Lintlha-khōlō Tsa
Le ha lijo tse nang le lignans (mohloli oa phytoestrogen ea lijo tse nang le sebopeho se ts'oanang le estrogen) li kanna tsa ba le metsoako ea bohlokoa e ka thusang ho fokotsa kotsi ea mefuta e fapaneng ea mofetše, kamano lipakeng tsa plasma enterolactone le kotsi ea mofetše ha e hlake . Phuputso ea morao tjena e fumane hore maemo a phahameng a enterolactone a kanna a amahanngoa le kotsi e fokotsehileng ea lefu le tšoaetsanoang ke mofets'e har'a basali le kotsi e kholo ea ho shoa har'a banna. Boithuto bo bong bo ileng ba lekola litlamorao tsa khatello ea mali ea "enterolactone" kankere ea matsoele, ea senya le ea "endometrial" ha ea ka ea fumana mokhatlo kapa ea qetella e bile le litholoana tse hananang. Kahoo, ho fihlela joale, ha ho na bopaki bo hlakileng bo supang hore maemo a phahameng a potoloho ea enterolactone a ka fana ka litlamorao tse matla khahlanong le kotsi ea mofetše o amanang le lihormone.
Lignans ke eng?
Lignans ke li-polyphenol hape ke mohloli o ka sehloohong oa phepo ea phytoestrogen (semela se nang le sebopeho se ts'oanang le estrogen), e fumanoang haholo lijong tse fapaneng tsa limela tse kang peo ea folaxe le peo ea sesame le ka bongata bo bonyenyane linate, lithollo, litholoana le meroho. Lijo tsena tse nang le lignan hangata li sebelisoa e le karolo ea phepo e nepahetseng. Tse ling tsa li-pre-precise tsa lignan tse tsebahalang lijong tse thehiloeng lijalong ke secoisolariciresinol, pinoresinol, lariciresinol le matairesinol.
Enterolactone ke eng?
Limela tsa limela tseo re li jang li fetoloa ka enjutara ke libaktheria tsa mala tse lebisang ho thehoeng ha metsoako e bitsoang Enterolignans. Li-enterolignans tse peli tse ka sehloohong tse potolohang 'meleng ea rona ke:
a. Enterodiol le
b. Enterolactone
Enterolactone ke e 'ngoe ea lignans tsa mammalian tse ngata ka ho fetisisa. Enterodiol e ka boela ea fetoloa ho enterolactone ke libaktheria tsa mala. (Meredith AJ Hullar et al, Cancer Epidemiol Biomarkers Prev., 2015) Ka bobeli enterodiol le enterolactone, li tsejoa li na le ts'ebetso e fokolang ea estrogenic.
Ntle le palo ea phepelo ea limela tsa limela, li-enterolactone ka serum le moroto le tsona li ka bonts'a tšebetso ea libaktheria tsa mala. Hape, ts'ebeliso ea lithibela-mafu e amahanngoa le khatello e tlase ea serum enterolactone.
Ha ho tluoa ho phytoestrogen (motsoako oa semela o nang le sebopeho se ts'oanang le estrogen) lijo tse ruileng, li-isoflavones tsa soya hangata li hlahella, leha ho le joalo, lignans ke tsona mohloli o ka sehloohong oa li-phytoestrogens haholo lijong tsa Bophirimela.
Lijo Tseo U ka li Jang Kamora Ho Khetholla Kankere!
Ha ho kankere tse peli tse tšoanang. Fetela ka n the'ane ho tataiso e tloaelehileng ea phepo bakeng sa motho e mong le e mong 'me u etse liqeto tse ikhethileng mabapi le lijo le li-supplement ka kholiseho.
Khokahano ea Plasma Enterolactone le Kotsi ea Kankere
Leha lijo tse nang le lignans tse ngata (mohloli oa phytoestrogen ea lijo tse nang le sebopeho se ts'oanang le estrogen) li nkuoa li phetse hantle 'me li na le metsoako e fapaneng ea bohlokoa e ka thusang ho fokotsa kotsi ea mefuta e fapaneng ea mofets'e, kamano lipakeng tsa maemo a enterolactone le kotsi ea kankere ha e hlake.
