Doro Kunwa uye Njodzi yeCancer

Muchidimbu

Meta-ongororo yezvakasiyana zvidzidzo zvekucherechedza zvinoratidza kuti kunwa doro kunokonzeresa migumisiro isingadiwe sekuwedzera kwenjodzi yemhando dzakasiyana dzekenza senge kenza yemusoro neyemutsipa inosanganisira mukanwa uye gomarara gomarara, gomarara rekuzvimba, gomarara rekenza uye gomarara redundiro, pamwe macolorectal, chiropa uye kenza yemazamu, zvisinei, kunyangwe doro rinokonzera gomarara remapapu uye gomarara reprostate hazvizivikanwe.

Chirwere chegomarara ndicho chimwe chezvikonzero zviri kukonzera ndufu pasi rose. Ngozi yekubatwa negomarara inotsamira pazvinhu zvakawanda zvisiri pasi pesimba redu zvinosanganisira genetic mutations, zera, nhoroondo yemhuri kenza uye zvinhu zvakatipoteredza zvakadai sekusangana nemwaranzi. Nekudaro, kune zvimwe zvakawanda zvinokonzeresa / zvinobatsira zvakanyanya mukuvandudzwa kwemhando dzakasiyana dzegomarara (sezamu, mapapu, prostate, colorectal, musoro nemutsipa kenza uye nezvimwe) asi zviri pasi pesimba redu, senge tsika dzekudya dzinosanganisira. kunwa doro, kushandiswa kwefodya , kudya nyama tsvuku, nyama yakagadzikiswa uye kudya kwekupedzisira-yakagadzirwa pamwe chete nemararamiro emararamiro akadai sekushaikwa kwekuita basa rekuita uye maekisesaizi uye kuwedzera uremu / kufutisa. 

Doro rakagara richitaridzirwa sechikamu chakakosha chemhemberero, mapato uye kushamwaridzana. Nepo vazhinji vachinwa doro muzvikamu zvine mwero sechikamu che "kunwa munharaunda", vanhu vazhinji vanonwa doro rakawandisa nguva dzose, izvo zvinoguma zvave nemhedzisiro isingadiwe kusanganisira dzakasiyana siyana dzinotyisa hupenyu nenjodzi dzemumigwagwa. Kufa kwakawanda nguva isati yakwana (ingave yekutanga muhupenyu) kunogona kunzi kunwa doro, zvichitungamira kune vangangoita 13.5% kufa muboka rezera pakati pemakore makumi maviri kusvika makumi matatu nemapfumbamwe. (Sangano Rinoona nezve Utano Pasi pose) 

Kunwa Doro Kunogona Kenza Kanzera?

Sekureva kweWorld Health Organisation, munhu mumwe chete pamakumi maviri anofa (anenge 1% yenzufu dzepasi rose) imhaka yekunwa doro uye 20 pavatanhatu vanofa negomarara pasi rose. Nokudaro, zvidzidzo zvakasiyana zvakaitwa nevatsvakurudzi pasi rose kuti vaongorore kushamwaridzana pakati pedoro uye kenza. Mienzaniso yeimwe meta-ongororo yakadzidza kana doro rinogona kukonzera mhando dzegomarara dzakasiyana (semusoro nemutsipa, zamu, mapapu, prostate uye colorectal) zvakabatanidzwa mune ino blog. 

