Ukutya koMhlaza weNdlala!

intshayelelo

Ukutya koMhlaza weNdlala kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kuhlengahlengiswe xa unyango lomhlaza okanye utshintsho lwemfuza yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

NgoMhlaza we-Thyroid ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza we-Cancer of Thyroid Cancer ingaba ibalulekile into yokuba kukutya endikutyayo okanye endingakutyiyo? Okanye ukuba ndilandela ukutya okusekelwe kwizityalo ngaba oko kwanele kumhlaza onjengeCancer ye-Thyroid?

Umzekelo ingaba inomsebenzi ukuba iCauliflower yemifuno ityiwa kakhulu xa ithelekiswa neKale? Ngaba kuyawenza umahluko ukuba isiqhamo se-Sea-buckthornberry siyakhethwa kune-Black Mulberry? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane/iimbewu ezifana neButternut phezu kweFlaxseed kunye nezityalo ezifana neCowpea phezu kwembotyi eluhlaza. Kwaye ukuba into endiyityayo ibalulekile - umntu uchonga njani ukutya okucetyiswayo kwi-Cancer ye-Thyroid kwaye ingaba yimpendulo efanayo kuye wonke umntu onokuxilongwa okufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kuMhlaza weNdlala!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo i-Sea-buckthornberry iqulethe izithako ezisebenzayo iLycopene, iCatechol, iCaffeine, iLupeol, iCinnamaldehyde. Kwaye iBlack Mulberry iqulethe izithako ezisebenzayo iQuercetin, iCatechol, iMorusin, iLupeol, iCinnamaldehyde kunye nabanye.

Impazamo eqhelekileyo eyenziwa xa kusenziwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Cancer ye-Thyroid - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungayihoyi enye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo soMhlaza weNdlala.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kuMhlaza weNdlala?

Izondlo zomntu zomntu zomhlaza ezifana noMhlaza weThyroid ziquka ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchule kwi-Thyroid Cancer biology, isayensi yokutya, i-genetics, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nobuthathaka obunxulumeneyo apho unyango lunokuyeka ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana ne-Thyroid Cancer

Yonke imihlaza efana noMhlaza we-Thyroid inokubonakaliswa ngeseti eyodwa yeendlela ze-biochemical - iindlela zokutyikitya zoMhlaza weNdlala. Iindlela ze-Biochemical ezifana ne-RAS-RAF Signaling, i-Inositol Phosphate Signaling, i-MAPK Signaling, i-PI3K-AKT-MTOR Ukubonakaliswa yinxalenye yenkcazo yesignesha ye-Thyroid Cancer. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kuMhlaza weNdlala kufuneka luthathele ingqalelo utyikityo lweendlela zebhayomichi enxulumene nesigulana ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Cancer ye-thyroid xa uthatha unyango lomhlaza i-Dabrafenib, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-BRAF, i-TERT, i-NRAS, i-EIF1AX kunye ne-ATM zezona zakhi zemfuza ezikwinqanaba eliphezulu ezixeliweyo zoMhlaza weNdlala. I-BRAF ixelwe kwi-15.8 % yezigulane ezimele kuwo onke amalingo onyango. Kwaye i-TERT ixelwe kwi-15.2%. Idatha ehlanganisiweyo yedatha yesigulane igubungela iminyaka yobudala ukusuka kuma-22 ukuya kuma-87. Ama-51.5 % edatha yezigulane ichongwe njengamadoda. Ibhayoloji yoMhlaza we-Thyroid kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela ze-biochemical kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zoMhlaza weNdlala

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable CAULIFLOWER okanye i-KALE?

ICauliflower yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana neCatechol, iLupeol, iCinnamaldehyde, iCurcumin, iFormononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuSayina kwe-MAPK, ukusinda kweSeli, i-Angiogenesis kunye neeJunctions zeSeli kunye nezinye. ICauliflower iyacetyiswa kuMhlaza Wedlala Ledlala xa unyango lomhlaza oluqhubekayo yiDabrafenib. Oku kungenxa yokuba iCauliflower iguqula ezo ndlela zebhayomikhali ezixelwe ngokwenzululwazi ukuze zikhuthaze isiphumo seDabrafenib.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno Kale yiCatechol, Lupeol, Cinnamaldehyde, Curcumin, Protocatechuic Acid. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye noxinzelelo lwe-Oxidative kunye nezinye. I-Kale ayinconywa kuMhlaza we-thyroid xa unyango lomhlaza oluqhubekayo yi-Dabrafenib kuba luguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli ngokukhawuleza.

