Tilmaamaha
Daraasad dhowaan lagu sameeyay 2018 ayaa soo jeedisay in indole-3-carbinol (I3C) laga yaabo inay faa'iido u yeelato sida daaweynta dayactirka ee bukaannada kansarka ugxan-sidaha ee horumarsan iyo daraasad hore ayaa lagu ogaaday dib u dhac weyn oo ku saabsan ilmo-galeenka Intra-epithelial Neoplasia (CIN) ee bukaannada lagu daweeyay I3C. Si kastaba ha noqotee, daraasado si fiican loo qeexay ayaa looga baahan yahay si loo xaqiijiyo suurtagalnimada chemoprevention iyo saamaynta ka hortagga burooyinka ee Indole-3-Carbinol (I3C) iyo dheef-shiidkeeda Diindolylmethane (DIM) ee kansarka naasaha, maadaama DIM laga yaabo inay la falgasho heerka daryeelka daaweynta hoormoonka. , Tamoxifen. Cunista cunto ay ku jiraan indole-3-carbinol (I3C) cuntooyinka hodanka ku ah sida khudaarta cruciferous ayaa laga yaabaa in la doorbido in la yareeyo kansarka khatarta, halkii aad si aan kala sooc lahayn u cuni lahayd waxyaabahan dheeriga ah, haddii aan lagugula talin sharraxaad cilmiyaysan.
Indole-3-Carbinol (I3C) iyo ilaha cuntada
Cunto hodan ku ah khudradda iskutallaabta ah ayaa had iyo jeer loo tixgeliyaa nafaqo iyo caafimaad. Daraasado indho-indheyn kala duwan ayaa sidoo kale taageeray kartida khudaartaasi yareynta halista noocyada kala duwan ee kansarrada.
Indole-3-carbinol (I3C) waa curiye laga sameeyay walax la yiraahdo glucobrassicin, kaas oo badanaa laga helo khudradda iskutallaabta sida:
- broccoli
- brussels ka baxay
- kaabash
- tufaaxa
- qalcaddii
- bok choy
- kohlrabi
- malayga
- arugula
- bagalka
- cagaarka isku urursan
- radishes
- biyo-biyood
- wasabi
- mustard
- rutabagas
Indole-3-carbinol (I3C) waxaa badanaa la sameeyaa marka khudradda iskutallaabta la jaro, la calaliyo ama la kariyo. Asal ahaan, goynta, burburin, ruugista ama karinta khudaartaan waxay waxyeeleysaa unugyada dhirta taasoo u oggolaaneysa glucobrassicin inay la xiriirto enzyme loo yaqaan myrosinase taasoo keeneysa hydrolysis-ka indole-3-carbinol (I3C), glucose iyo thiocyanate. Qaadashada 350 mg ilaa 500 mg oo ah Indole-3-carbinol (I3C) waxay u dhigmi kartaa cunista qiyaastii 300 garaam ilaa 500 garaam oo kaabash ceyriin ah ama sprouts Brussels.
I3C sidoo kale waxay kicin kartaa enzymes sunta sunta ee mindhicirka iyo beerka.
Indole-3-carbinol (I3C) waa mid aan xasilooneyn oo ku jirta aashitada caloosha sidaas awgeedna waxaa loogu beddelay dimer bayooloji ahaan firfircoon oo loo yaqaan Diindolylmethane (DIM). DIM, badeecada uumiga ee Indole-3-carbinol (I3C) ayaa laga nuugaa mindhicirka yar.
Faa'iidooyinka Caafimaadka ee Indole-3-Carbinol (I3C)
- Inta badan ladagaalanka kansarka, anti-bararka, antioxidant iyo anti-estrogenic ee khudaarta iskutallaabta ah waxaa loo aaneyn karaa indole-3-carbinol (I3C) iyo sulforaphane.
- Daraasado badan oo vitro iyo in vivo ah oo hore ayaa soo jeedinaya waxtarka ka hortagga kiimikada ee indole-3-carbinol (I3C) ee kansarrada sida sanbabada, malawadka, qanjirka 'prostate', iyo kansarka naasaha oo xitaa xoojin kara waxqabadka qaar ka mid ah daawooyinka kemotherabi. Si kastaba ha noqotee, illaa iyo hadda, ma jiraan tijaabooyin caafimaad oo bina-aadam ah oo ansixiyay saameynta uu ku leeyahay kansarka.
