Ukutya kwi-Ovarian Cancer!

intshayelelo

Ukutya koMhlaza we-Ovarian kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kulungiswe xa unyango lomhlaza okanye utshintsho lwemfuza yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

Kwi-Ovarian Cancer ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza onje ngoMhlaza we-Ovarian ingaba ayinamsebenzi ukuba kukutya ntoni na endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekelwe kwisityalo oko kwanele umhlaza onjenge-Ovarian Cancer?

Umzekelo ingaba inomsebenzi ukuba iCauliflower yemifuno ityiwa kakhulu xa ithelekiswa neGarden Tomato? Ngaba kuyawenza umahluko ukuba isiqhamo esiMnyama i-Elderberry sikhethwa ngaphezu kwerharnati? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane/iimbewu ezifana neButternut ngaphezu kweBrazil Nut kunye neepulses ezifana neBroad Bean phezu kweChickpea. Kwaye ukuba into endiyityayo ibalulekile - ke umntu uchonga njani ukutya okucetyiswayo kwi-Ovarian Cancer kwaye ingaba impendulo efanayo kuye wonke umntu onokuxilongwa okufanayo okanye umngcipheko wemfuza?

Ewe! Ukutya okutyayo kubalulekile kwi-Ovarian Cancer!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Ngokomzekelo i-Black Elderberry iqulethe izithako ezisebenzayo iLycopene, i-Curcumin, i-Isoliquiritigenin, i-Quercetin, i-Myricetin. Kwaye iPomegranate iqulethe izithako ezisebenzayo i-Curcumin, i-Isoliquiritigenin, i-Quercetin, i-Myricetin, i-Naringin kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa kuthathwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Ovarian Cancer - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungawuhoyi ukuphumla. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha i-cherry izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo se-Ovarian Cancer.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kwiSondlo soMntu kuMhlaza we-Ovarian?

Izondlo zomntu zomhlaza ezifana noMhlaza we-Ovarian ziquka ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchule kwi-Ovarian Cancer biology, isayensi yokutya, i-genetics, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nokuba sesichengeni okunxulumene nonyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana ne-Ovarian Cancer

Zonke ii-cancer ezifana ne-Ovarian Cancer zingabonakaliswa ngeseti ekhethekileyo yeendlela ze-biochemical - iindlela zokutyikitya ze-Ovarian Cancer. Iindlela ze-Biochemical ezifana nokuvuvukala, ukubonakaliswa kwe-NFKB, ii-Checkpoints ze-Cell Cycle, i-Apoptosis ziyinxalenye yenkcazo yesiginesha ye-Ovarian Cancer. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kuMhlaza we-Ovarian kufuneka luthathele ingqalelo utyikityo olunxulumene neendlela zebhayokhemikhali kwisigulana ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto ezinye ukutya kunye nezongezelelo ziyacetyiswa kwi-Ovarian Cancer xa uthatha unyango lomhlaza i-Olaparib, kwaye ezinye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-TP53, i-MUC16, i-NF1, i-RYR2 kunye ne-KMT2C zezona ziphezulu iijene ezixeliweyo ze-Ovarian Cancer. I-TP53 ixelwe kwi-29.2% yezigulane ezimele kuzo zonke iimvavanyo zekliniki. Kwaye i-MUC16 inikwe ingxelo nge-3.2%. I-data yezigulane ezidityanisiweyo zibandakanya iminyaka yobudala ukusuka kuma-26 ukuya kuma-89. I-0.0 % yedatha yesigulane ichongwa njengamadoda. Ibhayoloji yoMhlaza we-Ovarian kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela ze-biochemical kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezelelo zoMhlaza we-Ovarian

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha iVegetable CAULIFLOWER okanye iTAMATO YEGADI?

I-Cauliflower yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Isoliquiritigenin, i-Cinnamaldehyde, i-Psoralen, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokudumba, ukuSayina kwe-MAPK, ukuSayina kwe-TWEAK kunye nokuSayina kwe-MYC kunye nabanye. I-Cauliflower iyacetyiswa kwi-Ovarian Cancer xa unyango lomhlaza oluqhubekayo i-Olaparib. Oku kungenxa yokuba iCauliflower ilungisa ezo ndlela zebhayomichi exelwe ngokwenzululwazi ukuze zinike impembelelo ye-Olaparib.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yeGarden Tomato yiLycopene, Curcumin, Isoliquiritigenin, Quercetin, Myricetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye nezinye. I-Garden Tomato ayikhuthazwa kwi-Ovarian Cancer xa unyango lomhlaza oluqhubekayo luyi-Olaparib kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye luphendule ngaphantsi.

