Zvokudya zveMedulloblastoma!

ziviso

Zvikafu zveMedulloblastoma zvinofanirwa kuve zvakasarudzika kune wega wega uye zvakare zvinofanirwa kuchinjika kana kenza kurapwa kana bundu genetic shanduko. Iyo yemunhu uye kugadzirisa kunofanirwa kufunga nezvese zvinoshanda zvinosanganiswa kana bioactives zviri muzvokudya zvakasiyana zvine chekuita negomarara biology, genetics, marapirwo, mararamiro uye zvido zvekudya. Saka nepo chikafu chiri chimwe chezvisarudzo zvakakosha zvemurwere wegomarara uye munhu ari panjodzi yegomarara - kusarudza chikafu chekudya harisi basa riri nyore.

Medulloblastoma imhando yekashoma, kenza yemupfungwa bundu inowanikwa mucerebellum (brain stem), uye inowanzoitika muvana kupfuura vakuru. Bundu iri riri kukura nekukurumidza uye rinogona kupararira kune dzimwe nzvimbo dzehuropi nemuzongoza. Zviratidzo zvemedulloblastoma zvinosanganisira kutemwa nemusoro, dzungu, kuda kurutsa uye kurutsa, kuneta, nyaya dzekuenzanisa, shanduko yekuona, kutadza kufamba, kurwadza kwemusana, weti kana matumbu. Zvikonzero zvemedulloblastoma hazvinzwisiswe zvizere, asi genetic mutations mumajini akadai seBRCA1 uye BRCA2 anogona kuita basa. Sarudzo dzekurapa dzemedulloblastoma dzinosanganisira kuvhiyiwa, radiation therapy, uye chemotherapy, yakarongedzwa kune chaiyo nyaya yemunhu. The prognosis uye mwero wekupona kwevakuru vane medulloblastoma inosiyana neiyo muvana. Mwero wemakore mashanu wekupona kwemedulloblastoma unopfuura makumi manomwe%. Hupenyu mushure memedulloblastoma inoda kutariswa kwepedyo nekutevera kutarisirwa

Kune Medulloblastoma zvine basa here kuti miriwo, michero, nzungu, mhodzi munhu anodya chii?

Mubvunzo wakajairika wekudya unobvunzwa nevarwere vegomarara uye vanhu vari pa-genetic njodzi yegomarara ndeye - kugomarara seMedulloblastoma zvine basa here kuti ndechipi chikafu chandinodya uye chandisingade? Kana kuti ndikatevera kudya-kwekudyara kunokwana kenza seMedulloblastoma?

Semuenzaniso zvine basa here kana muriwo weNew Zealand Sipinachi uchidyiwa zvakanyanya kana uchienzaniswa neJerusarema Artichoke? Zvinoita mutsauko here kana muchero Pummelo uchifarirwa pane Red Raspberry? Zvakare kana sarudzo dzakafanana dzikaitirwa nzungu/mhodzi dzakaita seButternut pamusoro peEuropean Chestnut uye yemapuruzi akaita seBroad Bean pamusoro peHyacinth Bean. Uye kana izvo zvandinodya zvine basa - zvino munhu angaziva sei chikafu chinokurudzirwa kuMedulloblastoma uye ndiyo mhinduro imwechete kune wese ane chirwere chakafanana kana genetic njodzi?

Ehe! Zvokudya zvaunodya zvine chekuita neMedulloblastoma!

Mazano echikafu anogona kunge asina kufanana kune wese munhu uye anogona kuve akasiyana kunyangwe kune imwechete kuongororwa uye genetic njodzi.

Zvokudya zvose (miriwo, michero, nzungu, mhodzi, pulses, mafuta nezvimwewo) uye zvokudya zvinovaka muviri zvinoumbwa nezvinodarika imwe inoshanda mamolecular ingredient kana bio-actives muzvikamu zvakasiyana uye uwandu. Chinhu chimwe nechimwe chinoshanda chine nzira yakasarudzika yekuita - iyo inogona kuve activation kana inhibition yeakasiyana biochemical nzira. Zvikafu zvakangotaurwa uye zvekuwedzera izvo zvinokurudzirwa ndezviya zvisingakonzere kuwedzera kwemamorekuru anotyaira cancer asi anodzideredza. Zvikasadaro izvo zvikafu hazvifanirwe kukurudzirwa. Chikafu chine akawanda anoshanda zvinongedzo - saka kana uchiongorora chikafu uye zvekuwedzera iwe unofanirwa kufunga nezve mabatiro ezvese zvinoshanda zvinongedzo zvakapetwa kwete zvega.

