Ngowuphi umhlaza onokuzuza ngokubandakanya iLarch kwisidlo sabo?

Iimbalasane

I-Larch yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweLarch kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Ngokomzekelo, i-Larch inokuzuza abo bane-Primary Monoclonal gammopathy yokubaluleka okungaqinisekanga okwenzeka kwi-Lenalidomide, kodwa kusenokungabi kuhle kwizigulana ezifumana iRadiation yePrimary Urethral Squamous Cell Carcinoma. Ngaphaya koko, ngelixa i-Larch inokunceda abantu abane-genetic risk factor "KIT", ayinakucetyiswa kwabo banomngcipheko wemfuzo owahlukileyo "CTNNB1". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweLarch kwisigulana somhlaza kufuneka kube ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekuthatheni isigqibo sokuba iLarch lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi ekukhetheni ukutya ibalulekile, igxile kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / nezongezo ezifana neLarch endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayihoyi ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iLarch kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iLarch ukuba unemfuza enokuthanani nomhlaza onxulumene nofuzo lwe-KIT? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-CTNNB1 gene? Ngaba kunenzuzo ukubandakanya iLarch ekutyeni kwakho ukuba ufunyaniswe une-Primary Urethral Squamous Cell Carcinoma, okanye ukuba ukuxilongwa kwakho yiPrimary Monoclonal gammopathy yokubaluleka okungachazwanga? Ngaphezu koko, kufuneka kuhlengahlengiswe njani ukusetyenziswa kwakho kweLarch ukuba ufumana unyango lweLenalidomide okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka eLenalidomide siye kwiRadiation? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neLarch yendalo, ngoko ke isoloko iluncedo' okanye 'iLarch inyusa ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya iLarch kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje ngeLarch kwisondlo sakho ngenxa yezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangethuba. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye lungabikho. Nje ukuba ufunyaniswe ukuba unohlobo oluthile lomhlaza, njenge-Primary Monoclonal gammopathy yokubaluleka okungachazwanga okanye i-Primary Urethral Squamous Cell Carcinoma, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, isigaba sesifo, kunye nezinto ezifana nobudala kunye isini.”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kujongwe imingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neLarch. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-KIT uneempembelelo zendlela yebhayokhemikhali efanayo njengotshintsho kwi-CTNNB1? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Monoclonal gammopathy yokubaluleka okungaqinisekanga ulingana nePrimary Urethral Squamous Cell Carcinoma? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kweRadiation njengabo bafumana iLenalidomide? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

ILarch – iSongezo seSondlo

I-Larch eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Maltol, i-Kaempferol, i-Vanillic Acid, i-Salicylic Acid kunye ne-Rutin, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela ze-molecular, ngokukodwa i-Angiogenesis, i-DNA Repair, i-Epithelial kwi-Mesenchymal Transition kunye ne-JAK-STAT Signaling, elawula iinkalo ezibalulekileyo zomhlaza kwinqanaba leselula, ezifana nokukhula kwe-tumor, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeLarch, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iLarch yomhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweLarch ayisosigqibo sehlabathi lonke esifanelekileyo kubo bonke abanomhlaza kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeLarch

Ukuphendula umbuzo othi 'Ndingamphepha nini uLarch kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zeLarch ziyahluka ngokuxhomekeke kwiimeko zomntu. Imiba efana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye nayo nayiphi na i-allergies yonke idlala indima ekuqinisekiseni ukuba i-Larch ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Larch Supplements iya kuxhamla kwi-Primary Urethral Squamous Cell Carcinoma izigulane eziphantsi konyango lweRadiation?

I-Primary Urethral Squamous Cell Carcinoma ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-BLM, i-BRCA1 kunye ne-CTCF, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-Androgen Signaling kunye ne-DNA Repair. Ukusebenza konyango lomhlaza, njengeRadiation, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Larch supplement, echaphazela ukulungiswa kwe-DNA, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Urethral Squamous Cell Carcinoma xa i-Radiation. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba iLarch Supplements iya kuyizuza iPrimary Monoclonal gammopathy ngokubaluleka okungachazwanga kwiZigulana eziphantsi koNyango lweLenalidomide?

I-Primary Monoclonal gammopathy yokubaluleka okungaqinisekanga ichongiwe ngokuguqulwa kofuzo oluthile, njenge-LATS2, i-ZMYM2 kunye ne-CDK8, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Angiogenesis kunye ne-Hippo Signaling. Ukusebenza konyango lomhlaza, njengeLenalidomide, kumiselwa kukudibana kwalo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo seLarch lukhetho olunengqiqo kwabo bane-Primary Monoclonal gammopathy yokubaluleka okungaqinisekanga okwenzeka kwiLenalidomide. Oku kungenxa yokuba iLarch inefuthe kwiindlela ezifana ne-Angiogenesis, enokuthi ithintele izinto eziqhuba i-Primary Monoclonal gammopathy yokubaluleka okungamiselwanga okanye inzuzo ekusebenzeni kweLenalidomide.

3. Ingaba izongezo zeLarch zikhuselekile kubantu abasempilweni abaneCTNNB1 Mutation Associated Genetic Risk?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-gene ye-CTNNB1 idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-CTNNB1 gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Adherens junction kunye ne-Epithelial kwi-Mesenchymal Transition, ebandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga ukuguqulwa kwe-CTNNB1 ehambelana nomngcipheko owongeziweyo we-Adrenocortical Carcinoma, ingqiqo yesayensi icebisa ukuphepha ukusetyenziswa kwe-Larch yokuncedisa. Oku kungenxa yokuba ukongeza i-Larch inefuthe kwiindlela ezifana ne-Epithelial ukuya kwi-Mesenchymal Transition, enokukhokelela kwimiphumo emibi kumxholo we-CTNNB1 yokuguqulwa kunye neemeko zomhlaza ezinxulumene nazo.

4. Ngaba izongezo zeLarch zikhuselekile kubantu abasempilweni abane-KIT Mutation eNxulunyaniswe neMngcipheko yeGenetic?

I-KIT idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-KIT kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-JAK-STAT Signaling kunye ne-Growth Factor Signaling, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuzo ityhila utshintsho kwi-KIT ehambelana noMhlaza weGastric, cinga ngokubandakanya izongezo zeLarch kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana ne-JAK-STAT yokuSayina, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanokuguqulwa kwe-KIT kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezelelo ezifana neLarch, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• I-HIF-1α yeeseli ze-bone marrow endothelial ithetha ukuphindaphinda kunye nokuxhatshazwa kweziyobisi kwizigulane ezine-myeloma ezininzi kwaye zingenza njengenjongo yonyango.
• cBioPortal for Cancer Genomics
• Iinhibitors ze-molecule ezincinci ze-NADPH oxidase 4.
• I-Flavonoids njenge-receptor tyrosine kinase FLT3 inhibitors.
• Ukuthintela uThintelo lwe-Vanillic Acid ekuLawulweni kwe-Redox Homeostasis, i-Matrix Metalloproteinases kunye ne-Cyclin D1 kwiigundane ezithwele i-Endometrial Carcinoma.
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.