Zvokudya zveGlioblastoma!

ziviso

Zvikafu zveGlioblastoma zvinofanirwa kuve zvakasarudzika kune wega wega uye zvakare zvinofanirwa kuchinjika kana kenza kurapwa kana bundu genetic shanduko. Iyo yemunhu uye kugadzirisa kunofanirwa kufunga nezvese zvinoshanda zvinosanganiswa kana bioactives zviri muzvokudya zvakasiyana zvine chekuita negomarara biology, genetics, marapirwo, mararamiro uye zvido zvekudya. Saka nepo chikafu chiri chimwe chezvisarudzo zvakakosha zvemurwere wegomarara uye munhu ari panjodzi yegomarara - kusarudza chikafu chekudya harisi basa riri nyore.

Glioblastoma ndiyo yakajairika uye yakaipisisa yemamota ekutanga ehuropi. Pakati peanofungidzirwa 17,000 ekutanga mamota ehuropi anowanikwa muUnited States gore rega rega, makumi matanhatu muzana ari glioblastomas kana gliomas, ine chiitiko che60-2 kesi nyowani pa3 vanhu pagore. Glioblastomas inonyanya kubata vanhu vakuru, uye inowanikwa zvakanyanya mucerebral hemispheres. Aya mapundu anogona kukura kubva pasi-giredhi astrocytoma kana anaplastic astrocytoma, asi kazhinji anoratidza de novo pasina humbowo hwechironda chinotyisa chisati chaitika. Zviratidzo zviri kuratidza zveglioblastoma zvinosanganisira zvishoma nezvishoma kufambira mberi neurologic deficits senge kushaya simba kwemota, kutemwa nemusoro, kuda kurutsa uye kurutsa, kutadza kuziva, uye pfari. Kufambira mberi kwakadzikama chete mukurapa glioblastoma kwakaitika mumakore makumi maviri nemashanu apfuura. Hapana marapiro azvino anorapa uye anowanzo gara achipora, ayo anosanganisira kuvhiyiwa, radiotherapy, uye chemotherapy, asi zvakaratidzwa kuti zvinorebesa kupona kwemhando yepamusoro kusvika pakati pekupona kwemwedzi ingangoita gumi nemaviri. Kupona kwemakore maviri ndeye 100,000% uye makore mashanu ekupona chiyero chegumi chete%. Pamusoro pekurapa, varwere vane glioblastoma vanogona zvakare kutsigirwa neiyo chaiyo yemunhu chikafu (chikafu uye chekuwedzera) chakaenderana neavo-anotemerwa nachiremba kurapwa uye nhanho yechirwere, kuti vawedzere kuwedzera hupenyu hwavo uye kurarama.

Kune Glioblastoma zvine basa here kuti miriwo, michero, nzungu, mhodzi munhu anodya chii?

Mubvunzo wakajairika wekudya unobvunzwa nevarwere vegomarara uye vanhu vari pa-genetic njodzi yegomarara ndeye - kumakonza akaita seGlioblastoma zvine basa here kuti ndechipi chikafu chandinodya uye chandisingade? Kana kuti ndikatevera kudya-kwekudyara kunokwana kenza seGlioblastoma?

Semuenzaniso zvine basa here kana muriwo weNew Zealand Sipinachi uchidyiwa zvakanyanya kana uchienzaniswa neTowel Gourd? Zvinoita mutsauko here kana muchero Pummelo uchifarirwa pane Black Mulberry? Zvakare kana sarudzo dzakafanana dzakaitirwa nzungu/mhodzi dzakaita seButternut pamusoro peCashew Nut uye dzemapunzi seBroad Bean pamusoro peYardlong Bean. Uye kana zvandinodya zvine basa - zvino munhu angaziva sei chikafu chinokurudzirwa kuGlioblastoma uye ndiyo mhinduro imwechete kune wese munhu ane chirwere chakafanana kana genetic njodzi?

Ehe! Zvokudya zvaunodya zvine chekuita neGlioblastoma!

Mazano echikafu anogona kunge asina kufanana kune wese munhu uye anogona kuve akasiyana kunyangwe kune imwechete kuongororwa uye genetic njodzi.

