Ukutya kwiPrimary Myelofibrosis!

intshayelelo

Ukutya kwePrayimari yeMyelofibrosis kufuneka ilungiselelwe umntu ngamnye kwaye kufuneka ilungelelanise xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

KwiPrimary Myelofibrosis ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu umntu ayityayo?

Umbuzo oxhaphake kakhulu ngesondlo obubuzwa zizigulane ezinomhlaza kunye nabantu abakumngcipheko wemfuzo womhlaza ngowokuba - kwimihlaza efana nePrimary Myelofibrosis ingaba ibalulekile into yokutya endikutyayo kwaye ndingakutyiyo? Okanye ukuba ndilandela ukutya okusekwe kwizityalo ngaba oko kwanela umhlaza onje ngePrimary Myelofibrosis?

Umzekelo ingaba inomsebenzi ukuba imifuno iCluster Bean ityiwa kakhulu xa ithelekiswa neCucurbita? Ngaba kuyawenza umahluko ukuba isiqhamo iBlack Elderberry siyakhethwa kuneBlack Mulberry? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane / iimbewu ezifana neWalnut emnyama ngaphezu kweChestnut yaseYurophu kunye neepulses ezifana neAlfalfa phezu kweCatjang Pea. Kwaye ukuba into endiyidlayo ibalulekile - ngoko umntu uchonga njani ukutya okucetyiswayo kwi-Primary Myelofibrosis kwaye ingaba impendulo efanayo kuye wonke umntu onokuxilongwa okufanayo okanye umngcipheko wemfuza?

Ewe! Ukutya okutyayo kubalulekile kwi-Primary Myelofibrosis!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Ngokomzekelo i-Black Elderberry iqulethe izithako ezisebenzayo i-Linalool, i-Formononetin, i-Quercetin, i-Lycopene, i-Apigenin. Kwaye i-Black Mulberry iqulethe izithako ezisebenzayo i-Formononetin, i-Quercetin, i-Apigenin, i-Protocatechuic Acid, i-Phloretin kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa kuthathwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Primary Myelofibrosis - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungayihoyi ezinye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha i-cherry izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo kwi-Primary Myelofibrosis.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwiPrimary Myelofibrosis?

Isondlo esilungiselelwe wena somhlaza njengePrayimari Myelofibrosis siquka ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwibhayoloji yasePrayimari yeMyelofibrosis, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nokuba sesichengeni okunxulumene nonyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana nePrimary Myelofibrosis

Yonke i-cancer efana ne-Primary Myelofibrosis inokubonakaliswa ngoluhlu olulodwa lweendlela ze-biochemical - iindlela zokutyikitya ze-Primary Myelofibrosis. Iindlela ze-Biochemical ezifana ne-RAS-RAF Signaling, i-Cytokine Signaling, i-Oncogenic Cancer Epigenetics, i-JAK-STAT Ukubonakaliswa yinxalenye yenkcazo yesignesha ye-Primary Myelofibrosis. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwiPrayimari yeMyelofibrosis kufuneka luthathele ingqalelo utyikityo lweendlela zebhayokhemikhali kwisigulana ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwi-Primary Myelofibrosis xa uthatha unyango lomhlaza i-Ruxolitinib, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-JAK2, i-ASXL1, i-TET2, i-DNMT3A kunye ne-CALR zizona ntlobo zofuzo ezixeliweyo eziphezulu kwi-Primary Myelofibrosis. I-JAK2 ixelwe kwi-58.3% yezigulane ezimele kuzo zonke izilingo zonyango. Kwaye i-ASXL1 ixelwe kwi-31.7%. Idatha yesigulana esidityanisiweyo sigubungela iminyaka ukusuka ukuya . I-0.0% yedatha yesigulane ichongwa njengamadoda. Ibhayoloji yasePrayimari yeMyelofibrosis kunye nemfuzo exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zePrimary Myelofibrosis

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable CLUSTER BEAN okanye iCUCURBITA?

