Ukutya kweOsteosarcoma!

intshayelelo

Ukutya kwe-Osteosarcoma kufuneka kulungiselelwe umntu ngamnye kwaye kufuneka kuhlengahlengiswe xa unyango lomhlaza okanye utshintsho lwemfuza yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

I-Osteosarcoma, ithumba eliyingozi eliphambili lamathambo, ngumhlaza onqabileyo onamatyala amatsha amalunga ne-1,000 afunyaniswe e-United States kunye nesehlo sehlabathi jikelele se-3.4 kwisigidi sabantu ngonyaka. Malunga nesiqingatha saba ngabantwana, abakwishumi elivisayo nakulutsha oluphakathi kweminyaka eli-10 nama-30 ubudala. I-Osteosarcoma idla ngokuchaphazela amathambo amade, njengalawo asezingalweni nasemilenzeni kwaye iqhele ukwenzeka kufutshane neziphelo zamathambo nakufutshane nedolo lakho apho ukukhula okukhawulezayo kwenzeka khona (kwimeko yolutsha). I-Osteosarcoma yenzeka kancinci kancinci kumakhwenkwe (emva kokufikisa), ngenxa yexesha elide lokukhula kwamathambo. Iimpawu ze-Osteosarcoma ziquka intlungu yethambo okanye ububele, ubunzima okanye i-lump, ukuvuvukala, ukuqhwala, ukunyakaza okulinganiselwe (ukuba kuchaphazela amalunga), ithambo eliphukile. Amazinga okusinda kweminyaka emi-5 ye-osteosarcoma yi> 65% ukuba iyindawo kodwa ukuba iye yasasazeka kwezinye iindawo zomzimba, izinga lokusinda liyehla ukuya kuma-30-50%. Ulawulo lwe-osteosarcoma ephezulu lubandakanya ukugxininiswa ngakumbi kwi-chemotherapy kunye nokuhlenga imilenze kwaye inokuxhaswa ngesondlo esifanelekileyo (ukutya kunye nezongezelelo zendalo) ezihambelana nomhlaza kunye nomxholo wonyango.

Kwi-Osteosarcoma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa ngabaguli abanomhlaza kunye nabantu abasengozini yomhlaza ngowomhlaza onje nge-Osteosarcoma ingaba ibalulekile na into yokutya endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekwe kwisityalo ngaba kwanele umhlaza onje ngeOsteosarcoma?

Umzekelo ingaba ibalulekile into yokuba iKhaphetshu yemifuno ityiwa kakhulu xa ithelekiswa neYautia? Ngaba kuyawenza umahluko ukuba isiqhamo iPassion Fruit sikhethwa ngaphezu kweJava Plum? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane / iimbewu ezifana neWalnut eqhelekileyo ngaphezu kweChestnut yaseYurophu kunye nezityalo ezifana neGram Bean phezu kweLima Bean. Kwaye ukuba into endiyityayo ibalulekile - umntu ukuchonga njani ukutya okucetyiswayo kwi-Osteosarcoma kwaye ingaba yimpendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kwi-Osteosarcoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo Passion Fruit iqulethe izithako ezisebenzayo Curcumin, Isoliquiritigenin, Apigenin, Lupeol, Psoralen. Kwaye i-Java Plum iqulethe izithako ezisebenzayo i-Curcumin, i-Isoliquiritigenin, i-Apigenin, i-Lycopene, i-Lupeol kwaye mhlawumbi nabanye.

Impazamo eqhelekileyo eyenziwa xa kusenziwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Osteosarcoma - kukuvavanya kuphela izithako ezisebenzayo ezikhethiweyo eziqulethwe kukutya kwaye ungahoyi ezinye. Kuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo se-Osteosarcoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwi-Osteosarcoma?