Khokahano ea Plasma Enterolactone le Mafu a Kankere a Colorectal
Phuputsong e phatlalalitsoeng ka 2019 ke bafuputsi ba Denmark, ba ile ba lekola kamano lipakeng tsa plasma concentrations ea enterolactone (the main lignan metabolite) pele ho tlhahlobo ea mofets'e, le ho phela kamora colorectal. tsoaroa ke kankere, e thehiloeng boitsebisong bo tsoang ho basali ba 416 le banna ba 537 ba fumanoeng ba e-na le mofetše oa colorectal, ba ileng ba kenya letsoho Thutong ea Denmark Diet, Cancer le Health cohort. Nakong ea tatellano, ho shoele basali ba 210 le banna ba 325, bao ho bona basali ba 170 le banna ba 215 ba shoeleng ka lebaka la kankere ea mala. (Cecilie Kyrø et al, Br J Phepo., 2019)
Liphumano tsa boithuto li ne li khahlisa haholo. Phuputso e fumane hore maemo a phahameng a Enterolactone a ne a amahanngoa le lefu le tlase le amanang le mofets'e har'a basali, haholo ho ba sa sebeliseng lithibela-mafu. Ho pheta-pheta khatello ea mali ea enterolactone ho basali ho ne ho amahanngoa le kotsi e tlase ea 12% ea batho ba shoang ka lebaka la mofetše o motala. Hape, basali ba nang le khatello ea mali e phahameng haholo ea enterolactone ba bile le palo e tlase ea lefu la 37% ka lebaka la mofetše oa 'mala, ha o bapisoa le ba nang le plasma e tlase ea enterolactone. Leha ho le joalo, ho banna, maemo a phahameng a enterolactone a ne a amahanngoa le lefu le phahameng le ikhethang la mofets'e. Ebile, ho banna, ho imena habeli ha methapo ea mali ea enterolactone ho ne ho amana le kotsi e phahameng ea 10% ea batho ba shoang ka lebaka la mofets'e oa 'mala.
Sena se tsamaellana le phuputso e fetileng e bonts'itseng hore estrogen, hormone ea basali ea thobalano, e na le kamano e fapaneng le kotsi ea mofets'e ea lefu la 'mala le lefu (Neil Murphy et al, J Natl Cancer Inst., 2015). Enterolactone e nkoa e le phytoestrogen. Li-phytoestrogens ke metsoako ea limela e nang le sebopeho se ts'oanang le estrogen, 'me lijo tse nang le limela tse nang le lignan ke mohloli oa tsona oa mantlha oa phepo.
Ka bokhutšoanyane, bafuputsi ba fihletse qeto ea hore maemo a phahameng a enterolactone a kanna a amahanngoa le kotsi e fokotsehileng ea lefu le ikhethang la mofets'e har'a basali le kotsi e eketsehileng ea lefu har'a banna.
Khokahano ea Plasma Enterolactone le Kotsi ea Kankere ea Endometrial
Khatello ea Kankere ea Enterolactone le Kankere ea Endometrial ho Basali ba Danish
Phuputsong e phatlalalitsoeng ke bafuputsi ba Setsi sa Patlisiso ea Mokhatlo oa Kankere ea Danish naheng ea Denmark, ba lekotse botsoalle lipakeng tsa maemo a plasma enterolactone le kankere ea endometrial, e ipapisitse le tlhaiso-leseling e tsoang linyeoeng tse 173 tsa endometriamo le basali ba 149 ba khethileng ba Denmark ba ngolisitsoeng ' Boithuto ba sehlopha sa Lijo, Kankere le Bophelo bo botle lipakeng tsa 1993 le 1997 mme ba ne ba le lilemo tse pakeng tsa 50 le 64. (Julie Aarestrup et al, Br J Nutriti., 2013)
Phuputso e fumane hore basali ba nang le "nololone" ea "plasma" e phahameng ea 20 nmol / l ba ka amahanngoa le kotsi e fokotsehileng ea mofetše oa endometrium. Leha ho le joalo, phokotso e ne e se bohlokoa hakaalo. Phuputso e boetse e lekotse mokhatlo kamora ho qhelela ka thoko lintlha tse tsoang ho basali ba nang le likhakanyo tse tlase tsa enterolactone ka lebaka la ts'ebeliso ea lithibela-mafu mme ba fumana hore mokhatlo o ba matla hanyane, leha ho le joalo, o ntse o lula o se bohlokoa. Phuputso ha ea ka ea fumana phapang mokhatlong ka lebaka la boemo ba ho ilela khoeli, kalafo ea li-hormone kapa BMI.