I-Vegetable Cluster Bean iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Stigmasterol, i-Vitamin C, i-Beta-sitosterol, i-Linolenic Acid, i-Oleic Acid. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-Hypoxia, i-RAS-RAF yokuSayina kunye ne-MAPK yokuSayina kunye nabanye. I-Cluster Bean icetyiswa kwi-Primary Myelofibrosis xa unyango lomhlaza oluqhubekayo yi-Ruxolitinib. Oku kungenxa yokuba i-Cluster Bean ilungisa ezo ndlela zebhayomikhemikhali ezixelwe ngokwenzululwazi ukwazisa isiphumo se-Ruxolitinib.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno Cucurbita yiFormononetin, iProtocatechuic Acid, iPhloretin, iCurcumin, iBergapten. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso kunye ne-MYC Signaling kunye nabanye. I-Cucurbita ayikhuthazwa kwi-Primary Myelofibrosis xa unyango lomhlaza oluqhubekayo yi-Ruxolitinib kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IMBOTYI YEEMBOTYI YEMIFUNO ICEBISIWE PHEZU KWE-CUCURBITA YEPrayimari Myelofibrosis KUNYE NONYANGO iRuxolitinib.

Khetha iSiqhamo EMNYAMA IMULBERRY okanye EMNYAMA ELDERBERRY?

Isiqhamo se-Mulberry emnyama siqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Formononetin, i-Quercetin, i-Apigenin, i-Protocatechuic Acid, i-Phloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling, Hypoxia, MAPK Signaling kunye ne-MYC Signaling kunye nabanye. IBlack Mulberry icetyiswa kwiPrimary Myelofibrosis xa unyango lomhlaza oluqhubekayo yiRuxolitinib. Oku kungenxa yokuba i-Black Mulberry iguqula ezo ndlela ze-biochemical ezixelwe ngokwesayensi ukuze zikhuthaze isiphumo se-Ruxolitinib.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwiziqhamo ze-Black Elderberry yi-Linalool, i-Formononetin, i-Quercetin, i-Lycopene, i-Apigenin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling kunye ne-Oncogenic Cancer Epigenetics kunye nabanye. I-Black Elderberry ayikhuthazwa kwi-Primary Myelofibrosis xa unyango lomhlaza oluqhubekayo yi-Ruxolitinib kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO OMNYAMA EMNYAMA KUNCEBISWA NGAPHEZU KWE-BLACK ELDERBERRY FOR Primary Myelofibrosis KUNYE NONYANGO iRuxolitinib.

Khetha Nut EMNYAMA WALNUT okanye EUROPEAN CHESTNUT?

I-Walnut emnyama iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Formononetin, i-Quercetin, i-Apigenin, i-Protocatechuic Acid, i-Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-RAS-RAF Signaling, i-PI3K-AKT-MTOR Umqondiso kunye ne-MYC Signaling kunye nabanye. IWalnut emnyama icetyiswa kwi-Primary Myelofibrosis xa unyango lomhlaza oluqhubekayo yi-Ruxolitinib. Oku kungenxa yokuba iWalnut Emnyama ilungisa ezo ndlela zebhayomichi exelwe ngokwenzululwazi ukuze zikhuthaze isiphumo se-Ruxolitinib.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Formononetin, i-Quercetin, i-Apigenin, i-Protocatechuic Acid, i-Phloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa kunye ne-Oncogenic Cancer Epigenetics kunye nabanye. I-Chestnut yaseYurophu ayikhuthazwa kwi-Myelofibrosis yasePrayimari xa unyango lomhlaza oluqhubekayo yi-Ruxolitinib kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IWALNUT EMNYAMA KUNCEBISWA NGE-CHESTNUT YAseYurophu kwi-Myelofibrosis yasePrayimari KUNYE NONYANGO i-Ruxolitinib.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwa ngabantu abasengozini yemfuza yePrayimari yeMyelofibrosis okanye imbali yentsapho ithi "Yintoni endimele ndiyitye ngokwahlukileyo ngaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable GREEN BELL PEPPER okanye iBEET EQHELEKILEYO?

Imifuno eluhlaza yeBell Pepper iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Resveratrol, i-Bergapten, i-Formononetin, i-Luteolin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Suppressive Histone Methylation, i-Cytokine Signaling, i-Oncogenic Cancer Epigenetics kunye ne-Hematopoiesis kunye nabanye. I-Green Bell Pepper icetyiswa kumngcipheko we-Primary Myelofibrosis xa ingozi yemfuza ehambelana nayo yi-ASXL1. Oku kungenxa yokuba iGreen Bell Pepper yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yeBeet eqhelekileyo yiBergapten, Formononetin, Stigmasterol, Phloretin, Myricetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cytokine Signaling kunye ne-Oncogenic Cancer Epigenetics kunye nabanye. I-Beet eqhelekileyo ayikhuthazwa xa umngcipheko we-Myelofibrosis ePhambili xa umngcipheko wezofuzo uhambelana ne-ASXL1 kuba inyusa iindlela zokutyikitya kuyo.

