Ukutya kweSinyi Adenocarcinoma!

intshayelelo

Ukutya kweSinyi I-Adenocarcinoma kufuneka ilungiselelwe umntu ngamnye kwaye kufuneka ilungelelanise xa unyango lomhlaza okanye utshintsho lwemfuza yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

Kwi-bladder Adenocarcinoma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza onje nge-Bladder Adenocarcinoma ingaba ibalulekile na into yokutya endikutyayo nendingakutyiyo? Okanye ukuba ndilandela ukutya okusekwe kwisityalo oko kwanele umhlaza njenge-Bladder Adenocarcinoma?

Umzekelo ingaba inomsebenzi ukuba iCalabash yemifuno ityiwa kakhulu xa ithelekiswa neChicory? Ngaba kuyawenza umahluko ukuba isiqhamo seAsian Pear sikhethwa ngaphezu kweRed raspberry? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane / iimbewu ezifana neHazelnut eqhelekileyo phezu kweChestnut kunye nezityalo ezifana neHyacinth Bean phezu kwePigeon Pea. Kwaye ukuba into endiyidlayo ibalulekile - ngoko umntu uchonga njani ukutya okucetyiswayo kwi-Bladder Adenocarcinoma kwaye ingaba impendulo efanayo kumntu wonke onokuxilongwa okufanayo okanye umngcipheko wemfuza?

Ewe! Ukutya okutyayo kubalulekile kwi-bladder Adenocarcinoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Ngokomzekelo i-Asian Pear iqulethe izithako ezisebenzayo i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein, i-Phloretin. Kwaye i-Red Raspberry iqulethe izithako ezisebenzayo i-Quercetin, i-Ellagic Acid, i-Curcumin, i-Formononetin, i-Lupeol kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa kuthathwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Bladder Adenocarcinoma - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungawuhoyi ukuphumla. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha i-cherry izithako ezisebenzayo ekutyeni kunye nezongezelelo ukwenza isigqibo sesondlo se-bladder Adenocarcinoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwi-Bladder Adenocarcinoma?

Isondlo esilungiselelwe wena somhlaza njenge-Bladder Adenocarcinoma siquka ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Bladder Adenocarcinoma biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nokuba semngciphekweni okunxulumene nonyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana neSinyi Adenocarcinoma

Yonke imihlaza efana ne-Bladder Adenocarcinoma inokuphawulwa ngoluhlu olulodwa lweendlela ze-biochemical - iindlela zokutyikitya ze-bladder Adenocarcinoma. Iindlela ze-Biochemical ezifana ne-RAS-RAF Signaling, i-mRNA Splicing, i-Oncogenic Cancer Epigenetics, i-Suppressive Histone Methylation iyingxenye yenkcazo yesignesha ye-Bladder Adenocarcinoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Bladder Adenocarcinoma kufuneka luthathele ingqalelo utyikityo lweendlela zebhayomichi enxulumene nesigulana somhlaza ngamnye kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Bladder Adenocarcinoma xa uthatha unyango lomhlaza Imitha, kunye nokunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-DNMT3A, TET2, ASXL1, PPM1D kunye ne-CHEK2 zezona ziphezulu iigenes ezixeliweyo ze-Bladder Adenocarcinoma. I-DNMT3A ixelwe kwi-31.8% yezigulane ezimele kuwo onke amalingo onyango. Kwaye i-TET2 ichazwe kwi-12.4%. Idatha yezigulane ezidityanisiweyo igubungela iminyaka yobudala ukusuka kwi-18 ukuya kuma-93. I-73.5 % yedatha yezigulane ichongwe njengamadoda. Ibhayoloji yeSinyi Adenocarcinoma kunye nemfuzo exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zeSinyi Adenocarcinoma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable CALABASH okanye CHICORY?

I-Calabash yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein, i-Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress, i-NFKB Signaling, i-JAK-STAT Signaling kunye ne-Cell Cycle kunye nabanye. ICalabash icetyiswa kwi-Bladder Adenocarcinoma xa unyango lomhlaza oluqhubekayo yiRadiation. Oku kungenxa yokuba iCalabash ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukuze zikhuthaze impembelelo yeRadiation.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Chicory yi-Quercetin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Extracellular Matrix Remodelling, i-TGFB yokuSayina kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Chicory ayikhuthazwa kwi-Bladder Adenocarcinoma xa unyango lomhlaza oluqhubekayo luyiRadiation kuba iguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

I-CALABASH YOMFUNO INCEBISWA NGAPHEZU KWE-CHICORY YE-Bladder Adenocarcinoma KUNYE NONYANGO LWERadiation.

Khetha iSiqhamo RED RASPBERRY okanye i-ASIAN PEAR?

Isiqhamo esiBomvu iRaspberry iqukethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Ellagic Acid, i-Curcumin, i-Formononetin, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Extracellular Matrix Remodelling, i-NFKB Signaling, i-Cell Cycle kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. I-Red Raspberry iyacetyiswa kwi-bladder Adenocarcinoma xa unyango oluqhubekayo lomhlaza luyiRadiation. Oku kungenxa yokuba i-Red raspberry iguqula ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukwazisa isiphumo seRadiation.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo zaseAsia Pear yiCurcumin, Formononetin, Lupeol, Daidzein, Phloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress kunye nezinye. I-Asian Pear ayikhuthazwa kwi-Bladder Adenocarcinoma xa unyango lomhlaza oluqhubekayo luyiRadiation kuba iguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO ESIBOMVU IRASPBHARI IYANCEBISWA NGAPHEZU KWEPEYARI YASEASIA NGE-Adenocarcinoma yeSinyi KUNYE NONYANGO Imitha.

