Ke mofetše ofe o ka ruang molemo ka ho kenyelletsa Asafoetida lijong tsa bona?

Lintlha-khōlō Tsa

Asafoetida e tsebahala haholo ka melemo ea eona ea bophelo bo botle 'me hangata e sebelisoa ke bakuli ba mofetše le ba kotsing ea lefutso. Leha ho le joalo, polokeho le katleho ea Asafoetida bakeng sa bakuli ba mofetše li itšetlehile ka lintlha tse ngata tse kang matšoao a mofetše, chemotherapy, liphekolo tse ling, le lefutso la hlahala. Ho tseba hore lijo tse ling le li-supplement, tse kang grapefruit le spinach, li ka 'na tsa sebelisana hampe le meriana ea mofetše le ho baka maikutlo a mabe ho bohlokoa.

Lijo li bohlokoa bakeng sa kalafo ea mofets'e kaha li ka ama litholoana tsa kalafo. Bakuli ba mofetše ba tlameha ho khetha ka hloko le ho kenyelletsa lijo tse loketseng le li-supplement lijong tsa bona. Ka mohlala, Asafoetida e ka thusa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin, empa ho ka 'na ha se ke ha e-ba molemo ho bakuli ba fumanang Radiation bakeng sa Primary Adamantinoma. Ho feta moo, le hoja Asafoetida e ka thusa batho ba nang le "KMT2D" ea kotsi ea lefutso, e ka 'na ea se ke ea buelloa ho ba nang le kotsi e fapaneng ea liphatsa tsa lefutso "HRAS". Ho iketsetsa merero ea ho ja ho latela bophelo bo botle, kalafo, le liphatsa tsa lefutso ho bohlokoa.

Ho utloisisa hore ho etsa qeto mabapi le ho tšoaneleha ha Asafoetida bakeng sa mokuli oa mofets'e ho bohlokoa ho ba motho ka mong. Lintlha tse mahlonoko tse kang mofuta oa mofetše, mekhoa ea phekolo, sebōpeho sa liphatsa tsa lefutso, likotsi tsa lefutso, lilemo, boima ba ’mele, le mokhoa oa bophelo li bohlokoa tabeng ea ho etsa qeto ea hore na Asafoetida ke khetho e nepahetseng. Liphatsa tsa lefutso le liphatsa tsa lefutso, haholoholo, li nahanoa haholo. Kaha lintlha tsena li ka fetoha, ho bohlokoa ho hlahloba khafetsa le ho fetola khetho ea lijo ho tsamaisana le liphetoho tsa boemo ba bophelo bo botle le kalafo.

Qetellong, mokhoa o akaretsang oa khetho ea lijo ke oa bohlokoa, o lebisa tlhokomelo liphellong tse akaretsang tsa likarolo tsohle tse sebetsang lijong / li-supplement tse kang Asafoetida ho e-na le ho hlahloba motsoako o mong le o mong o sebetsang ka thoko kapa ho o hlokomoloha ka ho feletseng. Maikutlo ana a pharaletseng a khothalletsa mokhoa o utloahalang le oa saense oa moralo oa lijo bakeng sa mofetše.

Kakaretso e Khutšoanyane

Tšebeliso ea lijo tse thehiloeng limela le li-supplement, tse kang livithamini, litlama, liminerale, li-probiotics, le lisebelisoa tse fapaneng tse khethehileng, li ntse li eketseha har'a bakuli ba mofetše. Li-supplement tsena li etselitsoe ho fana ka metsoako e phahameng ea metsoako e sebetsang, eo bongata ba eona e leng lijong tse fapaneng. Khokahano le mefuta e fapaneng ea metsoako e sebetsang e fapana lipakeng tsa lijo tse felletseng le li-supplement. Lijo hangata li fana ka mefuta e mengata ea metsoako e sebetsang empa maemong a tlase, athe li-supplement li fana ka metsoako e phahameng ea metsoako e itseng.

