Cuntooyinka kansarka ugxansidaha!

Hordhac

Cuntooyinka loogu talagalay Kansarka Ovarian-ka waa in loo shakhsiyeeyaa qof kasta oo waa in sidoo kale la qabsado marka daawaynta kansarka ama hidde-sidaha buradu ay isbeddelaan. Shakhsiyaynta iyo la qabsiga waa in ay tixgelisaa dhammaan maaddooyinka firfircoon ama bioactives ee ku jira cuntooyinka kala duwan marka loo eego bayooloojiyada unugyada kansarka, genetics, daawaynta, xaaladaha qaab nololeedka iyo doorbidka cuntada. Sidaa darteed iyadoo nafaqadu ay tahay mid ka mid ah go'aamada aadka muhiimka u ah bukaanka kansarka iyo qofka halista ugu jira kansarka inuu sameeyo - sida loo doorto cuntooyinka uu cuno maaha hawl fudud.

Kansarka Ovarian-ka miyay muhiim u tahay waxa khudaarta, miraha, lawska, iniinaha uu qofku cuno?

Su'aasha nafaqeynta ee aadka caanka ah ee ay weydiiyaan bukaannada kansarka iyo shakhsiyaadka halista ugu jira hidde-sidaha kansarka waa - kansarrada sida Kansarka Ovarian-ka miyay muhiim tahay cuntooyinka aan cuno iyo kuwa aanan samayn? Mise haddii aan raaco cunto ku salaysan geedka ma ku filan tahay kansarka sida Kansarka Ovarian-ka?

Tusaale ahaan miyay muhiim tahay haddii Cauliflower khudaarta la isticmaalo in ka badan marka la barbar dhigo tamaandhada beerta? Miyay wax farqi ah samaynaysaa haddii midhaha Black Elderberry laga doorbido rummaanka? Sidoo kale haddii xulashooyin la mid ah loo sameeyo lawska/abuurka sida Butternut oo ka sarreeya lowska Brazil iyo garaacyada sida Broad Bean oo ka sarreeya Chickpea. Oo haddii waxa aan cunaa ay arrintu khusayso - markaa sidee loo aqoonsan karaa cuntooyinka lagu taliyay Kansarka Ovarian-ka oo ma isku mid baa u tahay qof kasta oo leh isla cudurka ama khatarta hidde-sidaha?

Haa! Cuntooyinka aad cuntid waxay muhiim u yihiin Kansarka Ugxan-sidaha!

Talooyinka cuntadu waxay noqon karaan kuwo isku mid ah qof kasta oo way ka duwanaan karaan xitaa ogaanshaha isku midka ah iyo khatarta hidda-socodka.

Dhammaan cuntooyinka ( khudaarta, miraha, lawska, iniinaha, garaaca, saliidaha iwm.) iyo kaabayaasha nafaqadu waxay ka kooban yihiin wax ka badan hal walxo molecular ama bio-actives oo qiyaas iyo tiro kala duwan leh. Walax kasta oo firfircooni waxay leedahay hab u gaar ah oo wax qabad - kaas oo noqon kara firfircooni ama xannibaadda dariiqyada biochemical ee kala duwan. Cuntooyinka si fudud loo sheegay iyo kaabisyada lagu taliyay waa kuwa aan keenin korodhka wadayaasha molecular ee kansarka laakiin la yareeyo. Haddii kale cuntooyinkaas waa inaan lagu talin. Cuntooyinka waxaa ku jira maaddooyin badan oo firfircoon - markaa marka la qiimeynayo cuntooyinka iyo kaabayaasha waxaad u baahan tahay inaad tixgeliso saameynta dhammaan maaddooyinka firfircoon si wadajir ah halkii aad ka ahaan lahayd mid gaar ah.

Tusaale ahaan Black Elderberry waxaa ku jira maaddooyin firfircoon oo leh Lycopene, Curcumin, Isoliquiritigenin, Quercetin, Myricetin. Rumaankuna waxa uu ka kooban yahay maaddooyin firfircoon Curcumin, Isoliquiritigenin, Quercetin, Myricetin, Naringin iyo kuwo kale oo suurtogal ah.

