Ke mofetše ofe o ka ruang molemo ka ho kenyelletsa Kaempferol lijong tsa bona?

Lintlha-khōlō Tsa

Kaempferol e tsebahala haholo ka melemo ea eona ea bophelo bo botle mme e sebelisoa khafetsa ke bakuli ba mofetše le ba kotsing ea lefutso. Leha ho le joalo, polokeho le katleho ea Kaempferol bakeng sa bakuli ba mofetše li ipapisitse le lintlha tse ngata joalo ka sesupo sa mofets'e, chemotherapy, kalafo tse ling le liphatsa tsa lefutso tsa tumor. Ho tseba hore lijo tse ling le li-supplement, tse kang grapefruit le spinach, li ka 'na tsa sebelisana hampe le meriana ea mofetše le ho baka maikutlo a mabe ho bohlokoa.

Lijo li bohlokoa bakeng sa kalafo ea mofets'e kaha li ka ama litholoana tsa kalafo. Bakuli ba mofetše ba tlameha ho khetha ka hloko le ho kenyelletsa lijo tse loketseng le li-supplement lijong tsa bona. Ka mohlala, Kaempferol e ka thusa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin, empa e ka 'na ea se ke ea e-ba molemo ho bakuli ba fumanang Gemcitabine bakeng sa Primary Urachal adenocarcinoma. Ho feta moo, leha Kaempferol e ka thusa batho ba nang le lefutso la "TERT", e kanna ea se khothaletsoe ho ba nang le kotsi e fapaneng ea lefutso. Ho iketsetsa merero ea ho ja ho latela bophelo bo botle, kalafo, le liphatsa tsa lefutso ho bohlokoa.

Ho utloisisa hore ho etsa qeto mabapi le ho lekana ha Kaempferol bakeng sa mokuli oa mofets'e ho bohlokoa ho ba motho ka mong. Lintlha tse bohlokoa joalo ka mofuta oa mofetše, mekhoa ea kalafo, liphatsa tsa lefutso, likotsi tsa lefutso, lilemo, boima ba 'mele le mokhoa oa bophelo li bohlokoa ho etsa qeto ea hore na Kaempferol ke khetho e nepahetseng. Liphatsa tsa lefutso le liphatsa tsa lefutso, haholoholo, li nahanoa haholo. Kaha lintlha tsena li ka fetoha, ho bohlokoa ho hlahloba khafetsa le ho fetola khetho ea lijo ho tsamaisana le liphetoho tsa boemo ba bophelo bo botle le kalafo.

Qetellong, mokhoa o akaretsang oa khetho ea lijo ke oa bohlokoa, o lebisa tlhokomelo liphellong tse akaretsang tsa likarolo tsohle tse sebetsang lijong / lisebelisoa tse kang Kaempferol ho e-na le ho hlahloba motsoako o mong le o mong o sebetsang ka thoko kapa ho o hlokomoloha ka ho feletseng. Maikutlo ana a pharaletseng a khothalletsa mokhoa o utloahalang le oa saense oa moralo oa lijo bakeng sa mofetše.

Kakaretso e Khutšoanyane

Tšebeliso ea lijo tse thehiloeng limela le li-supplement, tse kang livithamini, litlama, liminerale, li-probiotics, le lisebelisoa tse fapaneng tse khethehileng, li ntse li eketseha har'a bakuli ba mofetše. Li-supplement tsena li etselitsoe ho fana ka metsoako e phahameng ea metsoako e sebetsang, eo bongata ba eona e leng lijong tse fapaneng. Khokahano le mefuta e fapaneng ea metsoako e sebetsang e fapana lipakeng tsa lijo tse felletseng le li-supplement. Lijo hangata li fana ka mefuta e mengata ea metsoako e sebetsang empa maemong a tlase, athe li-supplement li fana ka metsoako e phahameng ea metsoako e itseng.

Ha ho nahanoa ka mesebetsi e fapaneng ea saense le ea tlhaho ea motsoako o mong le o mong o sebetsang boemong ba limolek'hule, ho bohlokoa ho ikarabella bakeng sa litlamorao tse kopaneng tsa likarolo tsena ha u etsa qeto ea lijo le li-supplement tseo u ka li jang kapa che.

