Amaphuzu avelele
Izithako zokudla okunomsoco njenge-Retinol zinezinzuzo eziningi zezempilo futhi zisetshenziswa kakhulu iziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Kodwa, ingabe kuphephile ukuthatha izithasiselo ze-Retinol zazo zonke izinhlobo zomdlavuza futhi ngaphandle kokucabangela noma yikuphi ukwelashwa okuqhubekayo nezinye izimo zokuphila? Inkolelo evamile kodwa inganekwane kuphela ukuthi noma yini engokwemvelo ingazuzisa mina kuphela noma ingalimazi. Njengesibonelo esisodwa, ukusetshenziswa kwe-grapefruit ngemithi ethile akukhuthazwa. Esinye isibonelo, ukusetshenziswa kwesipinashi ngeminye imithi yokunciphisa igazi kungabangela ukusebenzisana okubi futhi kufanele kugwenywe. Ngoba umdlavuza, ukudla okunomsoco okubandakanya ukudla nezithako zemvelo kukhonjiswe ukuthi kunomthelela emiphumeleni. Ngakho-ke umbuzo ovame ukubuzwa iziguli ezinomdlavuza kuma-dieticians nodokotela uthi "Yini Okufanele Ngiyidle Futhi Yini Okufanele Ngiyigweme?".
Ukuthatha izithako zokudla okunomsoco i-Retinol kungazuzisa iziguli ze-Non-Hodgkin Lymphoma ekwelashweni komdlavuza we-Vorinostat. Kepha gwema izithasiselo zeRetinol uma ukwelashwa kwePaclitaxel kwe-Adenoid Cystic Carcinoma. Ngokufanayo, ukuthatha i-supplement yokudla okunempilo i-Retinol kungazuzisa abantu abaphilile abasengozini yofuzo yomdlavuza ngenxa yokuguqulwa kohlobo lwe-CDKN1B. Kepha gwema ukuthatha isithasiselo sokudla okunomsoco i-Retinol lapho usengozini yofuzo yomdlavuza ngenxa yokuguqulwa kohlobo lwe-CHEK2.
Ukuthatha - umongo wakho ngamunye uzoba nomthelela esinqumweni sakho uma isengezo sokudla okunempilo iRetinol iphephile noma cha. Futhi nokuthi lesi sinqumo sidinga ukubuyekezwa njalo njengoba izimo zishintsha. Izimo ezinjengohlobo lomdlavuza, ukwelashwa okuqhubekayo kwamanje nezithasiselo, ubudala, ubulili, isisindo, ukuphakama, indlela yokuphila kanye nanoma ikuphi ukuguqulwa kwezakhi zofuzo okukhonjisiwe. Ngakho-ke umbuzo osemthethweni ongawucela nganoma yisiphi isincomo sokudla nokengezelelwa kwemvelo ukuthi kuhlobene kanjani nomongo wakho ngamunye.
Ukufingqiwe Okufushane
Izithako zokudla okunomsoco - amavithamini, amakhambi, amaminerali, ama-probiotic, nezinye izigaba ezikhethekile ziyanda. Izithasiselo zingukugxila okuphezulu kwezithako ezisebenzayo ezitholakala futhi ekudleni okuhlukile. Umehluko wokudla unezithako ezingaphezu kwesisodwa ezisebenzayo ezingxenyeni eziphansi ezisabalalisiwe. Khumbula ukuthi ngayinye yalezi zithako inezindlela zayo zesayensi nezinto eziphilayo ezingeni lamangqamuzana - yingakho ukhethe inhlanganisela elungile yezithako ezifana neRetinol ngokususelwa kumongo nezimo zomuntu ngamunye.
