Ukutya koMhlaza woLwimi!

intshayelelo

Ukutya koMhlaza woLwimi kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kulungiswe xa unyango lomhlaza okanye utshintsho lwemfuza yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

KuMhlaza woLwimi ingaba imifuno, iziqhamo, amandongomane, imbewu utya ntoni?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza womhlaza ngowomhlaza onjengoMhlaza woLulwimi ingaba ibalulekile into yokuba kukutya endikutyayo okanye endingakutyiyo? Okanye ukuba ndilandela ukutya okusekelwe kwizityalo ngaba oko kwanele kumhlaza onjengoMhlaza woLwimi?

Umzekelo ingaba iyabaluleka na into yokuba imifuno ye-Giant Butterbur ityiwa kakhulu xa ithelekiswa neGarden Tomato? Ngaba kuyawenza umahluko ukuba isiqhamo i-Elderberry sikhethwa ngaphezu kweNance? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane / iimbewu ezifana neWalnut eqhelekileyo phezu kweChestnut kunye nemifuno efana ne-Black-eyed Pea phezu kwePigeon Pea. Kwaye ukuba into endiyityayo ibalulekile - umntu ukuchonga njani ukutya okucetyiswayo kuMhlaza woLwimi kwaye ingaba impendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kuMhlaza woLwimi!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Ngokomzekelo i-Elderberry iqulethe izithako ezisebenzayo i-Quercetin, i-Curcumin, i-Phloretin, i-Lupeol, i-Isoliquiritigenin. Kwaye i-Nance iqulethe izithako ezisebenzayo i-Curcumin, i-Phloretin, i-Lupeol, i-Isoliquiritigenin, i-Daidzein kwaye mhlawumbi nabanye.

Impazamo eqhelekileyo eyenziwa xa kusenziwa isigqibo nokukhetha ukutya okuza kutyiwa kuMhlaza Wolwimi - kukuvavanya kuphela izithako ezisebenzayo ezikhethiweyo eziqulethwe kukutya kwaye ungazihoyi ezinye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichaseneyo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo ukwenza isigqibo sesondlo soMhlaza woLwimi.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kuMhlaza woLwimi?

Isondlo esilungiselelwe wena somhlaza onjengoMhlaza woLwimi lubandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwibhayoloji yoMhlaza woLwimi, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nobuthathaka obunxulumeneyo apho unyango lunokuyeka ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana noMhlaza woLwimi

Yonke imihlaza efana noMhlaza woLwimi inokuphawulwa ngeseti eyodwa yeendlela zebhayoloji - iindlela zokutyikitya zoMhlaza woLwimi. Iindlela ze-Biochemical ezifana ne-Amino Acid Metabolism, i-Angiogenesis, i-PI3K-AKT-MTOR Ukubonakaliswa, ii-Cell Cycle Checkpoints ziyingxenye yenkcazo yesiginesha yeCancer yoLwimi. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kuMhlaza woLulwimi kufuneka luthathele ingqalelo utyikityo lweendlela zebhayomichi enxulumene nesigulana somhlaza ngamnye kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kuMhlaza woLwimi xa uthatha unyango lomhlaza iFluorouracil, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-TP53, i-TERT, i-CDKN2A, i-FAT1 kunye ne-NOTCH1 zezona ziphezulu kudidi lwemfuza ezixeliweyo zoMhlaza woLwimi. I-TP53 ixelwe kwi-56.8% yezigulane ezimele kuzo zonke iimvavanyo zekliniki. Kwaye i-TERT ixelwe kwi-30.5%. Idatha yesigulana esidityanisiweyo sigubungela iminyaka ukusuka ukuya . I-% yedatha yesigulane ichongwa njengamadoda. Ibhayoloji yoMhlaza woLwimi kunye nemfuzo exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zoMhlaza woLwimi

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable GIANT BUTTERBUR or GARDEN TOMATO?