I-CAULIFLOWER YOMFUNO INCEBISWA NGAPHEZU KWEGADI ITOMATO YE-Ovarian Cancer KUNYE NONYANGO Olaparib.

Khetha iSiqhamo sePOMEGRANATE okanye EMNYAMA ELDERBERRY?

Iziqhamo zePomegranate ziqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Isoliquiritigenin, i-Quercetin, i-Myricetin, i-Naringin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-Epithelial ukuya kwi-Mesenchymal Transition, ukuvuvukala kunye nokuSayina kwe-MAPK kunye nabanye. Irharnati iyacetyiswa kwi-Ovarian Cancer xa unyango lomhlaza oluqhubekayo yi-Olaparib. Oku kungenxa yokuba irharnati iguqula ezo ndlela zebhayomichi exelwe ngokwenzululwazi ukuze zikhuthaze isiphumo se-Olaparib.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwiziqhamo ze-Black Elderberry yiLycopene, i-Curcumin, i-Isoliquiritigenin, i-Quercetin, i-Myricetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye ne-MAPK Signaling kunye nabanye. I-Black Elderberry ayikhuthazwa ukuba i-Ovarian Cancer xa unyango lomhlaza oluqhubekayo luyi-Olaparib kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO EGORGRANATE KUCEBISWA NGAPHEZU KWE-BLACK ELDERBERRY FOR Ovarian Cancer NONYANGO Olaparib.

Khetha Nut BUTTERNUT okanye BRAZIL NUT?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Lycopene, i-Curcumin, i-Isoliquiritigenin, i-Myricetin, i-Caffeine. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-Epithelial ukuya kwi-Mesenchymal Transition, ukuvuvukala kunye nokuSayina kwe-MAPK kunye nabanye. I-Butternut iyacetyiswa kwi-Ovarian Cancer xa unyango lomhlaza oluqhubekayo luyi-Olaparib. Oku kungenxa yokuba i-Butternut ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukwazisa isiphumo se-Olaparib.

Ezinye zezinto ezisebenzayo okanye i-bioactives eBrazil Nut yi-Curcumin, i-Isoliquiritigenin, i-Cinnamaldehyde, i-Psoralen, i-Ellagic Acid. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Epithelial ukuya kwi-Mesenchymal Transition, ukudumba kunye ne-TWEAK Signaling kunye nabanye. I-Brazil Nut ayikhuthazwa kwi-Ovarian Cancer xa unyango lomhlaza oluqhubekayo luyi-Olaparib kuba luguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IBHUTTERNUT KUCEBISWA NGAPHEZU KWEBRAZIL NUT YOMHLAZA WESIOVA KUNYE NONYANGO Olaparib.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuza ye-Ovarian Cancer okanye imbali yentsapho "Yintoni endimele ndiyitye ngokwahlukileyo ngaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable KALE okanye AMERICAN POKEWEED?

I-Vegetable Kale iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Lupeol, i-Indole-3-carbinol, i-Daidzein, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuLungiswa kwe-DNA, uMjikelo weSeli, umqondiso we-MAPK kunye nokuSayina kwe-MYC kunye nabanye. I-Kale icetyiswa kumngcipheko we-Ovarian Cancer xa ingozi yemfuzo ehambelanayo yi-KMT2C. Oku kungenxa yokuba iKale yonyusa ezo ndlela zebhayomichi echasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yase-American Pokeweed yi-Apigenin, i-Curcumin, i-Lupeol, i-Quercetin, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye ne-MAPK Signaling kunye nabanye. I-American Pokeweed ayikhuthazwa xa umngcipheko we-Ovarian Cancer xa umngcipheko wezofuzo uhambelana ne-KMT2C kuba inyusa iindlela zokutyikitya.