- Daraasado tijaabo / shaybaar oo tiro yar ayaa sidoo kale soo jeedinaya waxtarka Indole-3-carbinol (I3C) ee waxtarka u leh howlaha difaaca jirka iyo howlaha ka hortagga fayraska, si kastaba ha noqotee, barashada aadanaha ayaa ka maqan wejigan sidoo kale.
- Dadku sidoo kale waxay u isticmaalaan I3C si loogu daaweeyo lupus erythematosus systemic (SLE), fibromyalgia iyo neefsashada soo noqnoqota (laryngeal) papillomatosis, hase yeeshe, ma jirto caddeyn cilmi ah oo wanaagsan oo lagu taageerayo adeegsigaas.
Qaadashada Indole-3-Carbinol (I3C) cuntooyinka hodanka ah sida khudradda iskutallaabta ah waxaa loo tixgeliyaa inay leeyihiin faa'iidooyin caafimaad oo badan. Marka laga reebo cuntooyinkan hodanka ah ee Indole-3-Carbinol (I3C), kaabista Indole-3-carbinol ayaa sidoo kale laga heli karaa suuqa oo badanaa loo arko inuu badbaado u yahay in lagu qaato tiro sax ah oo aan ka badnayn 400 mg maalintii. Dadka qaarkiis, waxay ku keeni kartaa waxyeelo gaar ah sida finanka maqaarka iyo shuban biyoodka. Si kastaba ha noqotee, iska ilaali qaadashada xad-dhaafka ah ama qiyaasta sare ee I3C maxaa yeelay waxay sababi kartaa waxyeelo sida dhibaatooyinka isku dheelitirka, gariir, iyo lallabbo.
Fadlan sidoo kale ogow inay jiraan daraasado xayawaan oo kooban oo soo jeediyay in I3C laga yaabo inay kobciso koritaanka burooyinka. Sidaa awgeed, daraasadaha ayaa loo baahan yahay si loo qiimeeyo saameynta indole-3-carbinol (I3C) cuntooyinka hodanka ah iyo nafaqada aadanaha. Faa'iidooyinka guud ee caafimaadka, cunista cunnooyinka hodanka ah ee Indole-3-carbinol ayaa laga doorbidaa kaabista I3C.
Cuntooyinka la Cuno Ka Dib Baaritaanka Kansarka!
Ma jiraan laba kansar oo isku mid ah. Ka gudub tilmaamaha guud ee nafaqada ee qof walba oo samee go'aanno shaqsiyeed oo ku saabsan cuntada iyo kaabayaasha si kalsooni leh.
Isticmaalka Indole-3-carbinol (I3C) ee Kansarka
Daraasado indho-indheyn iyo cunno-cunno kala duwan ayaa taageeray xiriirka ka dhexeeya qaadashada cuntada sare ee khudaarta iskutallaabta ah iyo hoos u dhigista halista kansarka. Saameyntan ka hortagga kiimikada ee cuntooyinkan hodanka ah-3-carbinol (I3C) waxaa suuragal ah in loo aaneeyo waxqabadka antitumor ee I3C iyo sidoo kale dheef-shiid kiimikaadkiisa Diindolylmethane (DIM), iyo sulforaphane. Si kastaba ha noqotee, ma jiraan daraasado badan oo qiimeeyay xiriirka ka dhexeeya indole-3-carbinol (I3C) iyo halista kansarka. Hoosta, waxaan ku bixinay faahfaahinta qaar ka mid ah daraasadaha la xiriira I3C iyo kansarka.
Faa'iidooyinka Indole-3-carbinol (I3C) iyo Epigallocatechin gallate (EGCG) ee Bukaanka Kansarka ugxan-sare ee ugxanta
Adduunweynaha, kansarka ugxansiduhu waa kan sideedaad ee ugu badan ee kansarka ku dhaca haweenka iyo 18-ka ugu badan ee kansarka guud ku dhaca guud ahaan, iyadoo ku dhowaad 300,000 xaaladood oo cusub 2018. (Sanduuqa Cilmi-baarista Kansarka Adduunka) Qiyaastii 1.2 boqolkiiba haweenka ayaa laga heli doonaa kansarka ugxansidaha ugxan sidaha ugxantu mar uun inta ay nool yihiin. (SEER, inta udhaxeysa 5-30% ee kansarka ugxansidaha ee ugxanta. 5-12% bukaanadan lagu daaweeyay heerka daaweynta kiimoteraabiga ee soo noqoshada 42 ilaa 60 bilood taasoo keentay baahida loo qabo daaweyn kiimiko oo dheeri ah, ugu dambeyntiina ka dhigeysa buro kansarka u adkeysata.