Qalad caadi ah oo la sameeyo marka la go'aaminayo oo la dooranayo cuntooyinka loo cuno Kansarka Ovarian - waa in la qiimeeyo oo kaliya maaddooyinka firfircoon ee la doortay ee ku jira cuntooyinka oo la iska indhatiro inta kale. Sababtoo ah maaddooyinka kala duwan ee firfircoon ee ku jira cuntooyinka ayaa laga yaabaa inay saameyn iska soo horjeeda ku yeeshaan darawalada kansarka - ma qaadan kartid maaddooyinka firfircoon ee cuntooyinka iyo kaabayaasha si loo gaaro go'aanka nafaqada ee Kansarka Ovarian-ka.

HAA – DOORASHOOYINKA CUNTADA EE KANSARKA WAXAY U TAAGAN YAHAY. GO'AANKA NAFAQADA waa in ay tixgeliyaan dhammaan walxaha firfircoon ee CUNTADA.

Xirfadaha Looga Baahan Yahay Nafaqaynta Shakhsiyaynta Kansarka Ovarian-ka?

Nafaqada shakhsi ahaaneed ee kansarka sida Kansarka Ovarian-ka waxa uu ka kooban yahay cuntooyin/kaabyo lagu taliyey; Cuntooyinka aan lagu talin/kabka tusaale ahaan cunto karinta kuwaas oo mudnaanta siiya isticmaalka cuntooyinka lagu taliyay. Tusaale nafaqeynta gaarka ah ayaa tan lagu arki karaa link.

Go'aaminta cuntooyinka lagu taliyay iyo in kale waa mid aad u adag, oo u baahan khibrad ku saabsan bayoolajiga Kansarka Ovarian, sayniska cuntada, genetics, biochemistry oo ay weheliso faham wanaagsan oo ku saabsan sida daawaynta kansarku u shaqeyso iyo baylahda la xidhiidha kuwaas oo daaweyntu ay joojin karto waxtarka.

Khibradda UGU YAR EE AQOONTA EE LOO BAAHAN YAHAY NAFAQADA SHAQSIYADEEDKA KANSARKA WAA: NOLOLIGA KANSARKA, CUNTADA CUNTADA, DAAWAYNTA KANSARKA IYO HIDDAHA HIDDAHA.

Astaamaha kansarka sida Kansarka Ovarian

Dhammaan kansarrada sida Kansarka Ovarian-ka waxa lagu gartaa hab gaar ah oo ah dariiqyada biochemical - dariiqooyinka saxeexa ee Kansarka ugxan-sidaha. Dariiqooyin kiimikaad sida bararka, Calaamadaynta NFKB, Isbaarada Wareegga Unugyada, Apoptosis waa qayb ka mid ah qeexida saxeexa Kansarka Ovarian-ka. Hidde-sideyaasha kansarku qof walba wuu ka duwanaan karaa sidaas darteed saxiixooda gaarka ah ee kansarku wuxuu noqon karaa mid gaar ah.

Daawaynta waxtarka u leh Kansarka Ovarian-ka waxay u baahan yihiin inay ogaadaan dariiqooyinka biochemical ee la xidhiidha saxeexa bukaanka kansarka iyo shakhsiga khatarta hidde-sidaha. Sidaa darteed daawayn kala duwan oo leh habab kala duwan oo ficil ah ayaa waxtar u leh bukaanada kala duwan. Si la mid ah iyo sababo la mid ah cuntooyinka iyo kaabista waxay u baahan yihiin in shaqsi kasta loo gaaryeelo. Sidaa awgeed cuntooyinka iyo kaabista qaar ayaa lagula taliyaa Kansarka Ovarian-ka marka la qaadanayo daawaynta kansarka Olaparib, iyo cuntooyinka qaar iyo kaabista laguma talinayo.

