Ukutya kwePolycythemia Vera!

intshayelelo

Ukutya kwePolycythemia Vera kufuneka ilungiselelwe umntu ngamnye kwaye kufuneka ilungelelanise xa unyango lomhlaza okanye utshintsho lwemfuza yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

I-Polycythemia vera yinto enqabileyo, engapheliyo, ingxaki yeeseli zegazi, ehlelwa njenge-myeloproliferative neoplasm okanye i-MPN. I-Polycythemia vera ibangelwa kukuveliswa okugqithisileyo kweeseli ezibomvu zegazi (RBCs) kumongo wethambo, kunye nokuveliswa ngokugqithiseleyo kweeseli ezimhlophe zegazi kunye neeplatelet nazo. Ichaphazela kancinane amadoda kunamabhinqa kwaye iyenzeka rhoqo kubantu abangaphezulu kweminyaka engama-60 ubudala. Abantu abane-polycythemia vera banenani eliphezulu ngokungaqhelekanga le-RBCs ejikelezayo egazini labo, ebangela ukuba igazi lijiye kwaye lonyuke nomthamo (imeko ebizwa ngokuba yi-hyperviscosity). Igazi elijiyileyo alinakuhamba kakuhle kwimithambo yegazi emincinci (iicapillaries). Uluhlu lweempawu lunokuthi lwenzeke kubantu abane-polycythemia vera kuquka iimpawu ezingabonakaliyo ezifana nentloko ebuhlungu, ukudinwa, ubuthathaka, isiyezi, ulusu olurhawuzelayo; i-spleen eyandisiweyo (splenomegaly); iingxaki ezahlukeneyo zesisu; kunye nomngcipheko omkhulu wokwakhiwa kwehlwili legazi, elinokuthi lithintele ukuhamba kwegazi kumalungu abalulekileyo. Ngaphezulu kwe-90% yabantu abane-polycythemia vera banotshintsho kwi-JAK2 gene. Unyango lwe-polycythemia vera lujolise ekunciphiseni amanqanaba eeseli ezibomvu zegazi kunye nokuthintela iingxaki ngokukodwa kwi-blood clot formation (thrombosis). Iinketho zonyango ziquka i-phlebotomy (ukutsalwa kwegazi ngamaxesha aqhelekileyo) ukunciphisa umthamo we-RBCs ejikelezayo ukuze igazi lihambe kakuhle. Izigulane nazo ziphathwa ngamachiza e-myelosuppressive afana ne-hydroxyurea kunye ne-busulfan, ecinezela ukubunjwa kweeseli zegazi kumongo wethambo. Kukho unyango olongezelelweyo olufana ne-aspirin yedosi ephantsi kunye neyeza elisanda kuvunywa elijoliswe kwi-enzyme ye-JAK2 efunyenwe isebenza. Ukongeza, ukhathalelo oluxhasayo kunye nesondlo esifanelekileyo (ukutya kunye nezongezelelo zendalo) ezine-bioactives engokwemvelo ukulungelelanisa isifo esibangela iindlela kunokunceda ukuphucula impilo yesigulane.

KwiPolycythemia Vera ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa ngabaguli abanomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza onje ngePolycythemia Vera ingaba ayinamsebenzi ukuba kukutya ntoni na endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekwe kwisityalo ngaba kwanele umhlaza onje ngePolycythemia Vera?

Umzekelo ingaba inomsebenzi ukuba iParsnip yemifuno ityiwa kakhulu xa ithelekiswa neBeet eqhelekileyo? Ngaba kuyawenza umahluko ukuba isiqhamo iBlack Elderberry siyakhethwa kuneBlack Mulberry? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane/iimbewu ezifana neWalnut emnyama ngaphezu kweChestnut yaseYurophu kunye nezityalo ezifana neAlfalfa phezu kweBean eYellow Wax. Kwaye ukuba into endiyityayo ibalulekile - umntu uchonga njani ukutya okucetyiswayo kwiPolycythemia Vera kwaye ingaba impendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuza?

Ewe! Ukutya okutyayo kubalulekile kwiPolycythemia Vera!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Ngokomzekelo i-Black Elderberry iqulethe izithako ezisebenzayo i-Formononetin, i-Phloretin, i-Apigenin, i-Quercetin, i-Stigmasterol. Kwaye i-Black Mulberry iqulethe izithako ezisebenzayo i-Formononetin, i-Phloretin, i-Apigenin, i-Quercetin, i-Stigmasterol kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa kuthathwa isigqibo kunye nokukhetha ukutya okutyayo kwiPolycythemia Vera - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungayihoyi ezinye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha i-cherry izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo sePolycythemia Vera.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwiPolycythemia Vera?

