Ke mofetše ofe o ka ruang molemo ka ho kenyelletsa Melatonin lijong tsa bona?

Lintlha-khōlō Tsa

Melatonin e tsebahala haholo ka melemo ea eona ea bophelo bo botle 'me hangata e sebelisoa ke bakuli ba mofetše le ba kotsing ea lefutso. Leha ho le joalo, polokeho le katleho ea Melatonin bakeng sa bakuli ba mofetše li ipapisitse le lintlha tse ngata joalo ka sesupo sa mofetše, chemotherapy, liphekolo tse ling le liphatsa tsa lefutso tsa hlahala. Ho tseba hore lijo tse ling le li-supplement, tse kang grapefruit le spinach, li ka 'na tsa sebelisana hampe le meriana ea mofetše le ho baka maikutlo a mabe ho bohlokoa.

Lijo li bohlokoa bakeng sa kalafo ea mofets'e kaha li ka ama litholoana tsa kalafo. Bakuli ba mofetše ba tlameha ho khetha ka hloko le ho kenyelletsa lijo tse loketseng le li-supplement lijong tsa bona. Ka mohlala, Melatonin e ka thusa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin, empa ho ka 'na ha se ke ha e-ba molemo ho bakuli ba fumanang Radiation bakeng sa Primary Sclerosing Epithelioid Fibrosarcoma. Ho feta moo, le hoja Melatonin e ka thusa batho ba nang le "CDH1" ea kotsi ea lefutso, e ka 'na ea se ke ea buelloa ho ba nang le kotsi e fapaneng ea lefutso "B2M". Ho iketsetsa merero ea ho ja ho latela bophelo bo botle, kalafo, le liphatsa tsa lefutso ho bohlokoa.

Ho utloisisa hore ho etsa qeto mabapi le ho lekana ha Melatonin bakeng sa mokuli oa mofets'e ho bohlokoa ho ba motho ka mong. Lintlha tsa bohlokoa tse kang mofuta oa mofetše, mekhoa ea phekolo, liphatsa tsa lefutso, likotsi tsa lefutso, lilemo, boima ba 'mele le mokhoa oa bophelo li bohlokoa ho etsa qeto ea hore na Melatonin ke khetho e nepahetseng. Liphatsa tsa lefutso le liphatsa tsa lefutso, haholoholo, li nahanoa haholo. Kaha lintlha tsena li ka fetoha, ho bohlokoa ho hlahloba khafetsa le ho fetola khetho ea lijo ho tsamaisana le liphetoho tsa boemo ba bophelo bo botle le kalafo.

Qetellong, mokhoa o akaretsang oa khetho ea lijo ke oa bohlokoa, o lebisa tlhokomelo liphellong tse akaretsang tsa likarolo tsohle tse sebetsang lijong / lisebelisoa tse kang Melatonin ho e-na le ho hlahloba motsoako o mong le o mong o sebetsang ka thoko kapa ho o hlokomoloha ka ho feletseng. Maikutlo ana a pharaletseng a khothalletsa mokhoa o utloahalang le oa saense oa moralo oa lijo bakeng sa mofetše.

Kakaretso e Khutšoanyane

Tšebeliso ea lijo tse thehiloeng limela le li-supplement, tse kang livithamini, litlama, liminerale, li-probiotics, le lisebelisoa tse fapaneng tse khethehileng, li ntse li eketseha har'a bakuli ba mofetše. Li-supplement tsena li etselitsoe ho fana ka metsoako e phahameng ea metsoako e sebetsang, eo bongata ba eona e leng lijong tse fapaneng. Khokahano le mefuta e fapaneng ea metsoako e sebetsang e fapana lipakeng tsa lijo tse felletseng le li-supplement. Lijo hangata li fana ka mefuta e mengata ea metsoako e sebetsang empa maemong a tlase, athe li-supplement li fana ka metsoako e phahameng ea metsoako e itseng.

