Ke mofetše ofe o ka ruang molemo ka ho kenyelletsa Kava lijong tsa bona?

Lintlha-khōlō Tsa

Kava e tsebahala haholo ka melemo ea eona ea bophelo bo botle mme e sebelisoa khafetsa ke bakuli ba mofetše le ba kotsing ea lefutso. Leha ho le joalo, polokeho le katleho ea Kava bakeng sa bakuli ba mofetše li ipapisitse le lintlha tse ngata joalo ka sesupo sa mofetše, chemotherapy, liphekolo tse ling le liphatsa tsa lefutso tsa hlahala. Ho tseba hore lijo tse ling le li-supplement, tse kang grapefruit le spinach, li ka 'na tsa sebelisana hampe le meriana ea mofetše le ho baka maikutlo a mabe ho bohlokoa.

Lijo li bohlokoa bakeng sa kalafo ea mofets'e kaha li ka ama litholoana tsa kalafo. Bakuli ba mofetše ba tlameha ho khetha ka hloko le ho kenyelletsa lijo tse loketseng le li-supplement lijong tsa bona. Ka mohlala, Kava e ka thusa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin, empa e ka 'na ea se ke ea e-ba molemo ho bakuli ba fumanang Gemcitabine bakeng sa Primary Urachal adenocarcinoma. Ho feta moo, le hoja Kava e ka thusa batho ba nang le "TERT" ea kotsi ea lefutso, e ka 'na ea se ke ea buelloa ho ba nang le kotsi e fapaneng ea liphatsa tsa lefutso "ASXL1". Ho iketsetsa merero ea ho ja ho latela bophelo bo botle, kalafo, le liphatsa tsa lefutso ho bohlokoa.

Ho utloisisa hore ho etsa qeto mabapi le ho lekana ha Kava bakeng sa mokuli oa mofets'e ho bohlokoa ho ba motho ka mong. Lintlha tsa bohlokoa tse kang mofuta oa mofetše, mekhoa ea phekolo, liphatsa tsa lefutso, likotsi tsa lefutso, lilemo, boima ba 'mele le mokhoa oa bophelo li bohlokoa ho etsa qeto ea hore na Kava ke khetho e nepahetseng. Liphatsa tsa lefutso le liphatsa tsa lefutso, haholo-holo, li nahanoa haholo. Kaha lintlha tsena li ka fetoha, ho bohlokoa ho hlahloba khafetsa le ho fetola khetho ea lijo ho tsamaisana le liphetoho tsa boemo ba bophelo bo botle le kalafo.

Qetellong, mokhoa o akaretsang oa khetho ea lijo ke oa bohlokoa, o lebisa tlhokomelo liphellong tse akaretsang tsa likarolo tsohle tse sebetsang lijong / li-supplement tse kang Kava ho e-na le ho hlahloba motsoako o mong le o mong o sebetsang ka thoko kapa ho o hlokomoloha ka ho feletseng. Maikutlo ana a pharaletseng a khothalletsa mokhoa o utloahalang le oa saense oa moralo oa lijo bakeng sa mofetše.

Kakaretso e Khutšoanyane

Tšebeliso ea lijo tse thehiloeng limela le li-supplement, tse kang livithamini, litlama, liminerale, li-probiotics, le lisebelisoa tse fapaneng tse khethehileng, li ntse li eketseha har'a bakuli ba mofetše. Li-supplement tsena li etselitsoe ho fana ka metsoako e phahameng ea metsoako e sebetsang, eo bongata ba eona e leng lijong tse fapaneng. Khokahano le mefuta e fapaneng ea metsoako e sebetsang e fapana lipakeng tsa lijo tse felletseng le li-supplement. Lijo hangata li fana ka mefuta e mengata ea metsoako e sebetsang empa maemong a tlase, athe li-supplement li fana ka metsoako e phahameng ea metsoako e itseng.