Doro Kunwa kunogona kukonzera Musoro uye Neck Cancer

1. Ongororo yakaitwa pahuwandu hwevanhu, pre-diagnostic mararamiro maitiro uye kiriniki data kubva kuongororo shanu mukati meInternational Head uye Neck Cancer Epidemiology (INHANCE) Consortium, iyo yaisanganisira 4759 yemusoro nemutsipa cancer (HNC) varwere vakaona kuti, pre-diagnostic alcohol kunwa chiitiko chekufungidzira chekupona kwese uye HNC-yakatarwa kupona kwevarwere vane gomarara remarara. (L (Giraldi et al, Ann Oncol., 2017)
2. Mune chidzidzo chakaburitswa muna2017, vatsvagiridzi vakashandisa doro rekumwa doro kwevarwere mazana masere negumi emusoro nemutsipa (HNC) uye ma811 ekudzora kubva kuTaiwan kuti vaongorore mubatanidzwa pakati pewaini neHNC nedzimwe nzvimbo uye vakaona kuti doro rekushandisa doro-rinotarisira kuwedzera njodzi yeHC ine njodzi yakanyanya kucherechedzwa yekenza yehypopharyngeal, inoteverwa nekenza ye oropharyngeal uye laryngeal. Iyo njodzi yakawanikwa zvakare kuve yakakwira kune vanhu vane inononoka ethanol metabolism. (Cheng-Chih Huang et al, Sci Rep., 940)
3. Meta-ongororo yedata yakawanikwa kubva kuPubmed yekutsvaga kusvika munaGunyana 2009 iyo yaisanganisira makumi mana neshanu-kutonga-uye cohort zvidzidzo zviviri zvinosanganisira 43 yemumuromo uye pharyngeal cancer (OPC) kesi dzakawana kuti vanonwa doro zvakanyanya vaibatanidzwa nenjodzi yakanyanya yekenza uye iyo njodzi yakawedzera nenzira inoenderana nedosi. Chidzidzo chacho chakawana zvakare kuti muyero wepakati we> r = 17,085 chinwiwa kana 1g ethanol / zuva rinogona zvakare kusangana neyakawedzera njodzi yeOCP. (Irene Tramacere et al, Oral Oncol., 10)
4. Kuongororwa kwedata rakawanikwa kubva mukutsvaga mabhuku mumadhata kusanganisira Embase, Latin American neCaribbean Hutano Sayenzi (LILACS), PubMed, Science Direct, uye Webhu reSainzi) kusvika Chikunguru 2018, iyo yaisanganisira zvinyorwa gumi neshanu, yakawana kuti kunwa doro nefodya zvakawedzera synergistically njodzi yemuromo squamous cell carcinoma. (Fernanda Weber Mello et al, Clin Oral Investig., 15)
5. Kuongorora kwakarongeka uye meta-ongororo yedata yakawanikwa kubva mukutsvaga kwemabhuku muPubMed uye Embase dhatabhesi kusvika muna Chikunguru 2012 iyo yaisanganisira 8 cohort / huwandu hwevanhu uye 11 nyaya-kutonga zvidzidzo zvakawana kuti kunwa doro kune varwere vane epamusoro aerodigestive turakiti (muromo wemuromo, pharynx, larynx, uye esophagus) kenza inosanganiswa nenjodzi yakawedzera yekenza yepiri yekutanga. (Nathalie Druesne-Pecollo et al, Cancer Epidemiol Biomarkers Prev. 2014)

Zvidzidzo zviri pamusoro zvinoratidza kuti kunwa doro zvakanyanya kunogona kukonzera kanzuru yemusoro neyemutsipa senge kenza yemuromo / yemuromo, gomarara reparyngeal uye gomarara redundiro. (Harindra Jayasekara, Doro Doro., 2016; V Bagnardi, Br J Cancer., 2015)

Doro Kunwa kunogona kukonzera cancer yekenza

Mune chidzidzo chakaburitswa muna 2016, vaongorori vekuChina vakaongorora data rakawanikwa kubva kuPubMed uye EMBASE dhatabhesi iyo yaisanganisira zvidzidzo makumi maviri nezvina ne24 chirwere chetachiona kesi uye ndikaona kuti kunwa zvakanyanya doro kunogona kunge kuchisanganiswa nekuwedzera kwenjodzi yekenza yeThyroid. (Xiaofei Wang et al, Oncotarget. 2016)

Chidzidzo ichi chinoratidza kuti kunwa doro zvakanyanya kunogona kukonzera cancer yekenza. 

Doro Kunwa kunogona kukonzera Esophageal Cancer

1. Mune chidzidzo chakaburitswa muna 2014, vaongorori vanobva kuYunivhesiti yeMichigan Medical School, Michigan vakaongorora data rakawanikwa kubva mukutsvaga mabhuku mumadhata kusanganisira MEDLINE, EBM wongororo, EMBASE, ISI Webhu reZivo uye BIOSIS iyo yaisanganisira zvinyorwa zvishanu uye vakaona kuti doro nefodya. kudya synergistically kwakawedzera njodzi ye kenza yegurokuro. (Anoop Prabhu et al, Am J Gastroenterol., 2014)
2. Kuongorora kwakarongeka uye meta-ongororo uchishandisa 40 kesi - kutonga uye gumi nemaviri cohort / huwandu hwevanhu hwaisanganisira 13 zvidzidzo kubva kuAmerica, 17 kubva kuAsia, 22 kubva kuAustralia uye 1 kubva kuEurope, vakawana kuti zvine mwero uye zvakanyanya kunwa doro kunogona kusangana nekuwedzera njodzi yekenza yesophageal. Chidzidzo ichi chakaona zvakare kuti kunwa doro zvakapfava kunogona zvakare kuverengerwa nekenza yesophageal muAsia, zvichiratidza mukana webasa rehutachiona hwehutachiona. (Farhad Islami et al, Int J Kenza. 13)