Ha ho nahanoa ka mesebetsi e fapaneng ea saense le ea tlhaho ea motsoako o mong le o mong o sebetsang boemong ba limolek'hule, ho bohlokoa ho ikarabella bakeng sa litlamorao tse kopaneng tsa likarolo tsena ha u etsa qeto ea lijo le li-supplement tseo u ka li jang kapa che.

Ho hlaha potso ea bohlokoa: Na u lokela ho kenyelletsa Melatonin lijong tsa hau e le ntho ea lijo kapa tlatsetso? Na ho bohlokoa ho sebelisa Melatonin haeba u na le liphatsa tsa lefutso tse amanang le mofetše oa CDH1? Ho thoe'ng haeba ho e-na le hoo kotsi ea hau ea liphatsa tsa lefutso e tsoa ho mofuta oa B2M? Na ho molemo ho kenyelletsa Melatonin lijong tsa hau haeba u fumanoa u e-na le Primary Sclerosing Epithelioid Fibrosarcoma, kapa haeba tlhahlobo ea hau e le Primary Penile Squamous Cell Carcinoma? Ho feta moo, tšebeliso ea hau ea Melatonin e lokela ho fetoloa joang haeba u ntse u fuoa phekolo ea Mitomycin kapa morero oa hau oa phekolo o tloha ho Mitomycin ho ea ho Radiation? Ho bohlokoa ho hlokomela hore lipolelo tse bonolo tse kang 'Melatonin ke ntho ea tlhaho, kahoo e lula e le molemo' kapa 'Melatonin e matlafatsa sesole sa' mele ha e lekane bakeng sa khetho ea lijo/tlatsetso.

Ho feta moo, ho bohlokoa ho hlahloba bocha ho nepahala ha ho kenyelletsa Melatonin lijong tsa hau haeba ho na le liphetoho mokhoeng oa hau oa kalafo. Ka bokhutšoanyane, ha u etsa liqeto mabapi le ho kenyelletsa lijo kapa li-supplement tse kang Melatonin lijong tsa hau bakeng sa melemo ea eona, u lokela ho nahana ka litlamorao tse akaretsang tsa biochemical ea metsoako eohle, ho nahanoa ka lintlha tse kang mofuta oa mofets'e, kalafo e ikhethileng eo u e fuoang, liphatsa tsa lefutso. , le khetho ea bophelo.

Cancer

Kankere e ntse e le phephetso e khōlō lefapheng la bongaka, hangata e bakang matšoenyeho a atileng. Leha ho le joalo, tsoelo-pele ea morao-rao e ntlafalitse liphello tsa phekolo, haholo-holo ka mekhoa ea phekolo ea motho ka mong, mekhoa ea ho hlahloba e sa hlaseleng ka ho sebelisa lisampole tsa mali le mathe, le nts'etsopele ea immunotherapy. Ho lemoha kapele le ho kenella ka nako ho bile bohlokoa ho ba le tšusumetso e ntle liphellong tsohle tsa phekolo.

Teko ea liphatsa tsa lefutso e fana ka ts'episo e kholo ea ho lekola kotsi ea mofetše le ho ba kotsing kapele. Leha ho le joalo, ho batho ba bangata ba nang le mekhoa ea malapa le ea liphatsa tsa lefutso ho kankere, mekhoa ea phekolo ea phekolo, esita le ka ho hlahloba kamehla, hangata e lekanyelitsoe kapa ha e eo. Hang ha ho fumanoa hore o na le mofuta o itseng oa kankere, o kang Primary Penile Squamous Cell Carcinoma kapa Primary Sclerosing Epithelioid Fibrosarcoma, mekhoa ea phekolo e lokela ho etsoa ho latela liphatsa tsa lefutso tsa hlahala, boemo ba lefu lena, hammoho le lintlha tse kang lilemo le bong. ”

Ka mor'a kalafo, tlhahlobo e tsoelang pele e bohlokoa ho bona matšoao leha e le afe a ho khutlela mokhoeng oa mofets'e le ho tsebisa liqeto tse latelang. Bakuli ba bangata ba mofetše le ba kotsing hangata ba batla likeletso mabapi le ho kenyelletsa lijo tse itseng le li-supplement lijong tsa bona, e leng se phethang karolo ea bohlokoa ts'ebetsong ea bona ea ho etsa liqeto ka kakaretso mabapi le tsamaiso ea bophelo bo botle.

