Ukutya kwePancreatic Adenocarcinoma!

intshayelelo

Ukutya kwePancreatic Adenocarcinoma kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kuziqhelanise xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

I-Pancreatic adenocarcinoma luhlobo lomhlaza olunamandla kakhulu oluchaphazela i-pancreas. Ukuqaphela iimpawu ze-pancreatic adenocarcinoma, ezinje ngeentlungu zesisu, i-jaundice, ukulahleka kwesisindo, kunye nemiba yokugaya ukutya, kubalulekile ekubhaqweni kwangaphambili. Izinga lokusinda kwe-pancreatic adenocarcinoma lisezantsi ngokubanzi, njengoko lihlala lifunyaniswa kumanqanaba aphezulu. Ukuma okufanelekileyo komhlaza kubalulekile ekuqinisekiseni ubungakanani kunye nokusasazeka kwesi sifo. Ikhowudi yezonyango echanekileyo kusetyenziswa ikhowudi ye-ICD-10 efanelekileyo ibalulekile kumaxwebhu afanelekileyo. Ukuqonda i-prognosis ye-pancreatic adenocarcinoma kubalulekile kwizigulane kunye neentsapho zabo. Ukuqhubela phambili kwi-radiology kudlala indima ebalulekileyo ekuxilongweni nasekuvavanyeni i-pancreatic adenocarcinoma. Iimpawu zePathology zibonelela ngolwazi oluxabisekileyo malunga neempawu zeeseli ze-pancreatic adenocarcinoma. Izinketho zonyango ze-pancreatic adenocarcinoma zingabandakanya utyando, i-chemotherapy, unyango lwe-radiation, kunye nonyango olujoliswe kuyo, ngenjongo yokuphucula amazinga okuphila. Ukuxilongwa ngokufanelekileyo kunye nokubekwa kwe-pancreatic adenocarcinoma kubalulekile ekumiseleni ukubanakho konyango lokunyanga. I-Adenocarcinoma lolona hlobo luxhaphakileyo lomhlaza wepancreatic, olwenza uninzi lwamatyala. Ukuqonda iintlobo ezahlukeneyo ze-pancreatic adenocarcinoma kunye neempawu zabo ezithile zibalulekile ekukhokeleni izigqibo zonyango. I-Chemotherapy yindlela yonyango esetyenziswa ngokuqhelekileyo kwi-pancreatic adenocarcinoma, mhlawumbi njenge-neoadjuvant okanye unyango lwe-adjuvant. Izikhokelo zinika iingcebiso zokulawulwa kwe-pancreatic adenocarcinoma kunye nenkxaso yeendlela zonyango zomntu. Indawo ye-pancreatic adenocarcinoma inokuhluka ngaphakathi kwe-pancreas, echaphazela iindawo ezahlukeneyo kunye nezakhiwo. Ngokuhlala unolwazi kunye nokufuna unyango olufanelekileyo, abantu abafunyaniswa bene-pancreatic adenocarcinoma banokufikelela kunyango lwamva nje kwaye baphucule iziphumo zabo.

KwiPancreatic Adenocarcinoma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza kukuba - kwimihlaza efana nePancreatic Adenocarcinoma ingaba ayinamsebenzi ukuba kukuphi ukutya endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekwe kwisityalo ngaba kwanele umhlaza onje ngePancreatic Adenocarcinoma?

Umzekelo ingaba inomsebenzi ukuba imifuno yeGlobe Artichoke ityiwa kakhulu xa ithelekiswa neBrokholi? Ngaba kuyawenza umahluko ukuba isiqhamo iAcerola sikhethwa ngaphezu kwerharnati? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane/iimbewu ezifana neButternut ngaphezu kweChestnut yaseYurophu kunye neentyatyambo ezifana neBroad Bean phezu kweSoy Bean. Kwaye ukuba into endiyityayo ibalulekile - ke umntu uchonga njani ukutya okucetyiswayo kwi-Pancreatic Adenocarcinoma kwaye ingaba yimpendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kwiPancreatic Adenocarcinoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo i-Acerola iqulethe izithako ezisebenzayo i-Quercetin, i-Apigenin, i-Myricetin, i-Isoliquiritigenin, i-Luteolin. Kwaye iPomegranate iqulethe izithako ezisebenzayo i-Quercetin, i-Apigenin, i-Myricetin, i-Isoliquiritigenin, i-Luteolin kwaye mhlawumbi nabanye.