Ho hlaha potso ea bohlokoa: Na u lokela ho kenyelletsa Kaempferol lijong tsa hau e le ntho ea lijo kapa tlatsetso? Na ho bohlokoa ho sebelisa Kaempferol haeba u na le liphatsa tsa lefutso tse amanang le mofetše oa TERT? Ho thoe'ng haeba ho e-na le hoo kotsi ea hau ea lefutso e bakoa ke lefutso? Na ho molemo ho kenyelletsa Kaempferol lijong tsa hau haeba u fumanoa u e-na le Primary Urachal adenocarcinoma, kapa haeba tlhahlobo ea hau e le Primary Penile Squamous Cell Carcinoma? Ho feta moo, tšebeliso ea hau ea Kaempferol e lokela ho fetoloa joang haeba u ntse u fuoa phekolo ea Mitomycin kapa morero oa hau oa phekolo o tloha ho Mitomycin ho ea Gemcitabine? Ho bohlokoa ho elelloa hore lipolelo tse bonolo tse kang 'Kaempferol ke tsa tlhaho, kahoo e lula e le molemo' kapa 'Kaempferol e matlafatsa sesole sa' mele ha e lekane bakeng sa khetho ea lijo/tlatsetso.

Ho feta moo, ho bohlokoa ho hlahloba bocha ho nepahala ha ho kenyelletsa Kaempferol lijong tsa hau haeba ho na le liphetoho mokhoeng oa hau oa kalafo. Ka bokhutšoanyane, ha u etsa liqeto mabapi le ho kenyelletsa lijo kapa li-supplement tse kang Kaempferol lijong tsa hau bakeng sa melemo ea eona, u lokela ho nahana ka liphello tse akaretsang tsa biochemical tsa metsoako eohle, u nahane ka lintlha tse kang mofuta oa kankere, phekolo e khethehileng eo u ntseng u e etsa, liphatsa tsa lefutso. , le khetho ea bophelo.

Cancer

Kankere e ntse e le phephetso e khōlō lefapheng la bongaka, hangata e bakang matšoenyeho a atileng. Leha ho le joalo, tsoelo-pele ea morao-rao e ntlafalitse liphello tsa phekolo, haholo-holo ka mekhoa ea phekolo ea motho ka mong, mekhoa ea ho hlahloba e sa hlaseleng ka ho sebelisa lisampole tsa mali le mathe, le nts'etsopele ea immunotherapy. Ho lemoha kapele le ho kenella ka nako ho bile bohlokoa ho ba le tšusumetso e ntle liphellong tsohle tsa phekolo.

Teko ea liphatsa tsa lefutso e fana ka ts'episo e kholo ea ho lekola kotsi ea mofetše le ho ba kotsing kapele. Leha ho le joalo, ho batho ba bangata ba nang le mekhoa ea malapa le ea liphatsa tsa lefutso ho kankere, mekhoa ea phekolo ea phekolo, esita le ka ho hlahloba kamehla, hangata e lekanyelitsoe kapa ha e eo. Hang ha ho fumanoa hore o na le mofuta o itseng oa mofetše, o kang Primary Penile Squamous Cell Carcinoma kapa Primary Urachal adenocarcinoma, mekhoa ea phekolo e lokela ho hlophisoa ho latela liphatsa tsa lefutso tsa hlahala, boemo ba lefu lena, hammoho le lintlha tse kang lilemo le bong.

Ka mor'a kalafo, tlhahlobo e tsoelang pele e bohlokoa ho bona matšoao leha e le afe a ho khutlela mokhoeng oa mofets'e le ho tsebisa liqeto tse latelang. Bakuli ba bangata ba mofetše le ba kotsing hangata ba batla likeletso mabapi le ho kenyelletsa lijo tse itseng le li-supplement lijong tsa bona, e leng se phethang karolo ea bohlokoa ts'ebetsong ea bona ea ho etsa liqeto ka kakaretso mabapi le tsamaiso ea bophelo bo botle.

Potso ea bohlokoa ke hore na ho ameha likotsing tsa lefutso le tlhahlobo e khethehileng ea mofetše ha u etsa qeto ea khetho ea lijo, joalo ka Kaempferol. Na kotsi ea lefutso bakeng sa mofets'e e bakoang ke phetoho e teng ho TERT e na le litlamorao tse ts'oanang tsa lik'hemik'hale tsa biochemical joalo ka phetoho ea mofuta o mong? Ho latela pono ea phepo e nepahetseng, na kotsi e amanang le Primary Penile Squamous Cell Carcinoma e lekana le Primary Urachal adenocarcinoma? Ho feta moo, na tlhokomelo ea lijo e lula e tšoana bakeng sa ba kenang Gemcitabine le ba amohelang Mitomycin? Lintlha tsena li bohlokoa ho etsa khetho e nepahetseng ea lijo bakeng sa batho ba nang le likotsi tse fapaneng tsa lefutso le kalafo ea mofets'e.