Bafuputsi ba fihletse qeto ea hore mohopolo o phahameng oa "enterolactone" oa plasma o ka fokotsa menyetla ea mofetše oa endometrium, empa tšusumetso e kanna ea se bohlokoa.
Khatello ea Kankere ea Enterolactone le Kotsi ea Endometrial ho basali ba Amerika
Bafuputsi ba tsoang Sekolong sa Bongaka sa New York University ho la US ba ne ba kile ba etsa phuputso e ts'oanang e neng e lekola botsoalle lipakeng tsa mofetše oa endometriamo le maemo a potolohang a enterolactone. Lintlha tsa thuto li fumanoe ho tsoa liphuputsong tsa sehlopha sa 3 New York, Sweden le Italy. Kamora ho lateloa ho bolelang ha lilemo tse 5.3, ho fumanoe linyeoe tse 153, tse kenyellelitsoeng phuputsong hammoho le li-control tse tšoanang tse 271. Phuputso ha ea ka ea fumana karolo e sirelletsang ea ho tsamaisa enterolactone khahlano le mofetše oa endometrial ho basali ba premenopausal kapa postmenopausal. (Anne Zeleniuch-Jacquotte et al, Kankere ea Int J., 2006)
Lithuto tsena ha li fane ka bopaki ba hore enterolactone e sireletsa khahlanong le mofetše oa endometrium.
Khokahano ea Plasma Enterolactone le Mafu a Kankere ea Prostate
Phuputsong e phatlalalitsoeng ka 2017 ke bafuputsi ba Denmark le Sweden, ba ile ba lekola kamano pakeng tsa mahloriso a prediagnostic a enterolactone le lefu har'a banna ba Danish ba nang le prostate. tsoaroa ke kankere. Boithuto bona bo ne bo kenyelletsa lintlha tse tsoang ho banna ba 1390 ba fumanoeng ba e-na le mofetše oa tšoelesa ea senya ba neng ba ngolisitsoe ho Danish Diet, Cancer le Health cohort Study. (AK Eriksen et al, Eur J Clin Nutr., 2017)
Phuputso ha ea ka ea fumana kamano ea bohlokoa lipakeng tsa 20 nmol / l e phahameng ea plasma ea enterolactone le lefu ho banna ba Danish ba nang le mofetše oa senya. Phuputso hape ha e fumane phapang mokhatlong ka lebaka la lintho tse kang ho tsuba, index ea boima ba 'mele kapa papali, hammoho le pefo ea mofetše oa senya.
Ka bokhutšoanyane, phuputso ha ea ka ea fumana kamano lipakeng tsa likhahla tsa enterolactone le lefu hara banna ba Danish ba fumanoeng ba na le mofetše oa tšoelesa ea senya.
Ho ipapisitsoe le tlhaiso-leseling e fokolang, ha ho na bopaki bo tšehetsang kamano e fapaneng lipakeng tsa lignan (mohloli oa phytoestrogen ea lijo le sebopeho se ts'oanang le estrogen) -ho ja lijo tse ngata, ho kenella ka serum enterolactone le kotsi ea mofetše oa senya.
