Ngowuphi umhlaza onokuzuza ngokubandakanya iZeaxanthin ekudleni kwabo?

Iimbalasane

I-Zeaxanthin yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweZeaxanthin kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Ngokomzekelo, i-Zeaxanthin inokuzuza abo bane-Primary Glioblastoma ehamba neTemozolomide. Ngaphaya koko, ngelixa i-Zeaxanthin inokunceda abantu abanomngcipheko wemfuza "TERT", inokungacetyiswa kwabo banomngcipheko wemfuzo owahlukileyo. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-Zeaxanthin kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekuthatheni isigqibo sokuba iZeaxanthin lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke iinxalenye ezisebenzayo kukutya / izongezo ezifana neZeaxanthin endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iZeaxanthin kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye i-Zeaxanthin ukuba unemfuza enokuthanani nomhlaza onxulumene nofuzo lwe-TERT? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza usuka kumfuza? Ngaba kuluncedo ukubandakanya iZeaxanthin kukutya kwakho ukuba ufunyaniswe unePrimary Glioblastoma? Ngaphezu koko, ukusetyenziswa kwakho kweZeaxanthin kufuneka kulungiswe njani ukuba ufumana unyango lweTemozolomide okanye ukuba isicwangciso sakho sonyango sisuka kwiTemozolomide? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neZeaxanthin yendalo, ngoko isoloko iluncedo' okanye 'iZeaxanthin yonyusa ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya iZeaxanthin kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana neZeaxanthin kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uthathele ingqalelo isiphumo se-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangethuba. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njengePrimary Glioblastoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeka kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neZeaxanthin. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-TERT uneempembelelo zendlela yebhayoloji efanayo njengotshintsho kwenye imfuza? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Glioblastoma ulingana nomnye umhlaza? Ngaphezu koko, ngaba ukuqwalaselwa kokutya kuhlala kufana nakwabo bafumana olunye unyango njengabo bafumana iTemozolomide? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Zeaxanthin -Isongezelelo seSondlo

I-Zeaxanthin eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Zeaxanthin, nganye ekhoyo kwiindawo ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-NFKB Signaling kunye ne-P53 Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeZeaxanthin, yedwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iZeaxanthin kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kwe-Zeaxanthin ayisosigqibo sehlabathi lonke esilungele zonke ii-cancer kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeZeaxanthin

Ukuphendula umbuzo othi 'Ndifanele ndiyiphephe nini i-Zeaxanthin kumxholo woMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zeZeaxanthin ziyahluka ngokuxhomekeke kwiimeko zomntu. Imiba efana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye nayo nayiphi na i-allergies yonke idlala indima ekuqinisekiseni ukuba i-Zeaxanthin ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Zeaxanthin Supplements iya kuxhamla kwiZigulana zeGlioblastoma eziphambili eziphantsi koNyango lweTemozolomide?

I-Glioblastoma eyiprayimari ichongiwe ngokuguqulwa kofuzo oluthile, njenge-TRBV7-7, TAS2R46 kunye ne-TP53, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-NFKB Signaling, i-Cell Cycle Checkpoints kunye ne-Apoptosis. Ukusebenza kwonyango lomhlaza, njengeTemozolomide, kuchongwa ngokusebenzisana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Zeaxanthin lukhetho olunengqiqo kulabo abane-Primary Glioblastoma ehamba neTemozolomide. Oku kungenxa yokuba i-Zeaxanthin inefuthe kwiindlela ezifana ne-NFKB Signaling, enokuthi inqanda izinto eziqhuba i-Primary Glioblastoma okanye izuze ukusebenza kweTemozolomide.

2. Ngaba izongezo ze-Zeaxanthin zikhuselekile kubantu abasempilweni abane-TERT Mutation eManyaniswa neMngcipheko yeGenetic?

I-TERT idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-TERT kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-P53 Signaling kunye ne-DNA Repair, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-TERT ehambelana noMhlaza we-Hematological, cinga ngokubandakanya izongezo ze-Zeaxanthin kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana ne-P53 Umqondiso, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-TERT kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanya ukutya kunye nezongezo ezifana neZeaxanthin, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• cBioPortal for Cancer Genomics
• I-NF-κB ivuliwe ekuphenduleni i-temozolomide ngendlela exhomekeke kwi-AKT kwaye inika ukhuseleko kwimpembelelo yokukhula kweyeza.
• I-Zeaxanthin yenza iziphumo zokukhusela kwi-acetic acid-induced colitis kwiimpuku ngokumodareyitha i-cytokines e-pro-inflammatory kunye noxinzelelo lwe-oxidative.
• Imeko ye-somatic genomic ye-glioblastoma.