Zvokudya zvose (miriwo, michero, nzungu, mhodzi, pulses, mafuta nezvimwewo) uye zvokudya zvinovaka muviri zvinoumbwa nezvinodarika imwe inoshanda mamolecular ingredient kana bio-actives muzvikamu zvakasiyana uye uwandu. Chinhu chimwe nechimwe chinoshanda chine nzira yakasarudzika yekuita - iyo inogona kuve activation kana inhibition yeakasiyana biochemical nzira. Zvikafu zvakangotaurwa uye zvekuwedzera izvo zvinokurudzirwa ndezviya zvisingakonzere kuwedzera kwemamorekuru anotyaira cancer asi anodzideredza. Zvikasadaro izvo zvikafu hazvifanirwe kukurudzirwa. Chikafu chine akawanda anoshanda zvinongedzo - saka kana uchiongorora chikafu uye zvekuwedzera iwe unofanirwa kufunga nezve mabatiro ezvese zvinoshanda zvinongedzo zvakapetwa kwete zvega.

Somuenzaniso Pummelo ine zvinhu zvinoshanda Quercetin, Curcumin, Isoliquiritigenin, Apigenin, Lycopene. Uye Black Mulberry ine zvinoshanda zvinosanganisa Quercetin, Curcumin, Isoliquiritigenin, Apigenin, Myricetin uye pamwe nevamwe.

Chikanganiso chakajairika pakusarudza nekusarudza chikafu chekudya cheGlioblastoma - kuongorora chete zvakasarudzwa zvinoshandiswa zviri muzvokudya uye kufuratira zvimwe. Nekuti zvakasiyana-siyana zvinoshanda zviri mukudya zvinogona kuva nemhedzisiro inopikisa kune vatyairi vegomarara - haugone kutora cherry inoshanda mukudya uye ma supplements ekuita sarudzo yekudya kune Glioblastoma.

HONGU – ZVOKUSARUDZA ZVOKUDYA ZVINOKOSHA NEGONSA. ZVISARUDZO ZVOKUDYA ZVINOFANIRA KUFUNGA ZVINHU ZVINHU ZVINHU ZVINOSHANDA PACHIDYA.

Unyanzvi Hunodiwa PaKudya Kwekudya Kwemunhu weGlioblastoma?

Kudya kwakasarudzika kwegomarara senge Glioblastoma ine zvinokurudzirwa zvekudya / zvinowedzera; zvisingakurudzirwe chikafu / ma supplements ane semuenzaniso mabikirwo anotungamira kushandiswa kwezvikafu zvinokurudzirwa. Muenzaniso wekudya kwakasiyana-siyana unogona kuonekwa pane izvi batanidzo.

Kufunga kuti ndezvipi zvekudya zvinokurudzirwa kana kwete zvakaomesesa, zvinoda hunyanzvi muGlioblastoma biology, sainzi yechikafu, genetics, biochemistry pamwe nekunzwisisa kwakanaka kwemashandiro anoita marapirwo egomarara uye kusagadzikana kwakabatana uko kurapwa kwaigona kumira kushanda.

ZVINONYANYA ZVINONYANYA ZVINODIWA KUTI ZVINOVAKA ZVINOVAKA MUNHU ZVINHU ZVINHU ZVINOITA: CANCER BIOLOGY, FOOD SCIENCE, KURAPA MAKANZA UYE GENETICS.

Hunhu hwegomarara seGlioblastoma

Magomarara ese akaita seGlioblastoma anogona kuratidzirwa neyakasiyana seti yebiochemical nzira - iyo siginecha nzira dzeGlioblastoma. Nzira dzeBiochemical dzakadai seDNA Kugadzirisa, Angiogenesis, PI3K-AKT-MTOR Kuratidzira, MAPK Kuratidzira chikamu chetsanangudzo yesaina yeGlioblastoma. Kenza yemunhu wega genetics inogona kuve yakasiyana uye nekudaro siginicha yavo yegomarara inogona kuve yakasarudzika.

Kurapa kunoshanda kuGlioblastoma kunoda kuziva nzira dzakasaina dzebiochemical kune wese murwere wegomarara uye munhu ari panjodzi yemajini. Saka marapirwo akasiyana ane maitiro akasiyana ezviito anoshanda kune varwere vakasiyana. Saizvozvo uye nekuda kwezvikonzero zvakafanana zvekudya uye zvekuwedzera zvinoda kuitirwa munhu wega wega. Saka zvimwe zvekudya uye zvekuwedzera zvinokurudzirwa kuGlioblastoma kana uchitora kurapwa kenza Temozolomide, uye zvimwe zvekudya uye zvekuwedzera hazvikurudzirwe.