Ilaha sida cBioPortal iyo qaar kale oo badan ayaa bixiya xogta bukaan-socodka ee aan la magacaabin ee laga helay tijaabooyinka bukaan-socodka ee dhammaan calaamadaha kansarka. Xogtan waxay ka kooban tahay tafaasiisha daraasadda tijaabada caafimaad sida cabbirka saamiga / tirada bukaannada, kooxaha da'da, jinsiga, qowmiyadda, daawaynta, goobta burooyinka iyo isbeddellada hidde-sidaha.

TP53, MUC16, NF1, RYR2 iyo KMT2C waa hiddo-wadaha ugu sarreeya ee la soo sheegay ee Kansarka Ovarian-ka. TP53 ayaa lagu soo warramey 29.2 % bukaanada matala dhammaan tijaabooyinka caafimaad. Iyo MUC16 ayaa lagu soo warramey 3.2 %. Isku darka xogta bukaanka ee dadweynaha waxay daboolaysaa da'da 26 ilaa 89. 0.0 % xogta bukaanka waxaa loo aqoonsaday inay yihiin rag. Biology-ga Kansarka Ovarian-ka oo ay weheliso hidde-sideyaasha la soo sheegay ayaa si wada jir ah u qeexaya dariiqooyinka biochemical ee saxeexa ee dadweynaha ee kansarkan. Haddii genetics-ka burada kansarka shakhsi ahaaneed ama hiddo-wadaha ka qaybqaata khatarta sidoo kale waa la yaqaan markaa waa in sidoo kale loo isticmaalo shakhsiyaynta nafaqada.

Dookhyada nafaqeynta waa in ay iswaafaqaan shaqsi walba saxiixiisa.

Cuntada iyo Kaabayaasha Kansarka Ugxan-sidaha

Bukaanka Kansarka

Bukaanjiifka kansarka ee ku jira daawaynta ama daryeelka palliative waxay u baahan yihiin inay go'aan ka gaadhaan cuntada iyo kaabista - kaloriinta cuntada ee loo baahan yahay, maaraynta waxyeellooyin kasta oo daawaynta iyo sidoo kale hagaajinta maaraynta kansarka. Dhammaan cuntooyinka dhirta ku salaysan maaha kuwo siman oo doorashada iyo kala horraysiinta cuntooyinka kuwaas oo shakhsi ahaan loo habeeyey oo loo habeeyey daawaynta kansarka ee socota waa muhiim oo dhib badan. Waa kuwan tusaalayaal siinaya tilmaamo lagu samaynayo go'aannada nafaqada.

Dooro CAULIFLOWER ama TAAMAD GARAB?

Cauliflower khudaarta waxaa ku jira waxyaabo badan oo firfircoon ama bioactives sida Curcumin, Isoliquiritigenin, Cinnamaldehyde, Psoralen, Daidzein. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Caabuqa, Calaamadaynta MAPK, Calaamadaynta TWEAK iyo Calaamadaynta MYC iyo kuwa kale. Cauliflower ayaa lagula taliyaa Kansarka Ovarian-ka marka daawaynta kansarka ee socota ay tahay Olaparib. Tani waa sababta oo ah Cauliflower waxay wax ka beddeshaa dariiqyada biochemical ee si cilmiyeysan loo soo sheegay si loo dareemo saameynta Olaparib.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira yaanyada beerta khudradda waa Lycopene, Curcumin, Isoliquiritigenin, Quercetin, Myricetin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida DNA Repair iyo kuwo kale. Beerta yaanyada laguma talinayo Kansarka Ovarian-ka marka daawaynta kansarka ee socota ay tahay Olaparib sababtoo ah waxay wax ka beddeshaa dariiqyada biochemical ee ka dhigaya daawaynta kansarka mid adkaysi u leh ama aan ka jawaabin.

ubaxa khudaarta leh waxaa lagula taliyaa tamaandhada beerta ee kansarka ugxansidaha iyo daawaynta Olaparib.

Dooro rummaanka miraha ama ODEYGA MADOW?

