Ngowuphi umhlaza onokuzuza ngokuquka iLavender ekutyeni kwabo?

Iimbalasane

ILavender ibonwa ngokubanzi ngenxa yeenzuzo zayo zempilo kwaye isetyenziswa rhoqo zizigulana ezinomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweLavender kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, iLavender inganceda abo banePrayimari yePenile Squamous Cell Carcinoma befumana iMitomycin. Ngaphaya koko, ngexa iLavender inokunceda abantu abanomngcipheko wemfuzo "CDKN2A", ayinakucetyiswa kwabo banomngcipheko wofuzo owahlukileyo "ASXL1". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweLavender kwisigulana somhlaza kufuneka kube ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iLavender lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke iinxalenye ezisebenzayo ekutyeni / izongezo ezifana neLavender endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iLavender kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iLavender ukuba unemfuza enokuthanani nomhlaza onxulumene nofuzo lwe-CDKN2A? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ASXL1 gene? Ngaba kuluncedo ukubandakanya iLavender kwisidlo sakho ukuba ufunyaniswe unePrimary Penile Squamous Cell Carcinoma? Ngaphezu koko, kufuneka kuhlengahlengiswe njani ukusetyenziswa kwakho kweLavender ukuba ufumana unyango lwe-Mitomycin okanye ukuba isicwangciso sakho sonyango siyatshintsha kwi-Mitomycin? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neLavender yendalo, ngoko ke isoloko iluncedo' okanye 'iLavender inyusa ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya iLavender kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Ngamafutshane, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana neLavender kwisidlo sakho ngenxa yezibonelelo zayo, kuya kufuneka uqwalasele iziphumo zebhayoloji yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, onje ngePrimary Penile Squamous Cell Carcinoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kujongwe imingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neLavender. Ngaba umngcipheko wemfuza womhlaza osuka kutshintsho kwi-CDKN2A unefuthe elifanayo le-biochemical pathway njengotshintsho kwi-ASXL1? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana nePrayimari yePenile Squamous Cell Carcinoma ulingana nomnye umhlaza? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo bafumana olunye unyango njengabo bafumana iMitomycin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

ILavender – Isongezo seSondlo

I-Lavender yokongeza ibandakanya uluhlu lwezithako ezisebenzayo, kubandakanywa i-Linalool, nganye ekhoyo kwiindidi ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngakumbi i-Apoptosis, i-Cytokine Signaling kunye ne-MYC Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leselula, njengokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeLavender, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iLavender kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufanayo nonyango lomhlaza, ukusetyenziswa kweLavender ayisosigqibo sehlabathi lonke esilungele zonke iicancer kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeLavender

Ukuphendula umbuzo othi 'Ndingayiphepha nini iLavender kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulane ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zeLavender ziyahluka ngokuxhomekeke kwiimeko zomntu. Imiba efana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye nayo nayiphi na i-allergies yonke idlala indima ekuqinisekiseni ukuba i-Lavender ifanelekile okanye kufuneka ithintelwe, kugxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba izongezo zeLavender ziya kuxhamla kwiZigulana eziphantsi koNyango lweMitomycin?

I-Primary Penile Squamous Cell Carcinoma ichongiwe ngokuguqulwa kofuzo oluthile, olufana ne-ABRAXAS1, i-PIK3CB kunye ne-NUP93, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Apoptosis, i-Hematopoiesis kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, njengeMitomycin, kumiselwa kukudibana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Umzekelo, isongezelelo seLavender lukhetho olunengqiqo kwabo banePrayimari yePenile Squamous Cell Carcinoma ehamba neMitomycin. Oku kungenxa yokuba iLavender inefuthe kwiindlela ezifana neApoptosis, enokuthi ithintele izinto eziqhuba iPrayimari yePenile Squamous Cell Carcinoma okanye izuze impumelelo yeMitomycin.

2. Ingaba izongezo zeLavender zikhuselekile kubantu abasempilweni abaneASXL1 Mutation eNxulunyaniswe neMngcipheko yeGenetic?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-ASXL1 gene idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-ASXL1 gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Cytokine Signaling, i-Oncogenic Cancer Epigenetics kunye ne-Suppressive Histone Methylation, ebandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga uguquko kwi-ASXL1 ehambelana nokunyuka komngcipheko we-Chronic Myelomonocytic Leukemia, ingqiqo yenzululwazi icebisa ukuphepha ukusetyenziswa kweLavender yokuncedisa. Oku kungenxa yokuba ukongeza iLavender inefuthe kwiindlela ezifana neCytokine Signaling, enokukhokelela kwimiphumo emibi kumxholo wenguqu ye-ASXL1 kunye neemeko zomhlaza ezinxulumene nazo.

3. Ingaba izongezo zeLavender zikhuselekile kubantu abasempilweni abaneCDKN2A Mutation Associated Genetic Risk?

I-CDKN2A idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CDKN2A kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-MYC Signaling, i-Cell Cycle Checkpoints kunye ne-Cell Cycle, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuzo ityhila utshintsho kwi-CDKN2A ehambelana noMhlaza woLusu, cinga ngokubandakanya izongezo zeLavender kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana ne-MYC yokuSayina, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-CDKN2A kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezo ezifana neLavender ngenxa yeenzuzo zayo, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• I-Linalool ibonisa iziphumo ze-cytotoxic ngokwenza i-antitumor immunity.
• I-Linalool ibangela ukubanjwa komjikelo weseli kunye ne-apoptosis kwiiseli ze-HepG2 ngokuvelisa uxinzelelo lwe-oxidative kunye nokuguqulwa kweRas / MAPK kunye neendlela ze-Akt / mTOR.
• cBioPortal for Cancer Genomics
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.
• I-Mitomycin C inamandla e-TRAIL-induced apoptosis ngokusebenzisa i-p53-independent upregulation of death receptors: ubungqina bendima ye-c-Jun N-terminal kinase activation.
• Isiphumo esikhuselayo se-linalool ngokuchasene ne-lipopolysaccharide/D-galactosamine-eyenziwe ukwenzakala kwesibindi kwiimpuku.