I-PEPPER YEBHELL YOMFUNO ELUHLAZA IYAKUGQIBISWA NGAPHEZU KWE-BEET EQHELEKILEYO KWI-ASXL1 GENETIC RISK YOMHLAZA.

Khetha iFIKA leSiqhamo okanye iPUMMELO?

Isiqhamo soMzobo siqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Bergapten, i-Formononetin, i-Phloretin, i-Stigmasterol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling, i-Suppressive Histone Methylation, i-AGE-RAGE Signaling kunye ne-Cytokine Signaling kunye nabanye. Umzobo ucetyiswa kumngcipheko we-Primary Myelofibrosis xa umngcipheko wemfuzo ohambelana ne-ASXL1. Oku kungenxa yokuba iFig inyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwiziqhamo iPummelo yiQuercetin, iBergapten, iFormononetin, iNaringin, iPhloretin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Post Translation Modification kunye ne-Cytokine Signaling kunye nezinye. IPummelo ayikhuthazwa xa umngcipheko weMyelofibrosis ePhambili xa umngcipheko wemfuza uhambelana ne-ASXL1 kuba inyusa iindlela zokutyikitya kuyo.

ISIQHAMO ESIQHELO IYACEBISWA PHEZU KWE-PUMMELO NGE-ASXL1 GENETIC RISK YOMHLAZA.

Khetha Nut IMBEWU YAMATHANGA okanye i-almond?

Imbewu yethanga iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana neCucurbitacin I, i-Stigmasterol, i-Linolenic Acid, i-Salicylic Acid, i-Beta-sitosterol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling, i-AGE-RAGE Signaling, i-Cytokine Signaling kunye ne-Hematopoiesis kunye nabanye. Imbewu yethanga icetyiswa kumngcipheko we-Primary Myelofibrosis xa umngcipheko wemfuzo ohambelana ne-ASXL1. Oku kungenxa yokuba Imbewu yethanga yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Almond yiBergapten, Formononetin, Phloretin, Stigmasterol, Isorhamnetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cytokine Signaling kunye ne-IL27 Signaling kunye nabanye. I-almond ayikhuthazwa xa umngcipheko we-Primary Myelofibrosis xa umngcipheko wezofuzo uhambelana ne-ASXL1 kuba yonyusa iindlela zokutyikitya kuyo.

IMBEWU YAMATHANGA KUNCEBISWA NGAPHEZU KWE-ALMOND NGE-ASXL1 GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana nePrimary Myelofibrosis. Izigulana eziphambili ze-Myelofibrosis kunye nabantu abanomngcipheko wemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye zingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana nePrayimari yeMyelofibrosis, nganye ineemfuza ezahlukeneyo zethumba elinolwahlulo olongezelelekileyo lwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana ne-Cluster Bean kuqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikhethe okanye ndingakhethi kwi-Primary Myelofibrosis?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Aml Ohsu 2018
• Iziphumo zokuthintela i-butyric acid, i-nicotinamide, i-calcium glucarate yodwa okanye idibene ngexesha le-7, i-12-dimethylbenz (a) i-anthracene ibangele i-tumorigenesis yesikhumba semouse ngokumodareyitha kwe-K-Ras-PI3K-AKTpathway kunye ne-RNAs ezincinci ezinxulumene nazo.
• Inkqubela phambili yophando kwiziphumo ze-anticancer ye-vitamin K2.
• I-Formononetin-induced oxidative stress isusa ukusebenza kwe-STAT3/5 yokubonisa i-axis kwaye icinezela ukukhula kwethumba kwimodeli ye-myeloma preclinical emininzi.
• I-Stigmasterol ibonisa iziphumo ezinamandla zokulwa ne-antitumor kwiiseli zomhlaza wesisu somntu olamlwa ngokuthintela ukufuduka kweeseli, ukubanjwa komjikelo weeseli, i-mitochondrial mediated apoptosis kunye nokuvinjwa kwendlela yokubonisa i-JAK/STAT.
• I-Isorhamnetin icinezela umhlaza wolusu ngokunqanda ngokuthe ngqo kwe-MEK1 kunye ne-PI3-K.