Rumaanka miraha waxaa ku jira waxyaabo badan oo firfircoon ama bioactives sida Curcumin, Isoliquiritigenin, Quercetin, Myricetin, Naringin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida DNA Repair, Epithelial ilaa Mesenchymal Transition, Bararka iyo Calaamadaynta MAPK iyo kuwa kale. Rumaanka ayaa lagula taliyaa Kansarka Ovarian-ka marka daawaynta kansarka ee socota ay tahay Olaparib. Tani waa sababta oo ah rummaanku waxay wax ka beddeshaa dariiqyada biochemical ee si cilmiyeysan loo soo sheegay si loo dareemo saameynta Olaparib.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira miro Black Elderberry waa Lycopene, Curcumin, Isoliquiritigenin, Quercetin, Myricetin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Dayactirka DNA-ga iyo Calaamadaynta MAPK iyo kuwa kale. Black Elderberry laguma talinayo Kansarka Ovarian-ka marka daawaynta kansarka ee socota ay tahay Olaparib sababtoo ah waxay wax ka beddeshaa dariiqyada biochemical ee ka dhigaya daawaynta kansarku mid adkaysi u leh ama aan ka jawaabin.

Rumaanka Miraha waxaa lagula talinayaa ODAYGA MADOW ee Kansarka ugxansidaha iyo daawaynta Olaparib.

Dooro lowska BUTTERNUT ama BRAZIL NUT?

Butternut wuxuu ka kooban yahay waxyaabo badan oo firfircoon ama bioactives sida Lycopene, Curcumin, Isoliquiritigenin, Myricetin, Caffeine. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida DNA Repair, Epithelial ilaa Mesenchymal Transition, Bararka iyo Calaamadaynta MAPK iyo kuwa kale. Butternut ayaa lagula talinayaa Kansarka Ovarian-ka marka daawaynta kansarka ee socota ay tahay Olaparib. Tani waa sababta oo ah Butternut waxay wax ka beddeshaa dariiqyada biochemical ee si cilmiyeysan loo soo sheegay si loo dareemo saameynta Olaparib.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee Brazil nuts waa Curcumin, Isoliquiritigenin, Cinnamaldehyde, Psoralen, Ellagic Acid. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Epithelial ilaa Mesenchymal Transition, bararka iyo calaamadaynta TWEAK iyo kuwa kale. Nut Brazil laguma talinayo Kansarka Ovarian-ka marka daawaynta kansarka ee socota ay tahay Olaparib sababtoo ah waxay wax ka beddeshaa dariiqyada biochemical ee ka dhigaya daaweynta kansarku mid adkaysi u leh ama ka jawaabi kara.

BUTTERNUT ayaa lagula taliyaa BRAZIL NUT ee kansarka ugxan-sidaha iyo daawaynta Olaparib.

Shakhsiyaadka leh Khatarta Hidde ee Kansarka

Su'aasha ay weydiiyaan shakhsiyaadka leh khatarta hidde-sidaha ee Kansarka Ovarian-ka ama taariikhda qoyska waa "Maxaan Cunnaa si ka duwan kii hore?" iyo sida ay tahay inay doortaan cuntooyinka iyo kaabista si loo maareeyo khatarta cudurka. Maadaama khatarta kansarku aanay jirin wax la qaban karo marka la eego daawaynta - go'aamada cuntooyinka iyo kaabista ayaa noqda mid muhiim ah iyo mid ka mid ah waxyaallaha aadka u yar ee la qaban karo. Dhammaan cuntooyinka dhirta ku salaysan maaha kuwo siman oo ku salaysan hidde-sidaha la aqoonsaday iyo saxeexa dariiqa - doorashooyinka cuntada iyo kaabista waa in la shakhsiyeeyo.

Dooro khudradda KALE ama POKEWEED AMERICA?