Isondlo somntu somhlaza njengePolycythemia Vera siquka ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Polycythemia Vera biology, isayensi yokutya, i-genetics, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nobuthathaka obunxulumeneyo apho unyango lunokuyeka ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana nePolycythemia Vera

Zonke ii-cancer ezifana ne-Polycythemia Vera zinokubonakaliswa ngoluhlu olulodwa lweendlela ze-biochemical - iindlela zokutyikitya zePolycythemia Vera. Iindlela ze-Biochemical ezifana ne-RAS-RAF Signaling, i-Cytokine Signaling, i-JAK-STAT Ukubonakaliswa, i-Hematopoiesis yinxalenye yenkcazo yesignesha ye-Polycythemia Vera. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Polycythemia Vera kufuneka luthathele ingqalelo utyikityo olunxulumene neendlela zebhayokhemikhali kwisigulana ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto ezinye ukutya kunye nezongezo zicetyiswayo kwiPolycythemia Vera xa uthatha unyango lomhlaza iRuxolitinib, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-JAK2, i-TET2, i-DNMT3A, i-SH2B3 kunye ne-ARID2 zezona zakhi zemfuza ezixeliweyo eziphezulu ze-Polycythemia Vera. I-JAK2 ixelwe kwi-76.5% yezigulane ezimele kuzo zonke izilingo zonyango. Kwaye i-TET2 ichazwe kwi-21.6%. Idatha yesigulana esidityanisiweyo sigubungela iminyaka ukusuka ukuya . I-0.0% yedatha yesigulane ichongwa njengamadoda. I-Polycythemia Vera biology kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenza isondlo somntu.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zePolycythemia Vera

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable PARSNIP okanye iBEET EQHELEKILEYO?

I-Vegetable Parsnip iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Formononetin, i-Phloretin, i-Quercetin, i-Stigmasterol, i-Curcumin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling, i-MAPK Signaling, i-Cytokine Signaling kunye ne-MYC Signaling kunye nabanye. I-Parsnip icetyiswa kwi-Polycythemia Vera xa unyango lomhlaza oluqhubekayo yi-Ruxolitinib. Oku kungenxa yokuba i-Parsnip ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukuze zikhuthaze isiphumo se-Ruxolitinib.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Beet eqhelekileyo yi-Formononetin, i-Phloretin, i-Apigenin, i-Stigmasterol, i-Curcumin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye ne-Oncogenic Cancer Epigenetics kunye nabanye. I-Beet eqhelekileyo ayikhuthazwa kwi-Polycythemia Vera xa unyango lomhlaza oluqhubekayo yi-Ruxolitinib kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

I-PARSNIP YOMFUNO KUCEBISWA NGE-BEET EQHELEKILEYO KWI-Polycythemia Vera KUNYE NONYANGO i-Ruxolitinib.

Khetha iSiqhamo EMNYAMA IMULBERRY okanye EMNYAMA ELDERBERRY?

Iziqhamo ze-Mulberry eziMnyama ziqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Formononetin, i-Phloretin, i-Apigenin, i-Quercetin, i-Stigmasterol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling, Hypoxia, MAPK Signaling kunye ne-MYC Signaling kunye nabanye. I-Black Mulberry iyacetyiswa kwi-Polycythemia Vera xa unyango lomhlaza oluqhubekayo yi-Ruxolitinib. Oku kungenxa yokuba i-Black Mulberry iguqula ezo ndlela ze-biochemical ezixelwe ngokwesayensi ukuze zikhuthaze isiphumo se-Ruxolitinib.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwiziqhamo ze-Black Elderberry yi-Formononetin, i-Phloretin, i-Apigenin, i-Quercetin, i-Stigmasterol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye ne-Oncogenic Cancer Epigenetics kunye nabanye. I-Black Elderberry ayikhuthazwa ukuba i-Polycythemia Vera xa unyango lomhlaza oluqhubekayo yi-Ruxolitinib kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO EMNYAMA EMNYAMA KUNCEBISWA PHEZULU EMNYAMA ELDERBERRY FOR Polycythemia Vera KUNYE NONYANGO Ruxolitinib.

Khetha Nut EMNYAMA WALNUT okanye EUROPEAN CHESTNUT?

I-Walnut emnyama iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Formononetin, i-Phloretin, i-Apigenin, i-Quercetin, i-Curcumin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-RAS-RAF Signaling, MAPK Signaling kunye ne-MYC Signaling kunye nabanye. IWalnut emnyama icetyiswa kwiPolycythemia Vera xa unyango lomhlaza oluqhubekayo yiRuxolitinib. Oku kungenxa yokuba iWalnut Emnyama ilungisa ezo ndlela zebhayomichi exelwe ngokwenzululwazi ukuze zikhuthaze isiphumo se-Ruxolitinib.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Formononetin, i-Phloretin, i-Apigenin, i-Quercetin, i-Stigmasterol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye ne-Oncogenic Cancer Epigenetics kunye nabanye. I-Chestnut yaseYurophu ayicetyiswa ukuba i-Polycythemia Vera xa unyango lomhlaza oluqhubekayo yi-Ruxolitinib kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IWALNUT EMNYAMA KUCEBISWA KWI-CHESTNUT YAseYurophu yePolycythemia Vera KUNYE NONYANGO iRuxolitinib.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwa ngabantu abasengozini yemfuza yePolycythemia Vera okanye imbali yosapho uthi "Yintoni endifanele nditye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable CAULIFLOWER okanye iKOHLRABI?