IMIFUNO KALE KUCEBISWA NGAPHEZU KWEPOKEWEED YASEMERICAN NGEMNGCIPHEKO YOMHLAZA YE-KMT2C.

Khetha iSiqhamo RED RASPBERRY okanye iPUMMELO?

Isiqhamo esiBomvu iRaspberry iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Ellagic Acid, i-Lupeol, i-Quercetin, i-Daidzein. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-DNA Repair kunye ne-MYC Signaling kunye nabanye. I-Red raspberry iyacetyiswa kumngcipheko we-Ovarian Cancer xa umngcipheko wemfuzo ohambelana ne-KMT2C. Oku kungenxa yokuba i-Red Raspberry yonyusa ezo ndlela ze-biochemical ezichasene nabaqhubi besignesha.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo iPummelo yi-Apigenin, i-Curcumin, i-Lupeol, i-Lycopene, i-Quercetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye ne-Extracellular Matrix Remodeling kunye nezinye. IPummelo ayikhuthazwa xa umngcipheko we-Ovarian Cancer xa umngcipheko wemfuzo uhambelana ne-KMT2C kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO ESIBOMVU ESIQINISEKISO ESIQINISEKISO PHEZU KWE-PUMMELO YE-KMT2C GENETIC RISK YOMHLAZA.

Khetha i-Nutt EMNYAMA WALNUT okanye i-CHESTNUT?

I-Walnut emnyama iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Ellagic Acid, i-Lupeol, i-Quercetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-MAPK yokuSayina kunye ne-Cell Cycle Checkpoints kunye nezinye. IWalnut emnyama icetyiswa kumngcipheko we-Ovarian Cancer xa umngcipheko wemfuzo ohambelana ne-KMT2C. Oku kungenxa yokuba iWalnut Emnyama yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yi-Apigenin, i-Curcumin, i-Ellagic Acid, i-Lupeol, i-Lycopene. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, i-Extracellular Matrix Remodeling kunye ne-Cell Cycle Checkpoints kunye nezinye. I-Chestnut ayikhuthazwa xa umngcipheko we-Ovarian Cancer xa umngcipheko wezofuzo uhambelana ne-KMT2C kuba yonyusa iindlela zokutyikitya.

IWALNUT EMNYAMA KUNCEBISWA NGAPHEZU KWE-CHESTNUT YE-KMT2C UMNGCIPHEKO WEMFUZO YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezelelo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana ne-Ovarian Cancer. Izigulana zoMhlaza we-Ovarian kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye zingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezinje ngoMhlaza we-Ovarian, nganye inemfuza eyahlukileyo ye-tumor enolunye utshintsho lwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana neCauliflower kuqulethe izinto ezahlukeneyo zebhayoloji kwimithamo eyahlukeneyo, enefuthe kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo somhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo somntu we-addon wesondlo senza ukuba kube lula ukwenza isigqibo kwaye sisuse yonke ingqikelelo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikhethe okanye ndingakhethi kwi-Ovarian Cancer?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Msk Impact 2017
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• I-Isoliquiritigenin Inqanda i-Ovarian Cancer Metastasis ngokuguqula i-Epithelial-to-Mesenchymal Transition.
• I-Betulinic Acid iNxinzelela iMetastasis yoMhlaza wamabele ngokuJonga i-GRP78-Mediated Glycolysis kunye ne-ER Stress Apoptotic Pathway.
• I-asidi ye-Gallic ixhokonxa umonakalo we-DNA kwaye icinezela i-DNA yokulungisa i-gene expression kwi-prostate cancer yomntu iiseli ze-PC-3.
• I-Brassinin inqanda indlela yokubonisa i-STAT3 ngokumodareyithwa kwe-PIAS-3 kunye ne-SOCS-3 intetho kwaye inike amandla i-xenograft yomhlaza wemiphunga yabantu kwiimpuku ezinqunu ukuya kwi-paclitaxel.
• IVithamin C ibulala ngokukhetha i-KRAS kunye ne-BRAF iiseli zomhlaza eziguqukayo ze-colorectal ngokujolisa kwi-GAPDH.
• I-Geraniol, icandelo lee-oyile ezibalulekileyo zesityalo, ikhuthaza iiseli zomhlaza wekholoni yomntu kwi-5-Fluorouracil unyango.