Khudaarta Kale waxay ka kooban tahay waxyaabo badan oo firfircoon ama bioactives sida Curcumin, Lupeol, Indole-3-carbinol, Daidzein, Formononetin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Dayactirka DNA, Wareegga Unugyada, Calaamadaynta MAPK iyo Calaamadaynta MYC iyo kuwa kale. Kale waxaa lagula talinayaa halista kansarka ugxan-sidaha marka khatarta hidde-sidaha la xiriirta ay tahay KMT2C. Tani waa sababta oo ah Kale waxay kordhisaa dariiqyada biochemical ee ka soo horjeeda wadayaasha saxiixa.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira khudradda Pokeweed American waa Apigenin, Curcumin, Lupeol, Quercetin, Daidzein. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Dayactirka DNA-ga iyo Calaamadaynta MAPK iyo kuwa kale. Pokeweed American laguma talinayo marka khatarta kansarka ugxan-sidaha marka khatarta hidde-sidaha ay tahay KMT2C sababtoo ah waxay kordhisaa dariiqyada saxiixa.

KMT2C HALISTA KMTXNUMXC EE KANSARKA WAXAA LAGULA TALAGALINAYAA POKWEEEDKA AMERICA.

Dooro midhaha raspberry cas ama PUMMELO?

Khudradu waxay ka kooban tahay waxyaabo badan oo firfircoon ama bioactives sida Curcumin, Ellagic Acid, Lupeol, Quercetin, Daidzein. Maaddooyinkan firfircooni waxay wax ka qabtaan dariiqooyin kiimikaad oo kala duwan sida wareegga unugyada, P53 Signaling, Dayactirka DNA iyo Calaamadaynta MYC iyo kuwa kale. Raspberry cas ayaa lagula talinayaa halista kansarka ugxan-sidaha marka khatarta hidde-sidaha la xidhiidha ay tahay KMT2C. Tani waa sababta oo ah Raspberry-ka Cas wuxuu kordhiyaa dariiqyada biochemical ee ka soo horjeeda wadayaasha saxiixa.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira miro Pummelo waa Apigenin, Curcumin, Lupeol, Lycopene, Quercetin. Maaddooyinkan firfircooni waxay wax ka qabtaan dariiqooyin kiimikaad oo kala duwan sida Dayactirka DNA-ga iyo Dib-u-habaynta Matrix-ka Ka-baxsan iyo kuwa kale. Pummelo laguma talinayo marka khatarta kansarka ugxan-sidaha marka khatarta hidde-sidaha la xidhiidha ay tahay KMT2C sababtoo ah waxay kordhisaa dariiqooyinka saxeexa.

Raspberry cas ee miraha waxaa lagula talinayaa PUMMELO KMT2C Khatarta Hidde ee Kansarka.

Dooro lowska walnut madow ama xabadka?

Walnut madow waxaa ku jira waxyaabo badan oo firfircoon ama bioactives sida Apigenin, Curcumin, Ellagic Acid, Lupeol, Quercetin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Unug Wareegga, Calaamadaynta P53, Calaamadaynta MAPK iyo Isbaarooyinka Wareegga Unugyada iyo kuwa kale. Walnut madow waxa lagula taliyaa halista Kansarka Ovarian-ka marka khatarta hidde-sidaha la xidhiidha ay tahay KMT2C. Tani waa sababta oo ah walnut madow waxay kordhisaa dariiqyada biochemical ee ka soo horjeeda wadayaasha saxeexa.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira Chestnut waa Apigenin, Curcumin, Ellagic Acid, Lupeol, Lycopene. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida DNA Repair, Dib-u-habaynta Matrix-ka-ka-baxa ah iyo Isbaarooyinka Wareegga Unugyada iyo kuwa kale. Chestnut laguma talinayo marka halista kansarka ugxan-sidaha marka khatarta hidde-sidaha la xidhiidha ay tahay KMT2C sababtoo ah waxay kordhisaa dariiqyada saxeexa.

Walaska madow waxa lagula talinayaa laabta si loo helo KMT2C Khatarta Hiddada ee Kansarka.

