Cuntooyinka loogu talagalay Osteosarcoma!

Hordhac

Cuntooyinka loogu talagalay Osteosarcoma waa in loo gaaryeelaa qof kasta oo waa in sidoo kale la qabsado marka daawaynta kansarka ama hidde-sidaha buradu ay isbeddelaan. Shakhsiyaynta iyo la qabsiga waa in ay tixgelisaa dhammaan maaddooyinka firfircoon ama bioactives ee ku jira cuntooyinka kala duwan marka loo eego bayooloojiyada unugyada kansarka, genetics, daawaynta, xaaladaha qaab nololeedka iyo doorbidka cuntada. Sidaa darteed iyadoo nafaqadu ay tahay mid ka mid ah go'aamada aadka muhiimka u ah bukaanka kansarka iyo qofka halista ugu jira kansarka inuu sameeyo - sida loo doorto cuntooyinka uu cuno maaha hawl fudud.

Osteosarcoma, oo ah buro halis ah oo aasaasiga ah ee lafaha, waa kansar naadir ah oo leh ilaa 1,000 xaaladood oo cusub oo laga helay Maraykanka iyo dhacdooyinka adduunka oo dhan oo ah 3.4 kiis malaayiin qof sanadkii. Qiyaastii kala badh kuwan waxay ku jiraan carruur, dhallinyaro, iyo dhallinyaro waaweyn oo da'doodu u dhaxayso 10 iyo 30 sano. Osteosarcoma waxay inta badan ku dhacdaa lafaha dhaadheer, sida kuwa gacmaha iyo lugaha waxayna badanaa ku dhacdaa meel u dhow darafyada lafaha iyo meel u dhow jilibkaaga halkaasoo koritaanka ugu dhakhsaha badan uu ka socdo (haddii ay dhacdo dhalinyaro). Osteosarcoma waxay ku dhacdaa wax yar marar badan wiilasha ( qaan-gaarnimada ka dib), sababtoo ah muddada dheer ee koritaanka lafaha. Calaamadaha Osteosarcoma waxaa ka mid ah lafo xanuun ama jilicsanaan, barar ama barar, barar, dhutin, dhaqdhaqaaq xaddidan (haddii ay saamayso kala goysyada), lafo jaban. Heerarka badbaadada 5-ta sano ee osteosarcoma waa> 65% haddii la xaddiday laakiin haddii ay ku faaftay qaybaha kale ee jirka, heerka badbaadadu wuxuu hoos ugu dhacayaa 30-50%. Maareynta heerka sare ee osteosarcoma waxaa ka mid ah in xoogga la saaro kemotherabi iyo badbaadinta addimada waxaana lagu taageeri karaa nafaqada saxda ah (cuntooyinka iyo kaabisyada dabiiciga ah) ee ku habboon kansarka iyo xaaladda daaweynta.

Osteosarcoma miyay muhiim u tahay waxa khudaarta, miraha, lawska, miraha uu qofku cuno?

Su'aasha nafaqeynta ee aadka caanka ah ee ay weydiiyaan bukaannada kansarka iyo shakhsiyaadka halista ugu jira hidde-sidaha kansarka waa - kansarrada sida Osteosarcoma miyay muhiim tahay cuntooyinka aan cuno iyo kuwa aanan samayn? Mise haddii aan raaco cunto ku salaysan geedka ma ku filan tahay kansarka sida Osteosarcoma?

Tusaale ahaan miyay muhiim tahay haddii Kaabashka khudradda la isticmaalo in ka badan marka loo eego Yautia? Miyay wax farqi ah samaynaysaa haddii midhaha laga door bido Plum Java? Sidoo kale haddii xulashooyin la mid ah loo sameeyo nuts/abuurka sida Walnut-ka Caadiga ah ee Chestnut Yurub iyo garaacyada sida Gram Bean oo ka sarreeya Lima Bean. Oo haddii waxa aan cunaa ay arrintu khusayso - markaa sidee loo aqoonsan karaa cuntooyinka lagu taliyay Osteosarcoma oo ma isku mid bay jawaab u tahay qof kasta oo leh isla cudurka ama khatarta hidde-sidaha?

