Nderipi gomarara raizobatsirwa nekubatanidza Vitamin B3 mukudya kwavo?

Muchidimbu

Vitamin B3 inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevanorwara nekenza uye avo vari panjodzi yemagene. Asi, kuchengetedzeka uye kushanda kweVitamin B3 kune varwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Vitamin B3 inogona kubatsira avo vane Primary Richter syndrome vari pasi peDoxorubicin, asi zvingasava zvakanaka kune varwere vanowana Mitomycin yePrimary Penile Squamous Cell Carcinoma. Uyezve, nepo Vitamin B3 ichigona kubatsira vanhu vane genetic risk factor "ERCC2", inogona kunge isingakurudzirwe kune avo vane imwe genetic ngozi "ALK". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweVitamin B3 kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, njodzi dzemajini, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Vitamin B3 iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, nzira yakasarudzika yesarudzo yekudya yakakosha, tichitarisa pane zvese zvinokonzeresa zvese zvinoshanda zvinoringana muzvikafu / zvekuwedzera seVhitamini B3 pachinzvimbo chekuongorora chega chega chega chega chega kana kuregeredza zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Vitamin B3 mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Vitamin B3 kana uine genetic predisposition kune cancer inoenderana neERCC2 gene? Ko kana pachinzvimbo chako genetic ngozi ichibva kune ALK gene? Zvinobatsira here kuisa Vitamin B3 mukudya kwako kana ukawanikwa uine Primary Penile Squamous Cell Carcinoma, kana kuti chirwere chako chiri Primary Richter syndrome? Uyezve, manwiro ako eVitamin B3 anofanira kugadziriswa sei kana uri kurapwa neDoxorubicin kana chirongwa chako chekurapa chichibva kuDoxorubicin kuenda kuMitomycin? Izvo zvakakosha kuti uzive kuti kutaura kwakapusa senge 'Vitamin B3 ndeyemusikirwo, saka inogara ichibatsira' kana 'Vitamin B3 inosimudzira kusadzivirirwa kwemuviri' haina kukwana kune ruzivo rwekudya / yekuwedzera sarudzo.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekusanganisira Vitamin B3 mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo dzekubatanidza chikafu kana ma supplements seVitamin B3 mukudya kwako kune zvakanakira, iwe unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga zvinhu zvakaita serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic. predispositions, uye mararamiro esarudzo.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Richter syndrome kana Primary Penile Squamous Cell Carcinoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu genetics, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvesarudzo dzekudya, senge Vitamin B3. Ko genetic njodzi yegomarara kubva mukushandurwa muERCC2 ine zvakafanana biochemical nzira nzira sekuchinja muALK? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Richter syndrome inofanana nePrimary Penile Squamous Cell Carcinoma? Uyezve, kutariswa kwekudya kunoramba kwakafanana here kune avo vari kuitiswa Mitomycin sekune avo vanogamuchira Doxorubicin? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Vitamin B3 - A Nutritional Supplement

Iyo yekuwedzera Vitamin B3 inosanganisira huwandu hwezvinhu zvinoshanda, kusanganisira Vitamin B3, yega yega iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya DNA Kugadzirisa, PI3K-AKT-MTOR Kuratidzira uye Angiogenesis, iyo inodzora zvinhu zvakakosha zvegomarara padanho remasero, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza akakodzera ekuwedzera seVitamin B3, ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezvekushandisa Vitamin B3 kune cancer, zvakakosha kufunga nezve izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa gomarara, kushandiswa kweVitamin B3 haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Vitamin B3 Zvekuwedzera

Kutarisana nemubvunzo wekuti 'Ndirini pandinofanira kudzivirira Vitamin B3 mumamiriro ezvinhu eCancer' zvinonetsa nokuti mhinduro yacho ndeyemunhu oga - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara kusingashande kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eVitamin B3 anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo azvino, mamwe ma supplements ari kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Vitamin B3 yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga kwemunhu. muzvisarudzo zvakadaro.