Izvi zvidzidzo zvinoratidza kuti kunwa doro zvakanyanya kunogona kukonzera kenza yesophageal. (V Bagnardi, Br J Cancer., 2015)

Doro Kunwa kunogona kukonzera Breast Cancer

1. Meta-ongororo yakaitwa nevatsvagiri veLanzhou University, China vachishandisa makumi maviri neshanu zvidzidzo zvakawana kuti kune hukama-hwekupindura hukama pakati pekunwa doro uye kufa nekenza yemazamu nekudzokororazve. Vakawana zvakare kuti kunwa doro kunodarika makumi maviri g / zuva kunogona kusangana nenjodzi yakawedzera yekufa nekenza yemazamu. (Yun-Jiu Gou et al, Asian Pac J Cancer Prev., 25)
2. Meta-ongororo iyo yaisanganisira chikafu chenguva zhinji yemibvunzo yakatemwa kubva ku6 vanotarisira zvidzidzo nemazana maviri ezviitiko zvekenza yemazamu kubva kuCanada, Netherlands, Sweden, neUnited States vakaona kuti kunwa doro kunogona kuve nekukwirana nemutsara mukuwedzera kwekenza yemazamu. vakadzi. Chidzidzo ichi chakaratidzawo kuti pakati pevakadzi vanonwa doro nguva dzese, kudzikisira kunwa doro kunogona kubatsira mukuderedza njodzi yekenza yemazamu. (SA Smith-Warner et al, JAMA, 200)

Izvi zvidzidzo zvinoratidza kuti kunwa doro zvakanyanya kunogona kukonzera kenza yemazamu. (V Bagnardi, Br J Cancer., 2015)

Doro Kunwa kunogona kukonzera Colorectal Cancer 

1. Meta-ongororo yakaitwa nevatsvagiri veZhejiang University Chikoro cheHuzhinji Hutano, China vachishandisa data rakawanikwa kubva mukutsvaga mabhuku muPubMed neWebhu yeSainzi kubva muna Ndira 1966 kusvika Chikumi 2013 iyo yaisanganisira zvidzidzo zveboka re9 zvakaona kuti kunwa doro zvakanyanya kunoenderana ne50. g / zuva reEthanol rinogona kuwedzera njodzi yekufa kwechirwere checancer. (Shaofang Cai et al, Eur J Cancer Prev., 2014)
2. Imwe yakafanana meta-ongororo yedata kubva ku27 cohort uye 34 kesi-yekudzora zvidzidzo zvakawanikwa kuburikidza nePapmed mabhuku kutsvagirwa kwakawana kuti kunwa doro kwe> 1 chinwiwa / zuva kunogona kusangana nenjodzi yakawedzera yekenza yakajeka. (V Fedirko et al, Ann Oncol., 2011)
3. Meta-ongororo yezvidzidzo gumi neshanu zvaisanganisira 16 macolorectal cancer kesi uye 14,276 kutonga kubva ku15,802 kesi-kutonga uye 5 nested kesi-kutonga zvidzidzo zvakawana kuti kunwisa zvakanyanya (zvinopfuura zvitatu zvinwiwa / zuva) kunogona kuve kwakabatana nekuwedzera kwakanyanya mungozi yekenza yakajeka. (Sarah McNabb, Int J Kenza., 2020)

Izvi zvidzidzo zvinoratidza kuti kunyanya kunwa doro kunogona kukonzera cancer yakajeka. (Harindra Jayasekara, Doro Doro. 2016; V Bagnardi, Br J Cancer., 2015)