Haa! Cuntooyinka aad cuntid waa arrin muhiim u ah Osteosarcoma!

Talooyinka cuntadu waxay noqon karaan kuwo isku mid ah qof kasta oo way ka duwanaan karaan xitaa ogaanshaha isku midka ah iyo khatarta hidda-socodka.

Dhammaan cuntooyinka ( khudaarta, miraha, lawska, iniinaha, garaaca, saliidaha iwm.) iyo kaabayaasha nafaqadu waxay ka kooban yihiin wax ka badan hal walxo molecular ama bio-actives oo qiyaas iyo tiro kala duwan leh. Walax kasta oo firfircooni waxay leedahay hab u gaar ah oo wax qabad - kaas oo noqon kara firfircooni ama xannibaadda dariiqyada biochemical ee kala duwan. Cuntooyinka si fudud loo sheegay iyo kaabisyada lagu taliyay waa kuwa aan keenin korodhka wadayaasha molecular ee kansarka laakiin la yareeyo. Haddii kale cuntooyinkaas waa inaan lagu talin. Cuntooyinka waxaa ku jira maaddooyin badan oo firfircoon - markaa marka la qiimeynayo cuntooyinka iyo kaabayaasha waxaad u baahan tahay inaad tixgeliso saameynta dhammaan maaddooyinka firfircoon si wadajir ah halkii aad ka ahaan lahayd mid gaar ah.

Tusaale ahaan khudradda xamaasaddu waxay ka kooban tahay maaddooyin firfircoon Curcumin, Isoliquiritigenin, Apigenin, Lupeol, Psoralen. Plum Java wuxuu ka kooban yahay maaddooyin firfircoon Curcumin, Isoliquiritigenin, Apigenin, Lycopene, Lupeol iyo kuwo kale oo suurtagal ah.

Qalad caadi ah oo la sameeyo marka la go'aaminayo oo la dooranayo cuntooyinka loo cuno Osteosarcoma - waa in la qiimeeyo oo kaliya maaddooyinka firfircoon ee la doortay ee ku jira cuntooyinka oo la iska indhatiro inta kale. Sababtoo ah maaddooyinka kala duwan ee firfircoon ee ku jira cuntooyinka ayaa laga yaabaa inay saameyn iska soo horjeeda ku yeeshaan darawalada kansarka - ma qaadan kartid maaddooyinka firfircoon ee cuntooyinka iyo kaabayaasha si aad go'aan uga gaartid Osteosarcoma.

HAA – DOORASHOOYINKA CUNTADA EE KANSARKA WAXAY U TAAGAN YAHAY. GO'AANKA NAFAQADA waa in ay tixgeliyaan dhammaan walxaha firfircoon ee CUNTADA.

Xirfadaha Loo Baahan Yahay Nafaqaynta Shakhsiyaynta Lafo-jileeca?

Nafaqada shakhsi ahaaneed ee kansarrada sida Osteosarcoma waxay ka kooban tahay cuntooyin/kaabyo lagu taliyey; Cuntooyinka aan lagu talin/kabka tusaale ahaan cunto karinta kuwaas oo mudnaanta siiya isticmaalka cuntooyinka lagu taliyay. Tusaale nafaqeynta gaarka ah ayaa tan lagu arki karaa link.

Go'aaminta cuntooyinka lagu taliyay iyo in kale waa mid aad u adag, waxay u baahan tahay khibrad xagga bayoolajiga Osteosarcoma, sayniska cuntada, genetics, biochemistry oo ay weheliso faham wanaagsan oo ku saabsan sida daawaynta kansarka u shaqeyso iyo baylahda la xidhiidha kuwaas oo daawadu ay joojin karto waxtarka.

Khibradda UGU YAR EE AQOONTA EE LOO BAAHAN YAHAY NAFAQADA SHAQSIYADEEDKA KANSARKA WAA: NOLOLIGA KANSARKA, CUNTADA CUNTADA, DAAWAYNTA KANSARKA IYO HIDDAHA HIDDAHA.