Somuenzaniso Pummelo ine zvinhu zvinoshanda Quercetin, Curcumin, Isoliquiritigenin, Apigenin, Lycopene. Uye Red Raspberry ine zvinoshanda zvinosanganisa Quercetin, Ellagic Acid, Curcumin, Isoliquiritigenin, Formononetin uye pamwe nevamwe.

Chikanganiso chinowanzoitwa pakusarudza nekusarudza chikafu chekudya cheMedulloblastoma - kuongorora chete zvakasarudzwa zvinoshandiswa zviri muzvokudya uye kufuratira zvimwe. Nekuti zvakasiyana-siyana zvinoshanda zviri mukudya zvinogona kuva nemhedzisiro inopikisa kune vatyairi vegomarara - haugone cherry kutora zvinoshanda muzvikafu uye zvinowedzera kuita sarudzo yekudya kweMedulloblastoma.

HONGU – ZVOKUSARUDZA ZVOKUDYA ZVINOKOSHA NEGONSA. ZVISARUDZO ZVOKUDYA ZVINOFANIRA KUFUNGA ZVINHU ZVINHU ZVINHU ZVINOSHANDA PACHIDYA.

Unyanzvi Hunodiwa Pakudya Kwekudya Kwemunhu kuMedulloblastoma?

Kudya kwakasarudzika kwegomarara seMedulloblastoma ine chikafu chinokurudzirwa / ma supplements; zvisingakurudzirwe chikafu / ma supplements ane semuenzaniso mabikirwo anotungamira kushandiswa kwezvikafu zvinokurudzirwa. Muenzaniso wekudya kwakasiyana-siyana unogona kuonekwa pane izvi batanidzo.

Kufunga kuti ndezvipi zvekudya zvinokurudzirwa kana kwete zvakaomesesa, zvinoda hunyanzvi muMedulloblastoma biology, sainzi yechikafu, genetics, biochemistry pamwe nekunzwisisa kwakanaka kwemashandiro anoita marapirwo egomarara uye kusagadzikana kwakabatana uko kurapwa kwaigona kumira kushanda.

ZVINONYANYA ZVINONYANYA ZVINODIWA KUTI ZVINOVAKA ZVINOVAKA MUNHU ZVINHU ZVINHU ZVINOITA: CANCER BIOLOGY, FOOD SCIENCE, KURAPA MAKANZA UYE GENETICS.

Hunhu hwegomarara seMedulloblastoma

Ese magomarara seMedulloblastoma anogona kuratidzirwa neyakasiyana seti yebiochemical nzira - iyo siginecha nzira dzeMedulloblastoma. Biochemical nzira dzakadai seDNA Kugadzirisa, Angiogenesis, Oncogenic Histone Methylation, Epithelial kusvika Mesenchymal Transition chikamu chetsanangudzo yesaina yeMedulloblastoma. Kenza yemunhu wega genetics inogona kuve yakasiyana uye nekudaro siginicha yavo yegomarara inogona kuve yakasarudzika.

Iwo marapirwo anoshanda kuMedulloblastoma anofanirwa kuziva iyo inosanganisirwa siginecha biochemical nzira kune yega yega murwere wegomarara uye munhu ari panjodzi yemajini. Saka marapirwo akasiyana ane maitiro akasiyana ezviito anoshanda kune varwere vakasiyana. Saizvozvo uye nekuda kwezvikonzero zvakafanana zvekudya uye zvekuwedzera zvinoda kuitirwa munhu wega wega. Saka zvimwe zvekudya uye zvekuwedzera zvinokurudzirwa kuMedulloblastoma kana uchitora kurapwa kenza Temozolomide, uye zvimwe zvekudya uye zvekuwedzera hazvikurudzirwe.

Sources like cBioPortal uye vamwe vazhinji vanopa mumiriri wehuwandu hwevarwere data risingazivikanwe kubva kukiriniki miedzo yezvese zviratidzo zvegomarara. Iyi dhata ine yekiriniki yekuongorora yeruzivo senge sampuli saizi / nhamba yevarwere, mapoka ezera, murume kana mukadzi, dzinza, marapirwo, bundu saiti uye chero genetic mutations.

