Ke mofetše ofe o ka ruang molemo ka ho kenyelletsa Milk Thistle lijong tsa bona?

Lintlha-khōlō Tsa

Lebese la Lebese le tsebahala haholo ka melemo ea lona ea bophelo bo botle 'me hangata le sebelisoa ke bakuli ba mofetše le ba kotsing ea lefutso. Leha ho le joalo, polokeho le katleho ea Milk Thistle bakeng sa bakuli ba mofetše li ipapisitse le lintlha tse ngata joalo ka sesupo sa mofetše, chemotherapy, liphekolo tse ling, le lefutso la hlahala. Ho tseba hore lijo tse ling le li-supplement, tse kang grapefruit le spinach, li ka 'na tsa sebelisana hampe le meriana ea mofetše le ho baka maikutlo a mabe ho bohlokoa.

Lijo li bohlokoa bakeng sa kalafo ea mofets'e kaha li ka ama litholoana tsa kalafo. Bakuli ba mofetše ba tlameha ho khetha ka hloko le ho kenyelletsa lijo tse loketseng le li-supplement lijong tsa bona. Mohlala, Lebese la Thistle le ka tsoela ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin, empa e kanna ea se be molemo ho bakuli ba fumanang Radiation bakeng sa Primary Fibromatosis. Ho feta moo, le hoja Lebese la Lebese le ka thusa batho ba nang le lefutso la "TERT", ho ka 'na ha se ke ha etsoa tlhahiso bakeng sa ba nang le kotsi e fapaneng ea lefutso "CTNNB1". Ho iketsetsa merero ea ho ja ho latela bophelo bo botle, kalafo, le liphatsa tsa lefutso ho bohlokoa.

Ho utloisisa hore ho etsa qeto mabapi le ho tšoaneleha ha Lebese la Letsoai bakeng sa mokuli oa mofets'e ho bohlokoa hore e be motho ka mong. Lintlha tsa bohlokoa joalo ka mofuta oa mofetše, mekhoa ea kalafo, liphatsa tsa lefutso, likotsi tsa lefutso, lilemo, boima ba 'mele le mokhoa oa bophelo li bohlokoa ho etsa qeto ea hore na Lebese ke khetho e nepahetseng. Liphatsa tsa lefutso le liphatsa tsa lefutso, haholoholo, li nahanoa haholo. Kaha lintlha tsena li ka fetoha, ho bohlokoa ho hlahloba khafetsa le ho fetola khetho ea lijo ho tsamaisana le liphetoho tsa boemo ba bophelo bo botle le kalafo.

Qetellong, mokhoa o akaretsang oa khetho ea lijo o bohlokoa, o shebane le litlamorao tse akaretsang tsa likarolo tsohle tse sebetsang lijong / litlatsetso tse joalo ka Lebese la Lebese sebakeng sa ho lekola motsoako o mong le o mong o sebetsang ka thoko kapa ho o hlokomoloha ka botlalo. Maikutlo ana a pharaletseng a khothalletsa mokhoa o utloahalang le oa saense oa moralo oa lijo bakeng sa mofetše.

Kakaretso e Khutšoanyane

Tšebeliso ea lijo tse thehiloeng limela le li-supplement, tse kang livithamini, litlama, liminerale, li-probiotics, le lisebelisoa tse fapaneng tse khethehileng, li ntse li eketseha har'a bakuli ba mofetše. Li-supplement tsena li etselitsoe ho fana ka metsoako e phahameng ea metsoako e sebetsang, eo bongata ba eona e leng lijong tse fapaneng. Khokahano le mefuta e fapaneng ea metsoako e sebetsang e fapana lipakeng tsa lijo tse felletseng le li-supplement. Lijo hangata li fana ka mefuta e mengata ea metsoako e sebetsang empa maemong a tlase, athe li-supplement li fana ka metsoako e phahameng ea metsoako e itseng.

