Ngowuphi umhlaza onokuthi uxhamle ngokuquka i-Olive ekutyeni kwabo?

Iimbalasane

I-Olive yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kakuhle kuka-Olive kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Ngokomzekelo, i-Olive ingaba luncedo kwabo bane-Primary Solitary Fibrous Tumor ephantsi kwe-Avastin, kodwa isenokungabi kuhle kwizigulana ezifumana i-Docetaxel yePrimary Cervical Neuroendocrine Tumor. Ngaphaya koko, ngelixa i-Olive inokunceda abantu abane-genetic risk factor "BRCA2", ayinakucetyiswa kwabo banomngcipheko wemfuzo owahlukileyo "ASXL1". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-Olive kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekugqibeni ukuba uMnquma lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, igxile kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezinjengoMnquma endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayihoyi ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise i-Olive kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye i-Olive ukuba une-genetic predisposition kumhlaza ohambelana ne-BRCA2 gene? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ASXL1 gene? Ngaba kunenzuzo ukuquka uMnquma kwisidlo sakho ukuba ufunyaniswe uneTumor yePrimary Cervical Neuroendocrine Tumor, okanye ukuba uxilongo lwakho yiPrimary Solitary Fibrous Tumor? Ngaphezu koko, ukusetyenziswa kwakho kwe-Olive kufuneka kuhlengahlengiswe njani ukuba ufumana unyango lwe-Avastin okanye ukuba isicwangciso sakho sonyango siyatshintsha ukusuka kwi-Avastin ukuya kwi-Docetaxel? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezinje 'umnquma yindalo, ngoko ke isoloko iluncedo' okanye 'umnquma womeleza ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuphinda uvavanye ukufaneleka kokuquka uMnquma kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje nge-Olive kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njenge-Primary Solitary Fibrous Tumor okanye iPrimary Cervical Neuroendocrine Tumor, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeka kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, njengo-Olive. Ngaba umngcipheko wemfuza womhlaza ovela kuguquko kwi-BRCA2 unefuthe elifanayo le-biochemical pathway njengenguqu kwi-ASXL1? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Solitary Fibrous Tumor ilingana nePrimary Cervical Neuroendocrine Tumor? Ngapha koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kweDocetaxel njengakwabo bafumana i-Avastin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

Umnquma – ISongezo seSondlo

I-Supplement Olive iquka uluhlu lwezithako ezisebenzayo, ezibandakanya i-Palmitic Acid, i-L-histidine, i-L-phenylalanine, i-Acteoside kunye ne-Quercetin 3-rutinoside, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-MYC Signaling, i-Apoptosis, i-DNA Repair kunye ne-Growth Factor Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo ezifana noMnquma, yedwa okanye ngokudibeneyo, kuba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa i-Olive kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufanayo kunyango lomhlaza, ukusetyenziswa kwe-Olive ayisosigqibo sehlabathi lonke esilungele zonke ii-cancer kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zoMnquma

Ukuphendula umbuzo othi 'Ndingamphepha nini uMnquma kwimeko yoMhlaza' kulucelomngeni kuba impendulo ixhomekeke kumntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye izibonelelo ze-Olive ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye nayo nayiphi na i-allergies yonke idlala indima ekunqumeni ukuba uMnquma ufanelekile okanye kufuneka uthintelwe, kugxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Olive Supplements iya kuzuza i-Primary Cervical Neuroendocrine Tumor Patients eziphantsi konyango lwe-Docetaxel?

I-Primary Cervical Neuroendocrine Tumor ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-ABHD6, STOX1 kunye ne-PDZD4, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-Apoptosis. Ukusebenza konyango lomhlaza, njenge-Docetaxel, kuxhomekeke kwindlela yayo yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, isongezelelo se-Olive, esichaphazela i-Apoptosis, ayinakuba lukhetho olufanelekileyo kwimeko ye-Primary Cervical Neuroendocrine Tumor xa i-Docetaxel. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba iiSongezo ze-Olive ziya kuzuza izigulana eziziiPrimary Solitary Fibrous Tumor eziphantsi koNyango lwe-Avastin?

I-Primary Solitary Fibrous Tumor ichongiwe ngokuguqulwa kofuzo oluthile, njenge-BRD4, i-FLI1 kunye ne-KMT2C, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-MYC Signaling, i-Chromatin Remodeling, i-DNA Repair, i-Oncogenic Histone Methylation kunye ne-Amino Acid Metabolism. Ukusebenza kwonyango lomhlaza, njenge-Avastin, kuchongwa ngokusebenzisana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Olive lukhetho olunengqiqo kwabo bane-Primary Solitary Fibrous Tumor ehamba ne-Avastin. Oku kungenxa yokuba i-Olive inefuthe kwiindlela ezinje nge-MYC Signaling, enokuthintela izinto eziqhuba i-Primary Solitary Fibrous Tumor okanye ixhamle ukusebenza kwe-Avastin.

3. Ngaba izongezo ze-Olive zikhuselekile kubantu abasempilweni abane-ASXL1 Mutation Associated Genetic Risk?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-ASXL1 gene idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-ASXL1 gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana nokulungiswa kwe-DNA, i-Oncogenic Cancer Epigenetics kunye ne-Suppressive Histone Methylation, ebandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga ukuguqulwa kwe-ASXL1 ehambelana nomngcipheko okhulayo we-Chronic Myelomonocytic Leukemia, ingqiqo yesayensi icebisa ukuphepha ukusetyenziswa kwe-Olive yokongeza. Oku kungenxa yokuba ukongeza i-Olive inefuthe kwiindlela ezifana nokulungiswa kwe-DNA, enokukhokelela kwimiphumo emibi kumxholo we-ASXL1 yokuguqulwa kunye neemeko zomhlaza ezinxulumene nazo.

4. Ingaba izongezo ze-Olive zikhuselekile kubantu abasempilweni abaneBRCA2 Mutation Associated Genetic Risk?

I-BRCA2 idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-BRCA2 kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Growth Factor Signaling kunye ne-DNA Repair, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-BRCA2 ehambelana noMhlaza wamabele, cinga ngokubandakanya izongezo ze-Olive kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngokufanelekileyo iindlela ezifana ne-Growth Factor Signaling, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-BRCA2 kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezo ezifana noMnquma, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• cBioPortal for Cancer Genomics
• Verbascoside: Ukuchongwa, Quantification, kunye nokuSensitization Okunokubakho kweeSeli zeCancer Colorectal ukuya kwi-5-FU ngokuJonga i-PI3K / AKT Pathway.
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• Ukuguqulwa kwendlela ye-apoptotic ye-mitochondrial ngundoqo ekufumaneni ukuxhathisa i-paclitaxel kwaye inokuguqulwa ngu-ABT-737.
• I-genomics yeklinikhi edibeneyo yomhlaza we-metastatic.
• cBioPortal for Cancer Genomics
• I-Phenylethanoid glycosides esuka kwi-Digitalis purpurea kunye ne-Penstemon linarioides kunye nomsebenzi we-PKCalpha-inhibitory.
• Indima ye-tumor microenvironment ekuchaseni unyango lwe-anti-angiogenic.