Ngowuphi umhlaza onokuzuza ngokubandakanya iZeaxanthin kunye neLutein kukutya kwabo?

Iimbalasane

I-Zeaxanthin Nge-Lutein yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweZeaxanthin NgeLutein kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengophawu lomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, i-Zeaxanthin Nge-Lutein inokuba luncedo kwabo bane-Primary Mucinous colorectal adenocarcinoma ephantsi kwe-Cetuximab, kodwa isenokungabi ilungile kwizigulana ezifumana i-Ibrutinib ye-Primary Waldenstrom Macroglobulinemia. Ngaphaya koko, ngelixa i-Zeaxanthin Nge-Lutein inokunceda abantu abane-genetic risk factor "CDH1", ayinakucetyiswa kwabo banomngcipheko wofuzo owahlukileyo "CALR". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweZeaxanthin kunye neLutein kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iZeaxanthin NgeLutein lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana neZeaxanthin NgeLutein endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iZeaxanthin kunye neLutein kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba udle i-Zeaxanthin Nge-Lutein ukuba unemfuzo enokuthanani nomhlaza onxulumene ne-CDH1 gene? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza uvela kumfuza we-CALR? Ngaba kunenzuzo ukuquka iZeaxanthin NgeLutein kukutya kwakho ukuba ufunyaniswe unePrimary Waldenstrom Macroglobulinemia, okanye ukuba uxilongo lwakho yiPrimary Mucinous colorectal adenocarcinoma? Ngaphezu koko, kufuneka kuhlengahlengiswe njani ukusetyenziswa kwakho kweZeaxanthin NgeLutein ukuba ufumana unyango lwe-Cetuximab okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka kwi-Cetuximab siye kwi-Ibrutinib? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neZeaxanthin NgeLutein yendalo, ngoko isoloko iluncedo' okanye 'iZeaxanthin NgeLutein yonyusa ukhuselo lomzimba' ayonelanga kukhetho lokutya / lokongezelela olunolwazi.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya iZeaxanthin NgeLutein kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana neZeaxanthin kunye neLutein kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, olufana nePrimary Mucinous colorectal adenocarcinoma okanye iPrimary Waldenstrom Macroglobulinemia, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwimfuza yethumba lomntu, inqanaba lesi sifo, kwakunye nezinto ezifana nobudala nesini.”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeka kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, njengeZeaxanthin NgeLutein. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-CDH1 uneempembelelo zendlela ye-biochemical efanayo njengotshintsho kwi-CALR? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana nePrimary Mucinous colorectal adenocarcinoma ulingana nePrimary Waldenstrom Macroglobulinemia? Ngapha koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kwe-Ibrutinib njengakwabo bafumana i-Cetuximab? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Zeaxanthin NgeLutein-Isongezelelo seSondlo

I-supplement ye-Zeaxanthin Nge-Lutein iquka uluhlu lwezithako ezisebenzayo, kuquka i-Lutein kunye ne-Zeaxanthin, nganye ekhoyo kwiindawo ezahlukeneyo. Ezi zithako zinefuthe kwiindlela ze-molecular, ngokukodwa i-Growth Factor Signaling, i-NFKB Signaling, i-Retinoic Acid Signaling kunye ne-Cell Cycle Checkpoints, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwe-tumor, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeZeaxanthin NgeLutein, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iZeaxanthin kunye neLutein kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweZeaxanthin NgeLutein ayisosigqibo sehlabathi lonke esifanelekileyo kubo bonke abanomhlaza kodwa kufuneka ibe yeyomntu.

Ukukhetha iZeaxanthin kunye neLutein Supplements

Ukujongana nombuzo othi 'Ndifanele ndiyiphephe nini i-Zeaxanthin ngeLutein kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zeZeaxanthin NgeLutein ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo oluthile lomzimba, zonke zidlala indima ekunqumeni ukuba i-Zeaxanthin eneLutein ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka kobuntu. ukuqwalaselwa kwizigqibo ezinjalo.

1. Ngaba i-Zeaxanthin NgeLutein Supplements iya kunceda i-Primary Waldenstrom Macroglobulinemia Izigulana eziphantsi konyango lwe-Ibrutinib?

