Ukutya kweEsophageal Squamous Cell Carcinoma!

intshayelelo

Ukutya kweEsophageal Squamous Cell Carcinoma kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kuziqhelanise xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

I-Esophageal squamous cell carcinoma (ESCC) luhlobo lomhlaza oluchaphazela iiseli ezijikeleze ummizo. Yenye yezona ntlobo zimbini ziphambili zomhlaza wommizo, enye yi-esophageal adenocarcinoma. Ikhowudi echanekileyo usebenzisa inkqubo ye-ICD-10 iqinisekisa amaxwebhu afanelekileyo e-esophageal squamous cell carcinoma kwiirekhodi zonyango. Iqonga lidlala indima ebalulekileyo ekumiseleni ubungakanani bomhlaza kunye nezigqibo ezikhokelayo zonyango. Izinto ezinobungozi kwi-esophageal squamous cell carcinoma ziquka ukusetyenziswa kwecuba kunye nokusetyenziswa kotywala, kunye nokutya okuncinci kwiziqhamo kunye nemifuno. Iimpawu ze-esophageal squamous cell carcinoma zinokubandakanya ubunzima bokugwinya, ukwehla kobunzima, intlungu yesifuba, kunye nokucaphuka. I-prognosis ye-esophageal squamous cell carcinoma iyahluka ngokuxhomekeke kwinqanaba lomhlaza kunye nempilo yonke yesigulane. Iinketho zonyango lwe-esophageal squamous cell carcinoma zinokubandakanya utyando, unyango lwemitha, ichemotherapy, okanye indibaniselwano yolu nyango. Izikhokelo ezifanelekileyo kunye neeprothokholi zonyango zinceda ekunikezeni ukhathalelo olubanzi nolulungiselelwe izigulane. Iinkcazo ze-Pathology zibonelela ngolwazi oluxabisekileyo malunga neempawu kunye neempawu ze-esophageal squamous cell carcinoma, ezincedisa ukuxilongwa ngokuchanekileyo. Ubuchule beRadiology budlala indima ebalulekileyo ekuboneni nasekuvavanyeni i-esophageal squamous cell carcinoma kunye nokwazisa ngezigqibo zonyango. Ukuqonda okwenzekayo kunye ne-epidemiology yalo mhlaza kubalulekile ekuphuhliseni izicwangciso zokuthintela kunye nokuphucula ukubonwa kwangoko. Amazinga okusinda kwi-esophageal squamous cell carcinoma ixhomekeke kwizinto ezahlukeneyo kunye nonyango. Ukuqatshelwa kwangethuba kwezinto ezinobungozi kunye nokungenelela ngexesha elifanelekileyo kunokufaka isandla ekunciphiseni iziganeko zalo mhlaza uhlaselayo. Ngokubanzi, ukulawula i-esophageal squamous cell carcinoma ibandakanya indlela ye-multidisciplinary kunye nokuhlala unolwazi malunga nezikhokelo zonyango zamva nje ukubonelela ngononophelo oluphezulu kunye nenkxaso kwizigulane.

Kwi-Esophageal Squamous Cell Carcinoma ingaba inomsebenzi ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu umntu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza onje nge-Esophageal Squamous Cell Carcinoma ingaba ayinamsebenzi ukuba kokuphi ukutya endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekwe kwisityalo oko kwanele umhlaza ofana ne-Esophageal Squamous Cell Carcinoma?

Umzekelo ingaba inomsebenzi ukuba imifuno iWax Gourd ityiwa kakhulu xa ithelekiswa neDaikon Radish? Ngaba kuyawenza umahluko ukuba umkhiwane uyathandwa kuneerharnati? Kwakhona ukuba ukhetho olufanayo lwenzelwe amandongomane/imbewu efana neButternut ngaphezulu kweChestnut yaseYurophu kunye neepulses ezifana neAlfalfa phezu kweCatjang Pea. Kwaye ukuba into endiyityayo ibalulekile - umntu uchonga njani ukutya okucetyiswayo kwi-Esophageal Squamous Cell Carcinoma kwaye ingaba impendulo efanayo kuye wonke umntu onokuxilongwa okufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kwi-Esophageal Squamous Cell Carcinoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo Umzobo uqulethe izithako ezisebenzayo i-Curcumin, i-Daidzein, i-Lycopene, i-Beta-sitosterol, i-Phloretin. Kwaye iPomegranate iqulethe izithako ezisebenzayo i-Ellagic Acid, i-Myricetin, i-Curcumin, i-Daidzein, i-Beta-sitosterol kwaye mhlawumbi nabanye.