I-Cauliflower yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Formononetin, i-Bergapten, i-Isoliquiritigenin, i-Catechol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Chemokine Signaling, i-RAS-RAF Signaling, i-PI3K-AKT-MTOR yokuSayina kunye ne-MYC Signaling kunye nabanye. ICauliflower iyacetyiswa kumngcipheko wePolycythemia Vera xa umngcipheko wemfuzo onxulumeneyo yiARID2. Oku kungenxa yokuba iCauliflower yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Kohlrabi yi-Quercetin, i-Curcumin, i-Formononetin, i-Bergapten, i-Isoliquiritigenin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa kunye ne-Hematopoiesis kunye nabanye. I-Kohlrabi ayikhuthazwa xa umngcipheko we-Polycythemia Vera xa umngcipheko wezofuzo uhambelana ne-ARID2 kuba yonyusa iindlela zokutyikitya kuyo.

I-CAULIFLOWER YOMFUNO INCEBISWA NGAPHEZU KWE-KOHLRABI NGE-ARID2 YOMNGCIPHEKO woMHLAZA.

Khetha iSiqhamo RED RASPBERRY okanye iPUMMELO?

Iziqhamo ezibomvu zeRaspberry ziqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Ellagic Acid, i-Curcumin, i-Formononetin, i-Bergapten. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MYC Signaling, i-RAS-RAF Signaling, i-PI3K-AKT-MTOR Umqondiso kunye ne-Hematopoiesis kunye nabanye. I-Red raspberry iyacetyiswa kumngcipheko we-Polycythemia Vera xa umngcipheko wemfuzo ohambelana ne-ARID2. Oku kungenxa yokuba i-Red Raspberry yonyusa ezo ndlela ze-biochemical ezichasene nabaqhubi batyikityo kuyo.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwisiqhamo iPummelo yi-Quercetin, i-Curcumin, i-Apigenin, i-Formononetin, i-Bergapten. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa kunye ne-Hematopoiesis kunye nabanye. IPummelo ayikhuthazwa xa umngcipheko wePolycythemia Vera xa umngcipheko wemfuzo unxulunyaniswa ne-ARID2 kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO ESIBOMVU ESIQINISEKISO ESIQINISEKILEYO PHEZU KWE-PUMMELO YE-ARID2 genetic RISK YOMHLAZA.

Khetha i-Nutt BUTTERNUT okanye i-CASHEW NUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Myricetin, i-Apigenin, i-Formononetin, i-Bergapten. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling, i-MYC Signaling, i-PI3K-AKT-MTOR Ukubonakaliswa kunye ne-Hematopoiesis kunye nabanye. I-Butternut iyacetyiswa kumngcipheko we-Polycythemia Vera xa umngcipheko wemfuzo ohambelana ne-ARID2. Oku kungenxa yokuba iButternut yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Cashew Nut yi-Quercetin, i-Curcumin, i-Myricetin, i-Formononetin, i-Bergapten. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa, i-Oncogenic Cancer Epigenetics kunye ne-MYC Signaling kunye nabanye. I-Cashew Nut ayikhuthazwa xa umngcipheko we-Polycythemia Vera xa umngcipheko wemfuza ohambelana ne-ARID2 kuba yonyusa iindlela zokutyikitya kuyo.

IBHUTTERNUT IYACEBISWA NGAPHEZU KWE-CASHEW NUT NGEMNGCIPHEKO YOMHLAZA YE-ARID2.

Ukuququmbela

Ukutya kunye nezongezo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana nePolycythemia Vera. Izigulana zePolycythemia Vera kunye nabantu abasengozini yemfuza bahlala benombuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana nePolycythemia Vera, nganye ineemfuza ezahlukeneyo zethumba ezinokwahluka kwe-genomic ngakumbi kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okunje ngeParsnip kuqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enefuthe kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo othi, "Yintoni ukutya endimele ndiyikhethe okanye ndingayikhethi iPolycythemia Vera?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

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• I-lipidomics esebenzayo: I-Palmitic acid iphazamisa uphuhliso lwe-hepatocellular carcinoma ngokumodareyitha ulwelo lwe-membrane kunye ne-glucose metabolism.
• I-Formononetin-induced oxidative stress isusa ukusebenza kwe-STAT3/5 yokubonisa i-axis kwaye icinezela ukukhula kwethumba kwimodeli ye-myeloma preclinical emininzi.
• I-Imperatorin icinezela ukwanda kunye ne-angiogenesis yeseli yomhlaza wekoloni yomntu ngokujolisa kwi-HIF-1α nge-mTOR/p70S6K/4E-BP1 kunye neendlela ze-MAPK.
• Iinxalenye ezithile zejusi yerharnati njengezithinteli ezinokubakho kwi-prostate cancer metastasis.
• https://www.lls.org/sites/default/files/file_assets/FS13_PolycythemiaVera_FactSheet_final5.1.15.pdf
• https://rarediseases.org/rare-diseases/polycythemia-vera