Potso ea bohlokoa ke hore na ho ameha likotsing tsa lefutso le tlhahlobo e khethehileng ea mofets'e ha u etsa qeto mabapi le khetho ea lijo, joalo ka Melatonin. Na kotsi ea liphatsa tsa lefutso bakeng sa mofets'e e bakoang ke phetoho ho CDH1 e na le mekhoa e ts'oanang ea biochemical joalo ka phetoho ho B2M? Ho latela pono ea phepo e nepahetseng, na kotsi e amanang le Primary Penile Squamous Cell Carcinoma e lekana le Primary Sclerosing Epithelioid Fibrosarcoma? Ho feta moo, na tlhokomelo ea lijo e lula e tšoana bakeng sa ba nang le Radiation le ba amohelang Mitomycin? Lintlha tsena li bohlokoa ho etsa khetho e nepahetseng ea lijo bakeng sa batho ba nang le likotsi tse fapaneng tsa lefutso le kalafo ea mofets'e.

Melatonin - Tlatsetso ea Phepo

Tlatsetso ea Melatonin e kenyelletsa mefuta e mengata ea metsoako e sebetsang, ho kenyeletsoa Melatonin, e 'ngoe le e' ngoe e teng ka maemo a fapaneng. Lithako tsena li susumetsa litsela tsa limolek'hule, haholo-holo PI3K-AKT-MTOR Signaling, TGFB Signaling le Growth Factor Signaling, e laolang likarolo tsa bohlokoa tsa mofets'e maemong a lisele, joalo ka kholo ea tumor, ho ata le lefu la lisele. Ka lebaka la tšusumetso ena ea tlhaho, ho khetha li-supplement tse loketseng joalo ka Melatonin, e le 'ngoe kapa ha e kopane, e fetoha qeto e boima molemong oa phepo ea mofets'e. Ha u nahana ka ho sebelisa Melatonin bakeng sa mofetše, ho bohlokoa ho nahana ka lintlha tsena tse fapaneng le mekhoa. Lebaka ke hobane, joalo ka kalafo ea mofets'e, ts'ebeliso ea Melatonin ha se qeto e akaretsang e loketseng mefuta eohle ea mofets'e empa e hloka ho etsoa motho ka mong.

Ho Khetha Melatonin Tlatsetso

Ho araba potso e reng 'Ke lokela ho qoba Melatonin neng maemong a Kankere' ho thata hobane karabo e itšetlehile haholo ka motho ka mong - e mpa feela e le 'Ho itšetlehile!'. Joalo ka ha kalafo efe kapa efe ea mofetše e kanna ea se sebetse ho mokuli e mong le e mong, bohlokoa le polokeho kapa melemo ea Melatonin e fapana ho latela maemo a motho. Lintho tse kang mofuta o itseng oa mofetše, liphatsa tsa lefutso, liphekolo tsa morao-rao, li-supplement tse ling tse nkuoang, mekhoa ea bophelo, BMI, le lintho tse ling tse amanang le ho kula, kaofela li na le karolo ho bona hore na Melatonin e nepahetse kapa e lokela ho qojoa, e totobatsa bohlokoa ba ho nahanela motho ka mong. liqeto tse joalo.

1. Na Melatonin Supplements e tla thusa bakuli ba Primary Sclerosing Epithelioid Fibrosarcoma ba ntseng ba etsoa kalafo ea Radiation?