Impazamo eqhelekileyo eyenziwa xa kusenziwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Esophageal Squamous Cell Carcinoma - kukuvavanya kuphela izithako ezisebenzayo ezikhethiweyo eziqulethwe kukutya kwaye ungayihoyi enye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha i-cherry izithako ezisebenzayo ekutyeni kunye nezongezelelo ukwenza isigqibo sesondlo se-Esophageal Squamous Cell Carcinoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwi-Esophageal Squamous Cell Carcinoma?

Isondlo somntu kumhlaza onje ngeEsophageal Squamous Cell Carcinoma ibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubungcali kwi-Esophageal Squamous Cell Carcinoma biology, isayensi yokutya, i-genetics, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nokuba sesichengeni okuhambelana nonyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana ne-Esophageal Squamous Cell Carcinoma

Zonke ii-cancer ezifana ne-Esophageal Squamous Cell Carcinoma zinokubonakaliswa ngoluhlu olulodwa lweendlela ze-biochemical - iindlela zokutyikitya ze-Esophageal Squamous Cell Carcinoma. Iindlela ze-Biochemical ezifana ne-Amino Acid Metabolism, i-Nucleotide metabolism, i-PI3K-AKT-MTOR Ukubonakaliswa, Ukubonakaliswa kwe-MAPK kuyingxenye yenkcazo yesignesha ye-Esophageal Squamous Cell Carcinoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Esophageal Squamous Cell Carcinoma kufuneka luthathele ingqalelo utyikityo olunxulumene neendlela zebhayokhemikhali kwisigulana somhlaza ngamnye kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Esophageal Squamous Cell Carcinoma xa uthatha unyango lomhlaza iCapecitabine, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-TP53, i-KMT2D, i-ROS1, i-NCOR1 kunye ne-MUC16 zezona ziphezulu iigenes ezixeliweyo ze-Esophageal Squamous Cell Carcinoma. I-TP53 ixelwe kwi-10.5% yezigulane ezimele kuzo zonke iimvavanyo zekliniki. Kwaye i-KMT2D ixelwe kwi-3.2%. Idatha yezigulane ezidityanisiweyo igubungela iminyaka yobudala ukusuka kuma-34 ukuya kuma-88. I-79.4 % yedatha yezigulane ichongwe njengamadoda. I-Esophageal Squamous Cell Carcinoma biology kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezelelo ze-Esophageal Squamous Cell Carcinoma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable WAX ​​GOURD okanye iDAIKON RADISH?

Imifuno ye-Wax Gourd iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Myricetin, i-Curcumin, i-Daidzein, i-Beta-sitosterol, i-Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-NFKB Signaling, i-Hypoxia kunye ne-Amino Acid Metabolism kunye nabanye. I-Wax Gourd icetyiswa kwi-Esophageal Squamous Cell Carcinoma xa unyango lomhlaza oluqhubekayo yi-Capecitabine. Oku kungenxa yokuba i-Wax Gourd iguqula ezo ndlela zebhayomikhali eziye zachazwa ngokwenzululwazi ukwazisa isiphumo se-Capecitabine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yeDaikon Radish yiMyricetin, Curcumin, Daidzein, Beta-sitosterol, Phloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye ne-Nucleotide metabolism kunye nezinye. I-Daikon Radish ayikhuthazwa kwi-Esophageal Squamous Cell Carcinoma xa unyango lomhlaza oluqhubekayo yi-Capecitabine kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli ngokukhawuleza.

IGAMA LEWAX YOMFUNO IYAKUGQIBISWA NGAPHEZU KWE-DAIKON RADISH YEEsophageal Squamous Cell Carcinoma KUNYE NONYANGO ICapecitabine.