Ha ho nahanoa ka mesebetsi e fapaneng ea saense le ea tlhaho ea motsoako o mong le o mong o sebetsang boemong ba limolek'hule, ho bohlokoa ho ikarabella bakeng sa litlamorao tse kopaneng tsa likarolo tsena ha u etsa qeto ea lijo le li-supplement tseo u ka li jang kapa che.

Ho hlaha potso ea bohlokoa: Na u lokela ho kenyelletsa Kava lijong tsa hau e le ntho ea lijo kapa tlatsetso? Na ho bohlokoa ho sebelisa Kava haeba u na le liphatsa tsa lefutso tse amanang le mofetše oa TERT? Ho thoe'ng haeba ho e-na le hoo kotsi ea hau ea liphatsa tsa lefutso e bakoa ke lefutso la ASXL1? Na ho molemo ho kenyelletsa Kava lijong tsa hau haeba u fumanoa u e-na le Primary Urachal adenocarcinoma, kapa haeba tlhahlobo ea hau e le Primary Penile Squamous Cell Carcinoma? Ho feta moo, tšebeliso ea hau ea Kava e lokela ho fetoloa joang haeba u ntse u fuoa phekolo ea Mitomycin kapa haeba moralo oa hau oa phekolo o tloha Mitomycin ho ea Gemcitabine? Ho bohlokoa ho hlokomela hore lipolelo tse bonolo tse kang 'Kava ke ea tlhaho, kahoo e lula e le molemo' kapa 'Kava e matlafatsa sesole sa' mele ha e lekane bakeng sa khetho ea lijo / tlatsetso.

Ho feta moo, ho bohlokoa ho hlahloba bocha ho nepahala ha ho kenyelletsa Kava lijong tsa hau haeba ho na le liphetoho mokhoeng oa hau oa kalafo. Ka bokhutšoanyane, ha u etsa liqeto mabapi le ho kenyelletsa lijo kapa li-supplement tse kang Kava lijong tsa hau bakeng sa melemo ea eona, u lokela ho nahana ka litlamorao tse akaretsang tsa biochemical ea metsoako eohle, ho nahanoa ka lintlha tse kang mofuta oa mofets'e, kalafo e ikhethileng eo u e fuoang, liphatsa tsa lefutso. , le khetho ea bophelo.

Cancer

Kankere e ntse e le phephetso e khōlō lefapheng la bongaka, hangata e bakang matšoenyeho a atileng. Leha ho le joalo, tsoelo-pele ea morao-rao e ntlafalitse liphello tsa phekolo, haholo-holo ka mekhoa ea phekolo ea motho ka mong, mekhoa ea ho hlahloba e sa hlaseleng ka ho sebelisa lisampole tsa mali le mathe, le nts'etsopele ea immunotherapy. Ho lemoha kapele le ho kenella ka nako ho bile bohlokoa ho ba le tšusumetso e ntle liphellong tsohle tsa phekolo.

Teko ea liphatsa tsa lefutso e fana ka ts'episo e kholo ea ho lekola kotsi ea mofetše le ho ba kotsing kapele. Leha ho le joalo, ho batho ba bangata ba nang le mekhoa ea malapa le ea liphatsa tsa lefutso ho kankere, mekhoa ea phekolo ea phekolo, esita le ka ho hlahloba kamehla, hangata e lekanyelitsoe kapa ha e eo. Hang ha ho fumanoa hore o na le mofuta o itseng oa mofetše, o kang Primary Penile Squamous Cell Carcinoma kapa Primary Urachal adenocarcinoma, mekhoa ea phekolo e lokela ho hlophisoa ho latela liphatsa tsa lefutso tsa hlahala, boemo ba lefu lena, hammoho le lintlha tse kang lilemo le bong.

