Lijo bakeng sa Lithothokiso Syndrome!

Selelekela

Foods for Poems Syndrome e lokela ho ba motho ka mong bakeng sa motho ka mong hape e tlameha ho ikamahanya le maemo ha kalafo ea mofetše kapa liphatsa tsa lefutso tsa hlahala li fetoha. Ho iketsetsa motho le ho ikamahanya le maemo ho tlameha ho nahanela metsoako eohle e sebetsang kapa li-bioactive tse fumanehang lijong tse fapaneng mabapi le baeloji ea mofetše, liphatsa tsa lefutso, kalafo, maemo a bophelo le likhetho tsa lijo. Kahoo le hoja phepo e nepahetseng e le e 'ngoe ea liqeto tsa bohlokoa haholo tseo mokuli oa mofetše le motho ea kotsing ea mofetše a lokelang ho li etsa - mokhoa oa ho khetha lijo tseo u ka li jang ha se mosebetsi o bonolo.

POEMS ke khutsufatso e emelang matšoao a mahlano a maholo le matšoao a lefu lena a kenyeletsang Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy le Skin abnormalities. Ke lefu le sa tloaelehang haholo le bakoang ke karabelo e sa tloaelehang ea 'mele ea' mele ho hlahala ea mofetše, moo 'mele o hlaselang lisele tse tloaelehileng tsamaisong ea methapo ka phoso. Liphuputso li tlalehile ka tsela e sa tloaelehang maemo a phahameng a vascular endothelial growth factor (VEGF) le pro-inflammatory cytokines maling a batho ba nang le lefu la POEMS. Lefu la POEMS le hlaha ka makhetlo a 1.5 hangata ho banna ho feta basali mme hangata le hlaha ho batho ba baholo ba lilemong tsa bo-50. Matšoao a tloaelehileng a lefu la POEMS a kenyelletsa bofokoli bo tsoelang pele ba methapo matsohong le maotong, sebete se holisitsoeng ka tsela e sa tloaelehang le / kapa spleen, li-lymph nodes tse atolositsoeng, ho fifala ha letlalo, ho teteana ha letlalo le ho hola ho feteletseng ha moriri. Lefu la POEMS ke lefu le sa foleng, 'me tsoelo-pele ea eona e itšetlehile ka boholo ba lefu lena le tsela eo batho ba arabelang ka eona kalafo. Ha ho na phekolo e tloaelehileng bakeng sa lefu la POEMS. Likhetho tsa kalafo li kenyelletsa kalafo ea radiation, chemotherapy, immune modulatory kapa hematopoietic cell transplant. Bophelo ba bohareng ba bakuli ba nang le lefu la POEMS ke lilemo tse fetang 14. Tlhokomelo e tšehetsang ka phepo e nepahetseng (lijo le li-supplement tsa tlhaho) le tsona li ka thusa ho ntlafatsa bophelo bo botle ba bakuli.

Bakeng sa Poems Syndrome na ho na le taba hore na motho o ja meroho, litholoana, linate, lipeo life?

Potso e atileng haholo ea phepo e botsoang ke bakuli ba mofets'e le batho ka bomong ba kotsing ea mofets'e ke - bakeng sa mofets'e joalo ka Poems Syndrome na ho na le taba hore na ke ja lijo life le tseo ke sa li jeng? Kapa haeba ke latela lijo tse thehiloeng limela na hoo ho lekane bakeng sa mofetše joalo ka Poems Syndrome?

Mohlala, na ho na le taba hore Wax Gourd ea meroho e jeoa haholo ha e bapisoa le Pepere e Tala? Na ho na le phapang e teng haeba litholoana tsa Pummelo li ratoa ho feta Red Raspberry? Hape haeba khetho e tšoanang e etsoa bakeng sa linate/peo e kang Hazelnut holim'a Brazil Nut le bakeng sa limela tse kang Pea e mahlo a matšo holim'a Cowpea. 'Me haeba seo ke se jang se le bohlokoa - joale motho o tseba joang lijo tse buelloang bakeng sa Poems Syndrome mme ke karabo e tšoanang bakeng sa bohle ba nang le tlhahlobo e tšoanang kapa kotsi ea lefutso?