Primary Sclerosing Epithelioid Fibrosarcoma e tšoauoa ka liphetoho tse itseng tsa lefutso, e leng PBRM1, ATRX le PIK3C2G, tse lebisang phetohong ea litsela tsa biochemical, haholo-holo TGFB Signaling le Inositol Phosphate Signaling. Katleho ea kalafo ea mofetše, joalo ka Radiation, e ipapisitse le mokhoa oa eona oa ts'ebetso litseleng tsena tse ikhethileng. Leano le nepahetseng le kenyelletsa ho hokahanya ts'ebetso ea kalafo le litsela tse tsamaisang mofets'e, ka hona ho netefatsa mokhoa oa motho ka mong le o sebetsang. Maemong a joalo, ho bohlokoa ho qoba lijo kapa lisebelisoa tsa phepo e nepahetseng tse ka hananang le litlamorao tsa kalafo kapa tsa fokotsa tumellano ena. Ka mohlala, tlatsetso ea Melatonin, e amang Letšoao la TGFB, e ka 'na ea se ke ea e-ba khetho e nepahetseng tabeng ea Primary Sclerosing Epithelioid Fibrosarcoma ha e etsoa ke Radiation. Lebaka ke hobane e ka 'na ea mpefatsa tsoelo-pele ea lefu lena kapa ea kena-kenana le katleho ea phekolo. Ha u khetha moralo oa phepo e nepahetseng, ho bohlokoa ho nahana ka lintlha tse kang mofuta oa mofets'e, kalafo e tsoelang pele, lilemo, bong, BMI, mokhoa oa bophelo le liphetoho life kapa life tse tsebahalang tsa lefutso.

2. Na Melatonin Supplements e tla thusa Bakuli ba Pele ba Penile Squamous Cell Carcinoma ba ntseng ba etsoa ka Kalafo ea Mitomycin?

Penile Squamous Cell Carcinoma e khetholloa ka liphetoho tse itseng tsa lefutso, tse kang ABRAXAS1, PIK3CB le NUP93, tse hlahisang liphetoho litseleng tsa lik'hemik'hale, haholo-holo PI3K-AKT-MTOR Signaling, Hematopoiesis le Inositol Phosphate Signaling. Katleho ea kalafo ea mofetše, joalo ka Mitomycin, e khethoa ke tšebelisano ea eona le litsela tsena. Sepheo ke ho netefatsa hore phekolo e lumellana hantle le litsela tse tsamaisang mofetše, e leng ho nolofalletsang mokhoa oa phekolo ea motho ka mong. Tabeng ena, lijo kapa li-supplement tse tsamaellanang le kalafo kapa tse matlafatsang tekano ena li lokela ho nahanoa. Ka mohlala, tlatsetso ea Melatonin ke khetho e utloahalang bakeng sa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin. Lebaka ke hobane Melatonin e susumetsa litsela tse kang PI3K-AKT-MTOR Signaling, e ka thibelang lintlha tse khanna Primary Penile Squamous Cell Carcinoma kapa ea rua molemo katlehong ea Mitomycin.

3. Na Melatonin Supplements e Sireletsehile ho Batho ba Phelang ba nang le B2M Mutation Associated Genetic Risk?

Likhamphani tse fapaneng li fana ka liphanele tsa lefutso bakeng sa ho lekola kotsi ea lefutso ea mefuta e fapaneng ea mofets'e. Liphanele tsena li kenyelletsa liphatsa tsa lefutso tse amanang le kankere ea matsoele, ea mahe a bomme, ea popelo, ea senya le ea mala. Ho lekola liphatsa tsa lefutso tsena ho ka netefatsa tlhahlobo le ho tsebisa mekhoa ea kalafo le taolo. Ho tseba phapang e bakang mafu ho ka thusa ho ea pele tlhahlobong le tlhahlobong ea beng ka bona ba ka bang kotsing. Mofuta oa B2M hangata o kenyelelitsoe liphanele tsena bakeng sa tlhahlobo ea kotsi ea mofetše.