Sources like cBioPortal uye vamwe vazhinji vanopa mumiriri wehuwandu hwevarwere data risingazivikanwe kubva kukiriniki miedzo yezvese zviratidzo zvegomarara. Iyi dhata ine yekiriniki yekuongorora yeruzivo senge sampuli saizi / nhamba yevarwere, mapoka ezera, murume kana mukadzi, dzinza, marapirwo, bundu saiti uye chero genetic mutations.

TP53, PTEN, LAMA1, MUC4 uye HLA-DRB1 ndiwo mazita epamusoro akashumwa majini eGlioblastoma. TP53 inoshumwa mu2.1% yevanomiririra varwere mukati meyese miedzo yekiriniki. Uye PTEN inoshumwa mu1.8%. Kubatanidzwa kwehuwandu hwehuwandu hwemurwere data inovhara makore kubva pa3 kusvika ku90. 61.3 % yedata revarwere vanoonekwa sevarume. Iyo Glioblastoma biology pamwe neyakashumwa genetics pamwe chete inotsanangura huwandu hwevanhu vanomiririrwa siginecha biochemical nzira dzegomarara iri. Kana iyo yega cancer tumor genetics kana majini anokonzera njodzi achizivikanwawo saka izvo zvinofanirwa kushandiswawo kune hutano hwemunhu.

ZVAKASARUDZA KUDYA ZVINODYA ZVINOFANIRA KUFANIRA NEMUNHU WEMUNHU WEMUNHU WEMUNHU WEGONSI.

Chikafu uye Zvekuwedzera zveGlioblastoma

Kune Varwere veCancer

Varwere vegomarara vari pakurapa kana pakuchengeta palliative vanofanira kuita sarudzo pazvekudya uye zvekuwedzera - zvemacalorie anodiwa ekudya, kubata chero mhedzisiro yekurapa uyezve nekugadzirisa kenza. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye kusarudza uye kuisa pamberi pezvikafu zvakagadzirirwa munhu uye zvakagadzirirwa kuenderera mberi kurapwa kwegomarara kwakakosha uye kwakaoma. Heano mimwe mienzaniso inopa nhungamiro yekuita sarudzo dzekudya.

Sarudza Vegetable NEW ZEALAND SPINACH kana TOWEL GOURD?

Vegetable New Zealand Sipinachi ine zvakawanda zvinoshanda zvinosanganisa kana bioactives zvakaita seQuercetin, Curcumin, Isoliquiritigenin, Apigenin, Myricetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge Microtubule Dynamics, Hypoxia, NFKB Signaling uye PI3K-AKT-MTOR Signaling nevamwe. New Zealand Sipinachi inokurudzirwa kuGlioblastoma apo kurapwa kwegomarara kuri kuramba kuchiitwa Temozolomide. Izvi zvinodaro nekuti New Zealand Sipinachi inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire kuita kweTemozolomide.

Zvimwe zvezvishandiso zvinoshandiswa kana bioactives mumuriwo Towel Gourd ndeye Curcumin, Isoliquiritigenin, Apigenin, Lycopene, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical senge MAPK Signaling, Autophagy, Notch Signaling uye Direct Repair nevamwe. Towel Gourd harikurudzirwe kuGlioblastoma kana ichiramba ichirapwa kenza iri Temozolomide nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara kurambe kana kusadaira.

MURIWO NEW ZEALAND SIPICHI INOKURUDZWA PAMUSORO PETAURO GOURD YEGlioblastoma UYE KURAPA Temozolomide.

Sarudza Fruit BLACK MULBERRY kana PUMMELO?

Fruit Black Mulberry ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seQuercetin, Curcumin, Isoliquiritigenin, Apigenin, Myricetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seMAPK Kusaina, DNA Kugadzirisa, Epithelial kune Mesenchymal Shanduko uye Sero Kupona uye nevamwe. Black Mulberry inokurudzirwa kuGlioblastoma apo chirwere chegomarara chiri kuramba chiri Temozolomide. Izvi zvinodaro nekuti Black Mulberry inogadzirisa idzo biochemical nzira dzakataurwa nesainzi kuti dzikurudzire maitiro eTemozolomide.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Pummelo ndeye Quercetin, Curcumin, Isoliquiritigenin, Apigenin, Lycopene. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seDNA Repair uye Oxidative Stress nevamwe. Pummelo haikurudzirwe kuGlioblastoma kana ichienderera mberi kurapwa kwegomarara iri Temozolomide nekuti inogadzirisa nzira dzebiochemical idzo dzinoita kuti kurapwa kwegomarara risarambe kana kusadaira.