PTCH1, TERT, DDX3X, KMT2D uye CTNNB1 ndiwo mazita epamusoro akashumwa majini eMedulloblastoma. PTCH1 inoshumwa mu6.3% yevanomiririra varwere mumakiriniki ese miedzo. Uye TERT inotaurwa mu6.2%. Iyo yakasanganiswa yehuwandu hwevarwere data inovhara mazera kubva pa1 kusvika ku50. 62.3 % yedata remurwere inozivikanwa sevarume. Iyo Medulloblastoma biology pamwe neyakashumwa genetics pamwe chete inotsanangura huwandu hwevanhu vanomiririra siginecha biochemical nzira dzegomarara iri. Kana iyo yega cancer tumor genetics kana majini anokonzera njodzi achizivikanwawo saka izvo zvinofanirwa kushandiswawo kune hutano hwemunhu.

ZVAKASARUDZA KUDYA ZVINODYA ZVINOFANIRA KUFANIRA NEMUNHU WEMUNHU WEMUNHU WEMUNHU WEGONSI.

Chikafu uye Zvekuwedzera zveMedulloblastoma

Kune Varwere veCancer

Varwere vegomarara vari pakurapa kana pakuchengeta palliative vanofanira kuita sarudzo pazvekudya uye zvekuwedzera - zvemacalorie anodiwa ekudya, kubata chero mhedzisiro yekurapa uyezve nekugadzirisa kenza. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye kusarudza uye kuisa pamberi pezvikafu zvakagadzirirwa munhu uye zvakagadzirirwa kuenderera mberi kurapwa kwegomarara kwakakosha uye kwakaoma. Heano mimwe mienzaniso inopa nhungamiro yekuita sarudzo dzekudya.

Sarudza Vegetable NEW ZEALAND SPINACH kana JERUSALEM ARTICHOKE?

Vegetable New Zealand Sipinachi ine zvakawanda zvinoshanda zvinosanganisa kana bioactives zvakaita seQuercetin, Curcumin, Isoliquiritigenin, Apigenin, Lycopene. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical senge Kukura Factor Signaling, Hypoxia, NFKB Signaling uye Focal Adhesion nevamwe. New Zealand Sipinachi inokurudzirwa kuMedulloblastoma apo chirwere chegomarara chiri kuramba chiri Temozolomide. Izvi zvinodaro nekuti New Zealand Sipinachi inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire kuita kweTemozolomide.

Zvimwe zvezvishandiso zvinoshanda kana bioactives mumuriwo weJerusarema Artichoke ndiwo Curcumin, Isoliquiritigenin, Apigenin, Formononetin, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge DNA Kugadzirisa uye TGFB Signaling nevamwe. Jerusalem Artichoke haikurudzirwe kuMedulloblastoma kana ichiramba ichirapwa gomarara iri Temozolomide nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara risarambe kana kusadaira.

MURIWO NEW ZEALAND SIPICHI INOKURUDZWA PAMUSORO PEJERUSALEM ARTICHOKE YEMedulloblastoma UYE KURAPA Temozolomide.

Sarudza Muchero RED RASPBERRY kana PUMMELO?

Chibereko Chitsvuku Raspberry chine zvakawanda zvinoshanda zvinosanganisa kana bioactives seQuercetin, Ellagic Acid, Curcumin, Isoliquiritigenin, Formononetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical nzira seMAPK Signaling, NFKB Signaling, Focal Adhesion uye Oxidative Stress nevamwe. Red Raspberry inokurudzirwa kuMedulloblastoma kana ichienderera mberi kurapwa kwegomarara iri Temozolomide. Izvi zvinodaro nekuti Red Raspberry inogadzirisa idzo biochemical nzira dzakataurwa nesainzi kuti dzikurudzire mhedzisiro yeTemozolomide.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Pummelo ndeye Quercetin, Curcumin, Isoliquiritigenin, Apigenin, Lycopene. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seDNA Repair uye Oxidative Stress nevamwe. Pummelo haikurudzirwe kuMedulloblastoma kana ichiramba ichirapwa kenza iri Temozolomide nekuti inogadzirisa nzira dzebiochemical idzo dzinoita kuti kurapwa kwegomarara risarambe kana kusadaira.

MUCHERO RED RASPBERRY INOKURURWA PAMUSORO PEPUMMELO YEMedulloblastoma UYE KURAPA Temozolomide.

Sarudza Nut BUTTERNUT kana EUROPEAN CHESTNUT?