Sidaa awgeed, cilmi-baarayaal ka socda Jaamacadda 'Saaxiibtinimada Dadweynaha ee Ruushka, Xarunta Sayniska ee Ruushka ee Roentgenoradiology (RSCRR) iyo MiraxBioPharma ee Ruushka iyo Jaamacadda Weyn ee Mareykanka waxay sameeyeen tijaabo caafimaad oo qotodheer si loo qiimeeyo waxtarka daaweynta muddada dheer ee daaweynta indole-3 -carbinol (I3C), iyo sidoo kale daaweynta dayactirka ee indole-3-carbinol (I3C) iyo epigallocatechin-3-gallate (EGCG) ee bukaanada kansarka ugxansidaha ugxan sare leh. Epigallocatechin gallate (EGCG) waa qayb muhiim ah oo firfircoon oo ku jirta shaaha cagaaran oo leh waxyaabo anti-bararka iyo antioxidant. (Vsevolod I Kiselev et al, Kansarka BMC., 2018)
Daraasadda ka socota RSCRR waxaa ka mid ahaa 5 kooxood (sida hoos lagu qeexay) wadar ahaan 284 haween ah oo da'doodu u dhaxayso 39 sano jir oo leh heerka III-IV kansarka ugxan-sidaha, oo ka diiwaangashan intii u dhaxeysay Janaayo 2004 iyo Diseembar 2009, oo qaatay daaweyn isku dhafan oo ay ku jiraan neoadjuvant platinum-taxane chemotherapy, qalliinka, iyo daaweynta kiimikada ee loo yaqaan 'platinaum-taxane chemotherapy'.
- Kooxda 1 waxay heleen daaweyn isku dhafan oo lagu daray I3C
- Kooxda 2 waxay heleen daaweyn isku dhafan oo lagu daray I3C iyo Epigallocatechin gallate (EGCG)
- Kooxda 3 waxay heleen daaweyn isku dhafan oo lagu daray I3C iyo Epigallocatechin gallate (EGCG) oo lagu daray daaweynta muddada dheer ee platinum-taxane chemotherapy
- Xakamaynta kooxda 4 daaweyn isku dhafan oo kali ah iyada oo aan lahayn daaweynta neopadum-taxane chemotherapy
- Kooxda xakamaynta 5 daaweyn isku dhafan oo keli ah
Waxyaabaha soo socdaa waa natiijooyinka ugu muhiimsan ee daraasadda:
- Kadib dabagal shan sano ah, haweenka qaatay daaweynta dayactirka ee indole-3-carbinol, ama I3C oo ay weheliso Epigallocatechin gallate (EGCG), waxay si aad ah u daba dheeraadeen Horumar Bilaash ah iyo Badbaadinta Guud marka la barbar dhigo haweenka ku jira kooxaha xakamaynta.
- Badbaadinta Guud ee Median waxay ahayd 60.0 bilood oo ka tirsan Kooxda 1, 60.0 bilood ee Kooxaha 2 iyo 3 ee helay daaweynta dayactirka halka 46.0 bilood ee Kooxda 4, iyo 44.0 bilood ee Kooxda 5.
- Badbaadinta Bilaashka ah ee Median waxay ka ahayd 39.5 bilood Kooxda 1, 42.5 bilood ee Kooxda 2, 48.5 bilood ee Kooxda 3, 24.5 bilood ee Kooxda 4, 22.0 bilood ee Kooxda 5.
- Tirada bukaanada qaba kansarka ugxan sidaha soo noqnoqda ee leh ascites ka dib daaweyn isku dhafan ayaa si weyn hoos ugu dhacday kooxihii helay daaweynta dayactirka ee indole-3-carbinol ama I3C oo leh Epigallocatechin gallate (EGCG), marka lala barbardhigo kooxaha xakamaynta.