Kaempferol - Tlatsetso ea Phepo

Tlatsetso ea Kaempferol e kenyelletsa mefuta e mengata ea metsoako e sebetsang, ho kenyeletsoa Kaempferol, e 'ngoe le e' ngoe e teng ka maemo a fapaneng. Lithako tsena li susumetsa litsela tsa limolek'hule, haholo-holo NFKB Signaling, Oxidative Stress, Insulin Signaling le JAK-STAT Signaling, e laolang likarolo tse mahlonoko tsa mofetše boemong ba lisele, joalo ka kholo ea tumor, ho ata le lefu la lisele. Ka lebaka la tšusumetso ena ea tlhaho, ho khetha li-supplement tse loketseng joalo ka Kaempferol, e le 'ngoe kapa e kopane, e fetoha qeto ea bohlokoa molemong oa phepo e nepahetseng ea mofets'e. Ha u nahana ka ho sebelisa Kaempferol bakeng sa mofetše, ho bohlokoa ho nahana ka lintlha tsena le mekhoa e fapaneng. Lebaka ke hobane, joalo ka kalafo ea mofets'e, ts'ebeliso ea Kaempferol ha se qeto e akaretsang e loketseng mefetše eohle empa e hloka ho etsoa motho ka mong.

Ho khetha lisebelisoa tsa Kaempferol

Ho araba potso e reng 'Ke lokela ho qoba Kaempferol neng maemong a Kankere' ho thata hobane karabo e itšetlehile haholo ka motho ka mong - e mpa feela e le 'Ho itšetlehile!'. Joalo ka ha kalafo efe kapa efe ea mofetše e kanna ea se sebetse ho mokuli e mong le e mong, bohlokoa le polokeho kapa melemo ea Kaempferol e fapana ho latela maemo a motho. Lintho tse kang mofuta o itseng oa mofetše, liphatsa tsa lefutso, liphekolo tsa morao-rao, li-supplement tse ling tse nkiloeng, mekhoa ea bophelo, BMI, le lintho tse ling tse amanang le ho kula, kaofela li phetha karolo ea ho tseba hore na Kaempferol e nepahetse kapa e lokela ho qojoa, e totobatsa bohlokoa ba ho nahanela motho ka mong. liqeto tse joalo.

1. Na Li-Supplement tsa Kaempferol li tla thusa bakuli ba Primary Urachal adenocarcinoma ba ntseng ba etsoa kalafo ea Gemcitabine?

Urachal adenocarcinoma ea mantlha e tšoauoa ka liphetoho tse itseng tsa liphatsa tsa lefutso, e leng NFE2L2, TP53 le GNAS, tse lebisang liphetohong litseleng tsa biochemical, haholo-holo khatello ea kelello ea oxidative, li-immune Checkpoints, Cell Cycle Checkpoints, Apoptosis, G-protein-coupled Receptor Signaling and Reproductive Hormone Signaling. Katleho ea kalafo ea mofetše, joalo ka Gemcitabine, e ipapisitse le mokhoa oa eona oa ts'ebetso litseleng tsena tse ikhethileng. Leano le nepahetseng le kenyelletsa ho hokahanya ts'ebetso ea kalafo le litsela tse tsamaisang mofets'e, ka hona ho netefatsa mokhoa oa motho ka mong le o sebetsang. Maemong a joalo, ho bohlokoa ho qoba lijo kapa lisebelisoa tsa phepo e nepahetseng tse ka hananang le litlamorao tsa kalafo kapa tsa fokotsa tumellano ena. Ka mohlala, tlatsetso ea Kaempferol, e amang Khatello ea Oxidative, e ka 'na ea se ke ea e-ba khetho e nepahetseng tabeng ea Primary Urachal adenocarcinoma ha u ntse u le Gemcitabine. Lebaka ke hobane e ka 'na ea mpefatsa tsoelo-pele ea lefu lena kapa ea kena-kenana le katleho ea phekolo. Ha u khetha moralo oa phepo e nepahetseng, ho bohlokoa ho nahana ka lintlha tse kang mofuta oa mofets'e, kalafo e tsoelang pele, lilemo, bong, BMI, mokhoa oa bophelo le liphetoho life kapa life tse tsebahalang tsa lefutso.

2. Na Li-Supplement tsa Kaempferol li tla thusa bakuli ba Primary Penile Squamous Cell Carcinoma ba ntseng ba le ka kalafo ea Mitomycin?