Khetha iSiqhamo seGORGRANATE okanye iFIG?

Iziqhamo zePomegranate ziqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Ellagic Acid, i-Myricetin, i-Curcumin, i-Daidzein, i-Beta-sitosterol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK yokuSayina, ukulungiswa kwe-DNA, i-Amino Acid Metabolism kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. Irharnati iyacetyiswa kwi-Esophageal Squamous Cell Carcinoma xa unyango lomhlaza oluqhubekayo yi-Capecitabine. Oku kungenxa yokuba irharnati iguqula ezo ndlela zebhayomichi exelwe ngokwenzululwazi ukwazisa isiphumo seCapecitabine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo Umzobo yiCurcumin, iDaidzein, iLycopene, iBeta-sitosterol, iPhloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, ukulungiswa kwe-DNA kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. I-Fig ayikhuthazwa kwi-Esophageal Squamous Cell Carcinoma xa unyango lomhlaza oluqhubekayo yi-Capecitabine kuba luguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli ngokukhawuleza.

ISIQHAMO EGORGRANATE IYAYINGCEBISWA NGAPHEZU KWEFIGI YEEsophageal Squamous Cell Carcinoma KUNYE NONYANGO ICapecitabine.

Khetha Nut BUTTERNUT okanye EUROPEAN CHESTNUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Myricetin, i-Curcumin, i-Daidzein, i-Lycopene, i-Beta-sitosterol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, Hypoxia, NFKB Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Butternut iyacetyiswa kwi-Esophageal Squamous Cell Carcinoma xa unyango lomhlaza oluqhubekayo yi-Capecitabine. Oku kungenxa yokuba i-Butternut ilungisa ezo ndlela zebhayokhemikhali eziye zaxelwa ngokwenzululwazi ukwazisa isiphumo se-Capecitabine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Ellagic Acid, i-Myricetin, i-Curcumin, i-Daidzein, i-Beta-sitosterol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye ne-Nucleotide metabolism kunye nezinye. I-Chestnut yaseYurophu ayikhuthazwa kwi-Esophageal Squamous Cell Carcinoma xa unyango lomhlaza oluqhubekayo yi-Capecitabine kuba lulungisa ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli ngokukhawuleza.

IBHUTTERNUT IYAKUCEBISWA NGAPHEZU KWE-EUROPA CHESTNUT YEEsophageal Squamous Cell Carcinoma KUNYE NONYANGO ICapecitabine.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuza ye-Esophageal Squamous Cell Carcinoma okanye imbali yentsapho ithi "Yintoni endimele ndiyitye ngokwahlukileyo ngaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable GIANT BUTTERBUR okanye GARDEN RHUBARB?

I-Vegetable Giant Butterbur iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-PI3K-AKT-MTOR yokuSayina, i-MYC Signaling kunye ne-Oxidative Stress kunye nabanye. I-Giant Butterbur iyacetyiswa kumngcipheko we-Esophageal Squamous Cell Carcinoma xa umngcipheko wemfuzo ohambelana ne-KMT2D. Oku kungenxa yokuba i-Giant Butterbur yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yaseGarden Rhubarb yi-Apigenin, i-Curcumin, i-Emodin, i-Rhein, i-Quercetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. IGarden Rhubarb ayikhuthazwa xa umngcipheko we-Esophageal Squamous Cell Carcinoma xa umngcipheko wezofuzo uhambelana ne-KMT2D kuba yonyusa iindlela zokutyikitya kuyo.

IBHUTTERBURE EYISINXIBA YOMFUNO INCEBISIWE PHEZU KWEGADI RHUBARB NGEMNGCIPHEKO YEMFUZO YE-KMT2D YOMHLAZA.

Khetha iSiqhamo RED RASPBERRY okanye iPUMMELO?