Butternut ine zvakawanda zvinoshanda zvinosanganisa kana bioactives zvakaita seCurcumin, Isoliquiritigenin, Apigenin, Lycopene, Formononetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seMAPK Signaling, DNA Repair, NFKB Signaling uye Focal Adhesion nevamwe. Butternut inokurudzirwa kuMedulloblastoma apo chirwere chegomarara chiri kuramba chiri Temozolomide. Izvi zvinodaro nekuti Butternut inogadzirisa idzo biochemical nzira dzakataurwa nesainzi kuti dzikurudzire mhedzisiro yeTemozolomide.

Zvimwe zvezvinhu zvinoshanda kana bioactives muEuropean Chestnut ndeye Quercetin, Ellagic Acid, Curcumin, Isoliquiritigenin, Apigenin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge DNA Kugadzirisa uye TGFB Signaling nevamwe. European Chestnut haikurudzirwe kuMedulloblastoma kana ichiramba ichirapwa kenza iri Temozolomide nekuti inogadzirisa nzira dzebiochemical idzo dzinoita kuti kurapwa kwegomarara risarambe kana kusadaira.

BUTTERNUT INOKURUKURWA PAMUSORO PEEUROPA CHESTNUT YEMedulloblastoma UYE KURAPA Temozolomide.

Kune Vanhu Vane Genetic Risk yeCancer

Mubvunzo wakabvunzwa nevanhu vane genetic risk yeMedulloblastoma kana nhoroondo yemhuri ndeye "Chii Chandinofanira Kudya Zvakasiyana Kubva Kare?" uye masarudzire avanofanira kuita chikafu nekuwedzera kuti vatarise njodzi dzechirwere. Sezvo kune njodzi yegomarara hapana chinogoneka maererano nekurapa - sarudzo dzezvekudya uye zvekuwedzera zvinove zvakakosha uye chimwe chezvinhu zvishoma zvingaite zvinogona kuitwa. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye zvichibva pane zvakazivikanwa genetics uye nzira siginecha - sarudzo dzechikafu nekuwedzera dzinofanirwa kuve munhu.

Sarudza Vegetable GIANT BUTTERBUR kana OSTRICH FERN?

Vegetable Giant Butterbur ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seCurcumin, Apigenin, Formononetin, Lupeol, Beta-sitosterol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana-siyana dzebiochemical seRAS-RAF Signaling, JAK-STAT Signaling, Oncogenic Cancer Epigenetics uye PI3K-AKT-MTOR Signaling nevamwe. Giant Butterbur inokurudzirwa kune njodzi yeMedulloblastoma kana yakabatana genetic njodzi iri CTNNB1. Izvi zvinodaro nekuti Giant Butterbur inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo Ostrich Fern ndeye Curcumin, Apigenin, Formononetin, Lupeol, Beta-sitosterol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical nzira seOncogenic Cancer Epigenetics, WNT Beta Catenin Signaling uye Stem Cell Signaling nevamwe. Ostrich Fern haikurudzirwe kana njodzi yeMedulloblastoma kana yakabatana genetic njodzi iri CTNNB1 nekuti inowedzera siginecha nzira dzayo.

MURIWO MURUME BUTTERBUR ANOKURUKURWA PAMUSORO PEOSTRICH FERN YECTNNB1 GENETIC RISK YECANCER.

Sarudza Chibereko NANCE kana ZHIzha GRAPE?

Chibereko Nance chine zvakawanda zvinoshanda zvinosanganisa kana bioactives seCurcumin, Apigenin, Formononetin, Betulinic Acid, Lupeol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seRAS-RAF Signaling, JAK-STAT Signaling, Oncogenic Cancer Epigenetics uye PI3K-AKT-MTOR Signaling nevamwe. Nance inokurudzirwa kune njodzi yeMedulloblastoma kana yakabatana genetic njodzi iri CTNNB1. Izvi zvinodaro nekuti Nance inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Zhizha Zambiringa Curcumin, Apigenin, Formononetin, Lupeol, Beta-sitosterol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical nzira seOncogenic Cancer Epigenetics, WNT Beta Catenin Signaling uye Stem Cell Signaling nevamwe. Zhizha Mazambiringa haakurudzirwe kana njodzi yeMedulloblastoma kana yakabatana genetic njodzi iri CTNNB1 nekuti inowedzera siginecha nzira dzayo.

FRUIT NANCE INOKURUKURIRWA PAMUSORO PEZHIZHIRA MABHIBHI ECTNNB1 GENETIC RISK YECANCER.

Sarudza Nut CHIA kana JAPANESE WALNUT?