Khokahano ea Plasma Enterolactone le Kankere ea Matsoele
Khatello ea Enterolactone le Pherekano ea Kankere ea Lebese ho Basali ba Danish Postmenopausal
Phuputsong e phatlalalitsoeng ka 2018 ke bafuputsi ba Setsi sa Patlisiso ea Mokhatlo oa Kankere ea Danish le Univesithi ea Aarhus naheng ea Denmark, ba lekotse botsoalle lipakeng tsa tlhahlobo ea mali ea pele ho lefu la enterolactone le tšoaetso ea mofetše oa matsoele ho basali ba postmenopausal joalo ka ho pheta-pheta, lefu le ikhethileng la mofets'e oa matsoele. le tsohle tse bakang lefu. Phuputso e kenyelelitse tlhaiso-leseling e tsoang ho linyeoe tsa kankere ea matsoele tsa 1457 tse tsoang ho Danish Diet, Cancer le Health cohort Study. Nakong ea nako e latelang ea lilemo tse 9, basali ba 404 ba hlokahetse, ho bona ba 250 ba bolailoe ke mofetše oa matsoele, mme ba 267 ba bile le boiphihlelo. (Cecilie Kyrø et al, Lithethefatsi tsa Kliniki., 2018)
Phuputso e fumane hore "enterolactone" e phahameng ea mali e na le kamano e nyane feela le mafu a tlase a lefu la mofets'e ho basali ba postmenopausal, mme ha ho kamano le lisosa tsohle tse bakang lefu le ho iphetha kamora ho nahana ka lintho tse kang ho tsuba, ho kena sekolo, BMI, ho ikoetlisa le tšebeliso ea li-hormone tsa ho ilela khoeli. Liphetho ha lia fetoha kamora ho kenyelletsa lintlha tse joalo ka litšobotsi tsa bongaka le kalafo.
Phuputso e phethile ka hore ho ne ho se na kamano e hlakileng lipakeng tsa likhakanyo tsa mali tsa pele ho tlhahlobo ea enterolactone le tšoaetso ea mofetše oa matsoele ho basali ba postmenopausal.
Kotsi ea kankere ea matsoele ea Enterolactone le Postmenopausal ka estrogen, progesterone le herceptin 2 boemo ba ho amohela
Phuputsong ea meta e entsoeng ke bafuputsi ba Setsi sa Patlisiso ea Kankere ea Jeremane, Heidelberg, Jeremane, ba lekotse botsoalle pakeng tsa serum enterolactone le kotsi ea mofets'e oa postmenopausal. Lintlha tsa tlhahlobo li fumanoe maemong a 1,250 a mofets'e oa matsoele le taolo ea 2,164 ho tsoa phuputsong e kholo e thehiloeng ho baahi. (Aida Karina Zaineddin le al, Kankere ea Int J., 2012)
Phuputso e fumane hore maemo a eketsehileng a serum enterolactone a amahanngoa le kotsi e fokotsehileng ea mofetše oa matsoele oa postmenopausal. Phuputso e boetse e totobalitse hore mokhatlo ona o bohlokoa haholo bakeng sa mofetše oa matsoele oa Estrogen Receptor (ER) -ve / Progesterone Receptor (PR) ha o bapisoa le mofetše oa matsoele oa ER + ve / PR + ve. Ho feta moo, polelo ea HER2 ha e na tšusumetso mokhatlong.
Phuputso ena e khothalelitse hore litekanyetso tse phahameng tsa serum enterolactone li kanna tsa amahanngoa le kotsi e fokotsehileng ea mofetše oa matsoele oa postmenopausal, haholo-holo ho Estrogen Receptor (ER) -ve / Progesterone Receptor (PR) - kankere ea matsoele.
Khatello ea Kankere ea Kankere ea Lebese le Kotsi ea Basali ho Basali ba French Postmenopausal
Phuputso e fetileng e phatlalalitsoeng ka 2007 ke bafuputsi ba Institut Gustave-Roussy, France le eona e hlahlobile likamano lipakeng tsa kotsi ea mofets'e oa matsoele oa postmenopausal le ho ja lijo tsa limela tse 'nè tsa lignans -pinoresinol, lariciresinol, secoisolariciresinol, le matairesinol, le ho pepesetsoa likhoebo tse peli. - enterodiol le enterolactone. Phuputso e sebelisitse tlhaiso-leseling e tsoang ho lipotso tsa nalane ea nalane ea lijo tse itsoelang ho tsoa ho basali ba Mafora ba 58,049 ba kamorao ho nako ba neng ba sa nke li-supplements tsa soya isoflavone. Nakong ea tatellano e bolelang ea lilemo tse 7.7, ho fumanoe linyeoe tse 1469 tsa mofets'e oa matsoele. (Marina S Touillaud et al, J Natl Cancer Inst., 2007)
Phuputso e fumane hore ha e bapisoa le basali ba nang le li-lignan tse tlase ka ho fetesisa, ba nang le lignan e phahameng ka ho fetesisa e lekanang le> 1395 microg / ka letsatsi, ba na le kotsi e fokotsehileng ea mofets'e oa matsoele. Phuputso e boetse e fumane hore mekhatlo e fapaneng lipakeng tsa phytoestrogen e kenang le kotsi ea kankere ea matsoele ea postmenopausal e ne e lekantsoe ho Estrogen Receptor (ER) le Progesterone Receptor (PR) - mofetše oa kankere oa matsoele.