1. Ko Vitamin B3 Supplements ichabatsira here Primary Penile Squamous Cell Carcinoma Varwere vari kurapwa Mitomycin?

Primary Penile Squamous Cell Carcinoma inoratidzwa neakanyanya genetic mutations, anoti ABRAXAS1, PIK3CB uye NUP93, izvo zvinotungamira kune shanduko munzira dzebiochemical nzira, kunyanya PI3K-AKT-MTOR Chiratidzo, Hematopoiesis uye Inositol Phosphate Signaling. Kubudirira kwekurapwa kwegomarara, senge Mitomycin, kunoenderana nemabatiro ayo ekuita panzira idzi chaidzo. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo Vitamin B3 yekuwedzera, iyo inobata iyo PI3K-AKT-MTOR Signaling, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Penile Squamous Cell Carcinoma kana ichiitwa Mitomycin. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Vitamin B3 Supplements ichabatsira here Primary Richter syndrome Varwere vari kurapwa neDoxorubicin?

Primary Richter syndrome inotaridzwa neyakajeka genetic mutations, seMYC, TRAF3 uye TP53, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya DNA Repair, Noncoding RNA Signaling, MAPK Signaling, Cytokine Signaling, Antigen Presentation, Cell Cycle Checkpoints uye Apoptosis. Kushanda kwekurapa cancer, seDoxorubicin, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Vitamin B3 yekuwedzera isarudzo ine musoro kune avo vane Primary Richter syndrome iri pasi peDoxorubicin. Izvi zvinodaro nekuti Vitamin B3 inokanganisa nzira dzakadai seDNA Repair, inogona kuvharisa zvinhu zvinotyaira Primary Richter syndrome kana kubatsira kushanda kweDoxorubicin.

3. Ko Vitamin B3 Supplements Yakachengeteka Kune Vanhu Vane Utano Vane ALK Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo ALK gene inowanzobatanidzwa mune aya mapaneru ekuongorora njodzi yekenza.

Kuchinja kweiyo ALK gene kunokanganisa nzira dzebiochemical kana maitiro, akadai seAngiogenesis uye Growth Factor Signaling, ayo akabatanidzwa zvakananga kana zvisina kunanga mukutyaira cancer padanho remamorekuru. Kana genetic panel ikaratidza shanduko muALK yakabatana nenjodzi yakawedzera yeCentral Nervous System, chikonzero chesainzi chinoratidza kusashandisa kuwedzera Vitamin B3. Izvi zvinodaro nekuti kuwedzera Vitamin B3 inokanganisa nzira senge Angiogenesis, izvo zvinogona kutungamira kune yakaipa mhedzisiro mumamiriro eiyo ALK mutation uye ane hukama nekenza mamiriro.

4. Ko Vitamin B3 Supplements Yakachengeteka Kune Vanhu Vane Utano Vane ERCC2 Mutation Associated Genetic Risk?

ERCC2 inoita basa rakakosha mukuongorora njodzi yegomarara. Kuchinja muERCC2 kunogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira DNA Repair, iyo inokanganisa kukura kwegomarara. Kana genetic panel yako ikaratidza shanduko muERCC2 yakabatana neGanda Reganda, funga kuisa Vitamin B3 yekuwedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita seDNA Kugadzirisa, kubatsirwa nekupa rutsigiro rwakakodzera kune vanhu vane ERCC2 shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvinowedzera seVitamin B3, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Nicotinamide inosimudzira kugadziriswa kweiyo ultraviolet radiation-induced DNA kukuvadzwa muvanhu keratinocytes uye ex vivo ganda.
• cBioPortal yeCancer Genomics
• Hunhu hwe epidermal kukura factor receptors mune astrocytic glial uye neuronal masero mune yekutanga tsika.
• Resveratrol inogadzirisa tumor cell kuwanda uye mapuroteni kududzira kuburikidza neSIRT1-inotsamira AMPK activation.
• Cancer therapy inoumba kusimba kwenzvimbo ye clonal hematopoiesis.
• Iyo PARP inhibitor olaparib inogonesa mhedzisiro yeDNA inokuvadza mumiririri doxorubicin mu osteosarcoma.
• SIRT1 inosimudzira DNA kugadzirisa basa uye deacetylation yeKu70.