Chia ine zvinhu zvakawanda zvinoshanda kana bioactives seCurcumin, Apigenin, Formononetin, Lupeol, Beta-sitosterol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical dzakaita seSero Cycle Checkpoints, RAS-RAF Signaling, Oncogenic Cancer Epigenetics uye PI3K-AKT-MTOR Signaling nevamwe. Chia inokurudzirwa kune njodzi yeMedulloblastoma kana yakabatana genetic njodzi iri CTNNB1. Izvi zvinodaro nekuti Chia inowedzera idzo nzira dzebiochemical dzinopesana nemadhiraivha ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives muWalnut yeJapan ndeye Curcumin, Apigenin, Formononetin, Lupeol, Beta-sitosterol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical nzira seOncogenic Cancer Epigenetics, WNT Beta Catenin Signaling uye Stem Cell Signaling nevamwe. Japanese Walnut haikurudzirwe kana njodzi yeMedulloblastoma kana yakabatana genetic njodzi iri CTNNB1 nekuti inowedzera siginecha nzira dzayo.

CHIA INOKURUKURWA PAMUSORO PAMUSORO PEJAPANESE WALNUT YECTNNB1 GENETIC RISK YECANCER.

Mhedziso

Chikafu uye Zvekuwedzera zvakasarudzwa sarudzo dzakakosha kune cancer seMedulloblastoma. Varwere veMedulloblastoma uye vanhu vane genetic-njodzi vanogara vaine mubvunzo uyu: "Ndezvipi zvekudya uye zvinovaka muviri zvinokurudzirwa kwandiri uye izvo zvisiri?" Pane chitendero chakajairika chinova fungidziro isiriyo yekuti zvese zvinodyarwa-zvikafu zvinogona kubatsira kana kwete asi zvisingakuvadze. Zvimwe zvekudya uye zvekuwedzera zvinogona kukanganisa marapirwo egomarara kana kusimudzira mamorekuru enzira yegomarara.

Kune marudzi akasiyana ezviratidzo zvegomarara seMedulloblastoma, imwe neimwe iine bundu genetics ine mamwe ma genomic akasiyana pamunhu wega wega. Kuwedzera kurapwa kwegomarara uye chemotherapy ine yakasarudzika nzira yekuita. Chikafu chega chega senge New Zealand Sipinachi ine akasiyana bioactive muhuwandu hwakasiyana, iyo ine mhedzisiro pane dzakasiyana uye dzakasiyana seti dzebiochemical nzira. Tsanangudzo yekudya yakasarudzika ndeyakasarudzika chikafu kurudziro yegomarara chiratidzo, marapirwo, genetics, mararamiro uye zvimwe zvinhu. Sarudzo dzehutano hwemunhu hwegomarara dzinoda ruzivo rwegomarara biology, sainzi yechikafu uye kunzwisisa kweakasiyana chemotherapy marapirwo. Chekupedzisira kana paine shanduko yekurapa kana nyowani genomics inoonekwa - iyo inovaka muviri inoda kuongororwazve.

Iyo addon nutrition personalization mhinduro inoita kuti sarudzo ive nyore uye inobvisa zvese zvekufungidzira mukupindura mubvunzo, "Ndezvipi zvekudya zvandinofanira kusarudza kana kusasarudzira Medulloblastoma?". Iyo addon yakawanda-yekuranga timu inosanganisira varapi vegomarara, masayendisiti ekiriniki, mainjiniya esoftware uye masayendisiti edata.

References

• Brain Cptac 2020
• Pan-cancer kuongororwa kweiyo genomes yakazara.
• Mhedzisiro ye isoliquiritigenin pamasero egomarara reovarian.
• Iyo citrus flavonoid naringenin inokurudzira DNA kugadziriswa mumasero ekenza yeprostate.
• Daidzein mhedzisiro pahomoni refractory prostate cancer in vitro uye in vivo ichienzaniswa negenistein uye soy inobvisa: kugona kweradiotherapy.
• Retinol inoderedza beta-catenin mapuroteni mazinga mu retinoic acid-inodzivirira colon cancer cell mitsara.
• https://www.cancer.gov/rare-brain-spine-tumor/tumors/medulloblastoma
• Eibl T et al, Kuchembera (Albany NY), 2021
• https://my.clevelandclinic.org/health/diseases/22591-medulloblastoma
• https://www.cancer.gov/rare-brain-spine-tumor/tumors/medulloblastoma#:~:text=Medulloblastoma%20Prognosis,how%20they%20respond%20to%20treatment