Ha ho nahanoa ka mesebetsi e fapaneng ea saense le ea tlhaho ea motsoako o mong le o mong o sebetsang boemong ba limolek'hule, ho bohlokoa ho ikarabella bakeng sa litlamorao tse kopaneng tsa likarolo tsena ha u etsa qeto ea lijo le li-supplement tseo u ka li jang kapa che.

Ho hlaha potso e mahlonoko: Na u lokela ho kenyelletsa Milk Thistle lijong tsa hau e le lijo kapa tlatsetso? Na ho bohlokoa ho sebelisa Lebese la Lebese haeba u na le liphatsa tsa lefutso tse amanang le mofetše o amanang le lefutso la TERT? Ho thoe'ng haeba ho e-na le hoo kotsi ea hau ea lefutso e bakoa ke lefutso la CTNNB1? Na ho molemo ho kenyelletsa Lebese la Lebese lijong tsa hau haeba u fumanoa u e-na le Primary Fibromatosis, kapa haeba tlhahlobo ea hau e le Primary Penile Squamous Cell Carcinoma? Ho feta moo, tšebeliso ea hau ea Milk Thistle e lokela ho fetoloa joang haeba u ntse u fuoa phekolo ea Mitomycin kapa morero oa hau oa phekolo o tloha ho Mitomycin ho ea ho Radiation? Ho bohlokoa ho hlokomela hore lipolelo tse bonolo tse kang 'Lebese la Lebese ke la tlhaho, kahoo le molemo ka linako tsohle' kapa 'Lebese le matlafatsa sesole sa 'mele' ha lea lekana bakeng sa khetho ea lijo/tlatsetso.

Ho feta moo, ho bohlokoa ho hlahloba bocha boleng ba ho kenyelletsa Lebese la Lebese lijong tsa hau haeba ho na le liphetoho mokhoeng oa hau oa kalafo. Ka bokhutšoanyane, ha u etsa liqeto mabapi le ho kenyelletsa lijo kapa li-supplement tse kang Milk Thistle lijong tsa hau bakeng sa melemo ea tsona, u lokela ho nahana ka litlamorao tse akaretsang tsa biochemical tsa metsoako eohle, ho nahanoa ka lintlha tse joalo ka mofuta oa mofets'e, kalafo e khethehileng eo u ntseng u e fuoa, liphatsa tsa lefutso. maemo a pele, le khetho ea mokhoa oa bophelo.

Cancer

Kankere e ntse e le phephetso e khōlō lefapheng la bongaka, hangata e bakang matšoenyeho a atileng. Leha ho le joalo, tsoelo-pele ea morao-rao e ntlafalitse liphello tsa phekolo, haholo-holo ka mekhoa ea phekolo ea motho ka mong, mekhoa ea ho hlahloba e sa hlaseleng ka ho sebelisa lisampole tsa mali le mathe, le nts'etsopele ea immunotherapy. Ho lemoha kapele le ho kenella ka nako ho bile bohlokoa ho ba le tšusumetso e ntle liphellong tsohle tsa phekolo.

Teko ea liphatsa tsa lefutso e fana ka ts'episo e kholo ea ho lekola kotsi ea mofetše le ho ba kotsing kapele. Leha ho le joalo, ho batho ba bangata ba nang le mekhoa ea malapa le ea liphatsa tsa lefutso ho kankere, mekhoa ea phekolo ea phekolo, esita le ka ho hlahloba kamehla, hangata e lekanyelitsoe kapa ha e eo. Hang ha ho fumanoa hore o na le mofuta o itseng oa mofetše, o kang Primary Penile Squamous Cell Carcinoma kapa Primary Fibromatosis, mekhoa ea phekolo e lokela ho etsoa ka mokhoa o ikhethileng ho latela liphatsa tsa lefutso tsa hlahala, boemo ba lefu lena, hammoho le lintlha tse kang lilemo le bong.

