Muchidimbu
Iyo bioactive Silymarin kubva mugwenzi- Milk Thistle, ndeye antioxidant uye yakaratidza kuti ine zvimwe zvakanaka kenza varwere senge cardio-inodzivirira mhedzisiro kuburikidza nekudzikisa oxidative kusagadzikana. Kushandiswa kweMukaka Thistle inoshanda Silymarin pamwe neDoxorubicin inobatsira vana vane leukemia nekuderedza Doxorubicin-induced cardiotoxicity sezvakaratidzwa muchidzidzo chekiriniki nevana vane acute lymphoblastic leukemia.
Doxorubicin Chemotherapy & Cardiotoxicity muLeukemia
Doxorubicin mushonga wechemotherapy wakabvumidzwa kushandiswa seyakajairwa kurapwa mune dzakawanda cancer zviratidzo zvinosanganisira acute lymphoblastic leukemia (ALL), acute myeloblastic leukemia (AML), neuroblastoma, sarcomas, zamu, ovarian, dundira, thyroid, gastric uye akawanda. mamwe magomarara. Doxorubicin inokwanisa kuuraya kukurumidza kukurumidza kukura kenza masero nekukonzera kuwandisa kweDNA kukuvadzwa uye kuwedzera oxidative kusagadzikana iyo inokonzeresa kufa kwesero. Nekudaro, kukanganiswa kweDoxorubicin uku kunokonzeresa kukuvadzwa kwakanyanya kumasero ane hutano, ane cardiotoxicity seimwe yeakanyanya mhedzisiro ine mukana wekuuraya unouraya congestive heart failure, izvo zvinogona kuitika panguva yekurapwa kana mwedzi kana makore mushure mekurapwa. . Kuwedzera mukana we cardiotoxicity, sekuongororwa nezviratidzo nezviratidzo zvakasiyana zvinosanganisira kudzikira kwekushanda kwemoyo kana shanduko yemazinga eiyo enzyme maki mamaki e cardiotoxicity, inowedzera nekuwedzera kwese kuunganidzwa kwedosi yeDoxorubicin.
Iyi conundrum yekubvisa gomarara vs.kuita neakakomba uye dzimwe nguva asingachinjiki mhedzisiro mhedzisiro dambudziko riri kuitika munharaunda yekenza. Nekudaro, kune kuenderera mberi kwekuedza kutsvaga nzira dzinogona kubatsira kudzikamisa kana kudzivirira murwere kubva kune yakaipa mhedzisiro-mhedzisiro. Vanotsvagurudza vakaongorora zvinoitika zvakasiyana zvezvirimwa zvakasikwa zvinowedzerwa kana zvichitorwa pamwe chete neDoxorubicin pane cardiotoxicity endpoints mumasero egomarara uye nemhando dzezvirwere zvemhuka, zvakafanana neizvo zvinoshandiswa mukugadzirwa kwemishonga yemishonga inogamuchirwa. Imwe yemiti yakadai yakatora Silymarin anoshanda kubva muchirimwa Mukaka rukato yakaedzwa muzvidzidzo zvakawanda zvekuyedza uye yakaratidza zvinodzivirira pamoyo.
Mukaka Thistle uye inoshanda Silymarin
Mukaka munzwa chirimwa chave chichishandiswa kwemazana emakore sekurapa kwechiropa uye bile kusagadzikana muEurope. Inowanikwawo sekuwedzera kwekudya. Rukaka rwemukaka rwakawana zita raro kubva kune mukaka wemukaka unoburitswa kana mashizha apwanyika. Iwo akakosha bioactive zvinongedzo zveMukaka Thistle mbeu dzinosanganisira Silibinin (silybin), Isosilybin, Silychristin naSilydianin iyo iri pamwe inozivikanwa seSilymarin.
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
Kushandiswa kweMukaka Thistle inoshanda Silymarin yeDoxorubicin-inosimudzira Cardiotoxicity muLeukemia
Silymarin akaratidzirwa kuyedza kuve neopiroprotective mhedzisiro painopihwa pamwe neDoxorubicin (ichideredza Doxorubicin-inosimudzira cardiotoxicity). Silymarin anokwanisa kudzora kushushikana kweiyo oxidative, iyo yakakonzera cardiotoxicity. Iyo antioxidant uye inokwanisa kudzora kukuvara kweiyo membreni uye mapuroteni nemhando yemhando yemhuka, iyo inogadzirwa sechikamu cheDoxorubicin mashandiro ekuita, nekudzivirira kupera kweiyo yakasikwa antioxidant michina yemasero ane hutano (Roskovic A et al, Molecule 2011) .
Clinical Study paSilymarin Use & Doxorubicin-inosimudzira Cardiotoxicity
Chidzidzo chekiriniki kubva kuYunivhesiti yeTanta kuEgypt chakaedza mabhenefiti / cardio-inodzivirira mhedzisiro yaSilymarin kubva kuMukaka Thistle muvana vane acute lymphoblastic leukemia (ALL), vanorapwa neDoxorubicin (Hagag AA et al, Infect Disord Zvinodhaka Zvinangwa. 2019). Muchidzidzo ichi pavana makumi masere vaneVOSE, makumi mana vavo vakarapwa naDoxorubicin pamwe naSilymarin pa80 mg / zuva (Boka I - rekuyedza) uye makumi mana vakasara vaingorapwa naDoxorubicin pasina Silymarin (Boka 40 - placebo). Kuongororwa kwekuita kwemoyo muvana ava kwakaitwa kuburikidza neyakajairika echo-Doppler zviyero zvemoyo systolic uye diastolic basa. Vakaona kuti muboka reSilymarin, pakange paine 'kuderera kwekutanga kweDoxorubicin-inosimudzira kuruboshwe ventricular systolic basa kusagadzikana (cardiotoxicity)' pamusoro penzvimbo ye placebo.
mhedziso
Chidzidzo ichi chinoratidza kuti Milk Thistle inoshanda Silymarin inogona kunge ine mabhenefiti muvarwere vegomarara senge kuderera kweDoxorubicin-induced Cardiotoxicity muVana vane leukemia. Ichi chidzidzo chekiriniki, kunyangwe chiine nhamba diki yevana leukemia, chiri kupa humwe husimbiso hwe cardioprotective mhedzisiro (benefits) yeMukaka thistle inoshanda Silymarin sezvinoonekwa mumamodhiyo echirwere chekuedza. Zvisinei nerubatsiro rwezvinowedzera zvechisikigo zvakavakirwa pakuyedza uye zvidiki zvidzidzo zvekiriniki, varwere vegomarara vanofanirwa kungwarira pakutora izvi zvinowedzera pamwe neavo kenza marapirwo. Izvi zvechisikigo zvekuwedzera hazvina kupinda mukuyedzwa kwakawanda uye kubvumidzwa kwemutemo uye hazvireve kurapa, kudzivirira kana kurapa chirwere. Zvakare, kune mikana yekuwedzera chirimwa uye kusangana kwezvinodhaka izvo zvinogona kukanganisa kurapwa uye zvinogona kuve nengozi mune dzimwe nguva. Nekudaro, varwere vegomarara vanofanirwa kugara vachionana nachiremba wavo vasati vashandisa chero chekuwedzera chepanyama.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (Kudzivirira kufungidzira uye kusarudzika kusarudza) ndiyo yakanyanya kurongeka mushonga wekenza uye kurapwa kwakanangana nemhedzisiro.