Impazamo eqhelekileyo eyenziwa xa kusenziwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Pancreatic Adenocarcinoma - kukuvavanya kuphela izithako ezisebenzayo ezikhethiweyo eziqulethwe kukutya kwaye ungazihoyi ezinye. Kuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo ukwenza isigqibo sesondlo sePancreatic Adenocarcinoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwiPancreatic Adenocarcinoma?

Isondlo esilungiselelwe wena somhlaza njengePancreatic Adenocarcinoma siquka ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Pancreatic Adenocarcinoma biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nokuba sesichengeni okunxulumene noko unyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana nePancreatic Adenocarcinoma

Zonke ii-cancer ezifana ne-Pancreatic Adenocarcinoma zinokubonakaliswa ngeseti ekhethekileyo yeendlela ze-biochemical - iindlela zokutyikitya zePancreatic Adenocarcinoma. Iindlela ze-Biochemical ezifana ne-Extracellular Matrix Remodelling, i-MAPK Signaling, i-PI3K-AKT-MTOR Ukubonakaliswa, i-Cell Cycle iyingxenye yenkcazo yesignesha ye-Pancreatic Adenocarcinoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Pancreatic Adenocarcinoma kufuneka luthathelwe ingqalelo utyikityo lweendlela zebhayokhemikhali kwisigulana ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto okunye ukutya kunye nezongezo zicetyiswayo kwiPancreatic Adenocarcinoma xa uthatha unyango lomhlaza iPaclitaxel, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-CDKN2A, i-CTNNA2, i-MUC4, i-NOTCH1 kunye ne-RYR2 zezona ziphezulu iijene ezixeliweyo ze-Pancreatic Adenocarcinoma. I-CDKN2A ixelwe kwi-1.1% yezigulane ezimele kuzo zonke izilingo zeklinikhi. Kwaye iCTNNA2 ixelwe kwi-0.5%. Idatha yezigulane ezidityanisiweyo igubungela iminyaka yobudala ukusuka kuma-29 ukuya kuma-90. I-53.9 % yedatha yezigulane ichongwe njengamadoda. I-Pancreatic Adenocarcinoma biology kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zePancreatic Adenocarcinoma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable GLOBE ARTICHOKE okanye i-BROCCOLI?

I-Vegetable Globe Artichoke iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Myricetin, i-Isoliquiritigenin, i-Luteolin, i-Curcumin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana noMjikelo weSeli, ukudumba, ukuncamathela okugxilwe kuko kunye nokuSayina kwe-MYC kunye nezinye. IGlobe Artichoke iyacetyiswa kwiPancreatic Adenocarcinoma xa unyango lomhlaza oluqhubekayo yiPaclitaxel. Oku kungenxa yokuba i-Globe Artichoke iguqula ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukwazisa umphumo we-Paclitaxel.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Broccoli yemifuno yi-Quercetin, i-Isoliquiritigenin, i-Luteolin, i-Curcumin, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-WNT Beta Catenin Signaling, i-Focal Adhesion kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Brokholi ayikhuthazwa kwi-Pancreatic Adenocarcinoma xa unyango oluqhubekayo lomhlaza luyi-Paclitaxel kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IGLOBU YOMFUNO I-ARTICHOKE ICEBISWA NGAPHEZU KWE-BROCCOLI YEPancreatic Adenocarcinoma KUNYE NONYANGO I-Paclitaxel.

Khetha iSiqhamo sePOMEGRANATE okanye i-ACEROLA?