Doro Kunwa kunogona kukonzera Chiropa Kenza 

1. Meta ongororo yakaitwa ichishandisa dhata rakawanikwa kubva mukutsvaga mabhuku muPubMed kusvika Chivabvu 2014 iyo yaisanganisira 112 zvinyorwa zvakaburitsa kuti chinwiwa chimwe chinwiwa pazuva (~ 12 g / zuva) chinogona kusangana ne1.1 nguva yakanyanya njodzi yekenza yechiropa. Ongororo iyi yakaratidzawo kubatana kwekunwa doro nehepatitis uye nechirwere cheshuga panjodzi yekenza yechiropa, zvisinei, ivo vakurudzira kuti zvimwe zvidzidzo zviite zvakafanana. (Shu-Chun Chuang et al, Cancer Inokonzera Kudzora., 2015)
2. Imwe meta-ongororo yakaitwa ichishandisa data rakawanikwa kubva mukutsvaga kwemabhuku muPubMed neEMBASE kusvika munaKubvumbi 2013 iyo yaisanganisira zvinyorwa gumi nezvitanhatu (16 cohorts) ine 19 zviitiko zvezviitiko uye 4445 vakafa kubva mugomarara rechiropa, vakawana 5550% inofungidzirwa yakawandisa njodzi yekenza yechiropa 46 g ethanol pazuva uye 50% ye66 g pazuva. Ongororo iyi yakaratidza chinokuvadza chinomisikidza chinwiwa chakanyanya (kunwa kwe100 kana zvimwe zvinwiwa zvinodhaka pazuva) pagomarara rechiropa, uye kushomeka kwekusangana nekunwa zvine mwero

Chero zvazvingaitika, izvi zvidzidzo zvakare zvinoratidza kuti kunwa zvakanyanya doro kunogona kukonzera gomarara rechiropa. (V Bagnardi, Br J Kenza., 2015)

Doro Kunwa kunogona kukonzera Gastric Cancer 

1. Iyo yakarongeka meta-ongororo yakaitwa uchishandisa dhata yakawanikwa kubva kuMedline yekutsvaga kusanganisira gumi zvidzidzo zvakawanikwa kuti doro rakanyanya kunwiwa rinogona kunge riine njodzi yakakwira yekenza yemudumbu. Chidzidzo ichi chakasimbisawo kuti zvese kunwa zvine mwero uye kunwisa doro kunogona kusanganiswa nenjodzi yakawedzera yekenza yemudumbu. (Ke Ma et al, Med Sci Monit., 10)
2. Meta-ongororo ye11 cohort zvidzidzo zvakawanikwa kubva kuPUBMED uye Ichushi dhatabhesi tsvagiridzo pamwe nekutsvagisa kwemaoko pahuwandu hwevaJapan vakawana kuti muzvidzidzo gumi nepfumbamwe kubva pagumi pakange pasina kubatana pakati pekunwa doro nekenza yemudumbu, zvisinei, kumwe kuongorora kwakaratidza njodzi huru yegastric kenza muvarume vane yakanyanya kunwa doro. Vatsvakurudzi vakakurudzira zvimwe zvidzidzo pamusoro pevanhu veJapan kuti vasimbise zvakafanana. (Taichi Shimazu et al, Jpn J Clin Oncol., 9)

Kunwisa kunosanganisira kunwa katatu kana zvimwe zvinwiwa zvinodhaka pazuva kunogona kukonzera kenza yemudumbu.

Doro Kunwa uye Itsvo, Prostate uye Lung Cancer Njodzi

Kidney Cancer

1. Meta-ongororo yedata yakawanikwa kubva kuPubMed, EMBASE, uye MEDLINE dhatabhesi kusvika Nyamavhuvhu 2011 iyo yaisanganisira makumi maviri emakesi-kutonga zvidzidzo, 20 cohort zvidzidzo, uye 3 kuongororwa kwakaunganidzwa kwezvidzidzo zveboka zvakawana kuti, zvinoshamisa kuti, kunwa doro kunogona kusangana nenjodzi yakaderera. yekenza yesero renal, ine mashandisirwo ekushandisa inopa kuchengetedzwa uye yakanyanya kushandiswa isingapi mamwe mabhenefiti. (DY Song et al, Br J Cancer. 1) Chidzidzo ichi chakaratidza kuti kunwa zvine mwero doro kunogona kubatsira kudzikisa njodzi yerenal cell cancer.

