Ukutya kwe-Unclassified Renal Cell Carcinoma!

intshayelelo

Ukutya kweCarcinoma yeRenal Cell engachazwanga kufuneka ilungiselelwe umntu ngamnye kwaye kufuneka ilungelelanise xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

Kwi-Unclassified Renal Cell Carcinoma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu umntu ayityayo?

Umbuzo oxhaphake kakhulu ngesondlo obubuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza - ngoomhlaza ofana ne-Unclassified Renal Cell Carcinoma ingaba ibalulekile na into yokutya endikutyayo nendingakutyiyo? Okanye ukuba ndilandela ukutya okusekwe kwisityalo oko kwanela umhlaza ofana ne-Unclassified Renal Cell Carcinoma?

Umzekelo ingaba inomsebenzi ukuba imifuno yeZucchini emthubi ityiwa kakhulu xa ithelekiswa neSipinatshi seMostade? Ngaba kuyawenza umahluko ukuba iziqhamo zeSalmonberry zikhethwa ngaphezu kweHalf-highbush Blueberry? Kwakhona ukuba ukhetho olufanayo lwenziwa kumandongomane/imbewu efana neButternut ngaphezulu kweChestnut yaseYurophu kunye neentyatyambo ezifana neCowpea phezu kweCatjang Pea. Kwaye ukuba into endiyityayo ibalulekile - umntu uchonga njani ukutya okucetyiswayo kwi-Unclassified Renal Cell Carcinoma kwaye ingaba impendulo efanayo kuye wonke umntu onokuxilongwa okufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kwi-Unclassified Renal Cell Carcinoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo I-Salmonberry iqukethe izithako ezisebenzayo i-Apigenin, iCatechol, i-Isoliquiritigenin, i-Delphinidin, i-Myricetin. Kwaye i-Half-highbush Blueberry iqulethe izithako ezisebenzayo i-Quercetin, i-Apigenin, i-Catechol, i-Isoliquiritigenin, i-Delphinidin kwaye mhlawumbi nabanye.

Impazamo eqhelekileyo eyenziwa xa kusenziwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Unclassified Renal Cell Carcinoma - kukuvavanya kuphela izithako ezisebenzayo ezikhethiweyo eziqulethwe kukutya kwaye ungayihoyi ezinye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha i-cherry izithako ezisebenzayo ekutyeni kunye nezongezelelo ukwenza isigqibo sesondlo se-Unclassified Renal Cell Carcinoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwi-Unclassified Renal Cell Carcinoma?

Isondlo esilungiselelwe wena semihlaza efana ne-Unclassified Renal Cell Carcinoma ibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwibhayoloji ye-Renal Cell Carcinoma engachazwanga, isayensi yokutya, i-genetics, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nokuba sesichengeni okunxulumene nonyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana ne-Unclassified Renal Cell Carcinoma

Zonke ii-cancer ezifana ne-Unclassified Renal Cell Carcinoma zinokubonakaliswa ngeseti ekhethekileyo yeendlela ze-biochemical - iindlela zokutyikitya ze-Unclassified Renal Cell Carcinoma. Iindlela ze-Biochemical ezifana ne-RAS-RAF Signaling, i-PI3K-AKT-MTOR Ukubonakaliswa, i-Oncogenic Histone Methylation, i-Oncogenic Cancer Epigenetics iyingxenye yenkcazo yesignesha ye-Unclassified Renal Cell Carcinoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Unclassified Renal Cell Carcinoma kufuneka luthathele ingqalelo utyikityo lweendlela zebhayokhemikhali kwisigulane ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Unclassified Renal Cell Carcinoma xa uthatha unyango lomhlaza i-Temsirolimus, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-SETD2, i-NF2, i-BAP1, i-KMT2C kunye ne-MTOR zezona ntlobo zemfuza ezixeliweyo eziphezulu ze-Unclassified Renal Cell Carcinoma. I-SETD2 ixelwe kwi-16.4% yezigulane ezimele kuzo zonke iimvavanyo zeklinikhi. Kwaye iNF2 ixelwe kwi-16.4%. Idatha ehlanganisiweyo yedatha yesigulane igubungela iminyaka yobudala ukusuka kwi-12 ukuya kuma-84. I-63.6 % yedatha yesigulane ichongwa njengamadoda. I-Unclassified Renal Cell Carcinoma biology kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezelelo ze-Unclassified Renal Cell Carcinoma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable YELLOW ZUCCHINI okanye i-MUSTARD SPINACH?

