps nge Correct Diagnosis
Ezimweni eziningi, isiza kanye nembangela yomdlavuza oyinhloko akucaci futhi ukulandelana kwe-genome kwe-DNA yesimila kungasiza ngokukhomba kangcono indawo yokuqala yesimila kanye nezakhi zofuzo zomdlavuza ezisemqoka, ngaleyo ndlela zinikeze ukuxilongwa okunembe kakhudlwana. Ezimweni ezinjengalezi zomdlavuza ezingavamile noma umdlavuza ezitholwe sekwephuzile futhi zisabalale ezithweni ezahlukahlukene, ukuqonda izici zomdlavuza kungasiza ekutholeni izinketho zokwelashwa ezifanelekile.
Ukulandelana Komdlavuza we-Genomic helps nge Prognosis Engcono
Kusukela kudatha yokulandelana umuntu uthola iphrofayili ye-genomic ye- umdlavuza I-DNA. Ngokusekelwe ekuhlaziyweni kwedatha yokulandelana kwenani labantu bomdlavuza, amaphethini okungajwayelekile okuhlukile ahlotshaniswa nokuqina kwesifo kanye nokusabela kokwelashwa. Isb. Ukungabikho kofuzo lwe-MGMT kubikezela impendulo engcono nge-TMZ (Temodal) ezigulini ezinomdlavuza wobuchopho i-glioblastoma multiforme. (UHegi ME et al, New Engl J Med, 2005Ukuba khona kokushintshwa kwezakhi zofuzo kwe-TET2 kwandisa amathuba okuphendula esigabeni esithile semithi ebizwa ngama-hypomethylating agents ezigulini ze-leukemia. (Bejar R, Blood, 2014) Ngakho-ke lolu lwazi lunikeza ukuqonda ngobucayi nezimpawu zesifo futhi lusize ekukhetheni ukwelashwa okunamandla noma okunolaka kakhulu.
Ukulandelana Komdlavuza we-Genomic helps ngokuthola inketho yokwelashwa okwenzelwe wena
Kwabaningi umdlavuza iziguli ezingaphenduli ezingeni lokunakekelwa kwemithi yokwelapha ngamakhemikhali, ukulandelana kwesimila kusiza ekuhlonzeni kangcono ukungalungi okubalulekile okungase kwelashwe ngemithi eqondiswe kakhulu esanda kwakhiwa futhi ingasetshenziswa kuphela ezimeni ezithile ezidingekayo. isici. Emidlavuza eminingi enenkani, ebuyelwe kabusha futhi ekwazi ukumelana naso, ukuhlonza iphrofayili ye-DNA yesimila kuzokwenza kube lula ukufinyelela nokubhaliswa ezivivinyweni zokuhlolwa kwemithi emisha nemisha eqondiwe noma ukuthola izindlela zokwelashwa ezihlukile neziqondene nomuntu uqobo ngokusekelwe ezicini zomdlavuza.
Isiphetho
Okubalulekile ukuthi ukulandelana kwe-genome kuya ngokuya kuba okujwayelekile ezigulini ezitholakale zinazo umdlavuza namuhla. Njengamaphrinti aluhlaza anemininingwane aklanywa ngumdwebi ngaphambi kokuqala iphrojekthi yokwakha, idatha ye-genomic iyi-blue-print yomdlavuza wesiguli futhi ingasiza umtholampilo ukuthi enze kube ngokwakho ukwelashwa okusekelwe ezicini ezithile zomdlavuza futhi yingakho kulindeleke ukuthi kube nenzuzo kumdlavuza. ukwelashwa. Ukuhlola okungokoqobo mayelana nesimo nezimangaliso zokulandelana kwesimila kanye nokuchazwa komdlavuza kuchazwe kahle esihlokweni sakamuva sikaDavid H. Freedmen ku-'The Newsweek' ngomhlaka-7/16/19. Uxwayisa ngokuthi naphezu kwempumelelo yokukhomba isimila esiyingqayizivele sesiguli ngasinye ngomuthi onembile, kunengxenye kuphela yeziguli ezizuzayo kulokhu njengamanje. (https://www.newsweek.com/2019/07/26/targeting-each-patients-unique-tumor-precision-medicine-crushing-once-untretable-cancers-1449287.html)
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.