Izondlo zomntu zomhlaza ezifana ne-Osteosarcoma zibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwibhayoloji ye-Osteosarcoma, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nokuba sesichengeni okunxulumene nonyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana ne-Osteosarcoma

Yonke imihlaza efana ne-Osteosarcoma inokuphawulwa ngeseti eyodwa yeendlela ze-biochemical - iindlela zokutyikitya ze-Osteosarcoma. Iindlela ze-Biochemical ezifana ne-Cell Cycle Checkpoints, i-Cell Cycle, i-Extracellular Matrix Remodelling, i-Focal Adhesion iyingxenye yenkcazo yesignesha ye-Osteosarcoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Osteosarcoma kufuneka luthathelwe ingqalelo utyikityo lweendlela zebhayokhemikhali ezihambelana nesigulana somhlaza ngamnye kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto ezinye ukutya kunye nezongezo zicetyiswayo kwi-Osteosarcoma xa uthatha unyango lomhlaza i-Dacarbazine, kwaye ezinye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-DNMT3A, PPM1D, TET2, TP53 kunye ne-CHEK2 zezona ntlobo zemfuza zixeliweyo eziphezulu ze-Osteosarcoma. I-DNMT3A ixelwe kwi-21.6 % yezigulane ezimele kuwo onke amalingo onyango. Kwaye iPPM1D ixelwe kwi-9.7%. Idatha yezigulane ezidityanisiweyo zigubungela iminyaka yobudala ukusuka ku-1 ukuya kuma-93. Ama-29.2% edatha yesigulane ichongwa njengamadoda. Ibhayoloji ye-Osteosarcoma kunye nemfuzo exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenziwa kwesondlo.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezo zeOsteosarcoma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha ikhaphetshu yemifuno okanye iYAUTIA?

Iklabishi yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Curcumin, i-Isoliquiritigenin, i-Apigenin, i-Lycopene. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, ukudumba, ukubonakaliswa kwe-P53 kunye ne-Angiogenesis kunye nabanye. Ikhaphetshu iyacetyiswa kwi-Osteosarcoma xa unyango lomhlaza oluqhubekayo yi-Dacarbazine. Oku kungenxa yokuba Ikhaphetshu iguqula ezo ndlela ze-biochemical eziye zachazwa ngokwesayensi ukwazisa umphumo weDacarbazine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Yautia yi-Curcumin, i-Isoliquiritigenin, i-Apigenin, i-Lycopene, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA kunye noxinzelelo lwe-Oxidative kunye nezinye. I-Yautia ayikhuthazwa kwi-Osteosarcoma xa unyango lomhlaza oluqhubekayo yi-Dacarbazine kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IKHABHAYIJI YOMFUNO IYAKUGQIBISWA NGE-YAUTIA YE-Osteosarcoma KUNYE NONYANGO i-Dacarbazine.

Khetha iFruit JAVA PLUM okanye PASSION FRUIT?

Iziqhamo zeJava Plum ziqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Isoliquiritigenin, i-Apigenin, i-Lycopene, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana noMjikelo weSeli, ukudumba, ukulungiswa kwe-DNA kunye ne-TWEAK Signaling kunye nabanye. I-Java Plum iyacetyiswa kwi-Osteosarcoma xa unyango lomhlaza oluqhubekayo yi-Dacarbazine. Oku kungenxa yokuba i-Java Plum iguqula ezo ndlela ze-biochemical eziye zachazwa ngokwesayensi ukuze zikhuthaze umphumo we-Dacarbazine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo zePassion Fruit yi-Curcumin, i-Isoliquiritigenin, i-Apigenin, i-Lupeol, i-Psoralen. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, uxinzelelo lwe-Oxidative kunye ne-TWEAK Signaling kunye nabanye. Passion Fruit ayinconywa kwi-Osteosarcoma xa unyango lomhlaza oluqhubekayo yi-Dacarbazine kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO JAVA PLUM KUNCEBISWA NGAPHEZU KWEZIQHAMO ZOKUZITHANDA KWE-Osteosarcoma KUNYE NONYANGO Dacarbazine.

Khetha Nut WALNUT EQHELEKILEYO okanye i-EUROPEAN CHESTNUT?