Iziqhamo zePomegranate ziqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Apigenin, i-Myricetin, i-Isoliquiritigenin, i-Luteolin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-Adherens junction, i-TGFB Signaling kunye ne-Microtubule Dynamics kunye nabanye. Irharnati iyacetyiswa kwiPancreatic Adenocarcinoma xa unyango lomhlaza oluqhubekayo yiPaclitaxel. Oku kungenxa yokuba irharnati iguqula ezo ndlela zebhayomikhali eziye zaxelwa ngokwesayensi ukwazisa isiphumo sePaclitaxel.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo ze-Acerola yi-Quercetin, i-Apigenin, i-Myricetin, i-Isoliquiritigenin, i-Luteolin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-TGFB Signaling, Epithelial to Mesenchymal Transition kunye ne-WNT Beta Catenin Signaling kunye nabanye. I-Acerola ayikhuthazwa kwi-Pancreatic Adenocarcinoma xa unyango lomhlaza oluqhubekayo luyi-Paclitaxel kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO EGORGRANATE IYAKUNIKEZWA NGE-ACEROLA YE-Pancreatic Adenocarcinoma KUNYE NONYANGO I-Paclitaxel.

Khetha Nut BUTTERNUT okanye EUROPEAN CHESTNUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Myricetin, i-Isoliquiritigenin, i-Luteolin, i-Curcumin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-Adherens junction, i-Inflammation kunye ne-Focal Adhesion kunye nezinye. I-Butternut iyacetyiswa kwi-Pancreatic Adenocarcinoma xa unyango lomhlaza oluqhubekayo yi-Paclitaxel. Oku kungenxa yokuba i-Butternut iguqula ezo ndlela ze-biochemical eziye zaxelwa ngokwesayensi ukwazisa umphumo we-Paclitaxel.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Quercetin, i-Apigenin, i-Myricetin, i-Isoliquiritigenin, i-Luteolin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-TGFB Signaling, Epithelial to Mesenchymal Transition kunye ne-WNT Beta Catenin Signaling kunye nabanye. I-Chestnut yaseYurophu ayikhuthazwa kwi-Pancreatic Adenocarcinoma xa unyango lomhlaza oluqhubekayo i-Paclitaxel kuba luguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IBHUTTERNUT KUCEBISWA NGAPHEZU KWE-EUROPA CHESTNUT YEPancreatic Adenocarcinoma KUNYE NONYANGO lwePaclitaxel.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwayo ngabantu abasengozini yemfuza ye-Pancreatic Adenocarcinoma okanye imbali yosapho uthi "Yintoni endifanele nditye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenziwa malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nesignesha yendlela - ukhetho lokutya kunye nezongezelelo kufuneka lube lomntu.

Khetha imifuno ye-WILD CARROT okanye i-MOUNTAIN YAM?

I-Vegetable Wild Carrot iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Quercetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-Adherens junction, i-MAPK Signaling kunye ne-MYC Signaling kunye nezinye. Umnqathe wasendle ucetyiswa kumngcipheko wePancreatic Adenocarcinoma xa umngcipheko wemfuzo ohambelana neCDKN2A. Oku kungenxa yokuba i-Wild Carrot yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Mountain Yam yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Lycopene. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Extracellular Matrix Remodeling kunye ne-Cell Cycle Checkpoints kunye nezinye. I-Mountain Yam ayikhuthazwa xa umngcipheko we-Pancreatic Adenocarcinoma xa umngcipheko wezofuzo uhambelana ne-CDKN2A kuba inyusa iindlela zokutyikitya kuyo.

UMNQATHA WASEMTHETHO UYCEBISWA PHEZU KWENTABA YAM NGE-CDKN2A UMNGCIPHEKO wofuzo woMHLAZA.

Khetha iFruit NANCE okanye iLOGANBERRY?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Beta-sitosterol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-Adherens junction, i-MAPK Signaling kunye ne-MYC Signaling kunye nezinye. UNance ucetyiswa kumngcipheko wePancreatic Adenocarcinoma xa umngcipheko wemfuzo ohambelana neCDKN2A. Oku kungenxa yokuba i-Nance yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo iLoganberry yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Beta-sitosterol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Loganberry ayikhuthazwa xa umngcipheko we-Pancreatic Adenocarcinoma xa umngcipheko wemfuzo uhambelana ne-CDKN2A kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO NANCE KUCEBISWA NGAPHEZU KWELOGANBERRY YECDKN2A GENETIC RISK YOMHLAZA.