Ka mor'a kalafo, tlhahlobo e tsoelang pele e bohlokoa ho bona matšoao leha e le afe a ho khutlela mokhoeng oa mofets'e le ho tsebisa liqeto tse latelang. Bakuli ba bangata ba mofetše le ba kotsing hangata ba batla likeletso mabapi le ho kenyelletsa lijo tse itseng le li-supplement lijong tsa bona, e leng se phethang karolo ea bohlokoa ts'ebetsong ea bona ea ho etsa liqeto ka kakaretso mabapi le tsamaiso ea bophelo bo botle.

Potso ea bohlokoa ke hore na ho ameha likotsing tsa lefutso le tlhahlobo e khethehileng ea mofetše ha u etsa qeto ea khetho ea lijo, joalo ka Kava. Na kotsi ea lefutso ea mofets'e e bakoang ke phetoho ho TERT e na le litlamorao tse ts'oanang tsa biochemical le phetoho ho ASXL1? Ho latela pono ea phepo e nepahetseng, na kotsi e amanang le Primary Penile Squamous Cell Carcinoma e lekana le Primary Urachal adenocarcinoma? Ho feta moo, na tlhokomelo ea lijo e lula e tšoana bakeng sa ba kenang Gemcitabine le ba amohelang Mitomycin? Lintlha tsena li bohlokoa ho etsa khetho e nepahetseng ea lijo bakeng sa batho ba nang le likotsi tse fapaneng tsa lefutso le kalafo ea mofets'e.

Kava - Tlatsetso ea Phepo

Kava ea tlatsetso e kenyelletsa mefuta e mengata ea metsoako e sebetsang, ho kenyelletsa Kavain le Flavokawain B, e 'ngoe le e' ngoe e teng ka maemo a fapaneng. Lithako tsena li susumetsa litsela tsa limolek'hule, haholo-holo Apoptosis, Oxidative Stress, Cytokine Signaling le Angiogenesis, tse laolang likarolo tse mahlonoko tsa mofets'e maemong a lisele, joalo ka kholo ea tumor, ho ata le lefu la lisele. Ka lebaka la tšusumetso ena ea likokoana-hloko, ho khetha li-supplement tse loketseng joaloka Kava, e le 'ngoe kapa e kopane, e fetoha qeto ea bohlokoa tabeng ea phepo ea mofetše. Ha u nahana ho sebelisa Kava bakeng sa mofetše, ho bohlokoa ho nahana ka lintlha tsena tse fapaneng le mekhoa. Lebaka ke hobane, joalo ka kalafo ea mofets'e, ts'ebeliso ea Kava ha se qeto e akaretsang e loketseng mafu a mofetše empa e hloka ho etsoa motho ka mong.

Ho Khetha Lisebelisoa tsa Kava

Ho araba potso e reng 'Ke lokela ho qoba Kava neng maemong a Kankere' ho thata hobane karabo ke ea motho ka mong - e mpa feela e le 'Ho itšetlehile!'. Joalo ka ha kalafo efe kapa efe ea mofetše e kanna ea se sebetse ho mokuli e mong le e mong, bohlokoa le polokeho kapa melemo ea Kava e fapana ho latela maemo a motho. Lintlha tse joalo ka mofuta o itseng oa mofets'e, liphatsa tsa lefutso, liphekolo tsa morao-rao, litlatsetso tse ling tse nkuoang, mekhoa ea bophelo, BMI, le lintho tse ling tse amanang le ho kula, kaofela li na le karolo ho bona hore na Kava e nepahetse kapa e lokela ho qojoa, e totobatsa bohlokoa ba ho nahanela motho ka mong. liqeto tse joalo.