Ngakho-ke umbuzo uthi ngabe kufanele uthathe isithasiselo i-Retinol? Ingabe kufanele uyithathe lapho usengozini yezakhi zofuzo yomdlavuza wokushintsha kohlobo lwe-CHEK2? Ingabe kufanele uyithathe lapho usengozini yezakhi zofuzo zomdlavuza ngokuguquka kohlobo lwe-CDKN1B? Ingabe kufanele uyithathe lapho kutholakala ukuthi une-Adenoid Cystic Carcinoma? Ingabe kufanele uthathe isengezo seRetinol lapho kutholakala ukuthi une-Non-Hodgkin Lymphoma? Ingabe kufanele uyithathe lapho ukwelashwa kwePaclitaxel? Ngabe kufanele uqhubeke nokuyiphuza uma ushintsha indlela oyelashwa ngayo isuka ePaclitaxel iye eVorinostat? Ngakho-ke incazelo ejwayelekile efana nokuthi - kungokwemvelo noma kwandisa ukuzivikela komzimba kungahle kungamukeleki futhi kwanele ukukhetha iRetinol.
Cancer
Umdlavuza uhlala uyisitatimende senkinga esingaxazululiwe. Ukutholakala okuthuthukisiwe kokwelashwa okwenziwe ngezifiso nokuqapha umdlavuza ngegazi nangamathe kube yizici ezibalulekile zokwenza ngcono imiphumela. Ukungenelela kwangaphambilini - ngcono umthelela emphumeleni. Ukuhlolwa kofuzo kunamandla okuhlola ubungozi bomdlavuza nokuthambekela kusenesikhathi. Kepha ngaphandle kokuqapha okujwayelekile ezimweni eziningi azikho izinketho zokungenelela zokwelapha ezitholakalayo. Ngemuva kokuxilongwa ngomdlavuza onjenge-Adenoid Cystic Carcinoma noma i-Non-Hodgkin Lymphoma, imishanguzo iba ngeyomuntu uqobo kuma-tumor genomics nezinto ezifana nokuhlelwa kwezifo, ubudala nobulili. Ngesikhathi sokuxolelwa komdlavuza (ngemuva kokuthi umjikelezo wokwelashwa usuqedile) - ukuqapha kusetshenziselwa ukuhlolwa kwanoma yikuphi ukubuyela emuva futhi ngokufanele kunqunywe izinyathelo ezilandelayo. Iningi leziguli ezinomdlavuza nalabo abasengozini bathatha izithako zokudla okunempilo njengeRetinol.
Ngakho-ke umbuzo uthi ngabe zonke izingozi zokuguquka kwezakhi zofuzo nezinhlobo zomdlavuza okufanele zithathwe njengeyodwa lapho kunqunywa ukusetshenziswa kweRetinol? Ingabe imiphumela yendlela yamakhemikhali engcupheni yomdlavuza ngenxa yokushintshwa kofuzo CHEK2 iyafana nangenxa yokuguqulwa kofuzo lwe-CDKN1B? Ngabe okushiwo yi-Adenoid Cystic Carcinoma kuyafana ne-Non-Hodgkin Lymphoma? Ingabe kuyefana uma ukwelashwa ngePaclitaxel noma kuVorinostat?
I-Retinol - Isengezo Somsoco
I-retinol noma i-vitamin A1 iyivithamini encibilikayo emafutheni engowawo uvithamini A umndeni. Itholakala ekudleni okuhlukene futhi ibuye isetshenziswe njengesengezo sokudla. Ukuthathwa kwe-retinol kusekela isikhumba, iso, nempilo yokuzala, ukukhula okuvamile ezinganeni, kunikeza ukumelana nokutheleleka okufana nomkhuhlane nomkhuhlane, futhi kubalulekile ekusebenzeni komzimba. Kodwa-ke, imithamo ephezulu ye-retinol ingaholela ekwandeni kwesibindi, isikhumba esomile, noma i-hypervitaminosis A.
Njengoba kushiwo ngaphambili, iRetinol iyisithako esisebenzayo esitholakala ezintweni ezahlukahlukene zokudla. Ukudla okufana neBhali, Ummbila neQuinoa kuqukethe iRetinol emazingeni ehlukene wokuhlushwa kanye nezinye izithako ezisebenzayo. Izindlela zamangqamuzana ezilawulwa yiRetinol zifaka i-Focal Adhesion, Inflammation, Estrogen Signaling, Cell Cycle kanye neNFKB Signaling. Lezi zindlela zeselula ziqondisa ngqo noma ngokungaqondile imigqa ethile yamangqamuzana omdlavuza njengokukhula, ukusabalala nokufa. Ngenxa yalomthethonqubo webhayoloji - wokudla komdlavuza, ukukhetha okulungile kwezithako ezifana neRetinol ngawodwana noma ngokuhlangana kuyisinqumo esibalulekile okufanele senziwe. Lapho wenza izinqumo ngokusetshenziswa kwe-supplement Retinol yomdlavuza - cabanga ngazo zonke lezi zinto nezincazelo. Ngoba njengoba kunjalo nangokwelapha umdlavuza - Ukusetshenziswa kweRetinol akukwazi ukuba yisinqumo esilingana nazo zonke izinhlobo zomdlavuza.