I-Vegetable Yellow Zucchini iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, iCatechol, i-Isoliquiritigenin, i-Delphinidin, i-Myricetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Hypoxia, i-Angiogenesis, i-MAPK Signaling kunye ne-MYC Signaling kunye nezinye. I-Yellow Zucchini icetyiswa kwi-Unclassified Renal Cell Carcinoma xa unyango lomhlaza oluqhubekayo yi-Temsirolimus. Oku kungenxa yokuba iZucchini etyheli iguqula ezo ndlela zebhayoloji eziye zaxelwa ngokwesayensi ukwazisa isiphumo seTemsirolimus.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Mustard Spinach yi-Apigenin, iCatechol, i-Isoliquiritigenin, i-Delphinidin, i-Myricetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-RAS-RAF Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. ISipinatshi seMustard asikhuthazwa kwi-Unclassified Renal Cell Carcinoma xa unyango lomhlaza oluqhubekayo i-Temsirolimus kuba lulungisa ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IZUCCHINI YOMFUNO OMTHUCHINI KUNCEBISWA NGAPHEZU KWESIPINCHI SEMUSTARD NGENXA YOKWENZIWA KOMNQOPHISO weRenal Cell Carcinoma KUNYE NONYANGO lweTemsirolimus.

Khetha iSiqhamo IHALF-HIGHBUSH BLUEBERRY okanye iSALMONBERRY?

Isiqhamo I-Half-highbush I-Blueberry iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Apigenin, i-Catechol, i-Isoliquiritigenin, i-Delphinidin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling, i-Hypoxia, i-Angiogenesis kunye ne-MAPK yokuSayina kunye nabanye. I-Half-highbush Blueberry iyacetyiswa kwi-Unclassified Renal Cell Carcinoma xa unyango lomhlaza oluqhubekayo yi-Temsirolimus. Oku kungenxa yokuba i-Half-highbush Blueberry ilungisa ezo ndlela zebhayomichi exelwe ngokwenzululwazi ukuze zikhuthaze isiphumo se-Temsirolimus.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwisiqhamo i-Salmonberry yi-Apigenin, iCatechol, i-Isoliquiritigenin, i-Delphinidin, i-Myricetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-RAS-RAF Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Salmonberry ayikhuthazwa kwi-Unclassified Renal Cell Carcinoma xa unyango lomhlaza oluqhubekayo i-Temsirolimus kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO IHALF-HIGHBUSH BLUEBERRY IYAKUGQINAKISWA PHEZU KWESALMONBERRY NGENXA YOLAWULO LWERenal Cell Carcinoma KUNYE NONYANGO I-Temsirolimus.

Khetha Nut BUTTERNUT okanye EUROPEAN CHESTNUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, iCatechol, i-Isoliquiritigenin, i-Delphinidin, i-Myricetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Hypoxia, i-Angiogenesis, i-MAPK Signaling kunye ne-MYC Signaling kunye nezinye. I-Butternut icetyiswa kwi-Unclassified Renal Cell Carcinoma xa unyango lomhlaza oluqhubekayo yi-Temsirolimus. Oku kungenxa yokuba iButternut ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukwazisa isiphumo seTemsirolimus.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Ellagic Acid, i-Quercetin, i-Apigenin, i-Catechol, i-Isoliquiritigenin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-RAS-RAF Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Chestnut yaseYurophu ayikhuthazwa kwi-Unclassified Renal Cell Carcinoma xa unyango lomhlaza oluqhubekayo i-Temsirolimus kuba lulungisa ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IBHUTTERNUT KUCEBISIWE NGAPHEZU KWE-EUROPEY CHESTNUT NGENXA YOLAWULO LWERenal Cell Carcinoma KUNYE NONYANGO Temsirolimus.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwa ngabantu abasengozini yemfuzo ye-Unclassified Renal Renal Carcinoma okanye imbali yentsapho ithi "Yintoni endimele ndiyitye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable GIANT BUTTERBUR or GARLAND CHRYSANTHEMUM?