1. Na Kava Supplements e tla rua molemo Bakuli ba Mantlha ba Urachal adenocarcinoma ba etsoang kalafo ea Gemcitabine?

Urachal adenocarcinoma ea mantlha e tšoauoa ka liphetoho tse itseng tsa liphatsa tsa lefutso, e leng NFE2L2, TP53 le GNAS, tse lebisang liphetohong litseleng tsa biochemical, haholo-holo khatello ea kelello ea oxidative, li-immune Checkpoints, Cell Cycle Checkpoints, Apoptosis, G-protein-coupled Receptor Signaling and Reproductive Hormone Signaling. Katleho ea kalafo ea mofetše, joalo ka Gemcitabine, e ipapisitse le mokhoa oa eona oa ts'ebetso litseleng tsena tse ikhethileng. Leano le nepahetseng le kenyelletsa ho hokahanya ts'ebetso ea kalafo le litsela tse tsamaisang mofets'e, ka hona ho netefatsa mokhoa oa motho ka mong le o sebetsang. Maemong a joalo, ho bohlokoa ho qoba lijo kapa lisebelisoa tsa phepo e nepahetseng tse ka hananang le litlamorao tsa kalafo kapa tsa fokotsa tumellano ena. Ka mohlala, tlatsetso ea Kava, e amang Khatello ea Oxidative, e ka 'na ea se ke ea e-ba khetho e nepahetseng tabeng ea Primary Urachal adenocarcinoma ha u ntse u le Gemcitabine. Lebaka ke hobane e ka 'na ea mpefatsa tsoelo-pele ea lefu lena kapa ea kena-kenana le katleho ea phekolo. Ha u khetha moralo oa phepo e nepahetseng, ho bohlokoa ho nahana ka lintlha tse kang mofuta oa mofets'e, kalafo e tsoelang pele, lilemo, bong, BMI, mokhoa oa bophelo le liphetoho life kapa life tse tsebahalang tsa lefutso.

2. Na Kava Supplements e tla thusa Bakuli ba Pele ba Penile Squamous Cell Carcinoma ba ntseng ba etsoa ka Kalafo ea Mitomycin?

Primary Penile Squamous Cell Carcinoma e khetholloa ka liphetoho tse khethehileng tsa lefutso, tse kang ABRAXAS1, PIK3CB le NUP93, tse hlahisang liphetoho litseleng tsa lik'hemik'hale, haholo-holo Apoptosis, Hematopoiesis le Inositol Phosphate Signaling. Katleho ea kalafo ea mofetše, joalo ka Mitomycin, e khethoa ke tšebelisano ea eona le litsela tsena. Sepheo ke ho netefatsa hore phekolo e lumellana hantle le litsela tse tsamaisang mofetše, e leng ho nolofalletsang mokhoa oa phekolo ea motho ka mong. Tabeng ena, ho lokela ho nahanoa ka lijo kapa li-supplement tse tsamaellanang le kalafo kapa tse matlafatsang tekano ena. Ka mohlala, tlatsetso ea Kava ke khetho e utloahalang bakeng sa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin. Sena ke hobane Kava e susumetsa litsela tse kang Apoptosis, e ka thibelang mabaka a khanna Primary Penile Squamous Cell Carcinoma kapa ea rua molemo katlehong ea Mitomycin.

3. Na Kava Supplements Sireletsehile bakeng sa Bophelo bo Botle Batho ka bomong ba nang le ASXL1 Mutation Associated Genetic Risk?

Likhamphani tse fapaneng li fana ka liphanele tsa lefutso bakeng sa ho lekola kotsi ea lefutso ea mefuta e fapaneng ea mofets'e. Liphanele tsena li kenyelletsa liphatsa tsa lefutso tse amanang le kankere ea matsoele, ea mahe a bomme, ea popelo, ea senya le ea mala. Ho lekola liphatsa tsa lefutso tsena ho ka netefatsa tlhahlobo le ho tsebisa mekhoa ea kalafo le taolo. Ho tseba phapang e bakang mafu ho ka thusa ho ea pele tlhahlobong le tlhahlobong ea beng ka bona ba ka bang kotsing. Mofuta oa ASXL1 hangata o kenyeletsoa liphanele tsena bakeng sa tlhahlobo ea kotsi ea mofetše.