Ee! Lijo tseo u li jang li bohlokoa bakeng sa Poems Syndrome!

Litlhahiso tsa lijo li ka 'na tsa se ke tsa tšoana ho bohle' me li ka fapana esita le bakeng sa tlhahlobo e tšoanang le kotsi ea lefutso.

Lijo tsohle (meroho, litholoana, linate, lipeo, li-pulses, oli joalo-joalo) le litlatsetso tsa phepo li entsoe ka metsoako e fetang e le 'ngoe e sebetsang ea molek'hule kapa bio-active ka tekanyo le bongata bo fapaneng. Sejo se seng le se seng se sebetsang se na le mokhoa o ikhethileng oa ts'ebetso - e ka bang ts'ebetso kapa ho thibela litsela tse fapaneng tsa biochemical. Lijo le li-supplement tse khothalletsoang habonolo ke tse sa bakeng keketseho ea limolek'hule tsa mofetše empa li li fokotsa. Ho seng joalo, lijo tseo ha lia lokela ho khothaletsoa. Lijo li na le metsoako e mengata e sebetsang - ka hona, ha u hlahloba lijo le li-supplement, u lokela ho nahana ka phello ea metsoako eohle e sebetsang ka bonngoe ho e-na le hore u nahane ka bonngoe.

Ka mohlala, Pummelo e na le metsoako e sebetsang ea Quercetin, Apigenin, Caffeine, Isoliquiritigenin, Formononetin. 'Me Raspberry e khubelu e na le metsoako e sebetsang ea Quercetin, Ellagic Acid, Isoliquiritigenin, Formononetin, Curcumin le mohlomong tse ling.

Phoso e tloaelehileng e entsoeng ha ho etsoa qeto le ho khetha lijo tse jeoang bakeng sa Poems Syndrome - ke ho hlahloba feela metsoako e sebetsang e khethiloeng e fumanehang lijong le ho hlokomoloha tse ling. Hobane metsoako e fapaneng e sebetsang e fumanehang lijong e kanna ea ba le litlamorao tse fapaneng ho bakhanni ba mofets'e - u ke ke ua khetha metsoako e sebetsang lijong le li-supplement bakeng sa ho etsa qeto ea phepo bakeng sa Poems Syndrome.

EE – LIKHETHO TSA LIJO LI BOHLOKOA BAKENG SA KANKERE. LIQETO TSA PHEPO LI TLAMEHA HO NAHANA KA LITABA TSOHLE TSA LIJO.

Tsebo e Hlokahalang Bakeng sa Phepo ea Boipheliso bakeng sa Poems Syndrome?

Phepo e ikhethileng bakeng sa mofets'e joalo ka Poems Syndrome e na le lijo tse khothaletsoang / li-supplement; lijo tse sa khothaletsoang tse nang le mohlala oa diresepe tse etelletsang pele tšebeliso ea lijo tse khothaletsoang. Mohlala oa phepo e nepahetseng o ka bonoa ho sena link tsa.

Ho etsa qeto ea hore na ke lijo life tse khothalelitsoeng kapa che ho rarahane haholo, ho hloka boiphihlelo ho Poems Syndrome biology, mahlale a lijo, liphatsa tsa lefutso, biochemistry hammoho le kutloisiso e ntle ea hore na liphekolo tsa mofets'e li sebetsa joang le bofokoli bo amanang le bona boo liphekolo li ka emisang ho sebetsa.

BONYENYANE BO TSEBO BOHLOKOA BAKENG SA PHEPO MOTHO BATHO BA KANKERE KE: BOLOJI YA KANKERE, SAENSE YA DIJO, DIPHEKO LA MOFEPO LE LIFUTSO.

