Zvokudya zveMelanoma!

ziviso

Zvikafu zveMelanoma zvinofanirwa kuve zvakasarudzika kune wega wega uye zvakare zvinofanirwa kuchinjika kana kenza kurapwa kana bundu genetic shanduko. Iyo yemunhu uye kugadzirisa kunofanirwa kufunga nezvese zvinoshanda zvinosanganiswa kana bioactives zviri muzvokudya zvakasiyana zvine chekuita negomarara biology, genetics, marapirwo, mararamiro uye zvido zvekudya. Saka nepo chikafu chiri chimwe chezvisarudzo zvakakosha zvemurwere wegomarara uye munhu ari panjodzi yegomarara - kusarudza chikafu chekudya harisi basa riri nyore.

Melanoma imhando yegomarara reganda rinobva mumamelanocytes, ari masero anoburitsa pigment. Ndiyo nzira ine ngozi zvikuru yegomarara reganda uye inogona kukurumidza kupararira kune dzimwe nhengo dzemuviri kana isina kurapwa. Melanomas inogonawo kuumba muziso rinozivikanwa se ocular melanoma uye mukati memhino, muromo, huro, genital kana nal nzvimbo, inozivikanwa semucosal melanoma. Zviratidzo zve melanoma zvinogona kusanganisira kuchinja kwechimiro, ruvara, kana hukuru hwema moles aripo, kuonekwa kwema moles matsva, kana kukura kwemaronda asingapore. Kurapa kwe melanoma kunoenderana nedanho uye kunogona kusanganisira kuvhiyiwa, kurapwa nemwaranzi, chemotherapy, kana kurapa kwakanangwa. Zvakakosha kuziva nezvenjodzi dzine chekuita nemelanoma, zvinosanganisira genetics uye kubuda kwezuva, uye kutora matanho ekudzivirira sekupfeka mafuta ezuva uye zvipfeko zvinodzivirira. Kugara uchizviongorora, pamwe chete nekuongorora-nguva dzose nedermatologist, zvinogona kubatsira mukukurumidza kuongororwa uye kuvandudza mwero wekupona melanoma.

KuMelanoma zvine basa here kuti miriwo, michero, nzungu, mhodzi anodya chii?

Mubvunzo wakajairika wekudya unobvunzwa nevarwere vegomarara uye vanhu vari pa-genetic njodzi yegomarara ndeye - kumakonza akaita seMelanoma zvine basa here kuti ndechipi chikafu chandinodya uye chandisingade? Kana kuti ndikatevera kudya-kwekudyara kunokwana gomarara seMelanoma?

Semuenzaniso zvine basa here kana muriwo weCauliflower uchidyiwa zvakanyanya kana uchienzaniswa neAmerican Pokeweed? Zvinoita mutsauko here kana muchero Malabar Plum uchisarudzwa pane Black Mulberry? Zvakare kana sarudzo dzakafanana dzakaitirwa nzungu/mhodzi dzakaita seButternut pamusoro peEuropean Chestnut uye nemapurusi seBroad Bean pamusoro pePigeon Pea. Uye kana zvandinodya zvine basa - zvino munhu angaziva sei chikafu chinokurudzirwa kuMelanoma uye ndiyo mhinduro imwechete kune wese munhu ane chirwere chakafanana kana genetic njodzi?

Ehe! Zvokudya zvaunodya zvine chekuita neMelanoma!

Mazano echikafu anogona kunge asina kufanana kune wese munhu uye anogona kuve akasiyana kunyangwe kune imwechete kuongororwa uye genetic njodzi.

Zvokudya zvose (miriwo, michero, nzungu, mhodzi, pulses, mafuta nezvimwewo) uye zvokudya zvinovaka muviri zvinoumbwa nezvinodarika imwe inoshanda mamolecular ingredient kana bio-actives muzvikamu zvakasiyana uye uwandu. Chinhu chimwe nechimwe chinoshanda chine nzira yakasarudzika yekuita - iyo inogona kuve activation kana inhibition yeakasiyana biochemical nzira. Zvikafu zvakangotaurwa uye zvekuwedzera izvo zvinokurudzirwa ndezviya zvisingakonzere kuwedzera kwemamorekuru anotyaira cancer asi anodzideredza. Zvikasadaro izvo zvikafu hazvifanirwe kukurudzirwa. Chikafu chine akawanda anoshanda zvinongedzo - saka kana uchiongorora chikafu uye zvekuwedzera iwe unofanirwa kufunga nezve mabatiro ezvese zvinoshanda zvinongedzo zvakapetwa kwete zvega.