Ka mor'a kalafo, tlhahlobo e tsoelang pele e bohlokoa ho bona matšoao leha e le afe a ho khutlela mokhoeng oa mofets'e le ho tsebisa liqeto tse latelang. Bakuli ba bangata ba mofetše le ba kotsing hangata ba batla likeletso mabapi le ho kenyelletsa lijo tse itseng le li-supplement lijong tsa bona, e leng se phethang karolo ea bohlokoa ts'ebetsong ea bona ea ho etsa liqeto ka kakaretso mabapi le tsamaiso ea bophelo bo botle.

Potso ea bohlokoa ke hore na ho ameha likotsing tsa lefutso le tlhahlobo e khethehileng ea mofets'e ha u etsa qeto ea khetho ea lijo, joalo ka Milk Thistle. Na kotsi ea lefutso bakeng sa mofets'e e bakoang ke phetoho e teng ho TERT e na le litlamorao tse ts'oanang tsa biochemical le phetoho ho CTNNB1? Ho latela pono ea phepo e nepahetseng, na kotsi e amanang le Primary Penile Squamous Cell Carcinoma e lekana le Primary Fibromatosis? Ho feta moo, na tlhokomelo ea lijo e lula e tšoana bakeng sa ba nang le Radiation le ba amohelang Mitomycin? Lintlha tsena li bohlokoa ho etsa khetho e nepahetseng ea lijo bakeng sa batho ba nang le likotsi tse fapaneng tsa lefutso le kalafo ea mofets'e.

Lebese la Lebese - Tlatsetso ea Phepo

Tlatsetso ea Milk Thistle e kenyelletsa mefuta e mengata ea metsoako e sebetsang, ho kenyelletsa Silibinin, Vithamine E, Palmitic Acid, Oleic Acid le Linoleic Acid, e 'ngoe le e' ngoe e teng ka mefuta e fapaneng. Lithako tsena li susumetsa litsela tsa limolek'hule, haholo-holo Tokiso ea DNA, Epithelial to Mesenchymal Transition le MYC Signaling, e laolang likarolo tsa bohlokoa tsa mofets'e maemong a lisele, joalo ka kholo ea tumor, ho ata le lefu la lisele. Ka lebaka la tšusumetso ena ea tlhaho, ho khetha li-supplement tse nepahetseng joalo ka Lebese la Lebese, feela kapa ha li kopane, e ba qeto ea bohlokoa maemong a phepo e nepahetseng ea mofets'e. Ha u nahana ho sebelisa Lebese la Lebese bakeng sa mofetše, ho bohlokoa ho nahana ka lintlha tsena tse fapaneng le mekhoa. Lebaka ke hobane, joalo ka kalafo ea mofets'e, ts'ebeliso ea Milk Thistle ha se qeto e akaretsang e loketseng mafu a mofetše empa e hloka ho etsoa motho ka mong.

Ho Khetha Litlatsetso tsa Lebese

Ho araba potso e reng 'Ke lokela ho qoba Lebese la Thistle neng maemong a Kankere' ho thata hobane karabo e itšetlehile haholo ka motho ka mong - e mpa feela e le 'Ho ipapisitse le!'. Joalo ka ha kalafo efe kapa efe ea mofetše e kanna ea se sebetse ho mokuli e mong le e mong, bohlokoa le polokeho kapa melemo ea Milk Thistle e fapana ho latela maemo a motho. Lintlha tse kang mofuta o itseng oa mofetše, liphatsa tsa lefutso, liphekolo tsa morao-rao, li-supplement tse ling tse nkuoang, mekhoa ea bophelo, BMI, le lintho tse ling tse amanang le ho kula kaofela li phetha karolo ea ho tseba hore na Lebese la Lebese le loketse kapa le lokela ho qojoa, ho totobatsa bohlokoa ba ho nahanela motho ka mong. liqetong tse joalo.

1. Na Litlatsetso tsa Lebese la Lebese li tla tsoela Bakuli ba Pele ba Fibromatosis ba ntseng ba fuoa kalafo ea Radiation?