Astaamaha kansarka sida Osteosarcoma

Dhammaan kansarrada sida Osteosarcoma waxaa lagu sifeyn karaa waddooyin gaar ah oo biochemical ah - dariiqooyinka saxiixa ee Osteosarcoma. Dariiqooyin kiimikaad sida isbaarada wareegga unugyada, wareegga unugyada, Dib-u-habaynta Matrix-ka-ka-baxa ah, Ku-xidhka Focal waa qayb ka mid ah qeexida saxeexa Osteosarcoma. Hidde-sideyaasha kansarku qof walba wuu ka duwanaan karaa sidaas darteed saxiixooda gaarka ah ee kansarku wuxuu noqon karaa mid gaar ah.

Daawaynta waxtarka u leh Osteosarcoma waxay u baahan yihiin inay ogaadaan dariiqooyinka biochemical ee la xidhiidha saxeexa bukaanka kansarka iyo shakhsiga khatarta hidde-sidaha. Sidaa darteed daawayn kala duwan oo leh habab kala duwan oo ficil ah ayaa waxtar u leh bukaanada kala duwan. Si la mid ah iyo sababo la mid ah cuntooyinka iyo kaabista waxay u baahan yihiin in shaqsi kasta loo gaaryeelo. Sidaa awgeed cuntooyinka iyo kaabista qaar ayaa lagula taliyaa Osteosarcoma marka la qaadanayo daawaynta kansarka Dacarbazine, cuntooyinka iyo kaabista qaarna laguma talinayo.

Ilaha sida cBioPortal iyo qaar kale oo badan ayaa bixiya xogta bukaan-socodka ee aan la magacaabin ee laga helay tijaabooyinka bukaan-socodka ee dhammaan calaamadaha kansarka. Xogtan waxay ka kooban tahay tafaasiisha daraasadda tijaabada caafimaad sida cabbirka saamiga / tirada bukaannada, kooxaha da'da, jinsiga, qowmiyadda, daawaynta, goobta burooyinka iyo isbeddellada hidde-sidaha.

DNMT3A, PPM1D, TET2, TP53 iyo CHEK2 waa hiddo-wadaha ugu sarreeya ee la soo sheegay ee Osteosarcoma. DNMT3A waxaa lagu soo warramey 21.6 % bukaanada matala dhamaan tijaabooyinka kiliinikada. PPM1D waxaa lagu soo warramey 9.7 %. Isku darka xogta bukaan-socodka ee dadweynaha ayaa daboolaya da'da 1 ilaa 93. 29.2 % xogta bukaanka waxaa loo aqoonsaday inay yihiin rag. Bayoloji Osteosarcoma oo ay weheliso genetics-ka la soo sheegay ayaa si wada jir ah u qeexaya dariiqooyinka biochemical ee saxeexa dadweynaha ee kansarkan. Haddii genetics-ka burada kansarka shakhsi ahaaneed ama hiddo-wadaha ka qaybqaata khatarta sidoo kale waa la yaqaan markaa waa in sidoo kale loo isticmaalo shakhsiyaynta nafaqada.

Dookhyada nafaqeynta waa in ay iswaafaqaan shaqsi walba saxiixiisa.

Cuntada iyo Kaabayaasha Lafo-jileeca

Bukaanka Kansarka

Bukaanjiifka kansarka ee ku jira daawaynta ama daryeelka palliative waxay u baahan yihiin inay go'aan ka gaadhaan cuntada iyo kaabista - kaloriinta cuntada ee loo baahan yahay, maaraynta waxyeellooyin kasta oo daawaynta iyo sidoo kale hagaajinta maaraynta kansarka. Dhammaan cuntooyinka dhirta ku salaysan maaha kuwo siman oo doorashada iyo kala horraysiinta cuntooyinka kuwaas oo shakhsi ahaan loo habeeyey oo loo habeeyey daawaynta kansarka ee socota waa muhiim oo dhib badan. Waa kuwan tusaalayaal siinaya tilmaamo lagu samaynayo go'aannada nafaqada.

Dooro Kaabashka Qudaarta ama YAUTIA?