I-Butterbur enkulu yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Catechol, i-Lupeol, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Hypoxia, i-P53 Signaling, i-Angiogenesis kunye ne-MYC Signaling kunye nabanye. I-Giant Butterbur icetyiswa kumngcipheko we-Unclassified Renal Cell Carcinoma xa ingozi yemfuzo eyayanyaniswa nayo yi-BAP1. Oku kungenxa yokuba i-Giant Butterbur yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yeGarland Chrysanthemum yiCurcumin, i-Apigenin, iCatechol, iLupeol, iDaidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Garland Chrysanthemum ayikhuthazwa xa umngcipheko we-Unclassified Renal Cell Carcinoma xa umngcipheko wezofuzo unxulunyaniswa ne-BAP1 kuba yonyusa iindlela zokutyikitya kuyo.

IBHUTTERBURE EYISINXIBA YOMFUNO IYACEBISWA PHEZU KWEGARLAND CHRYSANTHEMUM NGE-BAP1 YOMNGCIPHEKO WEMFUZO YOMHLAZA.

Khetha iFruit NANCE okanye iPUMMELO?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Apigenin, i-Catechol, i-Lupeol, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Hypoxia, i-P53 Signaling kunye ne-Angiogenesis kunye nabanye. I-Nance icetyiswa kumngcipheko we-Unclassified Renal Cell Carcinoma xa umngcipheko wemfuzo ohambelana ne-BAP1. Oku kungenxa yokuba i-Nance yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo iPummelo yiCurcumin, iQuercetin, i-Apigenin, iCatechol, iLupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR yokuSayina kunye neCell Cycle Checkpoints kunye nabanye. IPummelo ayikhuthazwa xa umngcipheko we-Unclassified Renal Cell Carcinoma xa umngcipheko wemfuzo unxulunyaniswa ne-BAP1 kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO NANCE KUCEBISWA NGAPHEZU KWE-PUMMELO NGE-BAP1 GENETIC RISK YOMHLAZA.

Khetha Nut COMMON HAZELNUT okanye CHESTNUT?

I-Hazelnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Quercetin, i-Catechol, i-Lupeol, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Hypoxia, i-P53 Signaling, i-Angiogenesis kunye ne-MYC Signaling kunye nabanye. IHazelnut eqhelekileyo iyacetyiswa kumngcipheko we-Unclassified Renal Cell Carcinoma xa umngcipheko wemfuzo ohambelana ne-BAP1. Oku kungenxa yokuba iHazelnut eqhelekileyo yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Curcumin, i-Apigenin, i-Ellagic Acid, i-Catechol, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR yokuSayina kunye neCell Cycle Checkpoints kunye nabanye. I-Chestnut ayikhuthazwa xa umngcipheko we-Unclassified Renal Cell Carcinoma xa umngcipheko wezofuzo uhambelana ne-BAP1 kuba yonyusa iindlela zokutyikitya.

I-HAZELNUT EQHELEKILEYO IYAKUNCEBISWA PHEZU KWE-CHESTNUT YE-BAP1 GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana ne-Unclassified Renal Cell Carcinoma. Izigulana zeRenal Cell Carcinoma ezingachazwanga kunye nabantu abasengozini yemfuzo bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Unclassified Renal Cell Carcinoma, nganye ine-tumor genetics eyahlukileyo kunye nokwahluka kwe-genomic ngakumbi kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neZucchini emthubi iqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke ingqikelelo ekuphenduleni umbuzo othi, "Yintoni ukutya endimele ndiyikhethe okanye ndingakhethi kwi-Unclassified Renal Cell Carcinoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• I-Pan Origised 2020
• Uhlalutyo lwemolekyuli ye-aggressive renal cell carcinoma ene-unclassified histology ityhila iiseti ezahlukeneyo.
• I-Chlorogenic acid inqanda ukwanda kwaye ibangela i-apoptosis kwi-A498 yeeseli zomhlaza wezintso zomntu ngendlela engasebenziyo ye-PI3K/Akt/mTOR yokubonisa indlela.
• Ukukhula okukhuthazwayo kweeseli ze-pulmonary adenocarcinoma yabantu kunye neeseli ezincinci ze-epithelial zomoya nge-beta-carotene ngokusebenza kwe-cAMP, i-PKA, i-CREB kunye ne-ERK1/2.