Ha ho nahanoa ka mesebetsi e fapaneng ea saense le ea tlhaho ea motsoako o mong le o mong o sebetsang boemong ba limolek'hule, ho bohlokoa ho ikarabella bakeng sa litlamorao tse kopaneng tsa likarolo tsena ha u etsa qeto ea lijo le li-supplement tseo u ka li jang kapa che.

Ho hlaha potso ea bohlokoa: Na u lokela ho kenyelletsa Asafoetida lijong tsa hau e le ntho ea lijo kapa tlatsetso? Na ho bohlokoa ho ja Asafoetida haeba u na le liphatsa tsa lefutso tse amanang le mofetše oa KMT2D? Ho thoe'ng haeba ho e-na le hoo kotsi ea hau ea lefutso e bakoa ke lefutso la HRAS? Na ho molemo ho kenyelletsa Asafoetida lijong tsa hau haeba u fumanoa u e-na le Primary Adamantinoma, kapa haeba tlhahlobo ea hau e le Primary Penile Squamous Cell Carcinoma? Ho feta moo, tšebeliso ea hau ea Asafoetida e lokela ho fetoloa joang haeba u ntse u fuoa phekolo ea Mitomycin kapa morero oa hau oa phekolo o tloha ho Mitomycin ho ea ho Radiation? Ho bohlokoa ho hlokomela hore lipolelo tse bonolo tse kang 'Asafoetida ke ntho ea tlhaho, kahoo e lula e le molemo' kapa 'Asafoetida e matlafatsa sesole sa 'mele' ha e lekane bakeng sa khetho ea lijo/tlatsetso.

Ho phaella moo, ke habohlokoa ho hlahloba bocha ho nepahala ha ho kenyelletsa Asafoetida lijong tsa hau haeba ho na le liphetoho tsamaisong ea hau ea phekolo. Ka bokhutšoanyane, ha u etsa liqeto mabapi le ho kenyelletsa lijo kapa li-supplement tse kang Asafoetida lijong tsa hau bakeng sa melemo ea eona, u lokela ho nahana ka liphello tse akaretsang tsa lik'hemik'hale tsa metsoako eohle, u nahane ka lintlha tse kang mofuta oa kankere, phekolo e khethehileng eo u e etsang, liphatsa tsa lefutso. , le khetho ea bophelo.

Cancer

Kankere e ntse e le phephetso e khōlō lefapheng la bongaka, hangata e bakang matšoenyeho a atileng. Leha ho le joalo, tsoelo-pele ea morao-rao e ntlafalitse liphello tsa phekolo, haholo-holo ka mekhoa ea phekolo ea motho ka mong, mekhoa ea ho hlahloba e sa hlaseleng ka ho sebelisa lisampole tsa mali le mathe, le nts'etsopele ea immunotherapy. Ho lemoha kapele le ho kenella ka nako ho bile bohlokoa ho ba le tšusumetso e ntle liphellong tsohle tsa phekolo.

Teko ea liphatsa tsa lefutso e fana ka ts'episo e kholo ea ho lekola kotsi ea mofetše le ho ba kotsing kapele. Leha ho le joalo, ho batho ba bangata ba nang le mekhoa ea malapa le ea liphatsa tsa lefutso ho kankere, mekhoa ea phekolo ea phekolo, esita le ka ho hlahloba kamehla, hangata e lekanyelitsoe kapa ha e eo. Hang ha ho fumanoa hore o na le mofuta o itseng oa mofetše, o kang Primary Penile Squamous Cell Carcinoma kapa Primary Adamantinoma, mekhoa ea phekolo e lokela ho hlophisoa ho latela liphatsa tsa lefutso tsa hlahala, boemo ba lefu lena, hammoho le lintlha tse kang lilemo le bong.