Semuyenzaniso Malabar Plum ine zvinoshanda zvinosanganisa Myricetin, Lycopene, Curcumin, Isoliquiritigenin, Cinnamaldehyde. Uye Black Mulberry ine zvinoshanda zvinosanganisa Quercetin, Myricetin, Curcumin, Isoliquiritigenin, Cinnamaldehyde uye pamwe nevamwe.

Chikanganiso chinowanzoitwa pakusarudza nekusarudza chikafu chekudya cheMelanoma - kuongorora chete zvakasarudzwa zvinoshandiswa zviri mukudya uye kufuratira zvimwe. Nekuti zvakasiyana-siyana zvinoshanda zviri mukudya zvinogona kuve nemhedzisiro inopikisa kune vatyairi vegomarara - haugone kutora cherry inoshanda mukudya uye ma supplements ekuita sarudzo yekudya kuMelanoma.

HONGU – ZVOKUSARUDZA ZVOKUDYA ZVINOKOSHA NEGONSA. ZVISARUDZO ZVOKUDYA ZVINOFANIRA KUFUNGA ZVINHU ZVINHU ZVINHU ZVINOSHANDA PACHIDYA.

Hunyanzvi hunodiwa paKudya Kwekudya Kwemunhu kune Melanoma?

Chikafu chakasarudzika chegomarara senge Melanoma chine chikafu chinokurudzirwa / ma supplements; zvisingakurudzirwe chikafu / ma supplements ane semuenzaniso mabikirwo anotungamira kushandiswa kwezvikafu zvinokurudzirwa. Muenzaniso wekudya kwakasiyana-siyana unogona kuonekwa pane izvi batanidzo.

Kufunga kuti ndezvipi zvekudya zvinokurudzirwa kana kwete zvakaomesesa, zvinoda hunyanzvi muMelanoma biology, sainzi yechikafu, genetics, biochemistry pamwe nekunzwisisa kwakanaka kwemashandiro anoita marapirwo egomarara uye kusagadzikana kwakabatana uko kurapwa kwaigona kumira kushanda.

ZVINONYANYA ZVINONYANYA ZVINODIWA KUTI ZVINOVAKA ZVINOVAKA MUNHU ZVINHU ZVINHU ZVINOITA: CANCER BIOLOGY, FOOD SCIENCE, KURAPA MAKANZA UYE GENETICS.

Hunhu hwegomarara senge Melanoma

Magomarara ese akaita seMelanoma anogona kuratidzwa neyakasiyana seti yebiochemical nzira - iyo siginecha nzira dzeMelanoma. Nzira dzeBiochemical seRAS-RAF Signaling, Inositol Phosphate Signaling, Extracellular Matrix Remodelling, Focal Adhesion chikamu cheiyo siginecha tsananguro yeMelanoma. Kenza yemunhu wega genetics inogona kuve yakasiyana uye nekudaro siginicha yavo yegomarara inogona kuve yakasarudzika.

Kurapa kunoshanda kuMelanoma kunoda kuziva nzira inosaina yebiochemical yemurwere wega wega wegomarara uye munhu ari panjodzi yemagene. Saka marapirwo akasiyana ane maitiro akasiyana ezviito anoshanda kune varwere vakasiyana. Saizvozvo uye nekuda kwezvikonzero zvakafanana zvekudya uye zvekuwedzera zvinoda kuitirwa munhu wega wega. Saka zvimwe zvekudya uye zvekuwedzera zvinokurudzirwa kuMelanoma kana uchitora kurapwa kenza Dabrafenib, uye zvimwe zvekudya uye zvekuwedzera hazvikurudzirwe.

Sources like cBioPortal uye vamwe vazhinji vanopa mumiriri wehuwandu hwevarwere data risingazivikanwe kubva kukiriniki miedzo yezvese zviratidzo zvegomarara. Iyi dhata ine yekiriniki yekuongorora yeruzivo senge sampuli saizi / nhamba yevarwere, mapoka ezera, murume kana mukadzi, dzinza, marapirwo, bundu saiti uye chero genetic mutations.

