Ngowuphi umhlaza onokuzuza ngokubandakanya i-7-8-dihydroxyflavone ekutyeni kwabo?

Iimbalasane

I-7-8-dihydroxyflavone yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kwe-7-8-dihydroxyflavone kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengophawu lomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, i-7-8-dihydroxyflavone inokuba luncedo kwabo bane-Primary Penile Squamous Cell Carcinoma ehamba ne-Mitomycin, kodwa isenokungabi kuhle kwizigulana ezifumana i-Gemcitabine ye-Primary Urachal adenocarcinoma. Ngaphezu koko, ngelixa i-7-8-dihydroxyflavone inokunceda abantu abane-genetic risk factor "CDKN2A", ayinakucetyiswa kwabo banomngcipheko ohlukileyo wemfuza "ASXL1". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-7-8-dihydroxyflavone kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekuthatheni isigqibo sokuba i-7-8-dihydroxyflavone lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi ekukhetheni ukutya ibalulekile, igxile kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana ne-7-8-dihydroxyflavone endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise i-7-8-dihydroxyflavone ekudleni kwakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba udle i-7-8-dihydroxyflavone ukuba unemfuzo yomhlaza ohambelana ne-CDKN2A gene? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ASXL1 gene? Ngaba kunenzuzo ukubandakanya i-7-8-dihydroxyflavone ekudleni kwakho ukuba ufunyanwe une-Primary Urachal adenocarcinoma, okanye ukuba ukuxilongwa kwakho yi-Primary Penile Squamous Cell Carcinoma? Ngaphezu koko, kufuneka uhlengahlengiso njani ukusetyenziswa kwakho kwe-7-8-dihydroxyflavone ukuba ufumana unyango lwe-Mitomycin okanye ukuba isicwangciso sakho sonyango siyatshintsha ukusuka kwi-Mitomycin ukuya kwi-Gemcitabine? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'ne-7-8-dihydroxyflavone yendalo, ngoko isoloko iluncedo' okanye 'i-7-8-dihydroxyflavone yonyusa ukhuselo lomzimba' ayonelanga kukhetho lokutya/lokuncedisa.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-7-8-dihydroxyflavone kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana ne-7-8-dihydroxyflavone kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uthathele ingqalelo ifuthe le-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olulo. okwenzekayo, iimeko zofuzo, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njengePrayimari yePenile Squamous Cell Carcinoma okanye iPrimary Urachal adenocarcinoma, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeka kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana ne-7-8-dihydroxyflavone. Ngaba umngcipheko wemfuza womhlaza osuka kutshintsho kwi-CDKN2A unefuthe elifanayo le-biochemical pathway njengotshintsho kwi-ASXL1? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana nePrayimari yePenile Squamous Cell Carcinoma ilingana nePrimary Urachal adenocarcinoma? Ngapha koko, ngaba uqwalaselo lokutya luhlala lufana nakwabo baphantsi kweGemcitabine njengabo bafumana iMitomycin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-7-8-dihydroxyflavone-Isongezelelo seZondlo

I-supplement 7-8-dihydroxyflavone iquka uluhlu lwezithako ezisebenzayo, kuquka i-7-8-dihydroxyflavone, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-Apoptosis, i-Oxidative Stress, i-Endoplasmic Reticulum Stress kunye ne-Angiogenesis, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njenge-7-8-dihydroxyflavone, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa i-7-8-dihydroxyflavone kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kwe-7-8-dihydroxyflavone ayisosigqibo sehlabathi lonke esifanelekileyo kubo bonke abanomhlaza kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo ze-7-8-dihydroxyflavone

Ukuphendula umbuzo 'Ndingakuphepha nini ukunqanda i-7-8-dihydroxyflavone kwimeko yoMhlaza' ngumngeni kuba impendulo ixhomekeke kakhulu kumntu ngamnye - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulane ngasinye, ukubaluleka kunye nokhuseleko okanye inzuzo ye-7-8-dihydroxyflavone iyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo oluthile lwe-allergies zonke zidlala indima ekunqumeni ukuba i-7-8-dihydroxyflavone ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka. yokuqwalaselwa komntu ngamnye kwizigqibo ezinjalo.

1. Ngaba i-7-8-dihydroxyflavone Supplements iya kunceda i-Primary Urachal adenocarcinoma Izigulane ezifumana unyango lwe-Gemcitabine?