I-Primary Waldenstrom Macroglobulinemia ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-ARID1A, IGF1R kunye ne-MAP3K1, ekhokelela ekuguquleni kwiindlela ze-biochemical pathways, ngokukodwa i-NFKB Signaling, i-Androgen Signaling, i-Chromatin Remodeling, i-Growth Factor Signaling, i-PI3K-AKT Signaling kunye ne-MTOR ye-MAPK. Ukusebenza kwonyango lomhlaza, njenge-Ibrutinib, kuxhomekeke kwindlela yayo yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Zeaxanthin Nge-Lutein supplement, echaphazela i-NFKB Signaling, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Waldenstrom Macroglobulinemia xa ihamba nge-Ibrutinib. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba i-Zeaxanthin Ngezongezo zeLutein iya kuxhamla kwi-Primary Mucinous colorectal adenocarcinoma Izigulana eziphantsi koNyango lwe-Cetuximab?

I-Primary Mucinous colorectal adenocarcinoma ichongiwe ngokuguqulwa kofuzo oluthile, njenge-TTN, i-APC kunye ne-KRAS, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Angiogenesis, i-G-protein-coupled Receptor Signaling kunye ne-Growth Factor Signaling. Ukusebenza konyango lomhlaza, njenge-Cetuximab, kumiselwa yintsebenziswano nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Umzekelo, i-Zeaxanthin Nge-Lutein yongezelela lukhetho olunengqiqo kwabo bane-Primary Mucinous colorectal adenocarcinoma ehamba ne-Cetuximab. Oku kungenxa yokuba i-Zeaxanthin Nge-Lutein inefuthe kwiindlela ezifana ne-Growth Factor Signaling, enokuthi ithintele izinto eziqhuba i-Primary Mucinous colorectal adenocarcinoma okanye izuze ukusebenza kwe-Cetuximab.

3. Ingaba iZeaxanthin eneLutein Supplements ikhuselekile kubantu abasempilweni abaneCALR Mutation eNxulunyaniswe neMngcipheko yeGenetic?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. Ufuzo lwe-CALR luqhele ukubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-CALR gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Retinoic Acid Signaling kunye ne-Antigen Presentation, ezibandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga uguquko kwi-CALR ehambelana nomngcipheko owongeziweyo we-Myeloproliferative Neoplasms, ingqiqo yesayensi icebisa ukuphepha ukusetyenziswa kwe-supplement ye-Zeaxanthin NgeLutein. Oku kungenxa yokuba ukongeza i-Zeaxanthin Nge-Lutein inefuthe kwiindlela ezifana ne-Retinoic Acid Signaling, enokukhokelela kwimiphumo emibi kumxholo wenguqu ye-CALR kunye neemeko zomhlaza ezinxulumene nazo.

4. Ngaba i-Zeaxanthin eneLutein Supplements ikhuselekile kubantu abasempilweni abaneCDH1 Mutation eNxulunyaniswe neMngcipheko yeGenetic?

I-CDH1 idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CDH1 kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Cell Cycle Checkpoints, i-Adherens junction kunye ne-Epithelial kwi-Mesenchymal Transition, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-CDH1 ehambelana noMhlaza weGastric, cinga ukufaka i-Zeaxanthin Ngezongezo zeLutein kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela kakuhle iindlela ezifana neCell Cycle Checkpoints, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-CDH1 kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanya ukutya kunye nezongezelelo ezifana neZeaxanthin NgeLutein, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• cBioPortal for Cancer Genomics
• I-Zeaxanthin Ibangela i-Apoptosis nge-ROS-Regulated MAPK kunye ne-AKT yokuSayina Indlela kwiiseli zoMhlaza weGastric Gastric.
• I-Zeaxanthin yenza iziphumo zokukhusela kwi-acetic acid-induced colitis kwiimpuku ngokumodareyitha i-cytokines e-pro-inflammatory kunye noxinzelelo lwe-oxidative.
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• I-Zeaxanthin inqanda ukufuduka kwe-PDGF-BB kwi-fibroblasts yedermal yabantu.
• cBioPortal for Cancer Genomics
• I-CD40L ye-mediated enye indlela ye-NFκB-signal ibangela ukuxhathisa kwi-BCR-inhibitors kwizigulane ezine-mantle cell lymphoma.
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• I-genomic landscape yokuphendula kwi-EGFR blockade kumhlaza we-colorectal.