MUCHERO MUTEMA MUMARU INOKURUDZWA PAMUSORO PEPUMMELO YEGlioblastoma UYE KURAPA Temozolomide.

Sarudza Nut BUTTERNUT kana CASHEW NUT?

Butternut ine zvakawanda zvinoshanda zvinosanganisa kana bioactives zvakaita seCurcumin, Isoliquiritigenin, Apigenin, Myricetin, Lycopene. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge Microtubule Dynamics, Hypoxia, NFKB Signaling uye PI3K-AKT-MTOR Signaling nevamwe. Butternut inokurudzirwa kuGlioblastoma apo chirwere chegomarara chiri kuramba chiri Temozolomide. Izvi zvinodaro nekuti Butternut inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire mhedzisiro yeTemozolomide.

Zvimwe zvezvinhu zvinoshanda kana bioactives muCashew Nut ndeye Quercetin, Curcumin, Isoliquiritigenin, Myricetin, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge Autophagy, Interferon Signaling uye Direct Repair nevamwe. Cashew Nut haikurudzirwe kuGlioblastoma kana ichiramba ichirapwa gomarara iri Temozolomide nekuti inogadzirisa nzira dzebiochemical idzo dzinoita kuti kurapwa kwegomarara risarambe kana kusadaira.

BUTTERNUT INOKURUDZWA PAMUSORO PECASHEW NUT YEGlioblastoma UYE KURAPA Temozolomide.

Kune Vanhu Vane Genetic Risk yeCancer

Mubvunzo wakabvunzwa nevanhu vane genetic risk yeGlioblastoma kana nhoroondo yemhuri ndewekuti "Chii Chandinofanira Kudya Zvakasiyana Kubva Kare?" uye masarudzire avanofanira kuita zvekudya uye zvekuwedzera kuti vatarise njodzi dzechirwere. Sezvo kune njodzi yegomarara hapana chinogoneka maererano nekurapa - sarudzo dzezvekudya uye zvekuwedzera zvinove zvakakosha uye chimwe chezvinhu zvishoma zvingaite zvinogona kuitwa. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye zvichibva pane zvakazivikanwa genetics uye nzira siginecha - sarudzo dzechikafu nekuwedzera dzinofanirwa kuve munhu.

Sarudza Vegetable GIANT BUTTERBUR kana TURNIP?

Vegetable Giant Butterbur ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Curcumin, Lupeol, Myricetin, Daidzein. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge MAPK Kuratidzira, Cell Cycle Checkpoints, Stem Cell Signaling uye Focal Adhesion nevamwe. Giant Butterbur inokurudzirwa kune njodzi yeGlioblastoma kana yakabatana genetic njodzi iHLA-DRB1. Izvi zvinodaro nekuti Giant Butterbur inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo Turnip ndeye Curcumin, Ellagic Acid, Quercetin, Lupeol, Daidzein. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seStem Cell Signaling uye Focal Adhesion nevamwe. Turnip haikurudzirwe kana njodzi yeGlioblastoma kana yakabatana genetic njodzi iri HLA-DRB1 nekuti inowedzera siginecha nzira dzayo.

MURIWO MURUME BUTTERBUR ANOKURUKURWA PAKUSHANDURA CHEHLA-DRB1 GENETIC RISK YECANCER.

Sarudza Chibereko NANCE kana LOGANBERRY?

Chibereko Nance chine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Curcumin, Lupeol, Myricetin, Daidzein. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge MAPK Kuratidzira, Cell Cycle Checkpoints, Stem Cell Signaling uye Focal Adhesion nevamwe. Nance inokurudzirwa kune njodzi yeGlioblastoma kana yakabatana genetic njodzi iri HLA-DRB1. Izvi zvinodaro nekuti Nance inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Loganberry ndeye Apigenin, Curcumin, Lupeol, Myricetin, Daidzein. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge Insulin Signaling uye Stem Cell Signaling uye vamwe. Loganberry haikurudzirwe kana njodzi yeGlioblastoma kana yakabatana genetic njodzi iri HLA-DRB1 nekuti inowedzera siginecha nzira dzayo.

FRUIT NANCE INOKURUKURWA PAMUSORO PELOGANBERRY YEHLA-DRB1 GENETIC RISK YECANCER.