I-CAULIFLOWER YOMFUNO INCEBISWA NGAPHEZU KWE-KALE YOMHLAZA WE-Thyroid KUNYE NONYANGO I-Dabrafenib.

Khetha iSiqhamo EMNYAMA YEMULBERRY okanye USEA-BUCKTHORNBERRY?

Iziqhamo zeMulberry eziMnyama ziqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana neQuercetin, iCatechol, iMorusin, iLupeol, iCinnamaldehyde. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-Angiogenesis kunye nokusinda kweeseli kunye nezinye. I-Black Mulberry icetyiswa kuMhlaza weNdlala xa unyango lomhlaza oluqhubekayo yi-Dabrafenib. Oku kungenxa yokuba Iqunube eliMnyama lilungisa iindlela zebhayoloji ezixelwe ngokwenzululwazi ukuze zikhuthaze isiphumo seDabrafenib.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwisiqhamo se-Sea-buckthornberry yiLycopene, iCatechol, iCaffeine, iLupeol, iCinnamaldehyde. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye noxinzelelo lwe-Oxidative kunye nezinye. I-Sea-buckthornberry ayikhuthazwa kwiCancer ye-Thyroid xa unyango lomhlaza oluqhubekayo yi-Dabrafenib kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO OMNYAMA EMNYAMA KUNCEBISWA NGAPHEZU KWE-SEA-BUCKTHORNBERRY KUMhlaza weNyolo kunye noNyango lweDabrafenib.

Khetha i-Nutt BUTTERNUT okanye i-FLEXSEED?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana neLycopene, iCatechol, iCaffeine, iLupeol, iCinnamaldehyde. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-Growth Factor Signaling, i-Inositol Phosphate Signaling kunye ne-TGFB Signaling kunye nabanye. I-Butternut iyacetyiswa kuMhlaza Wedlala Ledlala xa unyango lomhlaza oluqhubekayo yi-Dabrafenib. Oku kungenxa yokuba i-Butternut ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukwazisa isiphumo se-Dabrafenib.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiFlaxseed yiCatechol, iLupeol, iCinnamaldehyde, iCurcumin, iProtocatechuic Acid. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cytoskeletal Dynamics, i-Cell Junctions kunye ne-Oxidative Stress kunye nabanye. I-Flaxseed ayikhuthazwa ngoMhlaza we-thyroid xa unyango lomhlaza oluqhubekayo yi-Dabrafenib kuba luguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IBHUTTERNUT IYAYINGCEBISWA NGAPHEZU KWEFLAXSEED KUMhlaza weNyolo kunye noNyango lweDabrafenib.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwayo ngabantu abasengozini yemfuza yoMhlaza we-Thyroid okanye imbali yentsapho ithi "Yintoni endifanele Ndiyitye Ngokwahlukileyo Ngaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable GIANT BUTTERBUR or NAPA CABAGE?

I-Butterbur enkulu yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Myricetin, i-Lycopene, i-Protocatechuic Acid. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-Hypoxia, i-P53 Signaling kunye ne-MYC Signaling kunye nabanye. I-Giant Butterbur iyacetyiswa kumngcipheko woMhlaza weNdlala xa umngcipheko wemfuzo ohambelana ne-ATM. Oku kungenxa yokuba i-Giant Butterbur yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Napa Iklabishi yi-Curcumin, i-Protocatechuic Acid, i-Lupeol, i-Isoliquiritigenin, i-Daidzein. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-PI3K-AKT-MTOR Umqondiso kunye ne-MYC Signaling kunye nabanye. Ikhaphetshu ye-Napa ayikhuthazwa xa umngcipheko we-Thyroid Cancer xa umngcipheko wezofuzo uhambelana ne-ATM kuba inyusa iindlela zokutyikitya.

IBHUTTERBURE EYISINXIBA YOMFUNO IYAKUNQITSHISWA PHEZU KWE-NAPA ikhaphetshu nge-ATM YOMNGCIPHEKO WOMHLAZA.

Khetha iSiqhamo ILAMONI okanye iPUMMELO?