2. Nekudaro, imwe meta-ongororo yedata yaisanganisira makumi maviri ekuongorora (20 cohort, 4 yakaunganidzwa uye gumi neshanu-kutonga) yakawanikwa kubva mukutsvaga mabhuku muPubMed uye EMBASE dhatabhesi kusvika munaNovember 1 yakawana kuti kunwa zvine mwero uye kwakanyanya doro kunogona kusanganisirwa ne kuwedzera kwengozi yekenza yesero renal.  

Pakazara, iko kusangana pakati pekunwa doro uye kenza yeitsvo hakugone.

Prostate Cancer

Zvidzidzo zvakawanda zvakaongororawo kusangana pakati peiyo doro nekenza yeprostate njodzi. Zvisinei, kupesana kwakafanana kwakawanikwawo mune izvi zvidzidzo zvine chekuita nekusangana pakati pekunwa doro uye njodzi yekenza yeprostate (Jinhui Zhao et al, BMC Cancer., 2016; Christine M Velicer et al, Cancer yeNutriti., 2006; Matteo Rota et al, Eur J Kenza Prev., 2012). 

Lung Cancer

Kunyangwe kunwa doro kuchikonzera kuwedzera kwengozi yekenza yemapapu hazvigoneke. Nepo kumwe kuongorora kwakakarakadza kuti “ngozi yakati kurei yemapapu kenza yakabatana nekunwa > kana = 30 g doro / zuva zvichienzaniswa nekusanwa doro "(Jo L Freudenheim et al, Am J Clin Nutr., 2005), chidzidzo chechipiri chakaratidza kusabatana pakati pekunwa doro uye njodzi yekenza yemapapu mu “never” vanosvuta. (V Bagnardi et al, Ann Oncol., 2011)

Dzimwe dzidzo dzinodiwa kupedzisa kana kunwa doro kunokonzera kenza yemapapu.

Doro Kunwa uye Njodzi yeEndometrial uye Ovarian Cancers

Multiple meta-analyses zvidzidzo zvakaongorora kushamwaridzana pakati pekunwa doro uye endometrial kenza. Zvisinei, zvidzidzo hazvina kuwana hukama hunokosha pakati pezviviri. Zvizhinji zvezvidzidzo izvi zvakaratidzawo kuti mhedzisiro yacho yaive yakafanana zvisinei nerudzi rwechinwiwa chinodhaka. (Quan Zhou et al, Arch Gynecol Obstet., 2017; Qingmin Sun et al, Asia Pac J Clin Nutr. 2011)

Meta-ongororo yedata yakawanikwa kubva mukutsvaga kwemabhuku muPubMed kusvika munaGunyana 2011 yaisanganisira makumi maviri neshanu ekucherechedza, eko 27 yaive kesi-yekudzora zvidzidzo, 23 cohort zvidzidzo uye kumwe kuongorora kwakaunganidzwa kweanotarisirwa cohort zvidzidzo, kusanganisira huwandu hwese 3 epithelial ovarian cancer kesi , haina kuwana hukama pakati pekunwa doro uye njodzi yekenza yeovari.

mhedziso

Zvidzidzo zvakawanda uye meta-kuongorora zvinoratidza kuti kunwa doro kunowedzera njodzi yemhando dzakasiyana-siyana dzekenza dzakadai sekenza yemusoro nemutsipa kusanganisira kenza yemuromo uye pharyngeal, kenza yesophageal, kenza yekenza, kenza yegomarara; colorectal cancer; kenza yechiropa negomarara rezamu. Nekudaro, meta-ongororo yezvidzidzo zvakasiyana yakaratidza kuti kunwa doro kunogona kunge kusingabatanidzwe kanzira senge endometrial uye ovarian cancers, asi kune mamwe magomarara akadai sekenza yemapapu neprostate, zvidzidzo hazvina kukwana. Nekudaro, kunyangwe zvisiri pachena kana doro richikonzera kenza yemapapu, zviri nani kudzivisa doro kuti ugare uine hutano.

Pamusoro peongororo uye humbowo hwesainzi hunoratidza zvakajeka kudiwa kwekudzikisa kana zvichikwanisika, mira / dzivirira kunwa doro kudzikisa njodzi yekenza Doro shoma ratinonwa, zvirinani remangwana rine hutano!

Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.

Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.

Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.

Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (kunzvenga kufungidzira uye kusarudzika kusarudza) ndiwo mushonga wepanyama wekenza uye mitezo inoenderana nekurapwa.

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