Fibromatosis ea mantlha e tšoauoa ka liphetoho tse itseng tsa liphatsa tsa lefutso, e leng CTNNB1, KDR le CIC, tse lebisang phetohong ea litsela tsa biochemical, haholo Epithelial ho Mesenchymal Transition, Adherens junction, Androgen Signaling, Angiogenesis le RAS-RAF Signaling. Katleho ea kalafo ea mofetše, joalo ka Radiation, e ipapisitse le mokhoa oa eona oa ts'ebetso litseleng tsena tse ikhethileng. Leano le nepahetseng le kenyelletsa ho hokahanya ts'ebetso ea kalafo le litsela tse tsamaisang mofets'e, ka hona ho netefatsa mokhoa oa motho ka mong le o sebetsang. Maemong a joalo, ho bohlokoa ho qoba lijo kapa lisebelisoa tsa phepo e nepahetseng tse ka hananang le litlamorao tsa kalafo kapa tsa fokotsa tumellano ena. Mohlala, tlatsetso ea Milk Thistle, e amang Epithelial to Mesenchymal Transition, e kanna ea se be khetho e nepahetseng tabeng ea Primary Fibromatosis ha e etsoa ke Radiation. Lebaka ke hobane e ka 'na ea mpefatsa tsoelo-pele ea lefu lena kapa ea kena-kenana le katleho ea phekolo. Ha u khetha moralo oa phepo e nepahetseng, ho bohlokoa ho nahana ka lintlha tse kang mofuta oa mofets'e, kalafo e tsoelang pele, lilemo, bong, BMI, mokhoa oa bophelo le liphetoho life kapa life tse tsebahalang tsa lefutso.

2. Na Litlatsetso tsa Lebese la Lebese li tla thusa bakuli ba Primary Penile Squamous Cell Carcinoma ba ntseng ba etsoa kalafo ea Mitomycin?

Penile Squamous Cell Carcinoma e khetholloa ka liphetoho tse khethehileng tsa lefutso, tse kang ABRAXAS1, PIK3CB le NUP93, tse hlahisang liphetoho litseleng tsa lik'hemik'hale, haholo-holo DNA Repair, Hematopoiesis le Inositol Phosphate Signaling. Katleho ea kalafo ea mofetše, joalo ka Mitomycin, e khethoa ke tšebelisano ea eona le litsela tsena. Sepheo ke ho netefatsa hore phekolo e lumellana hantle le litsela tse tsamaisang mofetše, e leng ho nolofalletsang mokhoa oa phekolo ea motho ka mong. Tabeng ena, ho lokela ho nahanoa ka lijo kapa li-supplement tse tsamaellanang le kalafo kapa tse matlafatsang tekano ena. Ka mohlala, tlatsetso ea Milk Thistle ke khetho e utloahalang bakeng sa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin. Lebaka ke hobane Lebese la Lebese le susumetsa litsela tse kang DNA Repair, tse ka thibelang lintho tse khannang Primary Penile Squamous Cell Carcinoma kapa tsa thusa katleho ea Mitomycin.

3. Na Litlatsetso tsa Lebese la Lebese li Sireletsehile ho Batho ba Phelang ba nang le CTNNB1 Mutation Associated Genetic Risk?

Likhamphani tse fapaneng li fana ka liphanele tsa lefutso bakeng sa ho lekola kotsi ea lefutso ea mefuta e fapaneng ea mofets'e. Liphanele tsena li kenyelletsa liphatsa tsa lefutso tse amanang le kankere ea matsoele, ea mahe a bomme, ea popelo, ea senya le ea mala. Ho lekola liphatsa tsa lefutso tsena ho ka netefatsa tlhahlobo le ho tsebisa mekhoa ea kalafo le taolo. Ho tseba phapang e bakang mafu ho ka thusa ho ea pele tlhahlobong le tlhahlobong ea beng ka bona ba ka bang kotsing. Mofuta oa CTNNB1 hangata o kenyelelitsoe liphanele tsena bakeng sa tlhahlobo ea kotsi ea mofetše.