Ukukhetha izithasiselo zeRetinol zomdlavuza wakho
Isizathu sokuthi ayikho indlela elula yokuphendula umbuzo othi "Kufanele ngiyigweme nini i-Retinol yeCancer" ngoba "Kuya Ngayo!". Njengokuthi ukwelashwa okufanayo akusebenzi kuzo zonke iziguli ezinomdlavuza, ngokususelwa kumongo wakho ngamunye i-Retinol ingaba yingozi noma iphephe. Ngokuhambisana nomdlavuza kanye nezakhi zofuzo ezihambisanayo - ukwelashwa okuqhubekayo, izithasiselo, imikhuba yokuphila, i-BMI kanye nokungezwani komzimba yizo zonke izici ezinquma ukuthi iRetinol kufanele igwenywe noma cha nokuthi kungani.
1. Ngabe ama-Retinol Supplements azosizakala nge-Adenoid Cystic Carcinoma / Cancer Iziguli ezelashwa i-Paclitaxel?
I-Adenoid Cystic Carcinoma ibonakala futhi iqhutshwa ukuguqulwa kofuzo okukhethekile okufana ne-NFIB ne-MYB okuholela ezinguqukweni zendlela ye-biochemical ku-Focal Adhesion, i-PI3K-AKT-MTOR Signaling, Notch Signaling kanye ne-Cholesterol Metabolism. A umdlavuza Ukwelashwa okufana ne-Paclitaxel kusebenza ngendlela ethile yokusebenza. Umgomo uwukuba nokushayisana okuhle phakathi kokwelashwa nezindlela zokushayela umdlavuza ukuze kube nendlela yomuntu siqu ephumelelayo. Esimeni esinjalo noma yikuphi ukudla noma isithasiselo somsoco esinomphumela ophambene nokwelashwa noma esinciphisa ukunqwabelana kufanele kugwenywe. Njengesibonelo, i-Retinol kufanele igwenywe nge-Adenoid Cystic Carcinoma kanye nokwelashwa kwe-Paclitaxel. I-Retinol inomthelela emizileni ye-Focal Adhesion ekhuthaza abashayeli besifo kanye/noma yenze ize umphumela wokwelapha. Ukwengeza, izithasiselo ze-Retinol zinokusebenzisana kwe-CYP3A4 (i-enzyme metabolizing yezidakamizwa) nokwelashwa kwe-Paclitaxel, ngakho-ke kufanele kugwenywe iziguli ezinomdlavuza ezithola lokhu kwelashwa. (UKun Wang et al, Biochem Pharmacol., 2008; UPius S Fasinu et al, Front Oncol., 2019Ezinye zezinto okufanele zicatshangelwe lapho kukhethwa umsoco uhlobo lomdlavuza, ukwelashwa kanye nezithasiselo ezithathwa njengamanje (uma zikhona), ubudala, ubulili, i-BMI, indlela yokuphila kanye nanoma yiluphi ulwazi lokuguqulwa kwezakhi zofuzo (uma lukhona).
2. Ngabe amaRedinol Supplements azosizakala Ngeziguli Ezingewona i-Hodgkin Lymphoma Ezelashwa yi-Vorinostat Cancer Treatment?