I-Butterbur enkulu yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Phloretin, i-Lupeol, i-Isoliquiritigenin, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Adherens junction, i-Amino Acid Metabolism, i-P53 yokuSayina kunye ne-Focal Adhesion kunye nabanye. I-Giant Butterbur iyacetyiswa kuMhlaza woLwimi xa unyango lomhlaza oluqhubekayo yiFluorouracil. Oku kungenxa yokuba i-Giant Butterbur ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukuze zikhuthaze isiphumo seFluorouracil.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yeGarden Tomato yi-Quercetin, i-Curcumin, i-Phloretin, i-Lupeol, i-Isoliquiritigenin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-WNT Beta Catenin Signaling, i-Microtubule Dynamics kunye ne-Oxidative Stress kunye nezinye. I-Garden Tomato ayikhuthazwa ngoMhlaza woLwimi xa unyango lomhlaza oluqhubekayo luyi-Fluorouracil kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IBHUTTERBURE EYISINXIBA YOMFUNO KUNCEBISWA NGAPHEZU KWEGAMA IMATATA YOMHLAZA wolwimi KUNYE NONYANGO Fluorouracil.

Khetha iFruit NANCE okanye ELDERBERRY?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Phloretin, i-Lupeol, i-Isoliquiritigenin, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Adherens junction, Hypoxia kunye ne-P53 Signaling kunye nezinye. UNance uyacetyiswa kuMhlaza woLwimi xa unyango lomhlaza oluqhubekayo iFluorouracil. Oku kungenxa yokuba uNance ulungisa ezo ndlela zebhayoloji eziye zaxelwa ngokwesayensi ukwazisa isiphumo seFluorouracil.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo i-Elderberry yi-Quercetin, i-Curcumin, i-Phloretin, i-Lupeol, i-Isoliquiritigenin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-WNT Beta Catenin Signaling, i-Microtubule Dynamics kunye ne-Oxidative Stress kunye nezinye. I-Elderberry ayikhuthazwa ngoMhlaza woLwimi xa unyango oluqhubekayo lomhlaza luyi-Fluorouracil kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO NANCE KUCEBISWA NGAPHEZU KWE-ELDERBERRY YOMHLAZA woLwimi kunye noNyango lweFluorouracil.

Khetha i-Nutt COMMON WALNUT okanye i-CHESTNUT?

I-Walnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Ellagic Acid, i-Curcumin, i-Phloretin, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-Adherens junction, i-Focal Adhesion kunye ne-Epithelial kwi-Mesenchymal Transition kunye nezinye. IWalnut eqhelekileyo iyacetyiswa kuMhlaza woLwimi xa unyango lomhlaza oluqhubekayo iFluorouracil. Oku kungenxa yokuba i-Walnut eqhelekileyo ilungisa ezo ndlela ze-biochemical ezixelwe ngokwenzululwazi ukuze zikhuthaze isiphumo se-Fluorouracil.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Ellagic Acid, i-Curcumin, i-Phloretin, i-Lupeol, i-Isoliquiritigenin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress kunye ne-Netrin Signaling kunye nabanye. I-Chestnut ayicetyiswa kuMhlaza woLwimi xa unyango lomhlaza oluqhubekayo i-Fluorouracil kuba iguqula ezo ndlela zebhayoloji ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IWALNUT EQHELEKILEYO IYANCEBISWA NGAPHEZU KWE-CHESTNUT YOMHLAZA woLwimi KUNYE NONYANGO I-Fluorouracil.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwayo ngabantu abasengozini yemfuza yoMhlaza woLwimi okanye imbali yosapho uthi "Yintoni endifanele nditye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha imifuno ye-CAULIFLOWER okanye i-MEXICAN GROUNDCHERRY?

I-Cauliflower yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Lupeol, i-Formononetin, i-Daidzein, i-Beta-sitosterol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-MAPK Signaling kunye ne-MYC Signaling kunye nabanye. Ikholifulawa icetyiswa kumngcipheko woMhlaza woLwimi xa umngcipheko wemfuzo onxulumeneyo yi-CDKN2A. Oku kungenxa yokuba iCauliflower yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yaseMexican Groundcherry yi-Apigenin, i-Curcumin, i-Lupeol, i-Formononetin, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Stem Cell Signaling kunye ne-Oncogenic Cancer Epigenetics kunye nezinye. I-Groundcherry yaseMexico ayikhuthazwa xa umngcipheko woMhlaza woLwimi xa umngcipheko wofuzo unxulumene ne-CDKN2A kuba yonyusa iindlela zokutyikitya.