Penile Squamous Cell Carcinoma e khetholloa ka liphetoho tse itseng tsa lefutso, tse kang ABRAXAS1, PIK3CB le NUP93, tse hlahisang liphetoho litseleng tsa biochemical, haholo-holo NFKB Signaling, Hematopoiesis le Inositol Phosphate Signaling. Katleho ea kalafo ea mofetše, joalo ka Mitomycin, e khethoa ke tšebelisano ea eona le litsela tsena. Sepheo ke ho netefatsa hore phekolo e lumellana hantle le litsela tse tsamaisang mofetše, e leng ho nolofalletsang mokhoa oa phekolo ea motho ka mong. Tabeng ena, ho lokela ho nahanoa ka lijo kapa li-supplement tse tsamaellanang le kalafo kapa tse matlafatsang tekano ena. Ka mohlala, tlatsetso ea Kaempferol ke khetho e utloahalang bakeng sa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin. Sena ke hobane Kaempferol e susumetsa litsela tse kang NFKB Signaling, e ka thibelang mabaka a khanna Primary Penile Squamous Cell Carcinoma kapa ea rua molemo katlehong ea Mitomycin.

3. Na Li-Supplement tsa Kaempferol li Sireletsehile ho Batho ba Phelang ba nang le TERT Mutation Associated Genetic Risk?

TERT e bapala karolo ea bohlokoa tlhahlobong ea kotsi ea mofetše. Liphetoho tse teng ho TERT li ka sitisa litsela tsa bohlokoa tsa biochemical, ho kenyelletsa le JAK-STAT Signaling le DNA Repair, tse susumetsang nts'etsopele ea mofetše. Haeba phanele ea liphatsa tsa lefutso ea hau e senola liphetoho tsa TERT tse amanang le Kankere ea Hematological, nahana ka ho kenyelletsa Kaempferol leanong la hau la phepo. Li-supplement tsena li ka susumetsa mekhoa e kang JAK-STAT Signaling, ho rua molemo ka ho fana ka tšehetso e nepahetseng bakeng sa batho ba nang le liphetoho tsa TERT le mathata a amanang le bophelo bo botle.

Ha re phethela

Lintho tse peli tsa bohlokoa ka ho fetisisa tseo u lokelang ho li hopola ke hore phekolo ea kankere le phepo e nepahetseng ha ho mohla li tšoanang ho bohle. Phepo e nepahetseng, ho kenyelletsa lijo le li-supplement joalo ka Kaempferol, ke sesebelisoa se sebetsang se ka laoloang ke uena ha u ntse u tobane le mofetše.

“Ke lokela ho ja eng?” ke potso e atisang ho botsoa ke bakuli ba mofetše le ba kotsing ea ho tšoaroa ke mofetše. Karabo e nepahetseng ke hore e ipapisitse le lintlha tse kang mofuta oa mofets'e, liphatsa tsa lefutso tsa hlahala, kalafo ea hajoale, ho kula, mokhoa oa bophelo le BMI.

Fumana phepo ea hau ea phepo e nepahetseng bakeng sa mofets'e ho tsoa ho addon ka ho tobetsa sehokelo se ka tlase le ho araba lipotso mabapi le mofuta oa mofets'e oa hau, kalafo, mokhoa oa bophelo, ho kula, lilemo le bong.

References

• cBioPortal bakeng sa Cancer Genomics
• Li-inhibitors tsa molek'hule tse nyane tsa NADPH oxidase 4.
• Flavonoids e le receptor tyrosine kinase FLT3 inhibitors.
• Kalafo ea mofets'e e theha sebopeho sa boikoetliso ba clonal hematopoiesis.
• Mekhoa ea ho Hlōla Khanyetso ea Intrinsic ho Gemcitabine ho Pancreatic Ductal Adenocarcinoma ka Redox Modulation.
• Boemo bo feto-fetohang ba mofetše oa metastatic bo senotsoe ho tsoa ho tatellano ea kliniki ea bakuli ba 10,000.
• Ho sibolloa ha li-flavone tse sa tsejoeng haholo e le li-inhibitors tsa pontšo ea NF-κB ho MDA-MB-231 lisele tsa kankere ea matsoele-Phuputso ea SAR.
• Piperine (PP) e ntlafalitse phekolo ea mitomycin-C (MMC) ea kankere ea molomo oa motho ka ho hatella tsela ea pontšo ea Bcl-2 ka ho thibela STAT3 / NF-κB.