I-Non-Hodgkin Lymphoma ibonakala futhi iqhutshwa ngokushintshwa kwezakhi zofuzo ezithile okufana ne-KMT2D ne-CREBBP okuholela ekuguqulweni kwendlela yamakhemikhali ku-Inflammation, i-NFKB Signaling, i-Endoplasmic Reticulum Stress, i-PI3K-AKT-MTOR Signaling ne-P53 Signaling. Ukwelashwa komdlavuza njengeVorinostat kusebenza ngezindlela ezithile zendlela. Umgomo ukuthi kube nokuhlangana okuhle phakathi kokwelashwa nemigwaqo yokushayela umdlavuza yendlela yomuntu uqobo. Esimweni esinjalo noma yikuphi ukudla noma isengezo sokudla okunempilo esinomphumela ofanayo ekwelashweni noma okwehlisa ukugqagqana kufanele kubhekwe. Njengesibonelo, isengezo seRetinol kufanele sicatshangelwe i-Non-Hodgkin Lymphoma kanye nokwelashwa kweVorinostat. I-Retinol supplement ithinta izindlela Ukuvuvukala nokusayinwa kwe-NFKB okungavimba abashayeli balesi sifo (i-Non-Hodgkin Lymphoma) kanye / noma kuthuthukise umphumela wokwelashwa.
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
3. Ngabe izithasiselo zeRetinol ziphephe kubantu abaphilile abane-CHEK2 Mutation Associated Risk Risk?
Izinkampani ezahlukahlukene zinikela ngamapaneli wezakhi zofuzo azohlolwa ukuze kuhlolwe ubungozi bezakhi zofuzo kumdlavuza ohlukile. Lawa mapaneli ahlanganisa izakhi zofuzo ezihambisana nomdlavuza webele, i-ovary, isibeletho, i-prostate, nesistimu yamathumbu nabanye. Ukuhlolwa kofuzo kwalezi zofuzo kungaqinisekisa ukuxilongwa futhi kusize ekuqondiseni izinqumo zokwelashwa nokuphathwa. Ukuhlonza okwahlukile okubanga izifo nakho kungakhombisa ukuhlolwa nokuxilongwa kwezihlobo ezisengcupheni. I-CHEK2 ingenye yezakhi zofuzo ezitholakala ngokujwayelekile kumaphaneli okuhlolelwa ubungozi bomdlavuza.
Ukuguqulwa kwe-CHEK2 kubangela izindlela zamakhemikhali ezinto eziphilayo Ukubonisana kwe-Estrogen, Ukulungiswa Kwe-DNA, Ukusayinwa Kweseli Yesiqu, Ukusayina kwe-P53 kanye Nomjikelezo Weseli ukuthi kube nomthelela. Lezi zindlela zingabashayeli abaqondile noma abangaqondile umdlavuza iziphetho zamangqamuzana. I-Retinol kufanele igwenywe lapho iphaneli yofuzo ikhomba ukuguqulwa kwe-CHEK2 kuCancer Webele. I-Retinol ithinta izindlela I-Estrogen Signaling kanye Nokulungiswa Kwe-DNA futhi idala imiphumela emibi nge-CHEK2 nezimo ezihlobene.
4. Ngabe izithasiselo zeRetinol ziphephe kubantu abaphilile abaneCDKN1B Mutation Associated Retic Risk?
I-CDKN1B ingenye yezakhi zofuzo ezitholakala kumaphaneli umdlavuza ukuhlolwa kobungozi. Ukuguqulwa kwe-CDKN1B kubangela izindlela ze-biochemical Cell Cycle, Stem Cell Signaling, FOXO Signaling, PI3K-AKT-MTOR Signal and Cell Cycle Checkpoints ukuthi zibe nomthelela. Lezi zindlela zingabashayeli abaqondile noma abangaqondile bokuphela kwamangqamuzana omdlavuza. I-Retinol lapho iphaneli yofuzo ikhomba ukuguqulwa kwe-CDKN1B ye-Neuroendocrine Cancer. I-Retinol ithinta izindlela ze-Cell Cycle kanye ne-Stem Cell Signaling futhi idale umphumela ongeziwe nge-CDKN1B nezimo ezihlobene.
* Ezinye izinto zifakiwe njenge-BMI, Izindlela Zokuphila, Ukwelashwa
Ekuphetheni
Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelashwa komdlavuza nokondleka akukaze kufane kuwo wonke umuntu. Ukudla okunomsoco okubandakanya izithasiselo zokudla nezomsoco ezifana neRetinol, kuyithuluzi elisebenzayo elingalawulwa nguwe, ngenkathi ubhekene nomdlavuza.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.