Litšobotsi tsa mofets'e joalo ka Poems Syndrome

Lik'hemik'hale tsohle tse kang Poems Syndrome li ka khetholloa ka sete e ikhethang ea litsela tsa lik'hemik'hale - litsela tsa ho saena tsa Poems Syndrome. Litsela tsa biochemical tse kang Extracellular Matrix Remodelling, Cytokine Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling ke karolo ea tlhaloso ea signature ea Poems Syndrome. Liphatsa tsa lefutso tsa mofetše oa motho ka mong li ka fapana, ka hona, tekeno ea bona ea mofetše e ka ikhetha.

Liphekolo tse sebetsang hantle bakeng sa Poems Syndrome li hloka ho ela hloko mekhoa ea lik'hemik'hale e amanang le eona bakeng sa mokuli e mong le e mong oa mofetše le motho ea kotsing ea lefutso. Ka hona liphekolo tse fapaneng tse nang le mekhoa e fapaneng ea liketso li sebetsa hantle ho bakuli ba fapaneng. Ka mokhoa o ts'oanang le ka mabaka a ts'oanang lijo le li-supplement li hloka ho etsoa ka bomong bakeng sa motho ka mong. Kahoo lijo tse ling le li-supplement li khothaletsoa bakeng sa Poems Syndrome ha u nka kalafo ea mofets'e Melphalan, 'me lijo tse ling le li-supplement ha li khothalletsoe.

Mehloli e kang cBioPortal 'me ba bang ba bangata ba fana ka lintlha tse sa tsejoeng tse tsoang litekong tsa bongaka bakeng sa matšoao ohle a mofetše. Lintlha tsena li na le lintlha tsa boithuto ba tleliniki joalo ka boholo ba sampole / palo ea bakuli, lihlopha tsa lilemo, bong, morabe, kalafo, sebaka sa tumor le liphetoho life kapa life tsa lefutso.

LATS2, CYSLTR2, IRS2, CUL4A le ERCC5 ke mefuta e kaholimo-limo e tlalehiloeng bakeng sa Poems Syndrome. LATS2 e tlalehoa ho 50.41176471 % ea bakuli ba baemeli ho pholletsa le liteko tsohle tsa bongaka. Mme CYSLTR2 e tlalehiloe ho 50.41176471%. Lintlha tse kopaneng tsa bakuli li akaretsa lilemo ho tloha ho. % ea lintlha tsa mokuli li tsejoa e le banna. The Poems Syndrome biology hammoho le liphatsa tsa lefutso tse tlalehiloeng hammoho li hlalosa palo ea batho ba emetseng mekhoa ea lik'hemik'hale tsa mofetše. Haeba liphatsa tsa lefutso tsa mofetše kapa liphatsa tsa lefutso tse kenyang kotsi le tsona li tsejoa, seo se lokela ho sebelisoa hape bakeng sa ho ja lijo.

LIKHETHO TSA PHEPO LI LOKELA HO TŠOANA LE MOTHO E MONG LE E MONG LE SAENYO EA MOTHO EA KANKERE.

Lijo le Tlatsetso bakeng sa Lithothokiso Syndrome

Bakeng sa Bakuli ba Kankere

Bakuli ba mofetše ba nakong ea kalafo kapa ba tlhokomelong ea pholiso ba lokela ho etsa liqeto mabapi le lijo le li-supplement - bakeng sa lik'hilojule tse hlokahalang tsa lijo, ho laola litla-morao life kapa life tsa kalafo le bakeng sa taolo e ntlafetseng ea mofetše. Lijo tsohle tse thehiloeng ho limela ha li lekane, 'me ho khetha le ho etelletsa pele lijo tse ikhethileng le tse etselitsoeng kalafo e tsoelang pele ea mofets'e ho bohlokoa ebile ho rarahane. Mehlala ke ena e fanang ka litataiso bakeng sa ho etsa liqeto tsa phepo e nepahetseng.

Khetha WAX GOURD kapa GREEN BELL PEPPER?

Meroho Wax Gourd e na le metsoako e mengata e sebetsang kapa bioactives tse kang Myricetin, Apigenin, Isoliquiritigenin, Formononetin, Curcumin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang JAK-STAT Signaling, MAPK Signaling, NFKB Signaling le MYC Signaling le tse ling. Wax Gourd e khothaletsoa bakeng sa Poems Syndrome ha kalafo ea mofetše e tsoelang pele e le Melphalan. Lebaka ke hobane Wax Gourd e fetola litsela tseo tsa biochemical tse tlalehiloeng ka mahlale hore li hlokomelisa phello ea Melphalan.

Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa meroho ea Green Bell Pepper ke Myricetin, Quercetin, Isoliquiritigenin, Resveratrol, Formononetin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang DNA Repair, Cytokine Signaling le PI3K-AKT-MTOR Signaling le tse ling. Green Bell Pepper ha e khothalletsoe bakeng sa Poems Syndrome ha kalafo e tsoelang pele ea mofets'e e le Melphalan hobane e fetola mekhoa ea biochemical e etsang hore kalafo ea mofets'e e se ke ea sebetsa kapa e se ke ea arabela.

KHARE YA WAX YA MERO E KHOTHATSWA HO FIHLELA PEPERE E TLHAKA E MONATE BAKENG SA Dithothokiso Syndrome LE PHEKO Melphalan.

Khetha Fruit RED RASPBERRY kapa PUMMELO?

Litholoana tsa Raspberry tse khubelu li na le metsoako e mengata e sebetsang kapa bioactives tse kang Quercetin, Ellagic Acid, Isoliquiritigenin, Formononetin, Curcumin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang DNA Repair, Hypoxia, MAPK Signaling le Oxidative Stress le tse ling. Red Raspberry e kgothaletswa bakeng sa Poems Syndrome ha phekolo ea kankere e tsoelang pele e le Melphalan. Lebaka ke hobane Raspberry e khubelu e fetola mekhoa ea biochemical eo ho tlalehiloeng ka mahlale ho thusa Melphalan.

Tse ling tsa metsoako e sebetsang kapa bioactives litholoana Pummelo ke Quercetin, Apigenin, Caffeine, Isoliquiritigenin, Formononetin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka DNA Repair le Oxidative Stress le tse ling. Pummelo ha e khothalletsoe bakeng sa Poems Syndrome ha kalafo e tsoelang pele ea mofets'e e le Melphalan hobane e fetola mekhoa ea biochemical e etsang hore kalafo ea mofets'e e se ke ea sebetsa kapa e se ke ea arabela.

FRUIT RED RASPBERRY E KHOTHATSOE HO FETA PUMMELO BAKENG SA Lithothokiso Syndrome LE PHEKO Melphalan.

Khetha Nut HAZELNUT kapa BRAZIL NUT?

Hazelnut e na le metsoako e mengata e sebetsang kapa bioactives tse kang Myricetin, Apigenin, Isoliquiritigenin, Formononetin, Curcumin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang JAK-STAT Signaling, Hypoxia, MAPK Signaling le MYC Signaling le tse ling. Hazelnut e buelloa bakeng sa Poems Syndrome ha phekolo ea kankere e tsoelang pele e le Melphalan. Sena ke hobane Hazelnut e fetola mekhoa ea biochemical eo ho tlalehiloeng ka mahlale hore e thusa Melphalan.

Tse ling tsa metsoako e sebetsang kapa bioactives Brazil Nut ke Ellagic Acid, Isoliquiritigenin, Formononetin, Curcumin, Phloretin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang DNA Repair, MAPK Signaling le MYC Signaling le tse ling. Brazil Nut ha e khothalletsoe bakeng sa Poems Syndrome ha kalafo e tsoelang pele ea mofets'e e le Melphalan hobane e fetola mekhoa ea biochemical e etsang hore kalafo ea mofets'e e se ke ea hana kapa e se ke ea arabela.

HAZELNUT E KHOTHATSOE HO PHETHA BRAZIL NUT BAKENG SA Poems Syndrome LE KAlafo Melphalan.