Phetoho ea liphatsa tsa lefutso tsa ASXL1 e ama litsela kapa mekhoa ea lik'hemik'hale, tse kang Cytokine Signaling, Oncogenic Cancer Epigenetics le Suppressive Histone Methylation, tse amehang ka ho toba kapa ka tsela e sa tobang ho khanna kankere boemong ba limolek'hule. Ha phanele ea liphatsa tsa lefutso e supa phetoho ho ASXL1 e amanang le kotsi e eketsehileng ea Chronic Myelomonocytic Leukemia, mabaka a saense a fana ka maikutlo a ho qoba tšebeliso ea tlatsetso Kava. Lebaka ke hobane tlatsetso ea Kava e susumetsa litsela tse kang Cytokine Signaling, e ka lebisang liphellong tse mpe molemong oa phetoho ea ASXL1 le maemo a amanang le kankere.

4. Na Li-Supplements tsa Kava li Sireletsehile ho Batho ba Phelang ba nang le TERT Mutation Associated Genetic Risk?

TERT e bapala karolo ea bohlokoa tlhahlobong ea kotsi ea mofetše. Liphetoho ho TERT li ka sitisa litsela tsa bohlokoa tsa biochemical, ho kenyelletsa Angiogenesis le DNA Repair, tse susumetsang nts'etsopele ea mofetše. Haeba phanele ea liphatsa tsa lefutso tsa hau e senola liphetoho tsa TERT tse amanang le Kankere ea Hematological, nahana ka ho kenyelletsa li-supplement tsa Kava moralong oa hau oa phepo. Li-supplement tsena li ka susumetsa mekhoa e kang Angiogenesis, ho rua molemo ka ho fana ka ts'ehetso e nepahetseng bakeng sa batho ba nang le liphetoho tsa TERT le mathata a amanang le bophelo bo botle.

Ha re phethela

Lintho tse peli tsa bohlokoa ka ho fetisisa tseo u lokelang ho li hopola ke hore phekolo ea kankere le phepo e nepahetseng ha ho mohla li tšoanang ho bohle. Phepo e nepahetseng, ho kenyelletsa lijo le li-supplement joalo ka Kava, ke sesebelisoa se sebetsang se ka laoloang ke uena ha u ntse u tobane le mofetše.

“Ke lokela ho ja eng?” ke potso e atisang ho botsoa ke bakuli ba mofetše le ba kotsing ea ho tšoaroa ke mofetše. Karabo e nepahetseng ke hore e ipapisitse le lintlha tse kang mofuta oa mofets'e, liphatsa tsa lefutso tsa hlahala, kalafo ea hajoale, ho kula, mokhoa oa bophelo le BMI.

Fumana phepo ea hau ea phepo e nepahetseng bakeng sa mofets'e ho tsoa ho addon ka ho tobetsa sehokelo se ka tlase le ho araba lipotso mabapi le mofuta oa mofets'e oa hau, kalafo, mokhoa oa bophelo, ho kula, lilemo le bong.

References

• Flavokawain B e thibela kholo ea lisele tsa squamous carcinoma ea motho: Kenyeletso ea apoptosis le dysregulation ea cell cycle in vitro le vivo.
• In vivo antitumor le litlamorao tsa antimetastatic tsa flavokawain B ho 4T1 litoeba tse nang le phephetso ea lisele tsa mofetše oa matsoele.
• cBioPortal bakeng sa Cancer Genomics
• Kalafo ea mofets'e e theha sebopeho sa boikoetliso ba clonal hematopoiesis.
• Mitomycin C e khona ho hlahisa apoptosis e bakoang ke TRAIL ka p53-e ikemetseng e ikemetseng ea li-receptors tsa lefu: bopaki ba karolo ea c-Jun N-terminal kinase activation.
• Mekhoa ea ho Hlōla Khanyetso ea Intrinsic ho Gemcitabine ho Pancreatic Ductal Adenocarcinoma ka Redox Modulation.
• Boemo bo feto-fetohang ba mofetše oa metastatic bo senotsoe ho tsoa ho tatellano ea kliniki ea bakuli ba 10,000.