Cilmi baarayaashu waxay soo gabagabeeyeen in isticmaalka muddada dheer ee indole-3-carbinol (I3C) iyo Epigallocatechin gallate (EGCG) ay hagaajin karaan natiijooyinka daaweynta (qiyaastii 73.4% horumarin sida lagu arkay daraasadda) bukaanada kansarka ugxan sidaha sare leh waxayna noqon kartaa dayactir rajo leh daaweynta bukaannadan.
Faa'iidooyinka Indole-3-carbinol (I3C) ee bukaanka qaba ilmo galeenka Intra-epithelial Neoplasia (CIN)
Cervical Intra-epithelial Neoplasia (CIN) ama Cerp dysplasia waa xaalad horudhac ah oo ah in unugyo aan caadi ahayn ay ku sameysmaan dusha sare ee makaanka afkiisa ama marinka endocervical kaas oo ah furitaanka u dhexeeya ilmagaleenka iyo xubinta taranka haweenka. Ilmo-galeenka Intra-epithelial Neoplasia waxaa badanaa lagu daaweeyaa qalliin ama daaweynta ablative si loo baabi'iyo unugyada aan caadiga ahayn.
Halkii lagu daaweyn lahaa kansarka ilmo galeenka ka dib ogaanshaha kansarka, had iyo jeer way ka fiican tahay in lagu ogaado marxalad hore ama marxaladda saxda ah isla markaana la farageliyo hore iyadoo la adeegsanayo iskudhaf ama dabiici dabiici ah sida indole-3-carbinol (I3C) oo looga hortago horumarinta horumarka cudur faafa. Iyadoo tan maskaxda lagu hayo, cilmi-baarayaasha ka socda Xarunta Caafimaadka ee Jaamacadda Louisiana-Shreveport ee Mareykanka, waxay qiimeeyeen indole-3-carbinol (I3C) oo lagu maamuusay afka si loogu daaweeyo haweenka qaba Cervical Intra-epithelial Neoplasia (CIN), oo ah daaweyn loogu talagalay CIN . (MC Bell et al, Gynecol Oncol., 2000)
Daraasadu waxay ka kooban tahay wadarta bukaanada 30 kuwaas oo qaatay placebo ama 200, ama 400 mg / maalin oo ah afka indole-3-carbinol (I3C).
Waxaa xigay natiijooyinka ugu muhiimsan ee daraasadda.
- Bukaannada 10-ka ah ee ka mid ah kooxda helay placebo, midkoodna ma lahayn dib-u-habeyn buuxda ee Cervical Intra-epithelial Neoplasia (CIN).
- 4 ka mid ah 8 bukaan oo ku jiray kooxdii heshay 200 mg / maalin ee afka indole-3-carbinol (I3C) ayaa si buuxda dib ugu noqdey Cervical Intra-epithelial Neoplasia (CIN).
- 4 ka mid ah 9 bukaan oo ku jiray kooxdii heshay 400 mg / maalin ee afka indole-3-carbinol (I3C) ayaa si buuxda dib ugu noqdey Cervical Intra-epithelial Neoplasia (CIN).
Marka la soo koobo, cilmi-baarayaashu waxay heleen dib-u-dhac weyn oo ku dhaca Cervical Intra-epithelial Neoplasia (CIN) ee bukaannada lagu daaweeyay indole-3-carbinol (I3C) hadal ahaan marka la barbar dhigo kuwa helay placebo.
Kahortaga Kiimikada Indole-3-Carbinol (I3C) ee Kansarka Naasaha
Sida ku cad warqad la daabacay 1997-kii oo ay soo saareen cilmi-baarayaasha Xarunta Kahortagga Kansarka ee Strang ee magaalada New York, Mareykanka, 60 haween ah oo halista ugu badan ugu jira kansarka naasaha ayaa lagu qorey tijaabada xakamaynta placebo si loo qiimeeyo awoodda ka hortagga kiimikada ee I3C. Kuwaas, 57 haween ah oo da'doodu dhexdhexaad tahay 47 sano ayaa dhammaystiray daraasadda. (GY Won et al, J Cell Biochem Suppl., 1997)
Haweenkan waxaa lagu soo daray mid ka mid ah 3-da kooxood (hoos ku faahfaahsan) oo midkood helay kaabsal lagu sii daayo ama kaabsol indole-3-carbinol (I3C) maalin kasta wadar ahaan 4 toddobaad.