Phetoho ea liphatsa tsa lefutso tsa CTNNB1 e ama litsela kapa mekhoa ea lik'hemik'hale, tse kang Adherens junction le Epithelial to Mesenchymal Transition, tse amehang ka ho toba kapa ka tsela e sa tobang ho khanna kankere boemong ba molek'hule. Ha phanele ea liphatsa tsa lefutso e supa phetoho ho CTNNB1 e amanang le kotsi e eketsehileng ea Adrenocortical Carcinoma, mabaka a saense a fana ka maikutlo a ho qoba tšebeliso ea tlatsetso ea Milk Thistle. Lebaka ke hobane tlatsetso ea Milk Thistle e susumetsa litsela tse kang Epithelial to Mesenchymal Transition, e ka lebisang litlamorao tse mpe maemong a phetoho ea CTNNB1 le maemo a amanang le mofetše.

4. Na Litlatsetso tsa Lebese la Lebese li Sireletsehile ho Batho ba Phelang ba Na le TERT Mutation Associated Genetic Risk?

TERT e bapala karolo ea bohlokoa tlhahlobong ea kotsi ea mofetše. Liphetoho ho TERT li ka sitisa litsela tsa bohlokoa tsa biochemical, ho kenyelletsa le MYC Signaling le DNA Repair, tse susumetsang nts'etsopele ea mofetše. Haeba phanele ea liphatsa tsa lefutso ea hau e senola liphetoho tsa TERT tse amanang le Kankere ea Hematological, nahana ka ho kenyelletsa li-supplement tsa Milk Thistle moralong oa hau oa phepo. Li-supplement tsena li ka susumetsa mekhoa e kang MYC Signaling, ho rua molemo ka ho fana ka ts'ehetso e nepahetseng bakeng sa batho ba nang le liphetoho tsa TERT le mathata a amanang le bophelo bo botle.

Ha re phethela

Lintho tse peli tsa bohlokoa ka ho fetisisa tseo u lokelang ho li hopola ke hore phekolo ea kankere le phepo e nepahetseng ha ho mohla li tšoanang ho bohle. Phepo e nepahetseng, ho kenyelletsa lijo le li-supplement joalo ka Milk Thistle, ke sesebelisoa se sebetsang se ka laoloang ke uena ha u ntse u tobane le mofetše.

“Ke lokela ho ja eng?” ke potso e atisang ho botsoa ke bakuli ba mofetše le ba kotsing ea ho tšoaroa ke mofetše. Karabo e nepahetseng ke hore e ipapisitse le lintlha tse kang mofuta oa mofets'e, liphatsa tsa lefutso tsa hlahala, kalafo ea hajoale, ho kula, mokhoa oa bophelo le BMI.

Fumana phepo ea hau ea phepo e nepahetseng bakeng sa mofets'e ho tsoa ho addon ka ho tobetsa sehokelo se ka tlase le ho araba lipotso mabapi le mofuta oa mofets'e oa hau, kalafo, mokhoa oa bophelo, ho kula, lilemo le bong.

References

• Ts'ebetso ea PPAR gamma le delta ka conjugated linoleic acid e sireletsa tšireletso khahlanong le lefu la mala a ho ruruha.
• Tšusumetso e thibelang ea tocotrienol ho eukaryotic DNA polymerase lambda le angiogenesis.
• cBioPortal bakeng sa Cancer Genomics
• Ho hanyetsa seea-le-moea liseleng tsa mofetše oa matsoele ho fetisoa ka pontšo ea TGF-β, hybrid epithelial-mesenchymal phenotype le lisele tsa kankere.
• Phello ea mefokolo ea tokiso ea DNA ho cytotoxicity ea lithethefatsi tse sebelisoang kalafong ea mofets'e - tlhahlobo.
• Kalafo ea mofets'e e theha sebopeho sa boikoetliso ba clonal hematopoiesis.
• cBioPortal bakeng sa Cancer Genomics
• Karolo ea phospholipase D ho falla le tlhaselo e bakoang ke linoleic acid liseleng tsa mofetše oa matsoele.