Kaabashka khudradda waxaa ku jira waxyaabo badan oo firfircoon ama bioactives sida Quercetin, Curcumin, Isoliquiritigenin, Apigenin, Lycopene. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida wareegga unugyada, bararka, P53 Signaling iyo Angiogenesis iyo kuwa kale. Kaabashka ayaa lagula talinayaa Osteosarcoma marka daawaynta kansarka ee socota ay tahay Dacarbazine. Tani waa sababta oo ah Kaabashka ayaa wax ka beddela dariiqyada biochemical ee si cilmiyeysan loo soo sheegay si loo dareemo saameynta Dacarbazine.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee khudaarta Yautia waa Curcumin, Isoliquiritigenin, Apigenin, Lycopene, Lupeol. Maaddooyinkan firfircooni waxay wax ka qabtaan dariiqooyin kiimikaad oo kala duwan sida Dayactirka DNA-ga iyo Cadaadiska Oxidative iyo kuwa kale. Yautia laguma talinayo Osteosarcoma marka daawaynta kansarka ee socota ay tahay Dacarbazine sababtoo ah waxay wax ka beddeshaa dariiqyada biochemical ee ka dhigaya daaweynta kansarku mid adkaysi u leh ama aan ka jawaabin.

Kaabashka khudaarta leh waxaa lagula talinayaa YAUTIA oo loogu talagalay lafo-saarista iyo daawaynta Dacarbazine.

Dooro Miraha JAVA PLUM ama MIDHAHA XAQIIQADA?

Khudradu waxay ka kooban tahay waxyaabo badan oo firfircoon ama bioactives sida Curcumin, Isoliquiritigenin, Apigenin, Lycopene, Lupeol. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida wareegga unugyada, bararka, dayactirka DNA-ga iyo calaamadaynta TWEAK iyo kuwa kale. Java Plum waxaa lagula talinayaa Osteosarcoma marka daawaynta kansarka ee socota ay tahay Dacarbazine. Tani waa sababta oo ah Java Plum waxay wax ka beddeshaa dariiqyada biochemical ee si cilmiyeysan loo soo sheegay si loo dareemo saameynta Dacarbazine.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira miro xamaasad leh waa Curcumin, Isoliquiritigenin, Apigenin, Lupeol, Psoralen. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida DNA Repair, Cadaadiska Oxidative iyo Calaamadaynta TWEAK iyo kuwa kale. Miraha xamaasadda laguma talinayo Osteosarcoma marka daawaynta kansarka ee socota ay tahay Dacarbazine sababtoo ah waxay wax ka beddeshaa dariiqyada biochemical ee ka dhigaya daaweynta kansarku mid adkaysi u leh ama aan ka jawaabin.

FRUIT JAVA Plum waxa lagu taliyaa in ka badan midhaha xamaasadda leh ee lafo-jileeca iyo daawaynta Dacarbazine.

Dooro Nut COMMON WALNUT ama XANUUNKA YURUB?

Walnut-ka caadiga ah waxa ku jira waxyaabo badan oo firfircoon ama bioactives sida Quercetin, Curcumin, Isoliquiritigenin, Lupeol, Ellagic Acid. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Dayactirka DNA, Wareegga Unugyada, Calaamadaynta P53 iyo Calaamadaynta TWEAK iyo kuwa kale. Walnut-ka caadiga ah ayaa lagula taliyaa Osteosarcoma marka daawaynta kansarka ee socota ay tahay Dacarbazine. Tani waa sababta oo ah Walnut Common waxay wax ka beddeshaa dariiqyada biochemical ee si cilmiyeysan loo soo sheegay si loo dareemo saameynta Dacarbazine.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira Chestnut Yurub waa Quercetin, Curcumin, Isoliquiritigenin, Apigenin, Lupeol. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida DNA Repair, Cadaadiska Oxidative iyo Calaamadaynta TWEAK iyo kuwa kale. Chestnut Yurub laguma talinayo Osteosarcoma marka daawaynta kansarka ee socota ay tahay Dacarbazine sababtoo ah waxay wax ka beddeshaa dariiqyada biochemical ee ka dhigaya daaweynta kansarku mid adkaysi u leh ama aan ka jawaabin.