I-CAULIFLOWER YOMFUNO INCEBISWA NGAPHEZU KWE-MEXICAN GROUNDCHERRY YE-CDKN2A GENETIC RISK YOMHLAZA.

Khetha iSiqhamo SOUR CHERRY okanye iPUMMELO?

I-Fruit Sour Cherry iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Quercetin, i-Lupeol, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-Angiogenesis kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. I-Sour Cherry icetyiswa kumngcipheko woMhlaza woLwimi xa umngcipheko wemfuzo onxulumeneyo yi-CDKN2A. Oku kungenxa yokuba iCherry emuncu yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwisiqhamo iPummelo yi-Apigenin, i-Curcumin, i-Quercetin, i-Lupeol, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana neStem Cell Signaling kunye neCell Cycle Checkpoints kunye nezinye. IPummelo ayikhuthazwa xa umngcipheko weCancer yoLwimi xa umngcipheko wofuzo unxulumene neCDKN2A kuba inyusa iindlela zokutyikitya.

ISIQHAMO SOUR CHERRY KUNCEBISWA NGAPHEZU KWE-PUMMELO YE-CDKN2A GENETIC RISK YOMHLAZA.

Khetha Nut BUTTERNUT okanye EUROPEAN CHESTNUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Formononetin, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-MAPK Signaling, i-P53 Signaling kunye ne-Angiogenesis kunye nabanye. I-Butternut iyacetyiswa kumngcipheko woMhlaza woLwimi xa umngcipheko wemfuzo onxulumeneyo yi-CDKN2A. Oku kungenxa yokuba i-Butternut yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Apigenin, i-Curcumin, i-Quercetin, i-Lupeol, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Stem Cell Signaling kunye ne-Oncogenic Cancer Epigenetics kunye nezinye. I-Chestnut yaseYurophu ayikhuthazwa xa umngcipheko weCancer yoLwimi xa umngcipheko wezofuzo unxulumene ne-CDKN2A kuba inyusa iindlela zokutyikitya.

IBHUTTERNUT KUCEBISIWE NGAPHEZU KWE-EUROPA CHESTNUT YE-CDKN2A UMNGCIPHEKO wofuzo woMHLAZA.

Ukuququmbela

Ukutya kunye nezongezo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana noMhlaza woLwimi. Izigulana zoMhlaza wolwimi kunye nabantu abasengozini yemfuza bahlala benombuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezinjengoMhlaza woLwimi, nganye inemfuza eyahlukileyo yethumba kunye nokwahluka kwe-genomic ngakumbi kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neGiant Butterbur kuqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enefuthe kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo se-addon yesondlo somntu senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikukhethe okanye ndingakhethi kwiCancer yoLwimi?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Impembelelo ye-Daidzein kumhlaza we-prostate refractory kwi-vitro kunye ne-vivo xa kuthelekiswa ne-genistein kunye ne-soy extract: amandla onyango lwe-radiotherapy.
• I-aple polyphenol phloretin inqanda ukufuduka kweeseli zomhlaza webele kunye nokwanda ngokuthintelwa kweempawu ngohlobo lwe-2 ye-glucose transporter.
• Ulawulo olubi lwe-transducer yesignali kunye ne-activator ye-transcription-3 yokubonisa i-cascade yi-lupeol inqanda ukukhula kwaye yenza i-apoptosis kwiiseli ze-hepatocellular carcinoma.
• Iziphumo kunye nokubaluleka kwe-formononetin kumanqanaba okubonakaliswa kwe-HIF-1α kunye ne-VEGF kwizicubu zomhlaza womlomo wesibeleko.
• I-In vitro kunye ne-vivo antitumor umsebenzi we-neochlorogenic acid kwiiseli ze-gastric carcinoma zesisu zincediswa kunye ne-ROS isizukulwana, ukulahlekelwa kwe-membrane ye-mitochondrial kunye ne-apoptosis induction.
• I-Brassinin inqanda indlela yokubonisa i-STAT3 ngokumodareyithwa kwe-PIAS-3 kunye ne-SOCS-3 intetho kwaye inike amandla i-xenograft yomhlaza wemiphunga yabantu kwiimpuku ezinqunu ukuya kwi-paclitaxel.