Ukutya kweBiliary Tract Carcinoma!

intshayelelo

Ukutya kwe-Biliary Tract Carcinoma kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kuziqhelanise xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

Kwi-Biliary Tract Carcinoma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza onje nge-Biliary Tract Carcinoma ingaba ayinamsebenzi ukuba kukutya ntoni na endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekwe kwisityalo oko kwanele umhlaza onje ngeBiliary Tract Carcinoma?

Umzekelo ingaba ibalulekile na into yokuba imifuno yaseGarden Tomato ityiwa kakhulu xa ithelekiswa nesipinatshi? Ngaba kuyawenza umahluko ukuba isiqhamo iBlack Elderberry siyakhethwa kuneMango? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane / iimbewu ezifana neWalnut emnyama phezu kweChestnut kunye nemifuno efana neChickpea phezu kweBean eqhelekileyo. Kwaye ukuba into endiyityayo ibalulekile - umntu uchonga njani ukutya okucetyiswayo kwi-Biliary Tract Carcinoma kwaye ingaba impendulo efanayo kuye wonke umntu onokuxilongwa okufanayo okanye umngcipheko wemfuza?

Ewe! Ukutya okutyayo yimicimbi yeBiliary Tract Carcinoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Ngokomzekelo i-Black Elderberry iqulethe izithako ezisebenzayo i-Quercetin, i-Linalool, i-Caffeine, i-Lycopene, i-Protocatechuic Acid. Kwaye iMango iqulethe izithako ezisebenzayo iQuercetin, iProtocatechuic Acid, iCurcumin, iLupeol, iFormononetin kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa uthatha isigqibo kunye nokukhetha ukutya okutyayo kwi-Biliary Tract Carcinoma - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungawuhoyi ukuphumla. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo se-Biliary Tract Carcinoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwi-Biliary Tract Carcinoma?

Izondlo zomntu zomhlaza ezifana neBiliary Tract Carcinoma ibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Biliary Tract Carcinoma biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nokuba sesichengeni okunxulumene nonyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza njenge-Biliary Tract Carcinoma

Zonke ii-cancer ezifana ne-Biliary Tract Carcinoma zinokubonakaliswa ngoluhlu olulodwa lweendlela ze-biochemical - iindlela zokutyikitya ze-Biliary Tract Carcinoma. Iindlela ze-Biochemical ezifana ne-RAS-RAF Signaling, i-mRNA Splicing, i-Oncogenic Cancer Epigenetics, i-DNA Repair iyingxenye yenkcazo yesignesha ye-Biliary Tract Carcinoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Biliary Tract Carcinoma kufuneka luthathele ingqalelo utyikityo lweendlela zebhayomichi enxulumene nesigulana somhlaza ngamnye kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Biliary Tract Carcinoma xa uthatha unyango lomhlaza IRadiation, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-DNMT3A, TET2, PPM1D, ASXL1 kunye ne-CHEK2 zezona ziphezulu iijene ezixeliweyo ze-Biliary Tract Carcinoma. I-DNMT3A ixelwe kwi-36.1 % yezigulane ezimele kuwo onke amalingo onyango. Kwaye i-TET2 ichazwe kwi-10.2%. Idatha yezigulane ezidityanisiweyo igubungela iminyaka yobudala ukusuka kuma-21 ukuya kuma-89. Ama-47.0 % edatha yezigulane ichongwe njengamadoda. I-Biliary Tract Carcinoma biology kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenza isondlo somntu.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zeBiliary Tract Carcinoma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable GARDEN TOMATO okanye ISIPINACH?

