Amaphuzu avelele
Ukuhlaziywa kwe-meta okwenziwe kuzo zonke izivivinyo zokwelashwa zesigaba 3 se- umdlavuza ophakeme noma we-metastatic ithole ukuthi kuneziguli ezingaphezu kuka-125,000 ezibhalise ezifundweni ezingazange zihlole ikhwalithi yemiphumela yokuphila. Ukuhlobana phakathi kwephoyinti lokugcina elibikiwe lokuqhubeka kokusinda kwamahhala, isilinganiso sesikhathi lapho umdlavuza ayizange ithuthuke, futhi izinga lempilo elithuthukisiwe, beliphansi. Lokhu kuhlaziya kubonisa ukuthi amaphoyinti okugcina abikwe ekuhlolweni komtholampilo akusona isilinganiso esihle semethrikhi ebalulekile yekhwalithi yokuhlolwa kwempilo yeziguli.
Ngisho noma umuntu exilongwa ngokucacile umdlavuza, isiguli nomndeni waso ngeke bagxumele ngokushesha ekuqaliseni ukwelashwa ngamakhemikhali ngakusasa ngoba ngokuvamile kudingeka bahlole ngokugcwele zonke izinketho zabo kuqala. Futhi ingxenye ebalulekile yalokho ukubona ukuthi indlela yokwelapha engaba khona izolithinta kanjani izinga lempilo yomuntu. Ukuvuma ukuqala nokubekezelela inqubo yokwelapha ngamakhemikhali kuyisinqumo esikhulu, ikakhulukazi ezigulini esezikhulile, ngoba kufanele zinqume ukuthi zingaki izinkinga ezingokomzimba ezingavuma ukubekezelela ukuze zingabi nawo umdlavuza. Uma imiphumela engemihle yomuthi othile mikhulu kangangokuthi yenza umuntu angaphili noma kunjalo, ukhumbula ukuthi akukho ukwelashwa okuqinisekile mayelana nokululama, kungaba okufanelekile yini ngesiguli ukuba sizibeke kulokho?
Okusemqoka ukuthi iziguli nemindeni yazo kufanele ngabe zona ngokwazo zithatha lezi zinqumo ezishintsha impilo futhi zazi ngokugcwele ngalokho okuyohileleka ekwelashweni okuthile. Kodwa-ke, izivivinyo zokwelashwa zivame ukwehluleka ukubika kahle ukuthi umuthi othile uzolithinta kanjani izinga lempilo yeziguli, okuwulwazi olubalulekile kulabo abangahle basebenzise izidakamizwa.
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
Ikhwalithi Yokuhlolwa Kwempilo
Ngo-2018, kwaba nocwaningo olwenziwe abacwaningi baseHarvard Medical School eBoston mayelana nenhlangano phakathi umdlavuza ukuqhubeka kwesiguli ukuphila kwamahhala kanye nezinga lempilo yazo. Empeleni, indinganiso efanelekile yokulinganisa ukusebenza kokuhlolwa komtholampilo kungaba ukukala izinga lokusinda (OS) lilonke kodwa lokho kungathatha isikhathi eside kakhulu ukuthola imiphumela, ngakho-ke kunezinye iziphetho ezisetshenziswa esikhundleni ezifana ne-progression free survival rate (PFS). ). I-PFS ikala izinga leziguli ezisindile ngaphandle kokuba isimila siqhubekele phambili. Kodwa-ke, inani elandayo lokuhlolwa komtholampilo emithini ye-chemo engaba khona lisebenzisa i-PFS esikhundleni sedatha yekhwalithi yempilo (QoL) yeziguli futhi. Kuzo zonke izivivinyo zomtholampilo zesigaba sesi-3 zomdlavuza oseqophelweni eliphezulu noma we-metastatic okubuyekezwe ngabacwaningi, “Isibalo seziguli eziyi-125,962 sabhaliswa ezifundweni ezintula noma ezingabiki izinga lemiphumela yempilo. Phakathi kwezivivinyo ezibike ikhwalithi yemiphumela yokuphila, ama-67% abike ukuthi awanamthelela, ama-26% abike umphumela omuhle futhi ama-7% abike umphumela omubi wokwelashwa kukhwalithi yempilo yomhlaba yeziguli. Okubalulekile, ukuhlobana phakathi kwe-PFS nezinga lempilo elithuthukisiwe bekuphansi, nge-coefficient yokuxhumanisa kanye nevelu ye-AUC engu-0.34 no-0.72, ngokulandelana” (UHwang TJ noGyawali B, Int J Cancer. 2019).
Okukhonjiswa lolu cwaningo ngokusobala ukuthi amanye ama-surrogate ayisona isilinganiso esihle sokuhlolwa kwekhwalithi yempilo yokuhlolwa kwemitholampilo. Imininingwane kufanele ihanjiswe ngokwehlukana ngokuthi umuthi ungalithinta kanjani ikhwalithi yempilo yesiguli ngoba ngokungafani nokuba yisibalo esiqondile njengezinyanga ze-PFS ngomuthi, ulwazi lwekhwalithi yempilo luyadingeka kuzo zombili iziguli nodokotela ukwenza izinqumo ezinolwazi mayelana ikusasa.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) ikhambi lemvelo elingcono kakhulu umdlavuza kanye nemiphumela engemihle ehlobene nokwelashwa.