I-Walnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Curcumin, i-Isoliquiritigenin, i-Lupeol, i-Ellagic Acid. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuLungiswa kwe-DNA, uMjikelo weSeli, umqondiso we-P53 kunye ne-TWEAK Signaling kunye nabanye. I-Walnut eqhelekileyo icetyiswa kwi-Osteosarcoma xa unyango oluqhubekayo lomhlaza yi-Dacarbazine. Oku kungenxa yokuba i-Walnut eqhelekileyo iguqula ezo ndlela ze-biochemical eziye zachazwa ngokwesayensi ukuze zikhuthaze umphumo we-Dacarbazine.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Chestnut yaseYurophu yi-Quercetin, i-Curcumin, i-Isoliquiritigenin, i-Apigenin, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokulungiswa kwe-DNA, uxinzelelo lwe-Oxidative kunye ne-TWEAK Signaling kunye nabanye. I-Chestnut yaseYurophu ayikhuthazwa kwi-Osteosarcoma xa unyango lomhlaza oluqhubekayo yi-Dacarbazine kuba luguqula ezo ndlela ze-biochemical eyenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IWALNUT EQHELEKILEYO IYANCEBISWA NGAPHEZU KWE-EUROPEY CHESTNUT YE-Osteosarcoma KUNYE NONYANGO i-Dacarbazine.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwe ngabantu abasengozini yemfuza ye-Osteosarcoma okanye imbali yosapho "Yintoni endifanele nditye ngokwahlukileyo kunangaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable GIANT BUTTERBUR or CHINESE BROCCOLI?

I-Butterbur enkulu yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-DNA Repair kunye ne-MYC Signaling kunye nabanye. I-Giant Butterbur iyacetyiswa kumngcipheko we-Osteosarcoma xa umngcipheko wemfuzo ohambelana ne-CHEK2. Oku kungenxa yokuba i-Giant Butterbur yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yaseShayina Broccoli yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress kunye nezinye. I-Brokholi yaseTshayina ayikhuthazwa xa umngcipheko we-Osteosarcoma xa umngcipheko wemfuzo unxulunyaniswa ne-CHEK2 kuba yonyusa iindlela zokutyikitya kuyo.

IBHUTTERBURE EYISINQIZI YOMFUNO IYACEBISWA PHEZU KWE-BROCCOLI YASETSHAYINA NGE-CHEK2 GENETIC RISK YOMHLAZA.

Khetha iSiqhamo se-NANCE okanye iGRAPEFRUIT?

I-Fruit Nance iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-DNA Repair kunye ne-MYC Signaling kunye nabanye. I-Nance icetyiswa kumngcipheko we-Osteosarcoma xa umngcipheko wemfuzo ohambelana ne-CHEK2. Oku kungenxa yokuba i-Nance yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo zeGrapefruit yi-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin, i-Beta-sitosterol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oxidative Stress kunye nezinye. I-Grapefruit ayikhuthazwa xa umngcipheko we-Osteosarcoma xa umngcipheko wezofuzo uhambelana ne-CHEK2 kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO NANCE IYACEBISWA NGAPHEZU KWEGRAPEFRUIT NGE-CHEK2 GENETIC RISK YOMHLAZA.

Khetha i Nut COMMON HAZELNUT okanye iFLXSEED?

I-Hazelnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin, i-Beta-sitosterol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana nokuLungiswa kwe-DNA, uMjikelo weSeli, umqondiso we-MAPK kunye nokuSayina kwe-MYC kunye nabanye. IHazelnut eqhelekileyo iyacetyiswa kumngcipheko we-Osteosarcoma xa umngcipheko wemfuzo ohambelana ne-CHEK2. Oku kungenxa yokuba iHazelnut eqhelekileyo yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Flaxseed yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-JAK-STAT Signaling, i-Oxidative Stress kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. I-Flaxseed ayikhuthazwa xa umngcipheko we-Osteosarcoma xa umngcipheko wemfuzo uhambelana ne-CHEK2 kuba yonyusa iindlela zokutyikitya kuyo.

I-HAZELNUT EQHELEKILEYO IYANCEBISWA NGAPHEZU KWEFLAXSEED YE-CHEK2 GENETIC RISK YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana ne-Osteosarcoma. Izigulana ze-Osteosarcoma kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye ezingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Osteosarcoma, nganye ine-tumor genetics eyahlukeneyo kunye nokwahluka kwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana nekhaphetshu kuqulethe izinto ezahlukeneyo zebhayoloji ngokwemiyinge eyahlukeneyo, enefuthe kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela zebhayoloji. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo kumhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo se-addon sesondlo senza ukuba kube lula ukwenza isigqibo kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo othi, "Kukuphi ukutya endimele ndikukhethe okanye ndingakhethi kwi-Osteosarcoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

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