MUC16, BRAF, APOB, MGAM neNRAS ndiwo mazita emajini akarondedzerwa eMelanoma. MUC16 inoshumwa mu7.5% yevanomiririra varwere mukati meyese miedzo yekiriniki. Uye BRAF inoshumwa mu4.9%. Huwandu hwehuwandu hwemurwere data inovhara makore kubva pa5 kusvika 90. 62.8 % yedata remurwere inozivikanwa sevarume. Iyo Melanoma biology pamwe neyakashumwa genetics pamwe chete inotsanangura huwandu hwevanhu vanomiririrwa siginecha biochemical nzira dzegomarara iri. Kana iyo yega cancer tumor genetics kana majini anokonzera njodzi achizivikanwawo saka izvo zvinofanirwa kushandiswawo kune hutano hwemunhu.

ZVAKASARUDZA KUDYA ZVINODYA ZVINOFANIRA KUFANIRA NEMUNHU WEMUNHU WEMUNHU WEMUNHU WEGONSI.

Zvokudya uye Zvekuwedzera zveMelanoma

Kune Varwere veCancer

Varwere vegomarara vari pakurapa kana pakuchengeta palliative vanofanira kuita sarudzo pazvekudya uye zvekuwedzera - zvemacalorie anodiwa ekudya, kubata chero mhedzisiro yekurapa uyezve nekugadzirisa kenza. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye kusarudza uye kuisa pamberi pezvikafu zvakagadzirirwa munhu uye zvakagadzirirwa kuenderera mberi kurapwa kwegomarara kwakakosha uye kwakaoma. Heano mimwe mienzaniso inopa nhungamiro yekuita sarudzo dzekudya.

Sarudza Vegetable CAULIFLOWER kana AMERICAN POKEWEED?

Vegetable Cauliflower ine akawanda anoshanda zvinhu kana bioactives akadai Curcumin, Isoliquiritigenin, Cinnamaldehyde, Formononetin, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seMAPK Chiratidzo, RAS-RAF Chiratidzo, Amino Acid Metabolism uye PI3K-AKT-MTOR Kuratidzira uye vamwe. Koliflower inokurudzirwa kuMelanoma kana ichiramba ichirapwa kenza iri Dabrafenib. Izvi zvinodaro nekuti Cauliflower inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire kuita kweDabrafenib.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo weAmerican Pokeweed ndeye Quercetin, Myricetin, Curcumin, Isoliquiritigenin, Cinnamaldehyde. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seDNA Repair uye Oxidative Stress nevamwe. American Pokeweed haikurudzirwe kuMelanoma kana ichiramba ichirapwa kenza iri Dabrafenib nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara kurambe kana kusadaira.

MURIWO WAKARIFLOWER INOKURUDZWA PAMUSORO PAMUSORO POKEWEED YEAMERICAN YEMelanoma UYE KURAPA Dabrafenib.

Sarudza Fruit BLACK MULBERRY kana MALABAR PLUM?

Fruit Black Mulberry ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seQuercetin, Myricetin, Curcumin, Isoliquiritigenin, Cinnamaldehyde. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge MAPK Kusaina, DNA Kugadzirisa, Kukura kweFactor Signaling uye Epithelial kune Mesenchymal Shanduko uye nevamwe. Black Mulberry inokurudzirwa kuMelanoma apo chirwere chegomarara chiri kuramba chiri Dabrafenib. Izvi zvinodaro nekuti Black Mulberry inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire kuita kweDabrafenib.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Malabar Plum ndeyeMyricetin, Lycopene, Curcumin, Isoliquiritigenin, Cinnamaldehyde. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seDNA Repair uye Oxidative Stress nevamwe. Malabar Plum haikurudzirwe kuMelanoma kana ichienderera mberi kurapwa kwegomarara iri Dabrafenib nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara kurambe kana kusadaira.

FRUIT BLACK MULBERRY INOKURUDZWA PAMUSORO PEMALABAR PLUM YEMelanoma UYE KURAPA Dabrafenib.

Sarudza Nut BUTTERNUT kana EUROPEAN CHESTNUT?

Butternut ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seMyricetin, Lycopene, Curcumin, Isoliquiritigenin, Cinnamaldehyde. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seMAPK Signaling, DNA Repair uye Insulin Signaling nevamwe. Butternut inokurudzirwa kuMelanoma kana chirwere chegomarara chiri kuramba chiri Dabrafenib. Izvi zvinodaro nekuti Butternut inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire kuita kweDabrafenib.