Khetha Nut COMMON HAZELNUT okanye CHESTNUT?

I-Hazelnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Curcumin, i-Formononetin, i-Lupeol, i-Caffeine. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Extracellular Matrix Remodelling, i-NFKB Signaling, i-Cell Cycle kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. IHazelnut eqhelekileyo iyacetyiswa kwi-Bladder Adenocarcinoma xa unyango oluqhubekayo lomhlaza luyiRadiation. Oku kungenxa yokuba iHazelnut eqhelekileyo iguqula ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukwazisa isiphumo seRadi.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Ellagic Acid, i-Curcumin, i-Formononetin, i-Lupeol, i-Caffeine. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress, i-Extracellular Matrix Remodeling kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. I-Chestnut ayikhuthazwa kwi-Bladder Adenocarcinoma xa unyango lomhlaza oluqhubekayo yiRadiation kuba iguqula ezo ndlela zebhayoloji ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IHAZELNUT EQHELEKILEYO IYANCEBISWA NGAPHEZU KWE-CHESTNUT YESinyi Adenocarcinoma KUNYE NONYANGO Imitha.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuzo ye-Bladder Adenocarcinoma okanye imbali yosapho "Yintoni endifanele nditye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable GIANT BUTTERBUR okanye iRAPINI?

I-Butterbur enkulu yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol, i-Protocatechuic Acid. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Apoptosis, i-PI3K-AKT-MTOR Ukubonisa, Ukulungiswa kwe-DNA kunye ne-P53 Umqondiso kunye nabanye. I-Giant Butterbur iyacetyiswa kumngcipheko we-Bladder Adenocarcinoma xa umngcipheko wemfuzo ohambelana ne-ASXL1. Oku kungenxa yokuba i-Giant Butterbur yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Rapini yi-Apigenin, i-Curcumin, i-Lupeol, i-Protocatechuic Acid, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye nezinye. I-Rapini ayikhuthazwa xa umngcipheko we-Bladder Adenocarcinoma xa umngcipheko wezofuzo uhambelana ne-ASXL1 kuba inyusa iindlela zokutyikitya kuyo.

IBHUTTERBURE EYISINXIBA YOMFUNO IYACEBISWA NGAPHEZU KWE-RAPINI NGE-ASXL1 GENETIC RISK YOMHLAZA.

Khetha iFruit NANCE okanye iPUMMELO?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Protocatechuic Acid, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Apoptosis, i-PI3K-AKT-MTOR Ukubonisa, Ukulungiswa kwe-DNA kunye ne-P53 Umqondiso kunye nabanye. I-Nance icetyiswa kumngcipheko we-Bladder Adenocarcinoma xa umngcipheko wemfuzo ohambelana ne-ASXL1. Oku kungenxa yokuba i-Nance yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo iPummelo yi-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol, i-Protocatechuic Acid. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye nezinye. IPummelo ayikhuthazwa xa umngcipheko we-Bladder Adenocarcinoma xa umngcipheko wemfuzo uhambelana ne-ASXL1 kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO NANCE KUCEBISWA NGAPHEZU KWE-PUMMELO NGE-ASXL1 GENETIC RISK YOMHLAZA.

Khetha Nut EMNYAMA WALNUT okanye PILI NUT?

I-Walnut emnyama iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Ellagic Acid, i-Protocatechuic Acid. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-RAS-RAF yokuSayina, ii-Checkpoints ze-Cell Cycle, i-PI3K-AKT-MTOR yokuSayina kunye ne-P53 yokuSayina kunye nabanye. IWalnut emnyama icetyiswa kumngcipheko weSinyi Adenocarcinoma xa umngcipheko wemfuzo ohambelana ne-ASXL1. Oku kungenxa yokuba iWalnut Emnyama yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Pili Nut yi-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol, i-Protocatechuic Acid. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye nezinye. I-Pili Nut ayikhuthazwa xa umngcipheko we-Bladder Adenocarcinoma xa umngcipheko wezofuzo uhambelana ne-ASXL1 kuba inyusa iindlela zokutyikitya kuyo.

IWALNUT EMNYAMA KUCEBISWA NGAPHEZU KWE-PILI NUT NGE-ASXL1 GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana ne-Bladder Adenocarcinoma. Izigulana ze-bladder Adenocarcinoma kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye zingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Bladder Adenocarcinoma, nganye ine-tumor genetics eyahlukeneyo kunye nokwahluka kwe-genomic ngakumbi kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okunje ngeCalabash kuqulethe izinto ezahlukeneyo zebhayoloji ngokwemiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo othi, "Yintoni ukutya endimele ndiyikhethe okanye ndingakhethi kwi-Bladder Adenocarcinoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Tmb Mskcc 2018
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.
• Iziphumo kunye nokubaluleka kwe-formononetin kumanqanaba okubonakaliswa kwe-HIF-1α kunye ne-VEGF kwizicubu zomhlaza womlomo wesibeleko.