Ho nka lintho tsa bohlokoa: Ho fihlela hajoale, ho na le liphetho tse hanyetsanang mme ka hona, re ke ke ra fihlela qeto ea hore na lignan e phahameng (mohloli oa phepo ea phytoestrogen e nang le sebopeho se ts'oanang le estrogen) -ho ja lijo tse ngata le ho kenella ha plasma ea enterolactone ho na le litlamorao khahlanong le mofetše oa matsoele.
fihlela qeto e
Leha ho ja lijo tse nang le lignan tse ngata (mohloli oa phytoestrogen ea lijo tse nang le sebopeho se tšoanang le estrogen) ho phetse hantle 'me ho ka ba le metsoako ea bohlokoa e ka thusang ho fokotsa kotsi ea mefuta e fapaneng ea mofets'e, kamano lipakeng tsa maemo a plasma ea enterolactone le kotsi. mefuta e sa tšoaneng ea kankere ha e e-s'o hlake. E 'ngoe ea liphuputso tsa morao-rao e khothalelitse karolo ea ts'ireletso ea enterolactone khahlano le lefu la mofetše oa colorectal ho basali, leha ho le joalo, mekhatlo e ne e fapane le banna. Lithuto tse ling tse ileng tsa lekola phello ea khatello ea plasma ea enterolactone ho mofetše o amanang le lihomone joalo ka mofetše oa matsoele, mofetše oa tšoelesa ea senya le mofetše oa endometrial ha lia ka tsa fumana kamano kapa li ile tsa fella ka liphetho tse hanyetsanang. Kahoo, hajoale, ha ho na bopaki bo hlakileng bo bontšang hore maemo a phahameng a potoloho ea enterolactone a ka fana ka litlamorao tse matla tsa ts'ireletso khahlano le kotsi ea ho ba le lihormone. kankere.
Lijo tseo u li jang le tse u tlatsetsang ke qeto eo u e etsang. Qeto ea hau e lokela ho kenyelletsa ho nahanisisa ka liphetoho tsa liphatsa tsa lefutso tsa mofetše, e leng mofetše, kalafo e tsoelang pele le litlatsetso, ho kula hohle, leseli la bophelo, boima, bolelele le litloaelo.
Morero oa phepo e nepahetseng bakeng sa mofets'e ho tsoa addon ha o ea ipapisa le lipatlisiso tsa inthanete. E iketsetsa liqeto bakeng sa hau e ipapisitse le mahlale a limolek'hule a kentsoeng tšebetsong ke bo-rasaense ba rona le lienjineri tsa software. Ho sa tsotelehe hore na o tsotella ho utloisisa metheo ea limolek'hule kapa che - bakeng sa moralo oa phepo ea mofets'e kutloisiso ea hlokahala.
Qala hona joale ka moralo oa hau oa phepo e nepahetseng ka ho araba lipotso lebitsong la mofetše, phetoho ea lefutso, kalafo e tsoelang pele le litlatsetso, ho kula hohle, litloaelo, mokhoa oa bophelo, sehlopha sa lilemo le bong.
Phepo e ikhethileng bakeng sa Kankere!
Kankere e fetoha ha nako e ntse e ea. Iketsetse 'me u fetole phepo ea hau ho latela sesupo sa mofets'e, kalafo, mokhoa oa bophelo, khetho ea lijo, lintho tse allergy le lintlha tse ling.
Bakuli ba mofets'e hangata ba tlameha ho sebetsana le tse fapaneng litla-morao tsa chemotherapy tse amang boleng ba bona ba bophelo le ho batla mekhoa e meng ea kalafo ea mofets'e. Ho nka phepo e nepahetseng le litlatsetso ho latela maikutlo a mahlale (ho qoba ho inahanela le ho khetha ka mokhoa o sa reroang) ke pheko ea tlholeho bakeng sa mofets'e le litla-morao tse amanang le kalafo