- Kooxda kantaroolka ayaa heshay kaabsoosha 'placebo'
- Kooxda qiyaasta yar waxay heleen 50, 100, iyo 200 mg oo ah I3C
- Kooxda qaadashada sare waxay heleen 300 iyo 400 mg oo ah I3C
Meesha ugu dambeysa ee beddelka loo adeegsaday daraasaddan waxay ahayd saamiga dheef-shiid kiimikaad ee estrogen ee 2-hydroxyestrone ilaa 16 alpha-hydroxyestrone.
Daraasadu waxay ogaatay in isbeddelka ugu sarreeya ee ku-meel-gaadhka ah ee dhammaadka ku-meel-gaadhka ah ee haweenka ku jira kooxda qaddarka sare uu si aad ah uga sarreeyo kan haweenka ku jira xakamaynta iyo kooxaha qiyaasta hooseeya ee qaddarka ku habboon ee la xidhiidha saamiga aasaasiga ah.
Natiijooyinka ka soo baxay daraasadda ayaa sidoo kale soo jeediyay in indole-3-carbinol (I3C) ee ugu yar ee jadwalka qiyaasta wax ku oolka ah ee 300 mg maalintii waxay noqon kartaa wakiil rajo leh oo ka hortagga kansarka naasaha. Si kastaba ha ahaatee, daraasado caafimaad oo si fiican loo qeexay ayaa loo baahan yahay si loo ansixiyo natiijooyinkan iyo in la yimaado qiyaasta ugu fiican ee I3C ee naaska muddada dheer. kansarka ka hortagga kiimikada
Diindolylmethane ee Kansarka Naasaha ee Bukaannada qaata Tamoxifen
Sababtoo ah suurtagalnimada ka hortagga kiimikada ee khudaarta iskutallaabta ah iyo saameynta ka hortagga burooyinka ee Indole-3-carbinol (I3C) ee kansarka naasaha, waxaa jiray xiise lagu qiimeynayo in Diindolylmethane, dheef-shiid kiimikaad hoose ee Indole-3-carbinol (I3C), uu leeyahay faa'iidooyinka kansarka naasaha. (Cynthia A Thomson et al, Daaweynta Kansarka Naasaha., 2017)
Cilmi-baarayaal ka socda Jaamacadda Arizona, Jaamacadda Arizona ee Xarunta Kansarka, Jaamacadda Stony Brook iyo Jaamacadda Hawaii ee Xarunta Kansarka ee Maraykanka ayaa sameeyay tijaabo caafimaad si ay u qiimeeyaan dhaqdhaqaaqa iyo badbaadada isticmaalka wadajirka ah ee Diindolylmethane (DIM) iyo Tamoxifen ee naaska. kansarka bukaanka.
Wadar ahaan 98 haween ah oo qaba kansarka naasaha oo loo qoray tamoxifen ayaa helay DIM (47 haween ah) ama placebo (51 haween ah). Daraasadu waxay ogaatay in isticmaalka maalinlaha ah ee DIM uu sare uqaadayo isbeddelada wanaagsan ee dheef-shiid kiimikaadka dheef-shiid kiimikaadka iyo heerarka wareegaya ee hormoonka galmada ku xidha globulin (SHBG). Si kastaba ha noqotee, heerarka dheef-shiid kiimikaadka plasma tamoxifen ee firfircoon oo ay ku jiraan endoxifen, 4-OH tamoxifen, iyo N-desmethyl-tamoxifen ayaa lagu yareeyay haweenka helay DIM, iyagoo soo jeedinaya in DIM laga yaabo inuu leeyahay awood uu ku yareeyo waxtarka Tamoxifen. (NCT01391689).
Daraasad dheeri ah ayaa la damaanad qaadayaa si loo go'aamiyo in DIM (badeecada uumiga ee Indole-3-Carbinol (I3C)) ay la xiriirto hoos u dhigidda metabolajiinta tamoxifen sida endoxifen, waxay yareysaa faa iidada caafimaad ee tamoxifen. Ilaa iyo waqtigaas, maaddaama xogta caafimaad ay muujineyso isbeddel ku yimaada isdhexgalka DIM iyo daaweynta hormoonka tamoxifen, bukaannada kansarka naasaha inta ay ku jiraan daaweynta tamoxifen waa inay ka fogaadaan dhinaca taxaddarka oo ay ka fogaadaan qaadashada DIM.