I-Vegetable Garden Tomato iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Lycopene, i-Protocatechuic Acid, i-Curcumin, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Angiogenesis, i-RAS-RAF Signaling, i-JAK-STAT Signaling kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. IGarden Tomato icetyiswa kwi-Biliary Tract Carcinoma xa unyango lomhlaza oluqhubekayo yiRadiation. Oku kungenxa yokuba iGarden Tomato ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukwazisa isiphumo seRadiation.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno Isipinatshi yi-Quercetin, i-Protocatechuic Acid, i-Curcumin, i-Formononetin, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Notch Signaling, ukulungiswa kwe-DNA kunye ne-MAPK Signaling kunye nabanye. Isipinatshi asikhuthazwa kwi-Biliary Tract Carcinoma xa unyango lomhlaza oluqhubekayo yiRadiation kuba luguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IITAMATO YEGADI YEMIFUNO IYAKUNIKEZWA PHEZU KWESIPINCHI KWI-Biliary Tract Carcinoma KUNYE NONYANGO LWERadiation.

Khetha Fruit MANGO okanye EMNYAMA ELDERBERRY?

IMango yeziqhamo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Protocatechuic Acid, i-Curcumin, i-Lupeol, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Angiogenesis, i-PI3K-AKT-MTOR yokuSayina, i-MAPK yokuSayina kunye ne-RAS-RAF yokuSayina kunye nabanye. IMango inconywa kwiBiliary Tract Carcinoma xa unyango lomhlaza oluqhubekayo yiRadiation. Oku kungenxa yokuba iMango ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukuze zikhuthaze impembelelo yoMbane.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwiziqhamo ze-Black Elderberry yi-Quercetin, i-Linalool, i-Caffeine, i-Lycopene, i-Protocatechuic Acid. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso kunye nokulungiswa kweDNA kunye nabanye. I-Black Elderberry ayikhuthazwa kwi-Biliary Tract Carcinoma xa unyango lomhlaza oluqhubekayo luyiRadiation kuba luguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO UMANGO IYANCEBISWA NGAPHEZU KWE-BLACK ELDERBERRY YE-Biliary Tract Carcinoma KUNYE NONYANGO LWERadiation.

Khetha Nut BLACK WALNUT okanye CHESTNUT?

I-Walnut emnyama iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Ellagic Acid, i-Quercetin, i-Protocatechuic Acid, i-Curcumin, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-RAS-RAF Signaling, i-PI3K-AKT-MTOR yokuSayina, i-MAPK Signaling kunye ne-MYC Signaling kunye nabanye. IWalnut emnyama icetyiswa kwi-Biliary Tract Carcinoma xa unyango lomhlaza oluqhubekayo yiRadiation. Oku kungenxa yokuba iWalnut Emnyama ilungisa ezo ndlela zebhayomichi exelwe ngokwenzululwazi ukwazisa isiphumo seRadi.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Ellagic Acid, i-Caffeine, i-Lycopene, i-Protocatechuic Acid, i-Curcumin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso kunye nokulungiswa kweDNA kunye nabanye. I-Chestnut ayikhuthazwa kwi-Biliary Tract Carcinoma xa unyango lomhlaza oluqhubekayo luyiRadiation kuba iguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IWALNUT EMNYAMA KUNCEBISWA NGAPHEZU KWE-CHESTNUT YE-Biliary Tract Carcinoma KUNYE NONYANGO LWEmitha.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuzo ye-Biliary Tract Carcinoma okanye imbali yosapho ithi "Yintoni ekufuneka Ndiyitye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable GIANT BUTTERBUR or AGAVE?

I-Butterbur enkulu yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol, i-Protocatechuic Acid. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuLungiswa kwe-DNA, i-PI3K-AKT-MTOR Ukubonakaliswa, i-Oncogenic Cancer Epigenetics kunye ne-P53 Signaling kunye nabanye. I-Giant Butterbur iyacetyiswa kumngcipheko we-Biliary Tract Carcinoma xa umngcipheko wemfuzo ohambelana ne-ASXL1. Oku kungenxa yokuba i-Giant Butterbur yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Agave yemifuno yi-Apigenin, i-Curcumin, i-Lupeol, i-Protocatechuic Acid, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye nezinye. I-Agave ayikhuthazwa xa umngcipheko we-Biliary Tract Carcinoma xa umngcipheko wezofuzo uhambelana ne-ASXL1 kuba yonyusa iindlela zokutyikitya kuyo.

