Ngowuphi umhlaza onokuzuza ngokuquka i-Omega-3 kwisidlo sabo?

Iimbalasane

I-Omega-3 yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kwe-Omega-3 kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezifana nomhlaza, ichemotherapy, olunye unyango, kunye nemfuzo yethumba. Ukwazi ukuba okunye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, i-Omega-3 inokuba luncedo kwabo bane-Primary Penile Squamous Cell Carcinoma abafumana iMitomycin. Ngaphaya koko, ngexa i-Omega-3 inokunceda abantu abanomngcipheko wemfuzo “CDH1”, ayinakucetyiswa kwabo banengozi yemfuzo eyahlukileyo. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-Omega-3 kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba i-Omega-3 lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi yokhetho lokutya ibalulekile, igxile kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / nezongezo ezifana ne-Omega-3 endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo ovelayo: Ngaba kufuneka udibanise i-Omega-3 kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye i-Omega-3 ukuba unemfuza enokuthanani nomhlaza onxulumene ne-CDH1 gene? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza usuka kumfuza? Ngaba kuluncedo ukuquka i-Omega-3 kukutya kwakho ukuba ufunyaniswe une-Primary Penile Squamous Cell Carcinoma? Ngaphezu koko, indlela osebenzisa ngayo i-Omega-3 kufuneka ilungelelaniswe njani ukuba ufumana unyango lwe-Mitomycin okanye ukuba isicwangciso sakho sonyango siyatshintsha kwi-Mitomycin? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'ne-Omega-3 yendalo, ngoko isoloko iluncedo' okanye 'i-Omega-3 yonyusa ukhuselo lomzimba' akonelanga kukhetho lokutya/ lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Omega-3 kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana ne-Omega-3 kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo zebhayoloji yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, onje ngePrimary Penile Squamous Cell Carcinoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kujongwe kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana ne-Omega-3. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-CDH1 unefuthe elifanayo le-biochemical pathway njengotshintsho kwenye imfuza? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana nePrayimari yePenile Squamous Cell Carcinoma ulingana nomnye umhlaza? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo bafumana olunye unyango njengabo bafumana iMitomycin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Omega-3-Isongezelelo seSondlo

I-Omega-3 eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, ezibandakanya i-Docosahexaenoic Acid kunye ne-Eicosapentaenoic Acid, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-Apoptosis, i-Autophagy kunye ne-Epithelial kwi-Mesenchymal Transition, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njenge-Omega-3, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa i-Omega-3 kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kwe-Omega-3 ayisosigqibo sehlabathi lonke esilungele zonke iimhlaza kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeOmega-3

Ukuphendula umbuzo othi 'Ndingayiphepha nini i-Omega-3 kwimeko yoMhlaza' kulucelomngeni kuba impendulo ixhomekeke kumntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye izibonelelo ze-Omega-3 ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye naluphi na uhlobo oluthile lomzimba, zonke zidlala indima ekunqumeni ukuba i-Omega-3 ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka kobuntu. ukuqwalaselwa kwizigqibo ezinjalo.

1. Ingaba izongezo ze-Omega-3 ziyakuzinceda izigulana eziphantsi koNyango lwe-Mitomycin?

I-Primary Penile Squamous Cell Carcinoma ichongiwe ngokuguqulwa kofuzo oluthile, njenge-ABRAXAS1, PIK3CB kunye ne-NUP93, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Apoptosis, i-Hematopoiesis kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, njengeMitomycin, kumiselwa kukudibana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Umzekelo, isongezelelo se-Omega-3 lukhetho olunengqiqo kwabo banePrayimari yePenile Squamous Cell Carcinoma ehamba neMitomycin. Oku kungenxa yokuba i-Omega-3 ichaphazela iindlela ezifana ne-Apoptosis, enokuthi ithintele izinto eziqhuba i-Primary Penile Squamous Cell Carcinoma okanye izuze ukusebenza kweMitomycin.

2. Ingaba izongezo zeOmega-3 zikhuselekile kubantu abasempilweni abaneCDH1 Mutation eNxulunyaniswe neMngcipheko yeGenetic?

I-CDH1 idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CDH1 kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Adherens junction kunye ne-Epithelial kwi-Mesenchymal Transition, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-CDH1 ehambelana noMhlaza weGastric, cinga ukufaka izongezo ze-Omega-3 kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela kakuhle iindlela ezifana ne-Epithelial ukuya kwi-Mesenchymal Transition, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abane-CDH1 yokuguqulwa kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezo ezifana ne-Omega-3, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• I-Palaeonthropology. Ixesha leeNeanderthals zokugqibela.
• cBioPortal for Cancer Genomics
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.
• Unyango lweeseli ezinomhlaza we-colorectal ongahlukangayo kunye ne-oyile yentlanzi ephuma kwi-docosahexaenoic acid ibangela i-caspase-3 isebenze kunye ne-apoptosis.
• [I-Lung edema elandela ukunkcenkceshela amathumbu ngesisombululo se-golytely].