Ugu Dambeyn
Indole-3-carbinol (I3C) waxaa laga yaabaa inuu leeyahay astaamo lidka ku ah burooyinka sida lagu taliyay in vitro hore, in vivo iyo daraasaadka xoolaha iyo mala awaal ku saleysan daraasado indho indheyn ah oo muujiyay in guud ahaan isticmaalka sare ee khudaarta iskutallaabta ah ee cuntada ay si weyn ula xiriirtay halista kansarka. Si kastaba ha noqotee, ma jiraan daraasado badan oo bina-aadamka ah si loo dejiyo natiijooyinkaas.
Daraasad dhowaan la sameeyay 2018 ayaa lagu ogaaday in isticmaalka muddada-dheer ee indole-3-carbinol (I3C) laga yaabo inay faa'iidooyin ahaan u leedahay daaweynta dayactirka iyo hagaajinta natiijooyinka daaweynta bukaannada kansarka ugxan-sidaha ee horumarsan iyo daraasad hore ayaa lagu ogaaday dib-u-dhac weyn oo ah Intra-epithelial ilmo-galeenka. Neoplasia (CIN) ee bukaanada lagu daweeyay I3C. Si kastaba ha ahaatee, daraasado si wanaagsan loo qeexay ayaa loo baahan yahay si loo xaqiijiyo awoodda ka hortagga ka hortagga iyo saameynta ka hortagga burooyinka ee Indole-3-Carbinol (I3C) iyo dheef-shiidkeeda Diindolylmethane (DIM) ee naaska kansarka, maadaama DIM laga yaabo inay la falgasho heerka daryeelka daaweynta hoormoonka tamoxifen oo ay hoos u dhigto heerarka qaabkeeda firfircoon ee endoxifen, taas oo laga yaabo inay saameyn ku yeelato waxtarka daaweynta tamoxifen. Sidaa darteed, cunista cunto ay ku jiraan cuntooyinka sida khudaarta cruciferous ee hodanka ku ah Indole-3-Carbinol (I3C) ayaa la door bidaa, halkii la kaabi lahaa, ilaa uu kuu soo jeediyo bixiyaha xanaanada caafimaadkaaga.
Cuntada aad cunayso iyo waxyaalaha dheeraadka ah ee aad qaadato ayaa ah go'aanka aad gaadho. Go'aankaagu waa inuu ku jiraa tixgelinta isbeddellada hidda -wadaha kansarka, kansarka, daaweynta joogtada ah iyo kaabisyada, wixii xasaasiyad ah, macluumaadka hab -nololeedka, miisaanka, dhererka iyo caadooyinka.
Qorshaynta nafaqada kansarka ee addon kuma salaysna raadinta internetka. Waxay si otomaatig ah kuu siineysaa go'aanka adiga oo ku saleynaya sayniska molikalikada oo ay hirgeliyeen saynisyahannadeenna iyo injineerada software -ka. Iyadoo aan loo eegin haddii aad danaynayso inaad fahanto waddooyinka kelli -yaqaanka ee biochemical -ka hoose iyo haddii kale - qorshaynta nafaqada ee kansarka fahamka ayaa loo baahan yahay.
Hadda ku bilow qorshaynta nafaqada adiga oo ka jawaabaya su'aalaha ku saabsan magaca kansarka, isbeddellada hidda -socodka, daaweynta joogtada ah iyo kaabisyada, wixii xasaasiyad ah, caadooyin, hab -nololeed, kooxda da'da iyo jinsiga.
Nafaqada gaarka ah ee kansarka!
Kansarku wuu is beddelaa waqti ka dib. Habbee oo wax ka beddel nafaqadaada iyadoo lagu salaynayo calaamadda kansarka, daawaynta, qaab nololeedka, dookhyada cuntada, xasaasiyadda iyo arrimo kale.
Bukaannada kansarka badanaa waa inay la macaamilaan waxyaabo kala duwan waxyeellooyinka daaweynta kemotherabi kaas oo saameeya tayadooda nololeed isla markaana fiiriya daweynta kale ee kansarka. Qaadashada nafaqada saxda ah iyo kaabisyada ku saleysan tixgelinta cilmiga (iska ilaalinta mala-awaal iyo xulasho aan kala sooc lahayn) ayaa ah daaweynta ugu fiican ee dabiiciga ah ee kansarka iyo daaweynta la xiriirta dhibaatooyinka soo raaca.