Ka mor'a kalafo, tlhahlobo e tsoelang pele e bohlokoa ho bona matšoao leha e le afe a ho khutlela mokhoeng oa mofets'e le ho tsebisa liqeto tse latelang. Bakuli ba bangata ba mofetše le ba kotsing hangata ba batla likeletso mabapi le ho kenyelletsa lijo tse itseng le li-supplement lijong tsa bona, e leng se phethang karolo ea bohlokoa ts'ebetsong ea bona ea ho etsa liqeto ka kakaretso mabapi le tsamaiso ea bophelo bo botle.

Potso ea bohlokoa ke hore na ho ameha likotsing tsa lefutso le tlhahlobo e khethehileng ea mofets'e ha u etsa qeto mabapi le khetho ea lijo, joalo ka Asafoetida. Na kotsi ea lefutso bakeng sa mofets'e e bakoang ke phetoho ho KMT2D e na le litlamorao tse ts'oanang tsa tsela ea biochemical joalo ka phetoho ho HRAS? Ho latela pono ea phepo e nepahetseng, na kotsi e amanang le Primary Penile Squamous Cell Carcinoma e lekana le Primary Adamantinoma? Ho feta moo, na tlhokomelo ea lijo e lula e tšoana bakeng sa ba nang le Radiation le ba amohelang Mitomycin? Lintlha tsena li bohlokoa ho etsa khetho e nepahetseng ea lijo bakeng sa batho ba nang le likotsi tse fapaneng tsa lefutso le kalafo ea mofets'e.

Asafoetida - Tlatsetso ea Phepo

Tlatsetso ea Asafoetida e kenyelletsa mefuta e mengata ea metsoako e sebetsang, ho kenyelletsa Umbelliprenin le Linoleic Acid, e 'ngoe le e' ngoe e teng ka mefuta e sa tšoaneng. Lithako tsena li susumetsa litsela tsa limolek'hule, haholo-holo DNA Repair, Epithelial to Mesenchymal Transition, Growth Factor Signaling le PI3K-AKT-MTOR Signaling, e laolang likarolo tse mahlonoko tsa mofetše boemong ba lisele, tse kang ho hōla ha hlahala, ho ata le lefu la lisele. Ka lebaka la tšusumetso ena ea likokoana-hloko, ho khetha li-supplement tse loketseng tse kang Asafoetida, e le 'ngoe kapa e kopane, e fetoha qeto ea bohlokoa tabeng ea phepo ea mofets'e. Ha u nahana ka ho sebelisa Asafoetida bakeng sa mofetše, ho bohlokoa ho nahana ka lintlha tsena tse fapaneng le mekhoa. Lebaka ke hobane, joalo ka kalafo ea mofets'e, ts'ebeliso ea Asafoetida ha se qeto e akaretsang e loketseng mefuta eohle ea mofets'e empa e hloka ho etsoa motho ka mong.

Ho Khetha Tlatsetso ea Asafoetida

Ho araba potso e reng 'Ke lokela ho qoba Asafoetida neng maemong a Kankere' ho thata hobane karabo e itšetlehile haholo ka motho ka mong - e mpa feela e le 'Ho itšetlehile!'. Joalo ka ha kalafo efe kapa efe ea mofetše e kanna ea se sebetse hantle ho mokuli e mong le e mong, bohlokoa le polokeho kapa melemo ea Asafoetida e fapana ho latela maemo a motho. Lintlha tse kang mofuta o itseng oa mofetše, liphatsa tsa lefutso, phekolo ea morao-rao, li-supplement tse ling tse nkiloeng, mekhoa ea bophelo, BMI, le ho kula leha e le hofe ho phetha karolo ea ho tseba hore na Asafoetida e nepahetse kapa e lokela ho qojoa, e totobatsa bohlokoa ba ho nahanela motho ka mong. liqeto tse joalo.