In Gabagabo

Cuntooyinka iyo Kaabayaasha la doortay ayaa ah go'aamo muhiim u ah kansarka sida Kansarka Ovarian-ka. Bukaannada Kansarka Ovarian-ka iyo shakhsiyaadka leh khatarta hidde-sidaha waxay had iyo jeer qabaan su'aashan: "Waa maxay cuntooyinka iyo kaabisyada nafaqeynta ee lagu taliyay aniga iyo kuwa aan ahayn?" Waxaa jira aaminsanaan guud oo ah fikrad khaldan oo ah in dhammaan cuntooyinka dhirta ku salaysan ay faa'iido yeelan karaan ama aysan ahayn laakiin aan waxyeello lahayn. Cuntooyinka qaarkood iyo kaabisyada qaarkood waxay faragelin karaan daawaynta kansarka ama waxay kor u qaadi karaan wadayaasha dariiqyada molecular ee kansarka.

Waxaa jira noocyo kala duwan oo tilmaamayaasha kansarka sida Kansarka Ovarian, mid kasta oo leh hidde-sidaha burooyinka kala duwan oo leh kala duwanaansho genomic dheeraad ah oo qof kasta ah. Intaa waxaa dheer daawaynta kansar kasta iyo kiimoterabi kasta waxay leeyihiin hab wax-qabad oo gaar ah. Cunto kasta sida Cauliflower waxay ka kooban tahay bioactives kala duwan oo tirooyin kala duwan leh, kuwaas oo saameyn ku leh noocyo kala duwan oo kala duwan oo ah dariiqyada biochemical. Qeexida nafaqeynta shakhsi ahaaneed waa talooyinka cuntada ee gaarka ah ee tilmaamaya kansarka, daawaynta, genetics, qaab nololeedka iyo arrimo kale. Go'aannada shakhsiyaynta nafaqada ee kansarka waxay u baahan yihiin aqoonta bayoolajiga kansarka, sayniska cuntada iyo fahamka daaweynta kemotherabi ee kala duwan. Ugu dambeyntii marka ay jiraan isbeddel daaweyn ama genomics cusub ayaa la aqoonsaday - shakhsiyeynta nafaqeynta waxay u baahan tahay dib-u-qiimeyn.

Xalka shakhsiyaynta nafaqeynta ee addon ayaa ka dhigaysa go'aan qaadashada mid fudud oo meesha ka saaraysa dhammaan mala-awaalka ka jawaabaya su'aasha, "Cunto noocee ah ayaan dooran karaa ama ma dooran karaa Kansarka Ovarian?". Kooxda edbinta badan ee addon waxaa ka mid ah dhakhaatiirta kansarka, saynisyahano caafimaad, injineerada software iyo saynisyahano xogta.

tixraacyada

• Saamaynta Msk 2017
• Falanqaynta Pan-kansarka ee genomes oo dhan.
• Isoliquiritigenin wuxuu joojiyaa Metastasis-ka Kansarka Ovarian-ka isagoo ka beddelaya Epithelial-to-Mesenchymal Transition.
• Betulinic Acid waxa ay xakamaysaa Metastasis-ka Kansarka Naasaha iyada oo Bartilmaameedsanaysa GRP78-Glycolysis dhexdhexaadin ah iyo ER Pathway Apoptotic Stress.
• Gallic acid waxay kicisaa dhaawaca DNA waxayna xakameysaa muujinta hidda-socodka hagaajinta DNA ee kansarka qanjirka 'prostate' ee unugyada PC-3.
• Brassinin waxay xannibaysaa dariiqa calaamadaynta STAT3 iyada oo loo marayo habaynta PIAS-3 iyo SOCS-3 muujinta waxayna dareensiisaa kansarka sanbabada bini'aadamka ee xenograft ee jiirarka qaawan ee paclitaxel.
• Faytamiin C wuxuu si xushmad leh u dila unugyada kansarka mindhicirka ee KRAS iyo BRAF iyadoo la beegsanayo GAPDH.
• Geraniol, qayb ka mid ah saliidaha lagama maarmaanka ah ee dhirta, waxay dareensiisaa unugyada kansarka mindhicirka ee 5-Fluorouracil daaweynta.