Phetoho ea mofuta oa B2M e ama litsela kapa mekhoa ea lik'hemik'hale, tse kang TGFB Signaling le Antigen Presentation, tse amehang ka ho toba kapa ka tsela e sa tobang ho khanna kankere boemong ba limolek'hule. Ha phanele ea liphatsa tsa lefutso e supa phetoho ho B2M e amanang le kotsi e eketsehileng ea Diffuse Large B-cell Lymphoma, mabaka a saense a fana ka maikutlo a ho qoba tšebeliso ea tlatsetso ea Melatonin. Lebaka ke hobane tlatsetso ea Melatonin e susumetsa litsela tse kang TGFB Signaling, e ka lebisang litlamorao tse mpe molemong oa phetoho ea B2M le maemo a amanang le mofets'e.

4. Na Lisebelisoa tsa Melatonin li Sireletsehile ho Batho ba Phelang ba nang le CDH1 Mutation Associated Genetic Risk?

CDH1 e bapala karolo ea bohlokoa tlhahlobong ea kotsi ea mofetše. Liphetoho tsa CDH1 li ka sitisa litsela tsa bohlokoa tsa lik'hemik'hale tsa likokoana-hloko, ho kenyelletsa le Growth Factor Signaling, Adherens junction le Epithelial to Mesenchymal Transition, tse susumetsang nts'etsopele ea kankere. Haeba phanele ea liphatsa tsa lefutso tsa hau e senola liphetoho tsa CDH1 tse amanang le Kankere ea Gastric, nahana ka ho kenyelletsa Melatonin e tlatsetsang moralong oa hau oa phepo. Li-supplement tsena li ka susumetsa hantle litsela tse kang Growth Factor Signaling, ho rua molemo ka ho fana ka tšehetso e nepahetseng bakeng sa batho ba nang le liphetoho tsa CDH1 le mathata a amanang le bophelo bo botle.

Ha re phethela

Lintho tse peli tsa bohlokoa ka ho fetisisa tseo u lokelang ho li hopola ke hore phekolo ea kankere le phepo e nepahetseng ha ho mohla li tšoanang ho bohle. Phepo e nepahetseng, ho kenyelletsa lijo le li-supplement joalo ka Melatonin, ke sesebelisoa se sebetsang se ka laoloang ke uena ha u ntse u tobane le mofetše.

“Ke lokela ho ja eng?” ke potso e atisang ho botsoa ke bakuli ba mofetše le ba kotsing ea ho tšoaroa ke mofetše. Karabo e nepahetseng ke hore e ipapisitse le lintlha tse kang mofuta oa mofets'e, liphatsa tsa lefutso tsa hlahala, kalafo ea hajoale, ho kula, mokhoa oa bophelo le BMI.

Fumana phepo ea hau ea phepo e nepahetseng bakeng sa mofets'e ho tsoa ho addon ka ho tobetsa sehokelo se ka tlase le ho araba lipotso mabapi le mofuta oa mofets'e oa hau, kalafo, mokhoa oa bophelo, ho kula, lilemo le bong.

References

• Melatonin le vithamine D3 synergistically down-regulate Akt le MDM2 e lebisang ho TGFβ-1-e itšetlehileng ka kholo e thibelang lisele tsa kankere ea matsoele.
• cBioPortal bakeng sa Cancer Genomics
• Sebopeho sa li-receptor tsa epidermal growth factor ho astrocytic glial le lisele tsa neuronal moetlong oa mantlha.
• Kalafo ea mofets'e e theha sebopeho sa boikoetliso ba clonal hematopoiesis.
• Ho hanyetsa seea-le-moea liseleng tsa mofetše oa matsoele ho fetisoa ka pontšo ea TGF-β, hybrid epithelial-mesenchymal phenotype le lisele tsa kankere.
• Boemo bo feto-fetohang ba mofetše oa metastatic bo senotsoe ho tsoa ho tatellano ea kliniki ea bakuli ba 10,000.
• Melatonin e Attenuates Her-2, p38 MAPK, p-AKT, le MTOR Maemo a Ovarian Carcinoma ea Ethanol-Preferring Rats.