Nderipi gomarara raizobatsirwa nekubatanidza Sesamin mukudya kwavo?

Muchidimbu

Sesamin inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vegomarara uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweSesamin yevarwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinashi, zvinogona kupindirana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Sesamin inogona kubatsira avo vane Primary Glioblastoma vari pasi peTemozolomide, asi zvingasava zvakanaka kune varwere vanogamuchira Dacarbazine yePrimary Pulmonary artery intimal sarcoma. Uyezve, nepo Sesamin ichigona kubatsira vanhu vane genetic risk factor "ALK", inogona kunge isingakurudzirwe kune avo vane imwe genetic njodzi "ERCC2". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweSesamin kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Sesamin iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, maitiro akazara esarudzo dzekudya akakosha, achitarisa pane zvese zvinokonzeresa zvese zvinoshanda zvinoringana muzvikafu / zvekuwedzera seSesamin pachinzvimbo chekuongorora chimwe nechimwe chinoshanda chinosanganisa zvakasiyana kana kusachifuratira zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kubatanidza Sesamin mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa kushandisa Sesamin kana iwe uine genetic predisposition kune cancer yakabatana neiyo ALK gene? Ko kana pachinzvimbo chako genetic njodzi ichibva kuERCC2 gene? Zvinobatsira here kuisa Sesamin mukudya kwako kana waonekwa kuti une Primary Pulmonary artery intimal sarcoma, kana kuti chirwere chako chiri Primary Glioblastoma? Uyezve, kushandisa kwako kweSesamin kunofanira kugadziriswa sei kana uri kurapwa neTemozolomide kana kana chirongwa chako chekurapa chichibva kuTemozolomide kuenda kuDacarbazine? Izvo zvakakosha kuti uzive kuti zvirevo zvakareruka senge 'Sesamin ndeyezvakasikwa, saka zvinogara zvichibatsira' kana 'Sesamin inosimudzira kusadzivirirwa' hazvina kukwana kune ruzivo rwekudya / yekuwedzera sarudzo.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekubatanidza Sesamin mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo nezve kubatanidza chikafu kana ma supplements seSesamin mukudya kwako kune mabhenefiti ayo, iwe unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga zvinhu zvakaita serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic predispositions. , uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Glioblastoma kana Primary Pulmonary artery intimal sarcoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu genetics, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvesarudzo dzekudya, seSesamin. Ko genetic njodzi yegomarara kubva mukushandurwa muALK ine zvakafanana biochemical nzira nzira sekuchinja muERCC2? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Glioblastoma inoenzana nePrimary Pulmonary artery intimal sarcoma? Uyezve, kudya kwekudya kunoramba kwakafanana kune avo vari pasi peDacarbazine kune avo vanogamuchira Temozolomide? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Sesamin - A Nutritional Supplement

Iyo yekuwedzera Sesamin inotenderedza huwandu hwezvinhu zvinoshanda, kusanganisira Sesamin, imwe neimwe iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya JAK-STAT Signaling, Cell Cycle Checkpoints uye MAPK Signaling, iyo inogadzirisa zvakakosha zvegomarara padanho remaserura, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza akakodzera anowedzera seSesamin, ari ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezve kushandisa Sesamin yegomarara, zvakakosha kuti utarise izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweSesamin haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Sesamin Supplements

Kugadzirisa mubvunzo wekuti 'Ndirini pandinofanira kudzivirira Sesamin mumamiriro eCancer' zvinonetsa nekuti mhinduro yacho ndeyemunhu mumwe chete - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eSesamin anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo azvino, mamwe ma supplements ari kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Sesamin yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga kwemunhu zvisarudzo zvakadaro.