Walnut Caanka ah waxaa lagula talinayaa laabta YURUB oo loogu talagalay Lafo-jileeca iyo daawaynta Dacarbazine.

Shakhsiyaadka leh Khatarta Hidde ee Kansarka

Su'aasha ay weydiiyaan shakhsiyaadka leh khatarta hidde-sidaha ee Osteosarcoma ama taariikhda qoyska waa "Maxaan Cunnaa si ka duwan kii hore?" iyo sida ay tahay inay doortaan cuntooyinka iyo kaabista si loo maareeyo khatarta cudurka. Maadaama khatarta kansarku aanay jirin wax la qaban karo marka la eego daawaynta - go'aamada cuntooyinka iyo kaabista ayaa noqda mid muhiim ah iyo mid ka mid ah waxyaallaha aadka u yar ee la qaban karo. Dhammaan cuntooyinka dhirta ku salaysan maaha kuwo siman oo ku salaysan hidde-sidaha la aqoonsaday iyo saxeexa dariiqa - doorashooyinka cuntada iyo kaabista waa in la shakhsiyeeyo.

Dooro khudaar GIANT BUTTERBUR ama BROCCOLI CHINESE?

Khudaarta Giant Butterbur waxay ka kooban tahay waxyaabo badan oo firfircoon ama bioactives sida Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. Maaddooyinkan firfircooni waxay wax ka qabtaan dariiqooyin kiimikaad oo kala duwan sida wareegga unugyada, P53 Signaling, Dayactirka DNA iyo Calaamadaynta MYC iyo kuwa kale. Giant Butterbur waxaa lagula talinayaa halista Osteosarcoma marka khatarta hidde-sidaha la xiriirta ay tahay CHEK2. Tani waa sababta oo ah Giant Butterbur waxay kordhisaa dariiqyada biochemical ee ka soo horjeeda wadayaasha saxeexa.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira Broccoli Shiineeska ah waa Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. Maaddooyinkan firfircooni waxay wax ka qabtaan dariiqooyin kiimikaad oo kala duwan sida Cadaadiska Oxidative iyo kuwa kale. Broccoli Shiineys ah laguma talinayo marka halista Osteosarcoma marka khatarta hidde-sidaha la xiriirta ay tahay CHEK2 sababtoo ah waxay kordhisaa dariiqooyinka saxiixa.

BUTTERBUR WEYN OO Khudaar ah ayaa lagula talinayaa brooccoli CHINESKA AH HALISTA HIDDEEDKA EE CHEK2 EE KANSARKA.

Dooro Miraha NANCE ama GRAPEFRUIT?

Miraha Nance waxaa ku jira waxyaabo badan oo firfircoon ama bioactives sida Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. Maaddooyinkan firfircooni waxay wax ka qabtaan dariiqooyin kiimikaad oo kala duwan sida wareegga unugyada, P53 Signaling, Dayactirka DNA iyo Calaamadaynta MYC iyo kuwa kale. Nance waxa lagula talinayaa halista lafo-saarcoma marka khatarta hidde-sidaha la xidhiidha ay tahay CHEK2. Tani waa sababta oo ah Nance waxay kordhisaa dariiqyada biochemical ee ka soo horjeeda darawaliinta saxeexa.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee ku jira canabka miraha waa Curcumin, Lupeol, Daidzein, Formononetin, Beta-sitosterol. Maaddooyinkan firfircooni waxay wax ka qabtaan dariiqooyin kiimikaad oo kala duwan sida Cadaadiska Oxidative iyo kuwa kale. Grapefruit laguma talinayo marka halista Osteosarcoma marka khatarta hidde ee la xiriirta ay tahay CHEK2 sababtoo ah waxay kordhisaa dariiqyada saxiixa.

FRUIT NANCE waxaa lagula taliyaa canab ka mid ah khatarta hidda-socodka Chek2 ee kansarka.

Dooro Nut COMMON HAZELNUT ama FLAXSEED?