Sarudza Nut COMMON WALNUT kana EUROPEAN CHESTNUT?

Yakajairika Walnut ine akawanda anoshanda zvinongedzo kana bioactives seCurcumin, Ellagic Acid, Quercetin, Lupeol, Myricetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge MAPK Signaling, Insulin Signaling uye Focal Adhesion nevamwe. Yakajairika Walnut inokurudzirwa kune njodzi yeGlioblastoma kana yakabatana genetic njodzi iri HLA-DRB1. Izvi zvinodaro nekuti Common Walnut inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives muEuropean Chestnut ndeye Apigenin, Curcumin, Ellagic Acid, Quercetin, Lupeol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge Insulin Signaling uye Stem Cell Signaling uye vamwe. European Chestnut haikurudzirwe kana njodzi yeGlioblastoma kana yakabatana genetic njodzi iri HLA-DRB1 nekuti inowedzera siginicha nzira dzayo.

WALNUT YAKAWANDA INOKURUDZWA PAMUSORO PAEUROPA CHESTNUT YEHLA-DRB1 GENETIC RISK YECANCER.

Mhedziso

Chikafu uye Zvekuwedzera zvakasarudzwa sarudzo dzakakosha kune cancer seGlioblastoma. Varwere veGlioblastoma uye vanhu vane genetic-njodzi vanogara vaine mubvunzo uyu: "Ndezvipi zvekudya uye zvinovaka muviri zvinokurudzirwa kwandiri uye izvo zvisiri?" Pane chitendero chakajairika chinova fungidziro isiriyo yekuti zvese zvinodyarwa-zvikafu zvinogona kubatsira kana kwete asi zvisingakuvadze. Zvimwe zvekudya uye zvekuwedzera zvinogona kukanganisa marapirwo egomarara kana kusimudzira mamorekuru enzira yegomarara.

Kune marudzi akasiyana ezviratidzo zvegomarara seGlioblastoma, imwe neimwe iine bundu genetics ine mamwe ma genomic akasiyana pamunhu wega wega. Kuwedzera kurapwa kwegomarara uye chemotherapy ine yakasarudzika nzira yekuita. Chikafu chega chega senge New Zealand Sipinachi ine akasiyana bioactive muhuwandu hwakasiyana, iyo ine mhedzisiro pane dzakasiyana uye dzakasiyana seti dzebiochemical nzira. Tsanangudzo yekudya yakasarudzika ndeyakasarudzika chikafu kurudziro yegomarara chiratidzo, marapirwo, genetics, mararamiro uye zvimwe zvinhu. Sarudzo dzehutano hwemunhu hwegomarara dzinoda ruzivo rwegomarara biology, sainzi yechikafu uye kunzwisisa kweakasiyana chemotherapy marapirwo. Chekupedzisira kana paine shanduko yekurapa kana nyowani genomics inoonekwa - iyo inovaka muviri inoda kuongororwazve.

Iyo addon nutrition personalization solution inoita kuti sarudzo ive nyore uye inobvisa zvese zvekufungidzira mukupindura mubvunzo, "Ndezvipi zvekudya zvandinofanira kusarudza kana kusasarudzira Glioblastoma?". Iyo addon yakawanda-yekuranga timu inosanganisira varapi vegomarara, masayendisiti ekiriniki, mainjiniya esoftware uye masayendisiti edata.

References

• Pancan Pcawg 2020
• Mhedzisiro ye isoliquiritigenin pamasero egomarara reovarian.
• Kutora mulberry 1-deoxynojirimycin kunodzivirira gomarara remukati mumakonzo.
• Iyo citrus flavonoid naringenin inokurudzira DNA kugadziriswa mumasero ekenza yeprostate.
• Kukura kwekukurudzira kwemasero emunhu pulmonary adenocarcinoma uye madiki epithelial masero emhepo ne beta-carotene kuburikidza ne activation ye cAMP, PKA, CREB uye ERK1/2.
• Zvokudya D-glucarate zvinokonzerwa nehutachiona hwekuzvimba panguva yekutanga-yekutanga matanho e benzo [a] pyrene-induced lung tumorigenesis muA/J mice.
• Tsvagiridzo inofambira mberi pane anticancer mhedzisiro yevhitamini K2.
• Negative regulation ye signal transducer uye activator ye transcription-3 signing cascade ne lupeol inhibits kukura uye induces apoptosis muhepatocellular carcinoma masero.
• https://emedicine.medscape.com/article/283252-overview#a1