1. Ko Sesamin Supplements ichabatsira Primary Pulmonary artery intimal sarcoma Varwere vari kurapwa Dacarbazine?

Yekutanga Pulmonary artery intimal sarcoma inoratidzwa neakanyanya genetic mutations, anoti PDGFRB, ALK uye ATM, izvo zvinotungamira kune shanduko munzira dzebiochemical nzira, kunyanya MAPK Signaling, Growth Factor Signaling, JAK-STAT Signaling, DNA Repair uye Cell Cycle Checkpoints. Kubudirira kwekurapwa kwegomarara, senge Dacarbazine, kunoenderana nemaitiro ayo ekuita panzira idzi chaidzo. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo Sesamin yekuwedzera, iyo inobata Cell Cycle Checkpoints, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Pulmonary artery intimal sarcoma paunenge uchienda kuDacarbazine. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Sesamin Supplements ichabatsira Varwere veGlioblastoma Vekutanga vari kurapwa neTemozolomide?

Primary Glioblastoma inocherechedzwa nechaiyo genetic mutations, seTRBV7-7, TAS2R46 uye TP53, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya JAK-STAT Signaling, Cell Cycle Checkpoints uye Apoptosis. Kubudirira kwekurapa kenza, seTemozolomide, inotarwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Sesamin yekuwedzera isarudzo ine musoro kune avo vane Primary Glioblastoma vari pasi peTemozolomide. Izvi zvinodaro nekuti Sesamin inokanganisa nzira dzakadai seJAK-STAT Signaling, iyo inogona kuvharisa zvinhu zvinotyaira Primary Glioblastoma kana kubatsira kushanda kweTemozolomide.

3. Ko Sesamin Supplements Yakachengeteka Kune Vanhu Vane Utano Vane ERCC2 Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo ERCC2 gene inowanzobatanidzwa mune aya mapaneru ekuongorora njodzi yegomarara.

Kuchinja kweiyo ERCC2 gene kunokanganisa nzira dzebiochemical kana maitiro, akadai seCell Cycle Checkpoints uye DNA Repair, izvo zvinobatanidzwa zvakananga kana zvisina kunanga mukutyaira cancer padanho remamorekuru. Kana genetic panel yakaratidza shanduko muERCC2 ine chekuita nenjodzi yakawedzera yeGanda reGanda, chikonzero chesainzi chinoratidza kudzivirira kushandiswa kwekuwedzera Sesamin. Izvi zvinodaro nekuti yekuwedzera Sesamin inopesvedzera nzira senge Cell Cycle Checkpoints, izvo zvinogona kutungamira kune yakaipa mhedzisiro mumamiriro eERCC2 mutation uye ane hukama nekenza mamiriro.

4. Ko Sesamin Supplements Yakachengeteka Kune Vanhu Vane Utano Vane ALK Mutation Associated Genetic Risk?

ALK inoita basa rakakosha mukuongorora njodzi yegomarara. Shanduko muALK inogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira MAPK Signaling uye Kukura Factor Signaling, iyo inokanganisa kukura kwegomarara. Kana yako genetic panel ikaratidza shanduko muALK yakabatana neCentral Nervous System, funga kuisa Sesamin supplement muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita seMAPK Signaling, kubatsirwa nekupa rutsigiro rwakakodzera kune vanhu vane ALK mutations uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvinowedzera seSesamin, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Kuchinja munzira yep53 uye p16INK4a kutaura kunofanotaura kupona kwese mune metastatic melanoma varwere vanobatwa ne dacarbazine.
• cBioPortal yeCancer Genomics
• Mutational landscape yekenza yemetastatic yakaratidzwa kubva kune vangangove vanotarisirwa kutevedzana kwevarwere zviuru gumi.
• cBioPortal yeCancer Genomics
• Sesamin induces cell cycle kusungwa uye apoptosis kuburikidza nekudzivirirwa kwechiratidzo transducer uye activator yekunyorwa 3 kusaina mumunhu hepatocellular carcinoma cell line HepG2.
• RRAD inosimudzira EGFR-mediated STAT3 activation uye induces temozolomide kuramba kweakaipa glioblastoma.
• Iyo somatic genomic landscape ye glioblastoma.
• Inhibition of programmed death ligand 1 (PD-L1) kutaura mumasero ekenza yemazamu ne sesamin.