I-Primary Urachal adenocarcinoma ibonakaliswe ngokuguqulwa kwemfuza ethile, okuyi-NFE2L2, TP53 kunye ne-GNAS, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-Oxidative Stress, i-Immune Checkpoints, i-Cell Cycle Checkpoints, i-Apoptosis, i-G-protein-coupled Receptor Signaling kunye ne-Reproductive Hormone. Ukusebenza konyango lomhlaza, njengeGemcitabine, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-7-8-dihydroxyflavone supplement, echaphazela i-Oxidative Stress, ayinakuba yinto efanelekileyo kwimeko ye-Primary Urachal adenocarcinoma xa i-Gemcitabine. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho lwemfuza olwaziwayo.

2. Ngaba i-7-8-dihydroxyflavone Supplements iya kunceda i-Primary Penile Squamous Cell Carcinoma Izigulana eziphantsi koNyango lwe-Mitomycin?

I-Primary Penile Squamous Cell Carcinoma ichongiwe ngokuguqulwa kofuzo oluthile, njenge-ABRAXAS1, PIK3CB kunye ne-NUP93, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Apoptosis, i-Hematopoiesis kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, njengeMitomycin, kumiselwa kukudibana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-7-8-dihydroxyflavone lukhetho olunengqiqo kulabo abanePrayimari yePenile Squamous Cell Carcinoma ehamba neMitomycin. Oku kungenxa yokuba i-7-8-dihydroxyflavone inefuthe kwiindlela ezifana ne-Apoptosis, enokuthi ithintele izinto eziqhuba i-Primary Penile Squamous Cell Carcinoma okanye izuze ukusebenza kweMitomycin.

3. Ngaba i-7-8-dihydroxyflavone izongezo zikhuselekile kuBantu abasempilweni abane-ASXL1 yoGuquko oluNxulumene neMngcipheko yeGenetic?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-ASXL1 gene idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-ASXL1 gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Endoplasmic Reticulum Stress, i-Oncogenic Cancer Epigenetics kunye ne-Suppressive Histone Methylation, ebandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga ukuguqulwa kwe-ASXL1 ehambelana nomngcipheko okhulayo we-Chronic Myelomonocytic Leukemia, ingqiqo yesayensi ibonisa ukuphepha ukusetyenziswa kwe-supplement 7-8-dihydroxyflavone. Oku kungenxa yokuba ukongeza i-7-8-dihydroxyflavone inefuthe kwiindlela ezifana ne-Endoplasmic Reticulum Stress, enokukhokelela kwimiphumo emibi kumxholo wenguqu ye-ASXL1 kunye neemeko zomhlaza ezinxulumene nazo.

4. Ngaba i-7-8-dihydroxyflavone izongezo zikhuselekile kubantu abasempilweni abane-CDKN2A yoGuquko oluNxulumene neMngcipheko yeGenetic?

I-CDKN2A idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CDKN2A kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Angiogenesis, i-Cell Cycle Checkpoints kunye ne-Cell Cycle, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-CDKN2A ehambelana noMhlaza woLusu, cinga ukufaka i-7-8-dihydroxyflavone izongezo kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela kakuhle iindlela ezifana ne-Angiogenesis, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-CDKN2A kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanya ukutya kunye nezongezo ezifana ne-7-8-dihydroxyflavone, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Ukungeniswa kwe-Apoptosis ye-leukemia yabantu iiseli ze-U937 nge-7,8-dihydroxyflavone hydrate ngokumodareyitha kwe-Bcl-2 intsapho yeeprotheni kunye ne-MAPKs indlela yokubonisa indlela.
• Unyango lwe-7,8-DHF lubangela i-Cyr61 Expression to Suppress Hypoxia Induced ER Stress in HK-2 Cells.
• cBioPortal for Cancer Genomics
• Ukuphonononga i-Molecular Interactions ye-7,8-Dihydroxyflavone kunye ne-Derivatives yayo kunye ne-TrkB kunye neeProtheyini ze-VEGFR2.
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.
• I-7,8-Dihydroxyflavone isebenze i-Nrf2 / HO-1 iindlela zokubonisa kwaye ikhusela kwi-osteoarthritis.
• I-Mitomycin C inamandla e-TRAIL-induced apoptosis ngokusebenzisa i-p53-independent upregulation of death receptors: ubungqina bendima ye-c-Jun N-terminal kinase activation.
• Iindlela zokoyisa ukuchasana kwe-Intrinsic kwi-Gemcitabine kwi-Pancreatic Ductal Adenocarcinoma ngokusebenzisa i-Redox Modulation.
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.