IBHUTTERBURE EYISINXIBA YOMFUNO IYAKUNIKEZISWA NGAPHEZU KWE-AGAVE NGE-ASXL1 GENETIC RISK YOMHLAZA.

Khetha iFruit NANCE okanye iPUMMELO?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Protocatechuic Acid, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuLungiswa kwe-DNA, i-PI3K-AKT-MTOR Ukubonakaliswa, i-Oncogenic Cancer Epigenetics kunye ne-P53 Signaling kunye nabanye. I-Nance icetyiswa kumngcipheko we-Biliary Tract Carcinoma xa umngcipheko wemfuzo ohambelana ne-ASXL1. Oku kungenxa yokuba i-Nance yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo iPummelo yi-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol, i-Protocatechuic Acid. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye nezinye. IPummelo ayikhuthazwa xa umngcipheko we-Biliary Tract Carcinoma xa umngcipheko wezofuzo uhambelana ne-ASXL1 kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO NANCE KUCEBISWA NGAPHEZU KWE-PUMMELO NGE-ASXL1 GENETIC RISK YOMHLAZA.

Khetha i Nut COMMON HAZELNUT okanye iPILI NUT?

I-Hazelnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Lycopene, i-Lupeol, i-Protocatechuic Acid, i-Quercetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Apoptosis, i-PI3K-AKT-MTOR Ukubonisa, Ukulungiswa kwe-DNA kunye ne-P53 Umqondiso kunye nabanye. I-Hazelnut eqhelekileyo iyacetyiswa kumngcipheko we-Biliary Tract Carcinoma xa umngcipheko wemfuzo ohambelana ne-ASXL1. Oku kungenxa yokuba iHazelnut eqhelekileyo yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Pili Nut yi-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol, i-Protocatechuic Acid. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye nezinye. IPli Nut ayikhuthazwa xa umngcipheko we-Biliary Tract Carcinoma xa umngcipheko wezofuzo uhambelana ne-ASXL1 kuba yonyusa iindlela zokutyikitya kuyo.

I-HAZELNUT EQHELEKILEYO INCEBISWA NGAPHEZU KWE-PILI NUT YE-ASXL1 GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana ne-Biliary Tract Carcinoma. Izigulana ze-Biliary Tract Carcinoma kunye nabantu abanomngcipheko wemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye zingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Biliary Tract Carcinoma, nganye ine-tumor genetics eyahlukeneyo kunye nokwahluka kwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neTamato yeGadi kuqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikukhethe okanye ndingakhethi kwi-Biliary Tract Carcinoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Msk Ch 2020
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• Iziphumo zokuthintela i-butyric acid, i-nicotinamide, i-calcium glucarate yodwa okanye idibene ngexesha le-7, i-12-dimethylbenz (a) i-anthracene ibangele i-tumorigenesis yesikhumba semouse ngokumodareyitha kwe-K-Ras-PI3K-AKTpathway kunye ne-RNAs ezincinci ezinxulumene nazo.
• Ukukhula okukhuthazwayo kweeseli ze-pulmonary adenocarcinoma yabantu kunye neeseli ezincinci ze-epithelial zomoya nge-beta-carotene ngokusebenza kwe-cAMP, i-PKA, i-CREB kunye ne-ERK1/2.
• Imiphumo ye-antitumor ye-geraniol: Ukumodareyithwa kweendlela eziphawulekayo zomhlaza (Uphononongo).
• I-Paederia foetida yenza umsebenzi we-anticancer ngokumodareyitha i-chromatin modification enzymes kunye nokuguqula i-pro-inflammatory cytokine gene expression kwiiseli zomhlaza we-prostate.
• I-Lycopene ngokwahlukileyo idala i-quiescence kunye ne-apoptosis kwi-androgen-esabelayo kunye ne-independent ye-prostate cancer celllines.