1. Na Li-Supplement tsa Asafoetida li tla thusa Bakuli ba Pele ba Adamantinoma ba ntseng ba le kalafo ea Radiation?

Adamantinoma ea mantlha e tšoauoa ka liphetoho tse itseng tsa liphatsa tsa lefutso, e leng ARHGAP45, PI4KB le SDSL, tse lebisang liphetohong litseleng tsa biochemical, haholo-holo Epithelial ho Mesenchymal Transition le Inositol Phosphate Signaling. Katleho ea kalafo ea mofetše, joalo ka Radiation, e ipapisitse le mokhoa oa eona oa ts'ebetso litseleng tsena tse ikhethileng. Leano le nepahetseng le kenyelletsa ho hokahanya ts'ebetso ea kalafo le litsela tse tsamaisang mofets'e, ka hona ho netefatsa mokhoa oa motho ka mong le o sebetsang. Maemong a joalo, ho bohlokoa ho qoba lijo kapa lisebelisoa tsa phepo e nepahetseng tse ka hananang le litlamorao tsa kalafo kapa tsa fokotsa tumellano ena. Ka mohlala, tlatsetso ea Asafoetida, e amang Epithelial ho Mesenchymal Transition, e ka 'na ea se ke ea e-ba khetho e nepahetseng tabeng ea Primary Adamantinoma ha e etsoa ke Radiation. Lebaka ke hobane e ka 'na ea mpefatsa tsoelo-pele ea lefu lena kapa ea kena-kenana le katleho ea phekolo. Ha u khetha moralo oa phepo e nepahetseng, ho bohlokoa ho nahana ka lintlha tse kang mofuta oa mofets'e, kalafo e tsoelang pele, lilemo, bong, BMI, mokhoa oa bophelo le liphetoho life kapa life tse tsebahalang tsa lefutso.

2. Na Li-Supplement tsa Asafoetida li tla thusa bakuli ba Primary Penile Squamous Cell Carcinoma ba ntseng ba le ka kalafo ea Mitomycin?

Penile Squamous Cell Carcinoma e khetholloa ka liphetoho tse khethehileng tsa lefutso, tse kang ABRAXAS1, PIK3CB le NUP93, tse hlahisang liphetoho litseleng tsa lik'hemik'hale, haholo-holo DNA Repair, Hematopoiesis le Inositol Phosphate Signaling. Katleho ea kalafo ea mofetše, joalo ka Mitomycin, e khethoa ke tšebelisano ea eona le litsela tsena. Sepheo ke ho netefatsa hore phekolo e lumellana hantle le litsela tse tsamaisang mofetše, e leng ho nolofalletsang mokhoa oa phekolo ea motho ka mong. Tabeng ena, ho lokela ho nahanoa ka lijo kapa li-supplement tse tsamaellanang le kalafo kapa tse matlafatsang tekano ena. Ka mohlala, tlatsetso ea Asafoetida ke khetho e utloahalang bakeng sa ba nang le Primary Penile Squamous Cell Carcinoma ba nang le Mitomycin. Sena ke hobane Asafoetida e susumetsa litsela tse kang DNA Repair, e ka thibelang mabaka a khanna Primary Penile Squamous Cell Carcinoma kapa ea rua molemo katlehong ea Mitomycin.

3. Na Li-Supplement tsa Asafoetida li Sireletsehile ho Batho ba Phelang ba nang le HRAS Mutation Associated Genetic Risk?

Likhamphani tse fapaneng li fana ka liphanele tsa lefutso bakeng sa ho lekola kotsi ea lefutso ea mefuta e fapaneng ea mofets'e. Liphanele tsena li kenyelletsa liphatsa tsa lefutso tse amanang le kankere ea matsoele, ea mahe a bomme, ea popelo, ea senya le ea mala. Ho lekola liphatsa tsa lefutso tsena ho ka netefatsa tlhahlobo le ho tsebisa mekhoa ea kalafo le taolo. Ho tseba phapang e bakang mafu ho ka thusa ho ea pele tlhahlobong le tlhahlobong ea beng ka bona ba ka bang kotsing. Mofuta oa HRAS hangata o kenyelelitsoe liphanele tsena bakeng sa tlhahlobo ea kotsi ea mofetše.