Bakeng sa Batho ba nang le Kotsi ea Liphatsa tsa Kankere

Potso e botsoang ke batho ba nang le kotsi ea liphatsa tsa lefutso ea Poems Syndrome kapa nalane ea lelapa ke "Ke Lokela ho ja Eng e sa Tšoaneng le Pele?" le kamoo ba lokelang ho khetha lijo le li-supplement bakeng sa ho laola likotsi tsa lefu lena. Kaha bakeng sa kotsi ea mofets'e ha ho letho le ka etsoang mabapi le kalafo - liqeto tsa lijo le li-supplement li fetoha tsa bohlokoa 'me e le e' ngoe ea lintho tse fokolang haholo tse ka etsoang. Lijo tsohle tse thehiloeng ho limela ha li lekane 'me li ipapisitse le liphatsa tsa lefutso le mokhoa oa ho saena - khetho ea lijo le li-supplement li lokela ho etsoa ke motho ka mong.

Khetha Vegetable GIANT BUTTERBUR kapa Mustard SPINACH?

Vegetable Giant Butterbur e na le metsoako e mengata e sebetsang kapa bioactives tse kang Apigenin, Kaempferol, Myricetin, Isoliquiritigenin, Curcumin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang DNA Repair, P53 Signaling, Angiogenesis le MYC Signaling le tse ling. Giant Butterbur e khothaletsoa kotsing ea Poems Syndrome ha kotsi ea lefutso e amanang le CUL4A. Sena ke hobane Giant Butterbur e eketsa litsela tsa biochemical tse hanyetsanang le bakhanni ba eona.

Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa meroho Mustard Spinach ke Apigenin, Kaempferol, Myricetin, Isoliquiritigenin, Curcumin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka DNA Repair le Cell Cycle Checkpoints le tse ling. Mustard Spinach ha e khothalletsoe ha kotsi ea Poems Syndrome ha kotsi ea lefutso e amanang le CUL4A hobane e eketsa litsela tsa eona.

BUTERBURU E KHOLO EA MERO E KHOTHWA HO FETISISA SPINACH EA MUSTAD BAKENG SA CUL4A KOTSI EA LIFUTO EA KANKERE.

Khetha Litholoana tsa NANCE kapa FIG?

Litholoana tsa Nance li na le metsoako e mengata e sebetsang kapa bioactives tse kang Apigenin, Kaempferol, Myricetin, Isoliquiritigenin, Curcumin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka Hypoxia, P53 Signaling le Angiogenesis le tse ling. Nance e khothaletsoa bakeng sa kotsi ea Poems Syndrome ha kotsi ea lefutso e amanang le CUL4A. Lebaka ke hore Nance e eketsa litsela tsa biochemical tse hanyetsanang le bakhanni ba eona ba saenneng.

Tse ling tsa metsoako e sebetsang kapa li-bioactive ka litholoana Fig ke Quercetin, Kaempferol, Isoliquiritigenin, Curcumin, Catechol. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang MAPK Signaling, DNA Repair le PI3K-AKT-MTOR Signaling le tse ling. Fig ha e khothalletsoe ha kotsi ea Poems Syndrome ha kotsi ea liphatsa tsa lefutso e amanang le CUL4A hobane e eketsa litsela tsa eona.

THOLOANA NANCE E KHOTHATSOA HO FETISISA FIG FOR CUL4A genetic RISK OF KANSERE.

Khetha Nut BUTTERNUT kapa EUROPEAN CHESTNUT?

Butternut e na le metsoako e mengata e sebetsang kapa bioactives tse kang Apigenin, Kaempferol, Myricetin, Isoliquiritigenin, Curcumin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical tse kang DNA Repair, Hypoxia, P53 Signaling le MAPK Signaling le tse ling. Butternut e khothaletsoa kotsing ea Poems Syndrome ha kotsi ea lefutso e amanang le CUL4A. Lebaka ke hobane Butternut e eketsa litsela tsa biochemical tse khahlano le bakhanni ba eona ba saenneng.

Tse ling tsa metsoako e sebetsang kapa li-bioactive tsa Chestnut ea Europe ke Apigenin, Quercetin, Kaempferol, Myricetin, Isoliquiritigenin. Lisebelisoa tsena tse sebetsang li laola litsela tse fapaneng tsa biochemical joalo ka DNA Repair le tse ling. European Chestnut ha e khothalletsoe ha kotsi ea Poems Syndrome ha kotsi ea lefutso e amanang le CUL4A hobane e eketsa litsela tsa ho saena.