Isiqhamo esiBomvu iRaspberry iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Ellagic Acid, i-Quercetin, i-Formononetin, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-PI3K-AKT-MTOR yokuSayina, i-RAS-RAF yokubonisa kunye noxinzelelo lwe-Oxidative kunye nabanye. I-Red Raspberry iyacetyiswa kumngcipheko we-Esophageal Squamous Cell Carcinoma xa umngcipheko wemfuzo ohambelana ne-KMT2D. Oku kungenxa yokuba i-Red Raspberry yonyusa ezo ndlela ze-biochemical ezichasene nabaqhubi batyikityo kuyo.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwisiqhamo iPummelo yi-Apigenin, i-Curcumin, i-Quercetin, i-Formononetin, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress kunye nezinye. IPummelo ayikhuthazwa xa umngcipheko we-Esophageal Squamous Cell Carcinoma xa umngcipheko wezofuzo uhambelana ne-KMT2D kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO ESIBOMVU ESIQINISEKISO SESIQINISEKISO PHEZU KWE-PUMMELO YE-KMT2D GENETIC RISK YOMHLAZA.

Khetha Nut COMMON HAZELNUT okanye CHESTNUT?

I-Hazelnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Quercetin, i-Formononetin, i-Lupeol, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK yokuSayina, uxinzelelo lwe-Oxidative, i-MYC Signaling kunye ne-PI3K-AKT-MTOR yokuSayina kunye nabanye. IHazelnut eqhelekileyo iyacetyiswa kumngcipheko we-Esophageal Squamous Cell Carcinoma xa umngcipheko wemfuzo ohambelana ne-KMT2D. Oku kungenxa yokuba iHazelnut eqhelekileyo yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Apigenin, i-Curcumin, i-Ellagic Acid, i-Formononetin, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Chestnut ayikhuthazwa xa umngcipheko we-Esophageal Squamous Cell Carcinoma xa umngcipheko wezofuzo uhambelana ne-KMT2D kuba yonyusa iindlela zokutyikitya kuyo.

I-HAZELNUT EQHELEKILEYO IYANCEBISWA NGAPHEZU KWE-CHESTNUT NGE-KMT2D genetic RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana ne-Esophageal Squamous Cell Carcinoma. Izigulana ze-Esophageal Squamous Cell Carcinoma kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Esophageal Squamous Cell Carcinoma, nganye ine-tumor genetics eyahlukeneyo kunye nokwahluka kwe-genomic ngakumbi kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neWax Gourd kuqulethe i-bioactives eyohlukeneyo ngokwemiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela ze-biochemical. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo se-addon yesondlo somntu senza ukuba kube lula ukwenza isigqibo kwaye sisuse yonke ingqikelelo ekuphenduleni umbuzo othi, "Yintoni ukutya endimele ndiyikhethe okanye ndingakhethi kwi-Esophageal Squamous Cell Carcinoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Msk Impact 2017
• Ukuchongwa kweenguqu ze-genomic kumhlaza we-squamous cell.
• Iziphumo zokuthintela i-butyric acid, i-nicotinamide, i-calcium glucarate yodwa okanye idibene ngexesha le-7, i-12-dimethylbenz (a) i-anthracene ibangele i-tumorigenesis yesikhumba semouse ngokumodareyitha kwe-K-Ras-PI3K-AKTpathway kunye ne-RNAs ezincinci ezinxulumene nazo.
• Inkqubela phambili yophando kwiziphumo ze-anticancer ye-vitamin K2.
• I-asidi ye-Gallic ixhokonxa umonakalo we-DNA kwaye icinezela i-DNA yokulungisa i-gene expression kwi-prostate cancer yomntu iiseli ze-PC-3.
• I-Vitamin C iphucula ukuguqulwa kwe-epigenetic eyenziwa yi-5-azacytidine kunye nokubanjwa komjikelo weseli kwi-hepatocellular carcinoma celllines HLE kunye ne-Huh7.
• Impembelelo ye-Daidzein kumhlaza we-prostate refractory kwi-vitro kunye ne-vivo xa kuthelekiswa ne-genistein kunye ne-soy extract: amandla onyango lwe-radiotherapy.
• I-Lycopene ngokwahlukileyo idala i-quiescence kunye ne-apoptosis kwi-androgen-esabelayo kunye ne-independent ye-prostate cancer celllines.
• I-Formononetin icinezela ukwanda komhlaza wemiphunga ongeyonxalenye encinci yomntu ngokungeniswa kokubanjwa komjikelo weeseli kunye ne-apoptosis.