Phetoho ea mofuta oa HRAS e ama litsela kapa lits'ebetso tsa biochemical, joalo ka Growth Factor Signaling le RAS-RAF Signaling, tse amehang ka kotloloho kapa ka tsela e sa tobang ho khanna mofetše boemong ba limolek'hule. Ha phanele ea liphatsa tsa lefutso e supa phetoho ho HRAS e amanang le kotsi e eketsehileng ea Pheochromocytoma Le Paraganglioma, mabaka a mahlale a fana ka maikutlo a ho qoba tšebeliso ea tlatsetso ea Asafoetida. Sena ke hobane tlatsetso ea Asafoetida e susumetsa litsela tse kang Growth Factor Signaling, e ka lebisang litlamorao tse mpe molemong oa phetoho ea HRAS le maemo a amanang le mofets'e.

4. Na Li-Supplement tsa Asafoetida li Sireletsehile ho Batho ba Phelang ba nang le KMT2D Mutation Associated Genetic Risk?

KMT2D e bapala karolo ea bohlokoa tlhahlobong ea kotsi ea mofetše. Liphetoho ho KMT2D li ka sitisa litsela tsa bohlokoa tsa biochemical, ho kenyelletsa PI3K-AKT-MTOR Signaling le Oncogenic Histone Methylation, tse susumetsang nts'etsopele ea mofetše. Haeba phanele ea liphatsa tsa lefutso tsa hau e senola liphetoho tsa KMT2D tse amanang le Bladder Urothelial Carcinoma, nahana ka ho kenyelletsa li-supplement tsa Asafoetida moralong oa hau oa phepo. Li-supplement tsena li ka susumetsa hantle litsela tse kang PI3K-AKT-MTOR Signaling, ho rua molemo ka ho fana ka tšehetso e nepahetseng bakeng sa batho ba nang le liphetoho tsa KMT2D le mathata a amanang le bophelo bo botle.

Ha re phethela

Lintho tse peli tsa bohlokoa ka ho fetisisa tseo u lokelang ho li hopola ke hore phekolo ea kankere le phepo e nepahetseng ha ho mohla li tšoanang ho bohle. Phepo e nepahetseng, ho kenyelletsa lijo le li-supplement joalo ka Asafoetida, ke sesebelisoa se sebetsang se ka laoloang ke uena ha u ntse u tobane le mofetše.

“Ke lokela ho ja eng?” ke potso e atisang ho botsoa ke bakuli ba mofetše le ba kotsing ea ho tšoaroa ke mofetše. Karabo e nepahetseng ke hore e ipapisitse le lintlha tse kang mofuta oa mofets'e, liphatsa tsa lefutso tsa hlahala, kalafo ea hajoale, ho kula, mokhoa oa bophelo le BMI.

Fumana phepo ea hau ea phepo e nepahetseng bakeng sa mofets'e ho tsoa ho addon ka ho tobetsa sehokelo se ka tlase le ho araba lipotso mabapi le mofuta oa mofets'e oa hau, kalafo, mokhoa oa bophelo, ho kula, lilemo le bong.

References

• cBioPortal bakeng sa Cancer Genomics
• Ts'ebetso ea PPAR gamma le delta ka conjugated linoleic acid e sireletsa tšireletso khahlanong le lefu la mala a ho ruruha.
• cBioPortal bakeng sa Cancer Genomics
• Tlhahlobo ea kankere ea kankere ea liphatsa tsa lefutso tse feletseng.
• Kalafo ea mofets'e e theha sebopeho sa boikoetliso ba clonal hematopoiesis.
• Ho hanyetsa seea-le-moea liseleng tsa mofetše oa matsoele ho fetisoa ka pontšo ea TGF-β, hybrid epithelial-mesenchymal phenotype le lisele tsa kankere.
• Karolo ea phospholipase D ho falla le tlhaselo e bakoang ke linoleic acid liseleng tsa mofetše oa matsoele.