Zvimwe zvezvinhu zvinoshanda kana bioactives muEuropean Chestnut ndeye Quercetin, Ellagic Acid, Myricetin, Curcumin, Isoliquiritigenin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge DNA Kugadzirisa, WNT Beta Catenin Signaling, Epithelial kune Mesenchymal Transition uye Oxidative Stress nevamwe. European Chestnut haikurudzirwe kuMelanoma kana ichiramba ichirapwa kenza iri Dabrafenib nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara kurambe kana kusadaira.

BUTTERNUT INOKURUDZWA PAMUSORO PEEUROPA CHESTNUT YEMelanoma NEKURAPA Dabrafenib.

Kune Vanhu Vane Genetic Risk yeCancer

Mubvunzo wakabvunzwa nevanhu vane genetic risk yeMelanoma kana nhoroondo yemhuri ndeye "Chii Chandinofanira Kudya Zvakasiyana Kubva Kare?" uye masarudzire avanofanira kuita zvekudya uye zvekuwedzera kuti vatarise njodzi dzechirwere. Sezvo kune njodzi yegomarara hapana chinogoneka maererano nekurapa - sarudzo dzezvekudya uye zvekuwedzera zvinove zvakakosha uye chimwe chezvinhu zvishoma zvingaite zvinogona kuitwa. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye zvichibva pane zvakazivikanwa genetics uye nzira siginecha - sarudzo dzechikafu nekuwedzera dzinofanirwa kuve munhu.

Sarudza Vegetable GIANT BUTTERBUR kana TURNIP?

Vegetable Giant Butterbur ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Curcumin, Myricetin, Lycopene, Lupeol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical nzira seMAPK Kusaina, RAS-RAF Kuratidzira, MYC Kuratidzira uye PI3K-AKT-MTOR Kusaina uye vamwe. Giant Butterbur inokurudzirwa kune njodzi yeMelanoma kana yakabatana neiyo genetic njodzi iri APOB. Izvi zvinodaro nekuti Giant Butterbur inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo Turnip ndeye Ellagic Acid, Curcumin, Quercetin, Lupeol, Daidzein. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seMAPK Signaling, Cell Cycle uye PI3K-AKT-MTOR Signaling nevamwe. Turnip haikurudzirwe kana njodzi yeMelanoma kana yakabatana neiyo genetic njodzi iri APOB nekuti inowedzera siginicha nzira dzayo.

MURIWO MURUME BUTTERBUR ANOKURUKURIRWA PAKUSHANDA KUTI APOB GENETIC RISK YECANCER.

Sarudza Muchero RED RASPBERRY kana PUMMELO?

Chibereko Chitsvuku Raspberry chine zvakawanda zvinoshanda zvinosanganisa kana bioactives seEllagic Acid, Curcumin, Quercetin, Lupeol, Daidzein. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical nzira seMAPK Kusaina, RAS-RAF Kuratidzira, Kukura kweFactor Kuratidzira uye PI3K-AKT-MTOR Kuratidzira uye vamwe. Red Raspberry inokurudzirwa kune njodzi yeMelanoma kana yakabatana genetic njodzi iri APOB. Izvi zvinodaro nekuti Red Raspberry inowedzera idzo biochemical nzira dzinopokana nemasaini madhiraivha ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Pummelo ndeye Apigenin, Curcumin, Quercetin, Lycopene, Lupeol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seSero Cycle Checkpoints uye Extracellular Matrix Remodeling nevamwe. Pummelo haikurudzirwe kana njodzi yeMelanoma kana yakabatana genetic njodzi iri APOB nekuti inowedzera siginecha nzira dzayo.

MUCHERO RED RASPBERRY INOKURUKURWA PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO POB GENETIC RISK YECANCER.

Sarudza Nut COMMON HAZELNUT kana MACADAMIA NUT?