I-Fruit Lemon iqukethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-D-limonene, i-Curcumin, i-Linalool, i-Isorhamnetin, i-Protocatechuic Acid. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Apoptosis, i-P53 Signaling, i-MAPK yokuSayina kunye ne-Cell Cycle Checkpoints kunye nezinye. Ilamuni iyacetyiswa kumngcipheko woMhlaza weNdlala xa umngcipheko wemfuzo ohambelana neATM. Oku kungenxa yokuba iLamuni yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwisiqhamo iPummelo yi-Apigenin, i-Curcumin, i-Quercetin, i-Lycopene, i-Protocatechuic Acid. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-PI3K-AKT-MTOR Umqondiso kunye ne-MYC Signaling kunye nabanye. IPummelo ayikhuthazwa xa umngcipheko we-Thyroid Cancer xa umngcipheko wezofuzo unxulumene ne-ATM kuba yonyusa iindlela zokutyikitya kuyo.

I-LEMON YESIQHAMO KUNCEBISWA PHEZU KWE-PUMMELO NGE-ATM YOMNGCIPHEKO WOMFUZO WOMHLAZA.

Khetha Nut EMNYAMA WALNUT okanye EUROPEAN CHESTNUT?

I-Walnut emnyama iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Ellagic Acid, i-Curcumin, i-Myricetin, i-Quercetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Apoptosis, i-P53 Signaling, i-MAPK yokuSayina kunye ne-Cell Cycle Checkpoints kunye nezinye. IWalnut emnyama icetyiswa kumngcipheko woMhlaza weNdlala xa umngcipheko wemfuzo ohambelana ne-ATM. Oku kungenxa yokuba iWalnut emnyama yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Apigenin, i-Ellagic Acid, i-Curcumin, i-Myricetin, i-Quercetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-PI3K-AKT-MTOR Umqondiso kunye ne-MYC Signaling kunye nabanye. I-Chestnut yaseYurophu ayikhuthazwa xa umngcipheko we-Thyroid Cancer xa umngcipheko wezofuzo unxulumene ne-ATM kuba inyusa iindlela zokutyikitya kuyo.

IWALNUT EMNYAMA KUNCEBISWA KWI-CHESTNUT YAseYurophu NGE-ATM YOMNGCIPHEKO woMHLAZA.

Ukuququmbela

Ukutya kunye nezongezo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana noMhlaza weNdlala. Izigulana zoMhlaza we-thyroid kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezinje ngoMhlaza weNdlala, nganye ineemfuza ezahlukeneyo zethumba ezinolunye utshintsho lwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neCauliflower kuqulethe izinto ezahlukeneyo zebhayoloji kwimithamo eyahlukeneyo, enefuthe kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke ingqikelelo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikukhethe okanye ndingakhethi kwi-Cancer ye-Thyroid?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Msk Impact 2017
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• I-Morsin ibangela ukufa kweeseli ngokungasebenzisi umqondiso we-STAT3 kwiiseli zomhlaza wedlala lobudoda.
• Ukuthathwa kwe-mulberry 1-deoxynojirimycin kuthintela umhlaza we-colorectal kwiimpuku.
• I-Brassinin icinezela amandla okuHlabaza okuHlangeneyo kweeSeli ze-Lung Carcinoma ngoKucinywa kwe-PI3K/Akt/mTOR I-Signaling Cascade.
• Iingcamango ezintsha kwi-phospholipase D ebonisa ukuvuvukala kunye nomhlaza.
• I-Paederia foetida yenza umsebenzi we-anticancer ngokumodareyitha i-chromatin modification enzymes kunye nokuguqula i-pro-inflammatory cytokine gene expression kwiiseli zomhlaza we-prostate.
• I-D-Limonene imodareyitha ukuvuvukala, uxinzelelo lwe-oxidative kunye ne-Ras-ERK indlela yokuvimbela i-tumorigenesis yesikhumba se-murine.
• [Ukwenzeka kwee-immune complexes ezijikelezayo kwi-serum yegazi yezigulane ezinomhlaza womlomo wesibeleko ngaphambi kokuba unyango].
• I-Geraniol, icandelo lee-oyile ezibalulekileyo zesityalo, ikhuthaza iiseli zomhlaza wekholoni yomntu kwi-5-Fluorouracil unyango.