Khetha Nut EMNYAMA WALNUT okanye MACADAMIA NUT?

I-Walnut emnyama iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Ellagic Acid, i-Lupeol, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-MAPK yokuSayina kunye ne-Cell Cycle Checkpoints kunye nezinye. IWalnut emnyama icetyiswa kumngcipheko wePancreatic Adenocarcinoma xa umngcipheko wemfuzo ohambelana neCDKN2A. Oku kungenxa yokuba iWalnut Emnyama yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Macadamia Nut yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Beta-sitosterol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK yokuSayina, i-Notch Signaling kunye ne-PI3K-AKT-MTOR yokuSayina kunye nabanye. I-Macadamia Nut ayikhuthazwa xa umngcipheko we-Pancreatic Adenocarcinoma xa umngcipheko wezofuzo uhambelana ne-CDKN2A kuba yonyusa iindlela zokutyikitya kuyo.

IWALNUT EMNYAMA KUCEBISIWE PHEZU KWE-MACADAMIA NUT NGE-CDKN2A GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana nePancreatic Adenocarcinoma. Izigulana zePancreatic Adenocarcinoma kunye nabantu abasengozini yemfuza bahlala benombuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezinje ngePancreatic Adenocarcinoma, nganye ineemfuza ezahlukeneyo zethumba ezinolunye ulwahlulo lwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okunje ngeGlobe Artichoke kuqulethe izinto ezahlukeneyo zebhayoloji kwimiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo se-addon yesondlo somntu senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo, "Kukuphi ukutya endimele ndikhethe okanye ndingakhethi kwi-Pancreatic Adenocarcinoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Pancan Pcawg 2020
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• I-Betulinic acid inqanda ukukhula komhlaza we-prostate ngokunqanda izinto ezithile ezibhaliweyo zeprotheni.
• I-Gallic acid, i-phenolic compound, yenza i-anti-angiogenic effects ngokusebenzisa i-PTEN/AKT/HIF-1α/VEGF indlela yokubonisa kwiiseli zomhlaza we-ovarian.
• I-Chlorogenic acid inqanda ukwanda kwaye ibangela i-apoptosis kwi-A498 yeeseli zomhlaza wezintso zomntu ngendlela engasebenziyo ye-PI3K/Akt/mTOR yokubonisa indlela.
• Inkqubela phambili yophando kwiziphumo ze-anticancer ye-vitamin K2.
• I-β-Sitosterol kunye neGemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity ngokuModulating i-Apoptosis kunye ne-Inhibiting Epithelial-Mesenchymal Transition ngo-Deactivating Akt / GSK-3β Signaling.
• I-Vitamin C iphucula ukuguqulwa kwe-epigenetic eyenziwa yi-5-azacytidine kunye nokubanjwa komjikelo weseli kwi-hepatocellular carcinoma celllines HLE kunye ne-Huh7.
• I-Eugenol inamandla okwenza umsebenzi we-cisplatin wokuchasana nomhlaza ngokuvinjelwa kwe-ALDH-positive breast cancer cells kunye ne-NF-κB indlela yokubonisa.
• I-Geraniol, icandelo lee-oyile ezibalulekileyo zesityalo, ikhuthaza iiseli zomhlaza wekholoni yomntu kwi-5-Fluorouracil unyango.
• I-α-pinene ilawula i-miR-221 kwaye yenza i-G₂/ Isigaba se-M sokubanjwa komjikelo weseli kwiiseli ze-hepatocellular carcinoma.
• Ukukhula okukhuthazwayo kweeseli ze-pulmonary adenocarcinoma yabantu kunye neeseli ezincinci ze-epithelial zomoya nge-beta-carotene ngokusebenza kwe-cAMP, i-PKA, i-CREB kunye ne-ERK1/2.
• https://www.mayoclinic.org/diseases-conditions/pancreatic-cancer/diagnosis-treatment/drc-20355427
• Vareedayah AA et al, Mo Med, 2018
• https://emedicine.medscape.com/article/280605-overview