Common Hazelnut ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seCurcumin, Quercetin, Myricetin, Lycopene, Lupeol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical nzira seMAPK Kusaina, RAS-RAF Kuratidzira, Kukura kweFactor Kuratidzira uye PI3K-AKT-MTOR Kuratidzira uye vamwe. Common Hazelnut inokurudzirwa kune njodzi yeMelanoma kana yakabatana nejeneki njodzi iri APOB. Izvi zvinodaro nekuti Common Hazelnut inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives muMacadamia Nut ndeye Apigenin, Curcumin, Myricetin, Lupeol, Daidzein. Izvi zvinoshandiswa zvinoshandiswa zvinoshandisa nzira dzakasiyana-siyana dzebiochemical seMAPK Signaling uye PI3K-AKT-MTOR Signaling uye vamwe. Macadamia Nut haikurudzirwe kana njodzi yeMelanoma kana yakabatana genetic njodzi iri APOB nekuti inowedzera siginecha nzira dzayo.

COMMON HAZELNUT INOKURUDZWA PAMUSORO PEMACADAMIA NUT YEAPOB GENETIC RISK YECANCER.

Mhedziso

Chikafu uye Zvekuwedzera zvakasarudzwa sarudzo dzakakosha kune cancer seMelanoma. Varwere veMelanoma uye vanhu vane genetic-njodzi vanogara vaine mubvunzo uyu: "Ndezvipi zvekudya uye zvinovaka muviri zvinokurudzirwa kwandiri uye izvo zvisiri?" Pane chitendero chakajairika chinova fungidziro isiriyo yekuti zvese zvinodyarwa-zvikafu zvinogona kubatsira kana kwete asi zvisingakuvadze. Zvimwe zvekudya uye zvekuwedzera zvinogona kukanganisa marapirwo egomarara kana kusimudzira mamorekuru enzira yegomarara.

Kune marudzi akasiyana ezviratidzo zvegomarara seMelanoma, imwe neimwe iine bundu genetics ine mamwe ma genomic mutsauko pamunhu wega wega. Kuwedzera kurapwa kwegomarara uye chemotherapy ine yakasarudzika nzira yekuita. Chikafu chega chega seCauliflower chine mabioactive akasiyana muhuwandu hwakasiyana, izvo zvine chekuita neakasiyana uye akasiyana seti yebiochemical nzira. Tsanangudzo yekudya yakasarudzika ndeyakasarudzika chikafu kurudziro yegomarara chiratidzo, marapirwo, genetics, mararamiro uye zvimwe zvinhu. Sarudzo dzehutano hwemunhu hwegomarara dzinoda ruzivo rwegomarara biology, sainzi yechikafu uye kunzwisisa kweakasiyana chemotherapy marapirwo. Chekupedzisira kana paine shanduko yekurapa kana nyowani genomics inoonekwa - iyo inovaka muviri inoda kuongororwazve.

Iyo addon nutrition personalization solution inoita kuti sarudzo ive nyore uye inobvisa zvese zvekufungidzira mukupindura mubvunzo, "Ndezvipi zvekudya zvandinofanira kusarudza kana kusasarudzira Melanoma?". Iyo addon yakawanda-yekuranga timu inosanganisira varapi vegomarara, masayendisiti ekiriniki, mainjiniya esoftware uye masayendisiti edata.

References

• Summit 2018
• Curcuminoids Inokurudzira Reactive Oxygen Species uye Autophagy Kuwedzera Apoptosis muHuman Oral Cancer Cells.
• Morusin inokonzera kufa kwesero kuburikidza nekuita kusaina STAT3 mumaseru ekenza yeprostate.
• Kutora mulberry 1-deoxynojirimycin kunodzivirira gomarara remukati mumakonzo.
• Brassinin Inodzoreredza Inopindira Inogona YeLung Carcinoma Masero kuburikidza neDeactivation yePI3K/Akt/mTOR Signaling Cascade.
• Vitamin C inouraya masero egomarara rethyroid kuburikidza neROS-inotsamira inhibition yeMAPK/ERK uye PI3K/AKT nzira nenzira dzakasiyana.
• Kudzivirira mhedzisiro yebutyric acid, nicotinamide, calcium glucarate yoga kana musanganiswa panguva ye7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis kuburikidza nemodulation yeK-Ras-PI3K-AKTpathway uye yakabatana micro RNAs.
• Kukura kwekukurudzira kwemasero emunhu pulmonary adenocarcinoma uye madiki epithelial masero emhepo ne beta-carotene kuburikidza ne activation ye cAMP, PKA, CREB uye ERK1/2.
• https://www.ncbi.nlm.nih.gov/books/NBK470409
• https://www.cancer.org/cancer/types/melanoma-skin-cancer/about/what-is-melanoma.html