Hazelnut-ka caadiga ah waxa ku jira waxyaabo badan oo firfircoon ama bioactives sida Curcumin, Lupeol, Daidzein, Formononetin, Beta-sitosterol. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida Dayactirka DNA, Wareegga Unugyada, Calaamadaynta MAPK iyo Calaamadaynta MYC iyo kuwa kale. Hazelnut-ka caadiga ah ayaa lagula taliyaa halista Osteosarcoma marka khatarta hidde-sidaha la xiriirta ay tahay CHEK2. Tani waa sababta oo ah Hazelnut Common waxay kordhisaa dariiqyada biochemical ee ka soo horjeeda wadayaasha saxeexa.

Qaar ka mid ah maaddooyinka firfircoon ama bioactives ee Flaxseed waa Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. Maaddooyinkan firfircooni waxay maamulaan dariiqooyin kiimikaad oo kala duwan sida JAK-STAT Signaling, Oxidative Stress iyo PI3K-AKT-MTOR Signaling iyo kuwa kale. Flaxseed laguma talinayo marka halista Osteosarcoma marka khatarta hidda-socodka ee la xiriirta ay tahay CHEK2 sababtoo ah waxay kordhisaa dariiqyada saxiixa.

HAZELNUT caam ah ayaa lagula taliyaa FLAXSEEDKA CHEK2 HALISTA HIDDAHA EE KANSARKA.

In Gabagabo

Cuntooyinka iyo Kaabayaasha la doortay ayaa ah go'aamo muhiim u ah kansarka sida Osteosarcoma. Bukaannada Osteosarcoma iyo shakhsiyaadka leh khatarta hidde-sidaha waxay had iyo jeer qabaan su'aashan: "Waa maxay cuntooyinka iyo nafaqooyinka nafaqada ee lagu taliyey aniga iyo kuwa aan ahayn?" Waxaa jira aaminsanaan guud oo ah fikrad khaldan oo ah in dhammaan cuntooyinka dhirta ku salaysan ay faa'iido yeelan karaan ama aysan ahayn laakiin aan waxyeello lahayn. Cuntooyinka qaarkood iyo kaabisyada qaarkood waxay faragelin karaan daawaynta kansarka ama waxay kor u qaadi karaan wadayaasha dariiqyada molecular ee kansarka.

Waxaa jira noocyo kala duwan oo tilmaamayaasha kansarka sida Osteosarcoma, mid kasta oo leh hidde-sidaha burooyinka kala duwan oo leh kala duwanaansho genomic dheeraad ah oo qof kasta ah. Intaa waxaa dheer daawaynta kansar kasta iyo kiimoterabi kasta waxay leeyihiin hab wax-qabad oo gaar ah. Cunto kasta sida Kaabashka waxay ka kooban tahay noocyo kala duwan oo bioactives ah oo tirooyin kala duwan leh, kuwaas oo saameyn ku leh noocyo kala duwan oo kala duwan oo ah waddooyinka biochemical. Qeexida nafaqeynta shakhsi ahaaneed waa talooyinka cuntada ee gaarka ah ee tilmaamaya kansarka, daawaynta, genetics, qaab nololeedka iyo arrimo kale. Go'aannada shakhsiyaynta nafaqada ee kansarka waxay u baahan yihiin aqoonta bayoolajiga kansarka, sayniska cuntada iyo fahamka daaweynta kemotherabi ee kala duwan. Ugu dambeyntii marka ay jiraan isbeddel daaweyn ama genomics cusub ayaa la aqoonsaday - shakhsiyeynta nafaqeynta waxay u baahan tahay dib-u-qiimeyn.

Xalka shakhsiyaynta nafaqeynta ee addon ayaa ka dhigaysa go'aan qaadashada mid fudud oo meesha ka saaraysa dhammaan male-awaalka ka jawaabaya su'aasha, "Cunto noocee ah ayaan dooranayaa ama ma dooran karaa Osteosarcoma?". Kooxda edbinta badan ee addon waxaa ka mid ah dhakhaatiirta kansarka, saynisyahano caafimaad, injineerada software iyo saynisyahano xogta.

tixraacyada

• Isku-dhafka Kunga Msk 2022
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• Misaghi A et al., SICOT J, 2018