BUTTERNUT E KHOTHATSOE HO FETISISA CHESTNUT EA EUROPE BAKENG SA CUL4A genetic RISK EA KANKERE.

Ha re phethela

Lijo le Lisebelisoa tse khethiloeng ke liqeto tsa bohlokoa bakeng sa mofetše joalo ka Poems Syndrome. Bakuli ba Lithothokiso tsa Syndrome le batho ba nang le kotsi ea lefutso ba lula ba e-na le potso ena: "Ke lijo life le li-supplement tsa phepo tse khothalletsoang ho 'na le tse sa buelloang?" Ho na le tumelo e tloaelehileng eo e leng maikutlo a fosahetseng a hore lijo tsohle tse thehiloeng limela li ka ba molemo kapa che empa li ke ke tsa e-ba kotsi. Lijo tse ling le li-supplement li ka kena-kenana le phekolo ea mofetše kapa tsa khothalletsa bakhanni ba limolek'hule tsa mofetše.

Ho na le mefuta e fapaneng ea matšoao a mofets'e joalo ka Poems Syndrome, e 'ngoe le e' ngoe e na le liphatsa tsa lefutso tse fapaneng tse nang le mefuta e fapaneng ea genomic ho motho ka mong. Ho feta moo kalafo e 'ngoe le e' ngoe ea mofetše le chemotherapy e na le mokhoa o ikhethileng oa ts'ebetso. Sejo se seng le se seng joalo ka Wax Gourd se na le li-bioactive tse fapaneng ka bongata bo fapaneng, tse nang le tšusumetso litseleng tse fapaneng le tse ikhethileng tsa lik'hemik'hale tsa biochemical. Tlhaloso ea phepo e nepahetseng ke likhothaletso tsa motho ka mong bakeng sa sesupo sa mofetše, kalafo, liphatsa tsa lefutso, mokhoa oa bophelo le lintlha tse ling. Liqeto tsa phepo e nepahetseng bakeng sa mofetše li hloka tsebo ea biology ea mofets'e, mahlale a lijo le kutloisiso ea liphekolo tse fapaneng tsa chemotherapy. Qetellong ha ho e-na le liphetoho tsa phekolo kapa li-genomics tse ncha li khetholloa - phepo e nepahetseng e hloka ho hlahlojoa bocha.

Tharollo ea motho ka mong ea phepo e nepahetseng ea addon e etsa hore ho etsa liqeto ho be bonolo le ho tlosa likhakanyo tsohle ho araba potso e reng, "Ke lijo life tseo ke lokelang ho li khetha kapa ho se khethe bakeng sa Poems Syndrome?". Sehlopha sa li-addon tse nang le taeo e mengata se kenyelletsa lingaka tsa mofetše, bo-ramahlale ba bongaka, baenjiniere ba mananeo le bo-ramahlale ba data.

References

• Tšusumetso ea Daidzein ho mofets'e oa prostate refractory in vitro le in vivo ha e bapisoa le genistein le soy extract: potentiation of radiotherapy.
• Citrus flavonoid naringenin e thusa ho lokisa DNA liseleng tsa mofetše oa senya.
• Ho hlahisa li-receptor tse ka bang teng tsa nakoana tsa mofuta oa 1 (TRPV1) ka capsaicin ho etsa hore Fas / CD95-mediated apoptosis ea lisele tsa mofetše oa urothelial ka mokhoa o itšetlehileng ka ATM.
• Liphello tsa isoliquiritigenin liseleng tsa mofetše oa mahe a bomme.
• https://rarediseases.org/rare-diseases/poems-syndrome
• https://www.mayoclinic.org/diseases-conditions/poems-syndrome/symptoms-causes/syc-20352678#:~:text=POEMS%20syndrome%20is%20a%20rare,your%20hands%20%E2%80%94%20and%20difficulty%20breathing.
• https://my.clevelandclinic.org/health/diseases/17985-poems-syndrome )